WO2004046726A3 - Methods and kits for assays of rapid screening of diabetes - Google Patents

Methods and kits for assays of rapid screening of diabetes Download PDF

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Publication number
WO2004046726A3
WO2004046726A3 PCT/EP2003/012958 EP0312958W WO2004046726A3 WO 2004046726 A3 WO2004046726 A3 WO 2004046726A3 EP 0312958 W EP0312958 W EP 0312958W WO 2004046726 A3 WO2004046726 A3 WO 2004046726A3
Authority
WO
WIPO (PCT)
Prior art keywords
glucose
patient
diabetes
concentration
ophthalmic device
Prior art date
Application number
PCT/EP2003/012958
Other languages
French (fr)
Other versions
WO2004046726A2 (en
Inventor
Carol Ann Morris
Fiona Patricia Carney
Jennifer Dawn Lane
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Carol Ann Morris
Fiona Patricia Carney
Jennifer Dawn Lane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Carol Ann Morris, Fiona Patricia Carney, Jennifer Dawn Lane filed Critical Novartis Ag
Priority to JP2004552665A priority Critical patent/JP2006506631A/en
Priority to AU2003293704A priority patent/AU2003293704A1/en
Priority to CA002506400A priority patent/CA2506400A1/en
Priority to EP03789057A priority patent/EP1565750A2/en
Publication of WO2004046726A2 publication Critical patent/WO2004046726A2/en
Publication of WO2004046726A3 publication Critical patent/WO2004046726A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Abstract

The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.
PCT/EP2003/012958 2002-11-20 2003-11-19 Methods and kits for assays of rapid screening of diabetes WO2004046726A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2004552665A JP2006506631A (en) 2002-11-20 2003-11-19 Assay method and kit for rapid screening of diabetes
AU2003293704A AU2003293704A1 (en) 2002-11-20 2003-11-19 Methods and kits for assays of rapid screening of diabetes
CA002506400A CA2506400A1 (en) 2002-11-20 2003-11-19 Methods and kits for assays of rapid screening of diabetes
EP03789057A EP1565750A2 (en) 2002-11-20 2003-11-19 Methods and kits for assays of rapid screening of diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42770502P 2002-11-20 2002-11-20
US60/427,705 2002-11-20

Publications (2)

Publication Number Publication Date
WO2004046726A2 WO2004046726A2 (en) 2004-06-03
WO2004046726A3 true WO2004046726A3 (en) 2005-01-06

Family

ID=32326585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/012958 WO2004046726A2 (en) 2002-11-20 2003-11-19 Methods and kits for assays of rapid screening of diabetes

Country Status (6)

Country Link
US (2) US20050038329A1 (en)
EP (1) EP1565750A2 (en)
JP (1) JP2006506631A (en)
AU (1) AU2003293704A1 (en)
CA (1) CA2506400A1 (en)
WO (1) WO2004046726A2 (en)

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Also Published As

Publication number Publication date
AU2003293704A1 (en) 2004-06-15
EP1565750A2 (en) 2005-08-24
WO2004046726A2 (en) 2004-06-03
US20070154395A1 (en) 2007-07-05
CA2506400A1 (en) 2004-06-03
AU2003293704A8 (en) 2004-06-15
US7429462B2 (en) 2008-09-30
US20050038329A1 (en) 2005-02-17
JP2006506631A (en) 2006-02-23

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