WO2004047844A8 - Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain - Google Patents

Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain

Info

Publication number
WO2004047844A8
WO2004047844A8 PCT/US2003/037415 US0337415W WO2004047844A8 WO 2004047844 A8 WO2004047844 A8 WO 2004047844A8 US 0337415 W US0337415 W US 0337415W WO 2004047844 A8 WO2004047844 A8 WO 2004047844A8
Authority
WO
WIPO (PCT)
Prior art keywords
loxapine
amoxapine
pain
medicament
manufacture
Prior art date
Application number
PCT/US2003/037415
Other languages
French (fr)
Other versions
WO2004047844A1 (en
Inventor
Ron L Hale
Patrik Munzar
Joshua D Rabinowitz
Original Assignee
Alexza Molecular Delivery Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexza Molecular Delivery Corp filed Critical Alexza Molecular Delivery Corp
Priority to MXPA05005611A priority Critical patent/MXPA05005611A/en
Priority to NZ540207A priority patent/NZ540207A/en
Priority to DE60325888T priority patent/DE60325888D1/en
Priority to DK03789955T priority patent/DK1567164T3/en
Priority to EP03789955A priority patent/EP1567164B1/en
Priority to JP2004555617A priority patent/JP2006514934A/en
Priority to CA002507159A priority patent/CA2507159A1/en
Priority to AU2003294470A priority patent/AU2003294470B2/en
Publication of WO2004047844A1 publication Critical patent/WO2004047844A1/en
Publication of WO2004047844A8 publication Critical patent/WO2004047844A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Loxapine, amoxapine, or salts or prodrugs of either, is effective in alleviating pain, particularly headache pain such as migraine, cluster headaches and tension headaches. Preferably the loxapine or amoxapine is administered systemically, most preferably by inhalation.
PCT/US2003/037415 2002-11-26 2003-11-20 Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain WO2004047844A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA05005611A MXPA05005611A (en) 2002-11-26 2003-11-20 Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain.
NZ540207A NZ540207A (en) 2002-11-26 2003-11-20 Loxapine (2-chloro-11(4-methyl-1-piperazinyl)dibenz(b, f) (1,4) oxazepine) for the manufacture of a medicament for the treatment of headache
DE60325888T DE60325888D1 (en) 2002-11-26 2003-11-20 USE OF LOXAPINE FOR THE MANUFACTURE OF A MEANS FOR TREATING PAIN
DK03789955T DK1567164T3 (en) 2002-11-26 2003-11-20 Use of loxapine in the manufacture of a medicament for the treatment of pain
EP03789955A EP1567164B1 (en) 2002-11-26 2003-11-20 Use of loxapine for the manufacture of a medicament for the treatment of pain
JP2004555617A JP2006514934A (en) 2002-11-26 2003-11-20 Use of loxapine or amoxapine for the manufacture of drugs for the treatment of pain
CA002507159A CA2507159A1 (en) 2002-11-26 2003-11-20 Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
AU2003294470A AU2003294470B2 (en) 2002-11-26 2003-11-20 Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42940502P 2002-11-26 2002-11-26
US60/429,405 2002-11-26

Publications (2)

Publication Number Publication Date
WO2004047844A1 WO2004047844A1 (en) 2004-06-10
WO2004047844A8 true WO2004047844A8 (en) 2007-01-25

Family

ID=32393557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/037415 WO2004047844A1 (en) 2002-11-26 2003-11-20 Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain

Country Status (15)

Country Link
US (1) US8288372B2 (en)
EP (1) EP1567164B1 (en)
JP (1) JP2006514934A (en)
CN (2) CN101371843B (en)
AT (1) ATE420647T1 (en)
AU (1) AU2003294470B2 (en)
CA (1) CA2507159A1 (en)
DE (1) DE60325888D1 (en)
DK (1) DK1567164T3 (en)
ES (1) ES2321292T3 (en)
HK (1) HK1125845A1 (en)
MX (1) MXPA05005611A (en)
NZ (1) NZ540207A (en)
PT (1) PT1567164E (en)
WO (1) WO2004047844A1 (en)

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AU2003294470A1 (en) 2004-06-18
WO2004047844A1 (en) 2004-06-10
NZ540207A (en) 2008-06-30
CN101371843B (en) 2012-09-26
HK1125845A1 (en) 2009-08-21
PT1567164E (en) 2009-03-31
EP1567164B1 (en) 2009-01-14
CN1717237A (en) 2006-01-04
ATE420647T1 (en) 2009-01-15
MXPA05005611A (en) 2005-07-27
CA2507159A1 (en) 2004-06-10
JP2006514934A (en) 2006-05-18
CN101371843A (en) 2009-02-25
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US8288372B2 (en) 2012-10-16
AU2003294470B2 (en) 2009-09-17

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