WO2004047871A3 - Modified naturetic compounds, conjugates, and uses thereof - Google Patents

Modified naturetic compounds, conjugates, and uses thereof Download PDF

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Publication number
WO2004047871A3
WO2004047871A3 PCT/US2003/037996 US0337996W WO2004047871A3 WO 2004047871 A3 WO2004047871 A3 WO 2004047871A3 US 0337996 W US0337996 W US 0337996W WO 2004047871 A3 WO2004047871 A3 WO 2004047871A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugates
compounds
modified
disclosed
natriuretic
Prior art date
Application number
PCT/US2003/037996
Other languages
French (fr)
Other versions
WO2004047871A2 (en
Inventor
Kenneth D James
Balasingam Radhakrishnan
Navdeep B Malkar
Mark A Miller
Nnochiri N Ekwuribe
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Priority to DE60331584T priority Critical patent/DE60331584D1/en
Priority to AT03812053T priority patent/ATE459370T1/en
Priority to AU2003297583A priority patent/AU2003297583B2/en
Priority to BR0316560-4A priority patent/BR0316560A/en
Priority to CA002504287A priority patent/CA2504287A1/en
Priority to EP03812053A priority patent/EP1569683B1/en
Priority to JP2004555809A priority patent/JP2006515579A/en
Publication of WO2004047871A2 publication Critical patent/WO2004047871A2/en
Publication of WO2004047871A3 publication Critical patent/WO2004047871A3/en
Priority to HK06107556.5A priority patent/HK1087327A1/en
Priority to AU2010201455A priority patent/AU2010201455A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Abstract

Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, subcutaneous, and intravenous forms to of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.
PCT/US2003/037996 2002-11-26 2003-11-12 Modified naturetic compounds, conjugates, and uses thereof WO2004047871A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE60331584T DE60331584D1 (en) 2002-11-26 2003-11-12 MODIFIED NATRIURETIC COMPOUNDS, CONJUGATES, AND ITS USES
AT03812053T ATE459370T1 (en) 2002-11-26 2003-11-12 MODIFIED NATRIURETIC COMPOUNDS, CONJUGATES AND USES THEREOF
AU2003297583A AU2003297583B2 (en) 2002-11-26 2003-11-12 Modified naturetic compounds, conjugates, and uses thereof
BR0316560-4A BR0316560A (en) 2002-11-26 2003-11-12 Natriuretic Compound Conjugate, Pharmaceutical Formulation, Method of Treating a Condition, Method of Preparing the Natriuretic Compound Conjugate, Modified Pro-Polynatriuretic Peptide Conjugate, Natriuretic Peptide Analog, hbnp Analogue, Compound, and Method of Preparing a Compound
CA002504287A CA2504287A1 (en) 2002-11-26 2003-11-12 Natriuretic compounds, conjugates, and uses thereof
EP03812053A EP1569683B1 (en) 2002-11-26 2003-11-12 Modified natriuretic compounds, conjugates, and uses thereof
JP2004555809A JP2006515579A (en) 2002-11-26 2003-11-26 Natriuretic compounds, conjugates, and uses thereof
HK06107556.5A HK1087327A1 (en) 2002-11-26 2006-07-04 Modified natriuretic compounds, conjugates, and uses thereof
AU2010201455A AU2010201455A1 (en) 2002-11-26 2010-04-13 Modified natriuretic compounds, conjugates, and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42915102P 2002-11-26 2002-11-26
US60/429,151 2002-11-26

Publications (2)

Publication Number Publication Date
WO2004047871A2 WO2004047871A2 (en) 2004-06-10
WO2004047871A3 true WO2004047871A3 (en) 2005-03-17

Family

ID=32393512

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/037996 WO2004047871A2 (en) 2002-11-26 2003-11-12 Modified naturetic compounds, conjugates, and uses thereof

Country Status (13)

Country Link
US (1) US7662773B2 (en)
EP (1) EP1569683B1 (en)
JP (1) JP2006515579A (en)
CN (1) CN100558398C (en)
AT (1) ATE459370T1 (en)
AU (2) AU2003297583B2 (en)
BR (1) BR0316560A (en)
CA (1) CA2504287A1 (en)
DE (1) DE60331584D1 (en)
HK (1) HK1087327A1 (en)
PL (1) PL377813A1 (en)
SG (1) SG159387A1 (en)
WO (1) WO2004047871A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662773B2 (en) 2002-11-26 2010-02-16 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US9102707B2 (en) 2011-08-30 2015-08-11 Mayo Foundation For Medical Education And Research Natriuretic polypeptides

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
AU2003268531A1 (en) 2002-09-06 2004-03-29 University Of South Florida Materials and methods for treatment of allergic diseases
WO2004022579A2 (en) * 2002-09-06 2004-03-18 University Of South Florida Cellular delivery of natriuretic peptides
US20080214437A1 (en) * 2002-09-06 2008-09-04 Mohapatra Shyam S Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases
US7648962B2 (en) 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
PT1660047E (en) 2003-08-13 2014-02-27 Biocon Ltd Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
EP1727556A2 (en) * 2004-02-17 2006-12-06 University Of South Florida Materials and methods for treatment of inflammatory and cell proliferation disorders
DK2348114T3 (en) 2004-04-21 2018-09-03 Alexion Pharma Inc BONE DELIVERY CONJUGATES AND PROCEDURE TO USE IT FOR TARGETING PROTEINS AGAINST BONE
DE602005026014D1 (en) 2004-07-15 2011-03-03 Univ Queensland PROTEIN-type compounds and applications thereof
WO2006076471A2 (en) * 2005-01-12 2006-07-20 Nobex Corporation Bnp conjugates and methods of use
US7300494B2 (en) * 2005-02-24 2007-11-27 Hamilton Sundstrand Corporation On-board inert gas generation system with compressor surge protection
ES2554713T3 (en) 2005-04-07 2015-12-22 Cardiorentis Ag Use of a natriuretic peptide to treat heart failure
US7767784B2 (en) 2005-07-29 2010-08-03 Nektar Therapeutics Methods for preparing polymeric reagents and compositions of polymeric reagents
US7803901B2 (en) 2005-09-16 2010-09-28 Mayo Foundation For Medical Education And Research Polypeptides with natriuresis activity
WO2007047834A2 (en) * 2005-10-18 2007-04-26 Biocon Limited Oral peptide conjugates for metabolic diseases
CA2647146A1 (en) 2006-03-30 2007-10-11 Palatin Technologies, Inc. Linear natriuretic peptide constructs
BRPI0709427A2 (en) 2006-03-30 2011-07-12 Palatin Technologies Inc "Cyclic construct, pharmaceutical composition and use of a compound
EP2051585A4 (en) * 2006-04-28 2010-06-02 Univ South Florida Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor
DK2687223T3 (en) 2006-05-30 2017-10-23 Mayo Foundation Detection and treatment of dementia
EP2687223B1 (en) 2006-05-30 2017-07-12 Mayo Foundation For Medical Education And Research Detecting and treating dementia
US8486412B2 (en) 2006-06-01 2013-07-16 Mayo Foundation For Medical Education And Research Immunity to folate receptors
WO2008088582A2 (en) 2006-08-04 2008-07-24 Mayo Foundation For Medical Education And Research Methods and materials related to trail isoforms
EP2295445A1 (en) 2006-09-08 2011-03-16 Mayo Foundation for Medical Education and Research Aquaretic and natriuretic polypeptides lacking vasodilatory activity
BRPI0811052A2 (en) 2007-04-12 2015-01-27 Univ Minnesota ISCHEMIA / REPERFUSION PROTECTION COMPOSITIONS AND METHODS OF USE.
KR20080098216A (en) * 2007-05-04 2008-11-07 한미약품 주식회사 Natriuretic peptide conjugate using carrier substance
CL2008003476A1 (en) 2007-11-21 2009-08-14 Biomarin Pharm Inc C-type natriuretic peptide variant (cnp); pharmaceutical composition comprising it; and its use to treat skeletal dysplasia or vascular smooth muscle disorder.
WO2009156481A1 (en) * 2008-06-25 2009-12-30 Ascendis Pharma As Pegylated bnp
EP2334334A1 (en) 2008-09-19 2011-06-22 Nektar Therapeutics Polymer conjugates of nesiritide peptides
US20110166063A1 (en) 2008-09-19 2011-07-07 Nektar Therapeutics Polymer conjugates of therapeutic peptides
CA2758581C (en) 2009-05-20 2022-06-14 Biomarin Pharmaceutical Inc. Variants of c-type natriuretic peptide
US20120108514A1 (en) 2009-07-09 2012-05-03 University Of Iowa Research Foundation Long acting atrial natriuretic peptide (la-anp) and methods for use thereof
CN102470163B (en) 2009-07-23 2016-06-15 Igisu株式会社 Dermatologic preparation composition
SG10201503080XA (en) 2010-04-27 2015-06-29 Agency Science Tech & Res Eif4e binding peptides
WO2012013597A1 (en) * 2010-07-28 2012-02-02 Justus-Liebig-Universität Giessen Substances and the use thereof for influencing natriuretic peptide receptors
US9266939B2 (en) 2010-12-27 2016-02-23 Alexion Pharmaceuticals, Inc. Compositions comprising natriuretic peptides and methods of use thereof
US20120277155A1 (en) 2011-02-25 2012-11-01 Medtronic, Inc. Therapy for kidney disease and/or heart failure
US20140072557A1 (en) 2011-02-28 2014-03-13 National Cerebral And Cardiovascular Center Medicinal agent for suppressing malignant tumor metastasis
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
US9233143B2 (en) 2011-08-19 2016-01-12 National Cerebral And Cardiovascular Center Medicinal agent for preventing exacerbation of malignant tumor, comprising combination of natriuretic peptide receptor GC-A and GC-B agonists
EP2750697A4 (en) 2011-09-02 2015-03-25 Medtronic Inc Chimeric natriuretic peptide compositions and methods of preparation
KR20140084201A (en) 2011-10-19 2014-07-04 알렉시온 파마 홀딩 Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
WO2013138850A1 (en) * 2012-03-19 2013-09-26 Madeleine Pharmaceuticals Ρτy Ltd Method of producing a recombinant peptide
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
TW201442721A (en) 2013-01-23 2014-11-16 Daiichi Sankyo Co Ltd Glycosilated atrial natriuretic peptide
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
WO2016090251A1 (en) 2014-12-05 2016-06-09 Alexion Pharmaceuticals, Inc. Treating seizure with recombinant alkaline phosphatase
CA2973883A1 (en) 2015-01-28 2016-08-04 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
AU2016272282A1 (en) * 2015-05-29 2018-01-25 Igisu Co., Ltd. Cyclic peptide, and medicine, external preparation and cosmetic each containing said cyclic peptide
RU2745528C2 (en) 2015-08-17 2021-03-26 Алексион Фармасьютикалз, Инк. Production of alkaline phosphatases
US11229686B2 (en) 2015-09-28 2022-01-25 Alexion Pharmaceuticals, Inc. Reduced frequency dosage regimens for tissue non-specific alkaline phosphatase (TNSALP)-enzyme replacement therapy of hypophosphatasia
WO2017074466A1 (en) 2015-10-30 2017-05-04 Alexion Pharmaceuticals, Inc. Methods for treating craniosynostosis in a patient
CA3007987C (en) * 2016-01-08 2023-08-29 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with low npr-c binding
CA3008017C (en) 2016-01-08 2024-01-02 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with reduced side-effects
SG11201805028RA (en) 2016-01-08 2018-07-30 Ascendis Pharma Growth Disorders As Controlled-release cnp agonists with increased nep stability
CA3007979C (en) 2016-01-08 2023-12-19 Ascendis Pharma Growth Disorders A/S Cnp prodrugs with carrier attachment at the ring moiety
NZ743488A (en) * 2016-01-08 2023-02-24 Ascendis Pharma Growth Disorders As Controlled-release cnp agonists with low initial npr-b activity
CA3007976C (en) 2016-01-08 2023-09-26 Ascendis Pharma Growth Disorders A/S Cnp prodrugs with large carrier moieties
EP3426286A4 (en) 2016-03-08 2019-12-04 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
CA3019726A1 (en) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Treating muscle weakness with alkaline phosphatases
WO2017173395A1 (en) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
WO2017214130A1 (en) 2016-06-06 2017-12-14 Alexion Pharmaceuticals, Inc. Metal impact on manufacturing of alkaline phosphatases
JP7018933B2 (en) 2016-08-18 2022-02-14 アレクシオン ファーマシューティカルズ， インコーポレイテッド How to treat bronchomalacia
US10307398B2 (en) 2016-09-20 2019-06-04 Regents Of The University Of Minnesota Resuscitation composition and methods of making and using
CA3037448A1 (en) 2016-09-29 2018-04-05 Ascendis Pharma Growth Disorders A/S Combination therapy with controlled-release cnp agonists
US11072642B2 (en) 2016-11-09 2021-07-27 Mayo Foundation For Medical Education And Research MANP analogues
JP7126270B2 (en) * 2017-03-22 2022-08-26 ファーマイン コーポレイション NPRA agonists, compositions and uses thereof
AU2018243320A1 (en) 2017-03-31 2019-10-10 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia (HPP) in adults and adolescents
CN111432836A (en) 2017-09-05 2020-07-17 转矩医疗股份有限公司 Therapeutic protein compositions and methods of making and using same
KR20210031848A (en) 2017-09-05 2021-03-23 토크 테라퓨틱스, 인코포레이티드 Reversible linker and uses thereof
EP3770143A4 (en) 2018-03-20 2021-12-22 NOF Corporation Branched monodispersed polyethylene glycol, intermediate, and method for producing same
US11913039B2 (en) 2018-03-30 2024-02-27 Alexion Pharmaceuticals, Inc. Method for producing recombinant alkaline phosphatase
KR102022118B1 (en) * 2019-01-07 2019-09-18 주식회사 아스트로젠 Serine derivative compound for the prevention or treatment of centralnervous system diseases
CN110278941B (en) * 2019-07-11 2021-05-28 西安国际医学中心有限公司 Isolated heart protection solution containing natriuretic peptide
CN111978390B (en) * 2020-08-31 2022-10-14 上海景泽生物技术有限公司 Polyethylene glycol modified rhBNP and application thereof
CN111848776B (en) * 2020-08-31 2022-03-18 江苏璟泽生物医药有限公司 Polyethylene glycol modified rhBNP and preparation method thereof
WO2023039392A1 (en) * 2021-09-07 2023-03-16 Mayo Foundation For Medical Education And Research Methods and materials for determining pgc target dosage
CN114316020A (en) * 2021-12-28 2022-04-12 南京岚煜生物科技有限公司 BNP recombinant protein, preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0295679A2 (en) * 1987-06-17 1988-12-21 Daiichi Pure Chemicals Co. Ltd. Physiologically-active novel peptides
US5342940A (en) * 1989-05-27 1994-08-30 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, process for preparing the same
US6162902A (en) * 1996-03-04 2000-12-19 Scios Inc. Human BNP-specific antibodies
WO2000078302A1 (en) * 1999-06-19 2000-12-28 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydrolyzable lipophile components and methods for making and using the same
WO2002098446A1 (en) * 2001-06-04 2002-12-12 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4044196A (en) * 1972-03-30 1977-08-23 Bayer Aktiengesellschaft Crosslinked copolymers of α,β-olefinically unsaturated dicarboxylic anhydrides
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
EP0083367A1 (en) * 1981-07-02 1983-07-13 WALTON, Alan G. Glycosaminoglycan drug complexes
EP0092918B1 (en) 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Continuous release formulations
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5037741A (en) * 1986-08-18 1991-08-06 The Coca Cola Company Enzymatic method for the synthesis and separation of peptides
US5114923A (en) 1988-05-31 1992-05-19 California Biotechnology Inc. Recombinant techniques for production of novel natriuretic and vasodilator peptides
CA1339210C (en) * 1988-05-31 1997-08-05 John Lewicki Recombinant techniques for production of novel natriuretic and vasodilator peptides
JP2539665B2 (en) * 1988-06-20 1996-10-02 日本臓器製薬株式会社 Neurological drug
JP2561513B2 (en) 1988-07-04 1996-12-11 塩野義製薬株式会社 Monoclonal antibody that recognizes γ-ANP
JPH0720857B2 (en) 1988-08-11 1995-03-08 テルモ株式会社 Liposome and its manufacturing method
IT1229514B (en) 1989-01-30 1991-09-03 Farmhispania S A A Montme SYNTHETIC AMPHIPHILIC GLYCOCONUGATES FOR NEUROLOGICAL USE.
US20020086843A1 (en) 1989-03-01 2002-07-04 Daiichi Pure Chemicals Co., Ltd. Physiologically active polypeptide and DNA
DK0385476T4 (en) 1989-03-01 1999-12-20 Shionogi & Co Physiologically active polypeptide and DNA
JP3394040B2 (en) 1989-06-23 2003-04-07 ジェネンテック・インコーポレーテッド Compositions and methods of synthesis and use of natriuretic protein receptor B
US5108568A (en) * 1989-07-07 1992-04-28 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Controlled method of reducing electrophoretic mobility of macromolecules, particles or cells
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
SE8904407L (en) 1989-12-29 1991-06-30 Qingpingfeng MEDICATION FOR TREATMENT OF HEART FAILURE
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
US5202239A (en) 1990-08-07 1993-04-13 Scios Nova Inc. Expression of recombinant polypeptides with improved purification
JP3026354B2 (en) 1990-09-27 2000-03-27 壽之 松尾 Human CNP gene and precursor protein
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
ATE253639T1 (en) 1991-08-19 2003-11-15 Daiichi Suntory Pharma Co Ltd METHOD FOR PRODUCING PEPTIDES
JP2665850B2 (en) * 1991-11-14 1997-10-22 塩野義製薬株式会社 Monoclonal antibody recognizing the C-terminus of hBNP
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
WO1995028952A1 (en) 1992-12-09 1995-11-02 Haemopep Pharma Gmbh Use of brain natriuretic peptides (bnp), phosphorylated urodilatine, phosphorylated cdd/anp and combinations thereof
US6191105B1 (en) * 1993-05-10 2001-02-20 Protein Delivery, Inc. Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin
US5681811A (en) 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5512459A (en) * 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
WO1995006467A1 (en) 1993-08-28 1995-03-09 The University Of Sheffield Treatment of laminitis
US6525022B1 (en) 1993-11-12 2003-02-25 Genentech, Inc. Receptor specific atrial natriuretic peptides
US6037145A (en) 1994-09-07 2000-03-14 Suntory Limited Process for production of protein
EP0721105B1 (en) * 1994-12-09 1999-05-12 Shionogi & Co., Ltd. Sandwich immunoassay for N-peptide
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
EP0856026A1 (en) 1995-10-19 1998-08-05 Receptagen Corporation Discrete-length polyethylene glycols
ATE493141T1 (en) 1996-03-22 2011-01-15 Stryker Corp METHOD FOR IMPROVED FUNCTIONAL RECOVERY OF MOTOR COORDINATION, LANGUAGE OR SENSORY PERCEPTION AFTER CNS TRAUMA OR ISCHEMIA
AU4816497A (en) 1996-10-22 1998-05-15 Genentech Inc. Receptor specific brain natriuretic peptide (bnp)
US6028055A (en) 1996-10-22 2000-02-22 Genetech, Inc. Receptor selective BNP
WO1998045329A1 (en) 1997-04-04 1998-10-15 Novo Nordisk A/S Natriuretic peptide derivatives
GB9716790D0 (en) 1997-08-07 1997-10-15 Creative Peptides Sweden Ab Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof
US20040005669A1 (en) * 1997-08-07 2004-01-08 Stefan Stahl Recombinant expression of insulin C-peptide
US6013630A (en) 1997-08-21 2000-01-11 Curagen Corporation Atrial natriuretic factor mutants and ischemic stroke
DE69830668T3 (en) 1997-10-24 2011-07-14 Shionogi & Co., Ltd. PROCESS FOR INHIBITING THE DEGRADATION OF NATRIURETIC PEPTIDES AND IMPROVED METHOD FOR DETERMINING THE NATRIURETIC PEPTIDES
US6495514B1 (en) * 1998-01-21 2002-12-17 Mercer University Method for reducing inflammation and inducing an analgesic effect and compounds thereof
JP4394279B2 (en) * 1998-03-09 2010-01-06 ジーランド ファーマ アクティーゼルスカブ Pharmacologically active peptide conjugates with reduced propensity to enzymatic hydrolysis
US6117644A (en) * 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
SE9802946D0 (en) 1998-09-02 1998-09-02 Europrofil Ab Procedures and moldings to cover joints or make transitions in connection with coatings
JP3799465B2 (en) * 1998-09-28 2006-07-19 参天製薬株式会社 Eye drops for promoting lacrimal secretion or treating keratoconjunctival disorders containing natriuretic peptide as an active ingredient
ES2180511T3 (en) 1999-01-26 2003-02-16 Lilly Co Eli MONODISPERSE FORMULATIONS OF HEXAMERIC INSULIN ANALOGS.
EP1623994A3 (en) * 1999-05-17 2008-07-16 ConjuChem Biotechnologies Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
AU5043900A (en) 1999-05-24 2000-12-12 Mayo Foundation For Medical Education And Research Adenovirus vectors encoding brain natriuretic peptide
KR100345214B1 (en) * 1999-08-17 2002-07-25 이강춘 The nasal transmucosal delivery of peptides conjugated with biocompatible polymers
US6610043B1 (en) * 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
US6713454B1 (en) * 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
US6541508B2 (en) * 1999-09-13 2003-04-01 Nobex Corporation Taxane prodrugs
US7127290B2 (en) 1999-10-01 2006-10-24 Cardiac Pacemakers, Inc. Cardiac rhythm management systems and methods predicting congestive heart failure status
US6638906B1 (en) * 1999-12-13 2003-10-28 Nobex Corporation Amphiphilic polymers and polypeptide conjugates comprising same
US6407211B1 (en) 1999-12-17 2002-06-18 Mayo Foundation For Medical Education And Research Chimeric natriuretic peptides
JP4237375B2 (en) * 2000-03-31 2009-03-11 アスビオファーマ株式会社 Pharmaceutical composition used for treatment or prevention of ischemic disease
EP1642885B1 (en) * 2000-08-29 2009-11-11 Biocon Limited Use of a pharmaceutical composition containing a para-aminophenyl acetic acid derivative for treating inflammatory conditions of the gastrointestinal tract
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
FR2823993B1 (en) * 2001-04-27 2003-06-20 Rhodia Chimie Sa STABLE AQUEOUS COLLOIDAL DISPERSION, PREPARATION METHOD THEREOF
ATE458199T1 (en) * 2001-05-04 2010-03-15 Biosite Inc DIAGNOSTIC MARKERS OF ACUTE CORONARY SYNDROME AND THEIR USES
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) * 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6737913B2 (en) * 2001-06-15 2004-05-18 Silicon Laboratories, Inc. Differential mode circuitry and method of calibrating same without matched external current sources
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
DK1430082T3 (en) 2001-09-07 2010-01-18 Biocon Ltd Process for the Synthesis of Insulin Polypeptide Oligomer Conjugates and Proinsulin Polypeptide Oligomer Conjugates and Method for Synthesis thereof
WO2003081246A1 (en) * 2002-03-18 2003-10-02 Scios Inc. Treatment of congestive heart failure with natriuretic peptide and a diuretic
AU2003246500A1 (en) 2002-07-31 2004-02-16 Conjuchem Biotechnologies Inc. Long lasting natriuretic peptide derivatives
US20040152769A1 (en) 2002-11-09 2004-08-05 Ekwuribe Nnochiri Nkem Modified carbamate-containing prodrugs and methods of synthesizing same
CA2504287A1 (en) 2002-11-26 2004-06-10 Nobex Corporation Natriuretic compounds, conjugates, and uses thereof
US20060198819A1 (en) * 2003-08-08 2006-09-07 Novo Nordisk Healthcare A/G Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0295679A2 (en) * 1987-06-17 1988-12-21 Daiichi Pure Chemicals Co. Ltd. Physiologically-active novel peptides
US5342940A (en) * 1989-05-27 1994-08-30 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, process for preparing the same
US6162902A (en) * 1996-03-04 2000-12-19 Scios Inc. Human BNP-specific antibodies
WO2000078302A1 (en) * 1999-06-19 2000-12-28 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydrolyzable lipophile components and methods for making and using the same
WO2002098446A1 (en) * 2001-06-04 2002-12-12 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHANG T K ET AL: "Subtiligase: a tool for semisynthesis of proteins.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 20 DEC 1994, vol. 91, no. 26, 20 December 1994 (1994-12-20), pages 12544 - 12548, XP002280083, ISSN: 0027-8424 *
CONDON, J. AM. OIL. CHEM. SOC., vol. 71, no. 7, 1994, pages 739 - 741, XP001181312 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662773B2 (en) 2002-11-26 2010-02-16 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US9102707B2 (en) 2011-08-30 2015-08-11 Mayo Foundation For Medical Education And Research Natriuretic polypeptides
US9441027B2 (en) 2011-08-30 2016-09-13 Mayo Foundation For Medical Education And Research Natriuretic polypeptides
US9587004B2 (en) 2011-08-30 2017-03-07 Mayo Foundation For Medical Education And Research Natriuretic polypeptides

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