WO2004050678A3 - Compounds resistant to metabolic deactivation and methods of use - Google Patents

Compounds resistant to metabolic deactivation and methods of use Download PDF

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Publication number
WO2004050678A3
WO2004050678A3 PCT/US2003/038638 US0338638W WO2004050678A3 WO 2004050678 A3 WO2004050678 A3 WO 2004050678A3 US 0338638 W US0338638 W US 0338638W WO 2004050678 A3 WO2004050678 A3 WO 2004050678A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
fungal
infections
compounds resistant
Prior art date
Application number
PCT/US2003/038638
Other languages
French (fr)
Other versions
WO2004050678A2 (en
Inventor
Robert Ronald Kane
Hu-Min Chang
Original Assignee
Univ Baylor
Robert Ronald Kane
Hu-Min Chang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Baylor, Robert Ronald Kane, Hu-Min Chang filed Critical Univ Baylor
Priority to AU2003293404A priority Critical patent/AU2003293404A1/en
Priority to CA002508479A priority patent/CA2508479A1/en
Priority to JP2004557605A priority patent/JP2006510633A/en
Priority to EP03790351A priority patent/EP1581547A2/en
Publication of WO2004050678A2 publication Critical patent/WO2004050678A2/en
Publication of WO2004050678A3 publication Critical patent/WO2004050678A3/en
Priority to US11/145,550 priority patent/US20060122144A1/en
Priority to US11/789,809 priority patent/US20080070859A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Abstract

Therapeutic compounds having increased resistance to deamination and inactivation by metabolic enzymes are provided. The compounds include nucleotide analogs and nucleotide analogs, derivatized with aminal and/or thioaminal groups to prevent deamination of free amine. The compounds can be used in a variety of treatments, including treatment of neoplastic disorders, infections from fungal or fungal like organisms, and infections from parasites.
PCT/US2003/038638 2002-12-03 2003-12-03 Compounds resistant to metabolic deactivation and methods of use WO2004050678A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2003293404A AU2003293404A1 (en) 2002-12-03 2003-12-03 Compounds resistant to metabolic deactivation and methods of use
CA002508479A CA2508479A1 (en) 2002-12-03 2003-12-03 Compounds resistant to metabolic deactivation and methods of use
JP2004557605A JP2006510633A (en) 2002-12-03 2003-12-03 Compounds resistant to metabolic inactivation and methods of use
EP03790351A EP1581547A2 (en) 2002-12-03 2003-12-03 Compounds resistant to metabolic deactivation and methods of use
US11/145,550 US20060122144A1 (en) 2002-12-03 2005-06-02 Compounds resistant to metabolic deactivation and methods of use
US11/789,809 US20080070859A1 (en) 2002-12-03 2007-04-25 Compounds resistant to metabolic deactivation and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43039702P 2002-12-03 2002-12-03
US60/430,397 2002-12-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/145,550 Continuation US20060122144A1 (en) 2002-12-03 2005-06-02 Compounds resistant to metabolic deactivation and methods of use

Publications (2)

Publication Number Publication Date
WO2004050678A2 WO2004050678A2 (en) 2004-06-17
WO2004050678A3 true WO2004050678A3 (en) 2004-08-19

Family

ID=32469463

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038638 WO2004050678A2 (en) 2002-12-03 2003-12-03 Compounds resistant to metabolic deactivation and methods of use

Country Status (6)

Country Link
US (2) US20060122144A1 (en)
EP (1) EP1581547A2 (en)
JP (1) JP2006510633A (en)
AU (1) AU2003293404A1 (en)
CA (1) CA2508479A1 (en)
WO (1) WO2004050678A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006516641A (en) * 2003-02-03 2006-07-06 シーブイ・セラピューティクス・インコーポレイテッド Full and partial agonists of adenosine receptors
EP1804771A2 (en) * 2004-10-28 2007-07-11 Idexx Laboratories, Inc. Compositions for controlled delivery of pharmaceutically active compounds
US8114440B2 (en) * 2005-11-16 2012-02-14 Idexx Laboratories Inc. Pharmaceutical compositions for the administration of aptamers
US7754679B2 (en) * 2005-11-16 2010-07-13 Idexx Laboratories, Inc. Pharmaceutical compositions for the administration of aptamers
US8828960B2 (en) * 2007-07-17 2014-09-09 Idexx Laboratories, Inc. Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
CN105524008B (en) * 2014-10-21 2018-09-07 山东轩竹医药科技有限公司 The preparation method of oxazolidone antibacterial drug intermediate
CN104447925B (en) * 2014-11-26 2016-10-26 湖北省农业科学院农产品加工与核农技术研究所 A kind of method of cordycepin in hyperpressure extraction Cordyceps militaris rice medium
US11179349B2 (en) * 2016-02-04 2021-11-23 Yang Qin Use of tumor gene methylation regulator and anti-tumor drugs
CN109111445B (en) * 2018-11-02 2020-12-18 哈尔滨商业大学 Synthesis method and application of 5 '-furoyl ester-3' -deoxyadenosine
CN113717240B (en) * 2021-09-09 2023-10-17 哈尔滨商业大学 Nucleoside compound and preparation method thereof
CN114716494A (en) * 2022-04-06 2022-07-08 郑州大学 Antiviral cordycepin base N6 modified compound and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5589296A (en) * 1978-12-27 1980-07-05 Agency Of Ind Science & Technol Novel adenosine derivative having dhysiological activity
JPS55160795A (en) * 1979-06-01 1980-12-13 Yamasa Shoyu Co Ltd N6-dialkylaminomethylene cordycepin and its prparation
JPS57114516A (en) * 1981-07-27 1982-07-16 Agency Of Ind Science & Technol Inhibitor of phosphodiesterase reaction
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
WO2000075142A2 (en) * 1999-05-25 2000-12-14 The Penn State Research Foundation Dna methyltransferase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54112894A (en) * 1978-02-20 1979-09-04 Agency Of Ind Science & Technol Novel adenine derivative and its preparation
JPS5536452A (en) * 1978-09-07 1980-03-14 Agency Of Ind Science & Technol Novel adenine derivative stable under alkaline condition and its preparation
US5233041A (en) * 1991-10-07 1993-08-03 Glaxo Group Limited Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone from a 2,3-unsaturated-1-cyclopentanylpurinone
US5434257A (en) * 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
YU43193A (en) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-DEOXY-2 ', 2'-DIFLUORO (4-SUBSTITUTED) PYRIMIDINE NUCLEOSIDS OF ANTIVIRUS AND ANTICANCEROGENIC ACTIVITY AND INTERMEDIATES
US5679648A (en) * 1994-11-30 1997-10-21 The University Hospital Methods for the treatment and prevention of fungal infections by administration of 3'-deoxypurine nucleosides
AU709345B2 (en) * 1995-09-07 1999-08-26 Emory University Therapeutic azide compounds
US6509331B1 (en) * 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5589296A (en) * 1978-12-27 1980-07-05 Agency Of Ind Science & Technol Novel adenosine derivative having dhysiological activity
JPS55160795A (en) * 1979-06-01 1980-12-13 Yamasa Shoyu Co Ltd N6-dialkylaminomethylene cordycepin and its prparation
JPS57114516A (en) * 1981-07-27 1982-07-16 Agency Of Ind Science & Technol Inhibitor of phosphodiesterase reaction
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
WO2000075142A2 (en) * 1999-05-25 2000-12-14 The Penn State Research Foundation Dna methyltransferase inhibitors

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BRIDSON, PETER K. ET AL: "A novel method for the methylation of heterocyclic amino groups. Conversion of guanosine into its 2-N-methyl- and 2-N,2-N-dimethyl derivatives", BIOORGANIC CHEMISTRY , 8(3), 339-49 CODEN: BOCMBM; ISSN: 0045-2068, 1979, XP009031001 *
BRIDSON, PETER K. ET AL: "Reactions between ribonucleoside derivatives and formaldehyde in ethanol solution", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS , (5), 208-9 CODEN: JCCCAT; ISSN: 0022-4936, 1980, XP009031678 *
BRIMACOMBE, R. ET AL: "Oligonucleotidic compounds. XXIII. Protected derivatives of guanosine and adenosine 3'-phosphates. A synthesis of diribonucleoside phosphates starting from adenosine and guanosine derivatives bearing a free NH2 grou", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS , 33(6), 2074-86 CODEN: CCCCAK; ISSN: 0010-0765, 1968, XP009030999 *
HORWITZ, JEROME P. ET AL: "Nucleosides. XIII. Concurrent introduction of two different blocking groups into some ribonucleosides", JOURNAL OF ORGANIC CHEMISTRY , 36(19), 2809-12 CODEN: JOCEAH; ISSN: 0022-3263, 1971, XP002284906 *
PATENT ABSTRACTS OF JAPAN vol. 0041, no. 40 (C - 026) 3 October 1980 (1980-10-03) *
PATENT ABSTRACTS OF JAPAN vol. 0050, no. 35 (C - 046) 5 March 1981 (1981-03-05) *
PATENT ABSTRACTS OF JAPAN vol. 0062, no. 08 (C - 130) 20 October 1982 (1982-10-20) *
YAMAZAKI, YOSHIMITSU ET AL: "N6-Alkylthiomethyl and N6-arylthiomethyl derivatives of adenosine and their cytokinin activity", AGRICULTURAL AND BIOLOGICAL CHEMISTRY , 43(9), 1945-50 CODEN: ABCHA6; ISSN: 0002-1369, 1979, XP009031000 *
ZEMLICKA, JIRI ET AL: "Some transformations of DL-phenylalanine ortho esters and N-benzyloxycarbonyl-L-phenylalaninal", JOURNAL OF ORGANIC CHEMISTRY , 41(20), 3317-21 CODEN: JOCEAH; ISSN: 0022-3263, 1976, XP002284907 *

Also Published As

Publication number Publication date
AU2003293404A1 (en) 2004-06-23
WO2004050678A2 (en) 2004-06-17
US20080070859A1 (en) 2008-03-20
US20060122144A1 (en) 2006-06-08
JP2006510633A (en) 2006-03-30
CA2508479A1 (en) 2004-06-17
EP1581547A2 (en) 2005-10-05

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