WO2004064879A1

WO2004064879A1 - Dressing comprising an impressed wound pad and transparent fixing film

Info

Publication number: WO2004064879A1
Application number: PCT/EP2004/000420
Authority: WO
Inventors: Thorsten Berg; Guenther Sachau; Sebastian Trotter; Thomas Moeller
Original assignee: Beiersdorf Ag
Priority date: 2003-01-20
Filing date: 2004-01-20
Publication date: 2004-08-05
Also published as: DE10301835A1

Abstract

The invention relates to a dressing comprising an impressed wound pad and a transparent fixing film. The wound pad can be individually impressed and can be shaped, in particular, with regard to the contours of impressed motifs. The fixing film adhered, on one side, to the side facing the wound overlaps the wound pad at least on two sides and is made of a transparent material whereby reducing the cosmetic detraction caused by the dressing, in essence, to the size of the wound pad. The protruding adhesive transparent fixing film enables an optimal hold with additional segmentation even in problematic skin regions. The invention also relates to methods for producing this dressing, to the use thereof and to the methods for using it.

Description

Band-aids with printed wound dressing and transparent fixing film

The invention comprises a plaster with a printed wound dressing and a transparent fixing film.

Plaster, consisting of wound dressing and an adhesive fixing film, are known and are made from a wide variety of materials.

The fixing film mainly consists of textiles or film material such as PVC, PE, PET, PU, polyether esters and other polymer films. The wound dressing itself often consists of textiles, such as nonwovens or knitted fabrics, hydrogels, hydrocolloids or polyurethane gels, which can be impregnated to prevent sticking to the wound. The wound dressing can contain drugs or other substances that promote wound healing. The fixing film overlaps the wound dressing on at least two opposite sides or on all sides and is provided with an adhesive for fixing the plaster, which also fixes the wound dressing on the plaster. By means of suitable segmentation of the protruding adhesive area, the plaster can be optimally fixed, particularly on parts of the body that are difficult to glue.

The fixing film can be colored or printed with motifs, with the printing extending over the entire fixing film.

Patches for moist wound healing are known, for example, from the publications DE 4026 755 A1 and DE 199 50 295 A1, which preferably consist of a self-adhesive polyurethane layer which is flush with a printed film, which preferably also consists of polyurethane (= PU) ,

Transparent plasters with a milky colored wound dressing layer, e.g. in EP 1 190 723 A2, which is overlapped on at least two sides by an adhesive transparent polyurethane film.

All types of plaster described are cosmetically very noticeable due to the printing or coloring of the entire surface. A completely transparent design of plasters for moist wound healing have the disadvantage that the sometimes unsightly

Wound is visible. What for the observation of the healing process in the clinic of However, many patients do not want this to be an advantage in the context of wound care, since it entails an aesthetic impairment.

The object of the present invention is to provide a plaster which, with minimal cosmetic impairment, enables an optimal hold on the skin as well as light and visual protection of the wound.

Another object of the invention is to provide a plaster that is cost-effective and time-saving and, above all, simple to manufacture. Furthermore, it is the task of providing a plaster that enriches the state of the art. In particular, it is the object of the present invention to provide a plaster, the printing of which prevents the wound from showing through and at the same time fully meets the aesthetic requirements.

This object is achieved by a plaster according to claim 1.

Accordingly, the plaster comprises a transparent fixing film that adheres to the skin and a wound dressing that has a print on the side facing away from the wound, wherein a) the wound dressing is printed directly or b) an auxiliary film is printed that is connected to the wound dressing on the unprinted side or c) a transparent film is printed mirror-inverted, which is connected to the printed side with the wound dressing, and the wound dressing is connected to the fixing film in such a way that the printing can be seen through the fixing film and the fixing film on at least two sides or on all sides the wound dressing stands out.

The patch according to the invention has the following advantages:

1) Through the use of an overall adhesive, transparent fixing film that lets the skin underneath shine through, it can be selected to be sufficiently large and, if necessary, be segmented appropriately in order to ensure an optimal hold of the plaster without appearing visually.

2) The wound dressing, which is mainly decisive for the cosmetic impairment, can be reduced to the size of the wound. 3) The wound dressing, which essentially defines the appearance of the plaster, can be individually printed and shaped, which means that plasters with very different appearances can be produced in a very simple manner using the same manufacturing technique.

In particular, the wound dressing printed in one or more colors can be punched out into shapes which in the simplest case are rectangles, polygons or ellipses. The shape of the wound dressings can, however, also follow more demanding contours and in particular also be based on the contours of printed motifs.

4) The printing of the wound dressing has the following advantages over the usual coloring of the wound dressing for this type of plaster: a) The unsightly leakage of blood, exudate, etc. In contrast to wound dressings that are colored with pigments, it is still completely covered by the print even if the wound dressing contains them

Body fluids are completely soaked. b) Likewise, unsightly colored medicines or additives, which may have been incorporated into the wound dressing, are completely covered by printing on the wound dressing. c) A superficially applied on the side of the wound dressing facing away from the wound

Printing excludes interactions between the staining material and the wound. d) The printing of the wound dressing only in skin color, possibly graded to different shades of brown, reduces the cosmetic impairment of the plaster to a minimum. e) The colored printing on the wound dressing or the printing with motifs can lead to spatially limited, fashionable wound dressings, which increases acceptance e.g. in children, f) Since the printing is only on the wound pad, which is under the transparent

Fixing film, due to the production process may be in even deeper layers, is the printing in comparison to plasters in which the printing is on the outer

Layer is applied against mechanical abrasion and chemical

Influences (soap, solvents, etc.) significantly more resistant, which

Overall impression of the patch remains on for longer.

In a preferred embodiment, the wound dressing of the plaster according to the invention consists of hydrocolloids or hydrogels. In a particularly preferred In one embodiment, the wound dressing consists of a polyurethane mixture and is therefore particularly suitable for moist wound healing. In addition, medicaments, wound treatment agents and other suitable materials, such as, for example, absorber materials, for example partially neutralized polyacrylic acid, which can contribute to improved wound healing, can be incorporated into such hydra- or xerogels.

The thickness of the PU wound dressing is adapted to the requirements of the plaster, such as padding, absorbency and cosmetic conspicuity, and is preferably 0.2 mm to 10 mm and particularly preferably 0.5 to 1 mm.

In a preferred embodiment, in which the printing is applied to a carrier film between the fixing film and the wound dressing, it can additionally be covered with a cut-off lacquer or a thin film layer, in a preferred embodiment because of its water vapor permeability, with PU film. This measure prevents interactions between materials of the adhesive layer or the wound dressing with the printing inks.

The film referred to here as the carrier film is to be attributed to the wound dressing according to the invention.

In principle, any transparent film material, possibly also in the form of a composite film, is suitable for the fixing film. Preferred film materials are polyethylene, polyethylene terephthalate, polypropylene, polyurethane, polyvinyl chloride and / or polyether esters.

The transparent fixation film material is provided with a transparent adhesive on the side facing the wound, which on the one hand ensures the fixation of the plaster on the skin and on the other hand fixes the wound dressing on the fixation film.

In addition to products based on acrylate, the adhesive layer can be made of various other, preferably transparent, materials which are particularly suitable from the point of view of skin compatibility. Preferred adhesives are hot melts or solvent-based adhesives based on natural rubber, synthetic rubber, polyurethane and / or acrylates.

In a preferred embodiment, the fixing film consists of a polyurethane layer 0.02-0.1 mm thick, to which a skin-compatible transparent adhesive layer based on crosslinked polyacrylic acid derivatives 0.02-0.08 mm thick is applied. The adhesive layer is guaranteed with siliconized release paper or other suitable until the plaster is used.

The materials that are attached in such a way that easy removal when applying plasters can also be made sterilizable in combination with suitable packaging.

The wound dressing can remain unprinted for use in the clinic, which, when the wound dressing is carried out transparently, can be advantageous for observing the healing process, but it is not sufficient for aesthetic reasons.

The plasters described are essentially produced in the following steps:

1. Production of a wound dressing possibly doped with medicinal substances

2. Applying printing to the wound dressing

3. Shape of the wound dressing. 4. Production of the transparent fixing film

5. Apply an adhesive layer to the fixing film

6. Connect the wound dressing to the fixation film

7. Cover the adhesive layers

8. Pack the finished patch 9. Sterilize if necessary

The sequence of the steps can vary in its sequence depending on the manufacturing process; if necessary, several steps can take place in a single manufacturing process.

to 1) The production of wound dressings and, if necessary, their impregnation or doping with medicinal substances is carried out according to the usual methods.

A preferred embodiment of the wound dressing made of polyurethane can also be impregnated with pharmaceutical substances, as described, for example, in EP 1 104 679 A2.

The polyurethane composition can be used without foaming, foaming, unfilling or with additional fillers such as superabsorbents, titanium dioxide, zinc oxide, plasticizers, dyes, etc. For applications in the field of transdermal patch systems, it is also possible to dope the polyurethane mass in the central zone with active ingredients. Hydrogels in semi-solid to solid form with active components for the central zone can also be used. Suitable polyurethanes for the wound dressing are the subject of DE 196 18 825 A1, in which hydrophilic, self-adhesive polyurethane gels are disclosed, these consist of: a) 2 to 6 hydroxyl group-containing polyether polyols with OH numbers from 20 to 112 and an ethylene oxide (EO ) Content of> 10% by weight, b) antioxidants, c) in the polyols a) bismuth (III) carboxylates based on carboxylic acids with 2 to 18 C atoms as catalysts and d) hexamethylene diisocyanate, with a Product of the functionalities of the polyurethane-forming components a) and d) of at least 5.2, the amount of catalyst c) being 0.005 to 0.25% by weight, based on the polyol a), of the amount of antioxidants b) in the range from 0.1 to 1.0% by weight, based on polyol a), and a ratio of free NCO groups of component d) to free OH groups of component a) (isocyanate index) is in the range of 0.30 up to 0.70 is selected.

It is preferred to use 3 to 4, very particularly preferably 4-hydroxyl polyether polyols having an OH number in the range from 20 to 112, preferably 30 to 56. The ethylene oxide content in the polyether polyols used according to the invention is preferably> 20% by weight.

The polyether polyols are known per se and are obtained, for example, by polymerizing epoxides, such as ethylene oxide, propylene oxide, butylene oxide or tetrahydrofuran, with themselves or by adding these epoxides, preferably ethylene oxide and propylene oxide - optionally in a mixture with one another or separately - On starter components with at least two reactive hydrogen atoms, such as water, ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, glycerin, trimethylolpropane, pentaerythritol, sorbitol or succrose. Representatives of the higher molecular weight polyhydroxyl compounds to be used are listed, for example, in High Polymers, Vol. XVI, "Polyurethanes, Chemistry and Technology" (Saunders-Frisch, Interscience Publishers, New York, Vol. 1, 1962, pp. 32-42).

The isocyanate component is monomeric or trimerized hexamethylene diisocyanate or by biuret, uretdione, allophanate groups or by prepolymerization with polyether polyols or mixtures of polyether polyols based on the known

Starter components with 2 or> 2 reactive H atoms and epoxides, such as ethyl Lenoxide or propylene oxide with an OH number of <850, preferably 100 to 600, modified hexamethylene diisocyanate. Modified hexamethylene diisocyanate is preferred, in particular by prepolymerization with polyether diols having an OH number of 200 to 600 modified hexamethylene diisocyanate. Modifications of hexamethylene diisocyanate with polyether diols with an OH number of 200-600, the residual content of monomeric hexamethylene diisocyanate of which is below 0.5% by weight, are very particularly preferred.

Possible catalysts for the polyurethane gels according to the invention in the anhydrous polyether polyols a) are bismuth (III) carboxylates based on linear, branched, saturated or unsaturated carboxylic acids having 2 to 18, preferably 6 to 18, carbon atoms. Bi (III) salts of branched saturated carboxylic acids with tertiary carboxyl groups, such as 2,2-dimethyloctanoic acid (for example Versatic acids, Shell), are preferred. Preparations of these bi (III) salts in excess proportions of these carboxylic acids are very suitable. A solution of 1 mol of the Bi (III) salt of Versatic 10-acid (2,2-dimethyloctanoic acid) in an excess of 3 mol of this acid with a Bi content of approx. 17% has proven to be excellent.

The catalysts are preferably used in amounts of 0.03 to 0.1% by weight, based on the polyol a).

The antioxidants used for the polyurethane gels according to the invention are, in particular, sterically hindered phenolic stabilizers, such as BHT (2,6-di-tert-butyl-4-methylphenol), Vulkanox BKF (2.2 min -methylene-bis- (6-tert. -butyl-4-methyl phenol) (Bayer AG), Irganox 1010 (pentaerythrityl tetrakis [3- (3,5-ditert.-butyl-4-hydroxyphenyl) propionate]), Irganox 1076 (octadecyl-3- ( 3,5-ditert.-butyl-4-hydroxyphenyl) propionate) (Ciba-Geigy) or tocopherol (vitamin E), preferably those of the α-tocopherol type.

The antioxidants are preferably used in amounts of 0.15 to 0.5% by weight, based on the polyol a).

The isocyanate index (ratio of the free NCO groups used in the reaction to the free OH groups) of the polyurethane gel compositions according to the invention is in the range from 0.30 to 0.70, preferably in the range, depending on the functionality of the isocyanate and polyol components used from 0.45 to 0.60. The isocyanate index required for gel formation can be easily estimated using the following formula: f Poiyoi • (fisocyanate ~ 1) • Key figure «2

Key figure ^■ ■

J polyol

)

f: functionality of the isocyanate or polyol component

Depending on the desired stickiness or elasticity of the gel, the actually used isocyanate index can deviate from the calculated value by up to ± 20%. The polyurethane gel compositions according to the invention are produced by customary processes, as described, for example, in Becker / Braun, Kunststoff-Handbuch, Vol. 7, Polyurethane, p. 121 ff, Carl-Hauser, 1983.

Polyurethanes, as disclosed in EP 0 665 856 B1, are also preferably used.

The hydrophilic polyurethane gel foams are therefore available from:

1. a polyurethane gel, which

(A) 25-62% by weight, preferably 30-60% by weight, particularly preferably 40-57% by weight, based on the sum of (A) and (B), of a covalently cross-linked polyurethane as a high-molecular matrix and

(B) 75-38% by weight, preferably 70-40% by weight, particularly preferably 60-43% by weight, based on the sum of (A) and (B) of one or more in the matrix by secondary valence forces firmly bound polyhydroxyl compounds with an average molecular weight between 1000 and 12000, preferably between 1500 and 8000, particularly preferably between 2000 and 6000, and an average OH number between 20 and 112, preferably between 25 and 84, particularly preferably between 28 and 56, as liquid dispersant, the dispersant being essentially free of hydroxyl compounds with a molecular weight below 800, preferably below 1000, particularly preferably below 1500, and optionally

(C) 0 to 100% by weight, based on the sum of (A) and (B), of fillers and / or additives, and which can be obtained by reacting a mixture of a) one or more polyisocyanates, b) one or more polyhydroxyl compounds with an average molecular weight between 1000 and 12000, and an average OH number between 20 and 112, c) optionally catalysts or accelerators for the reaction between isocyanate and hydroxyl groups and optionally d) known per se from polyurethane chemistry Fillers and additives, this mixture being essentially free of hydroxyl compounds with a molecular weight below 800, the average functionality of the polyisocyanates (F |) is between 2 and 4, the average functionality of the polyhydroxyl compound (F _p ) is between 3 and 6 and the isocyanate index (K) of the formula

300 ± X

K - ^■ + 7 (E, ^« E -1

obeys, in which X <120, preferably X <100, particularly preferably X <90 and the characteristic number K lies between 15 and 70, the given average values of molecular weight and OH number being understood as number average,

2. a water absorbing material and

3. a non-aqueous foaming agent.

The polyurethane gels can be prepared from the starting compounds known per se from polyurethane chemistry by processes known per se, as are described, for example, in DE 31 03 499 A1, DE 31 03 500 A1 and EP 0 147 588 A1. However, it is essential for the self-adhesive property of the wound dressing that the conditions defined above are observed when selecting the gel-forming components, since otherwise, instead of self-adhesive gels, non-adhesive, elastic gels are obtained which reduce the overall adhesion of the plaster.

However, if wound dressings that are not self-adhesive are to be used according to the invention, this can be done without additional effort in accordance with the prior art.

Preferred polyhydroxyl compounds are polyether polyols, as are mentioned in detail in the above-mentioned laid-open publications.

Both (cyclo) aliphatic and aromatic isocyanates are suitable as polyisocyanate components. Preferred (cyclo) aliphatic polyisocyanates are 1,6-hexa- methylene diisocyanate and its biurets and trimerisates or hydrogenated diphenylmethane diisocyanate ("MDI") types. Preferred aromatic polyisocyanates are those obtained by distillation, such as MDI mixtures of 4,4'- and 2,4'-isomers or 4,4'-MDI, and tolylene diisocyanate ("TDI") types.

The diisocyanates can in particular be selected, for example, from the group of unmodified aromatic or aliphatic diisocyanates or from modified products formed by prepolymerization with amines, polyols or polyether polyols.

The polyurethane gels can optionally contain additives known per se from polyurethane chemistry, such as, for example, fillers and short fibers on an inorganic or organic basis, metal pigments, surface-active substances or liquid extenders such as substances with a boiling point above 150 ° C. Examples of inorganic fillers are heavy spar, chalk, gypsum, gravel, soda, titanium dioxide, cerium oxide, quartz sand, kaolin, carbon black and hollow microspheres

For organic fillers, for example, powders based on polystyrene, polyvinyl chloride, urea formaldehyde and polyhydrazodicarbonamide can be used.

Examples of surface-active substances which may be mentioned are cellulose powder, activated carbon and silica preparations.

To modify the adhesive properties of the gels, additions of polymeric vinyl compounds, polyacrylates and other copolymers or adhesives based on natural materials up to a content of 10% by weight, based on the weight of the gel mass, which are customary in adhesive technology, can optionally be added.

Preferred water-absorbing materials are water-absorbing salts of polyacrylates and their copolymers known as superabsorbers, in particular the sodium or potassium salts. They can be non-networked or networked and are also available as commercial products. Products such as those disclosed in DE 37 13 601 A1 and also superabsorbents of the new generation with only small proportions of dry water and high swelling capacity under pressure are particularly suitable. Preferred products are weakly crosslinked polymers based on acrylic acid / sodium acrylate. Such sodium polyacrylate are available as Favor ^® (Chemische Fabrik Stockhausen GmbH, Germany).

Other absorbers, for example carboxymethyl cellulose and karaya gum, are also suitable.

The wound dressing can be foamed either by the dispersion method (mechanical incorporation of gases) or by the condensation method (use of chemical foaming agents) before the film material solidifies. The degree of foaming can be varied within wide limits.

In a particularly preferred embodiment, this PU wound dressing is applied directly to the PU film printed as described under point 2 c.

Re 2) a) In the simplest case, the wound dressing is printed directly with a suitable technique so that the side that later turns away from the wound is colored and / or provided with a motif. b) If the wound dressing material cannot be printed directly, it is impregnated with a suitable carrier material (lacquer, for example Impranil ^® -

Types, etc.) made printable. c) If the non-directly printable wound dressing cannot be made printable, as described under b), the wound dressing is connected in a suitable manner with a film, preferably glued, which in turn is attached to the wound dressing from the side facing away from the wound before or after application is printed. d) In a preferred embodiment, a PU dispersion (for example Impranil types, from Bayer) is poured onto a carrier film, preferably a surface-embossed PE film, and is spread to the film using suitable processes (see, for example, EP 1 203 572 A2) and dried. This transparent PU layer is printed in a mirror-inverted manner from the side facing away from the PE film, so that an upright, laterally correct image appears later when the plaster is viewed. The printing can optionally be protected by a protective lacquer or further thin PU layers before the wound dressing described in item 1 of the manufacture is applied in the form of several thin layers, in a particularly preferred embodiment in the form of a thick layer, in a next step. The PE film serves exclusively as an auxiliary film for the manufacturing process and is removed again before the wound dressing is applied to the fixing film.

In the case of the manufacture according to 2c, 2d and 2e, a composite of a film and wound dressing is created, in which the film is on the side facing away from the wound in the case of 2c, the transparent film on the side facing the wound in the case of 2d and between 2 films in the case of 2e is arranged. This fixed unit of printed film and wound dressing is addressed as a printed wound dressing in the context of this patent application, just like the wound dressings printed directly according to FIGS. 2a and 2b.

Regarding 3) The wound dressing produced and printed in one of the processes described above is given a shape in a further working step by a suitable technique, preferably by punching or cutting, which in the simplest case is rectangular or ellipsoid. In a preferred new embodiment, the single-color or colorfully printed wound dressing is punched out in more sophisticated shapes such as stars, hearts, lucky pigs, zodiac signs, symbols, etc.

In a particularly preferred and new embodiment, the wound dressing is punched out taking into account the contours of the printed motifs (figures, flowers, etc.).

This contoured punching out of the printed wound dressing enables the spatial limitation of the area which appears to be only the wound dressing in a simple manner compared to the printing of the entire surface of a plaster which has been customary hitherto. By printing this area in skin color, the entire patch only minimally catches the eye.

In the case of plasters for children, adolescents and fashion-oriented people in particular, the wound dressing can appear very discreetly and / or with a wide range of variants thanks to suitable shapes and colors. In the case of children's plasters, by restricting a figure (for example printed and punched out), a close relationship can be established between the figure and the wound.

Re 4) For the production of suitable transparent fixing films, methods are used which are known from the prior art.

In a preferred embodiment for the production of a plaster for moist wound healing, a non-adhesive transparent PU dispersion (e.g.

Impranil grades, Bayer) poured, formed into films over rolls and dried. to for a detailed description of this production, see also DE 196 18 825 and EP 1203 572 A2. The PE film is an auxiliary film that is necessary for the manufacturing process. It is removed again at the end of the manufacturing process.

The PU film has the advantage of being impermeable to water from the outside, but at the same time being permeable to water vapor (sweat) and oxygen, which improves skin breathing and thus comfort.

The thickness of the PU fixing film is adapted to the requirements of the mechanical stress on the plaster and is 20-100 g / m ^2, preferably 40-70 g / m ² and particularly preferably 60 g / m ² .

To 5) The transparent fixation film is coated on the side facing the wound over the entire area or partially, uniformly or over the area with different densities (for example dome, grid-screen structure) with a transparent adhesive, for example a polyacrylate adhesive.

6) The wound dressing is glued with the printed side, preferably centered, onto the fixing film coated with adhesive on one side.

Possibly. the fixing film is cut in the adhesive area responsible for the adhesion to the skin so that it can also be optimally fixed on problem areas (e.g. between toes, on fingertips, etc.).

Re 7) The adhesive area protruding over the wound dressing is preferably covered with siliconized paper in a manner which enables this layer to be easily removed when the plaster is applied to the wound.

In a preferred embodiment, the adhesive layer is covered with two strips of siliconized paper in such a way that the strips are applied parallel, approximately centered over the center of the wound dressing, overlapping a few millimeters, otherwise in the same shape as the plaster.

Figure 1 illustrates the basic structure of the plaster according to the invention in the embodiment that a barrier layer (3), which is part of the wound dressing (4), is printed. The fixing film (1) is connected to the wound dressing (4) via the adhesive layer (2). In this embodiment, the wound dressing (4) has a barrier layer towards the fixing film (3) printed on the top. The printing is visible from above through the fixing film (5).

The simplest embodiment of the plaster according to the invention does not have the barrier layer (3), so that the wound dressing (4) is printed directly on the side facing away from the wound.

Examples

In a preferred embodiment of the plaster described below, both the fixing film and the wound dressing consist of films based on polyurethane. The wound dressing is provided with an absorption material for absorbing liquid, printed with a hedgehog and punched out taking into account its contours.

A PU dispersion (Impranil ^® types, Bayer) is poured onto the auxiliary carrier, a surface-embossed PE film, spread to form a film of 20 g / m ² (DIN 53352) and dried to form a film. The film produced in this way should withstand a maximum tensile force of 2 N / cm (DIN EN ISO 527-1 / 3) for further processing. This transparent PU layer is reversely printed with a hedgehog from the side facing away from the PE film.

The wound dressing, which is manufactured with a basis weight of 500 g / m ² , is applied to the printed side in one work step.

Mixing ratios of the reactants for the manufacture of the wound dressing:

Levagel, Bayer = polyether-polyol mixture Desmodur ^® , Bayer = isocyanate prepolymer Favor ^® , Degussa = partially neutralized polyacrylic acid Coscat ^® ; OH. Erbslöh = bismuth catalyst / activator

The fixing film is a PU film with a weight per unit area of 60 g / m ² , which is made in principle in the same way as the carrier film described above, but is constructed in several working steps from several thin layers, later not recognizable to the eye. On the one hand, the PU film is sufficiently firm to ensure the fixation of the wound dressing and to withstand the mechanical stresses of the plaster, but at the same time it has so much elasticity that it can adapt optimally to the skin. A transparent acrylic-based adhesive with a basis weight of 45 g / m ^{2 is} applied to the entire surface of this PU film. The printed side of the wound dressings punched out in hedgehog form are applied to the adhesive fixing film at such a sufficient distance from one another that each plaster can be punched out in an oval shape in a later step with a 3 cm wide adhesive area around the wound dressing. In a further step, each plaster is suitably covered on the adhesive side with two siliconized release paper strips so that the release paper strips overlap in the middle by 5 mm. The plasters prepared in this way are then punched out in the manner described.

Claims

claims

1) Plaster comprising a transparent fixing film which adheres to the skin and a wound dressing which has printing on the side facing away from the wound, with a) the wound dressing being printed directly or b) an auxiliary film being printed which is connected to the wound dressing on the unprinted side or d) a transparent film is printed mirror-inverted, which is connected with the printed side to the wound dressing, and the wound dressing is connected to the fixing film in such a way that the printing can be seen through the fixing film and the fixing film on at least two sides or on all sides the wound dressing stands out.

2) plasters according to claim 1, characterized in that the transparent fixing film used is made of polyurethane, polyethylene, polypropylene, polyether, polyester, polyetherester or polyethylene terephthalate or in the combination of these materials.

3) Patch according to one of the preceding claims, characterized in that the printed wound dressing consists of textiles, in particular nonwovens and / or knitted fabrics, hydrocolloids, hydrogels and / or polyurethane gels.

4) plaster according to claim 3, characterized in that the wound dressing consists of polyurethane.

5) Plaster according to one of the preceding claims, characterized in that the wound dressing is elipsoid, round, angular, square, polygonal or shaped in the form of the printed motifs or figures.

6) Patch according to one of the preceding claims, characterized in that the printing is sealed from the side facing the wound with a protective lacquer.

7) Patch according to one of the preceding claims, characterized in that the wound dressing contains a medicinal substance and / or wound treatment agent, in particular selected from the group of dexpanthenol, iodine-containing or cleaving substances or substance mixtures. ) Process for producing a plaster according to at least one of the preceding claims, characterized in that a) the wound dressing is printed on the side facing away from the wound or at least one printed film is applied to the wound dressing on the side facing away from the wound, b) the wound dressing, in particular in accordance with the Printing, is formed, c) a self-adhesive coating is applied to the wound-facing side of the fixation film or the wound-facing side of the fixation film is made of self-adhesive material and d) the wound dressing is connected to the fixation film with the printed side or with the applied film, so that the fixing film protrudes on at least two sides.