WO2004067700A3 - Liquid transfer system - Google Patents

Liquid transfer system Download PDF

Info

Publication number
WO2004067700A3
WO2004067700A3 PCT/GB2004/000383 GB2004000383W WO2004067700A3 WO 2004067700 A3 WO2004067700 A3 WO 2004067700A3 GB 2004000383 W GB2004000383 W GB 2004000383W WO 2004067700 A3 WO2004067700 A3 WO 2004067700A3
Authority
WO
WIPO (PCT)
Prior art keywords
pin
shaft
counterbores
capillary
pins
Prior art date
Application number
PCT/GB2004/000383
Other languages
French (fr)
Other versions
WO2004067700A2 (en
Inventor
Stuart Elmes
Jonathan Pearson
Alastair Taylor
Colin Reynolds
Dan Aldridge
Original Assignee
Apogent Robotics Ltd
Stuart Elmes
Jonathan Pearson
Alastair Taylor
Colin Reynolds
Dan Aldridge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0302281.1A external-priority patent/GB0302281D0/en
Application filed by Apogent Robotics Ltd, Stuart Elmes, Jonathan Pearson, Alastair Taylor, Colin Reynolds, Dan Aldridge filed Critical Apogent Robotics Ltd
Priority to EP04706726A priority Critical patent/EP1594951A2/en
Publication of WO2004067700A2 publication Critical patent/WO2004067700A2/en
Publication of WO2004067700A3 publication Critical patent/WO2004067700A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/022—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle
    • B01L2400/025—Drop detachment mechanisms of single droplets from nozzles or pins droplet contacts the surface of the receptacle tapping tip on substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

A liquid transfer tool comprising a ceramic capillary pin having a capillary channel that extends the entire length of the pin and a pin holder, wherein the pin holder comprises a metallic elongated shaft having a distal end configured for holding a proximal portion of the ceramic capillary pin, and a shaft head at the proximal end of the shaft of greater diameter than the shaft, the shaft having a radial vent hole in communication with the capillary. Also, a technique of cleaning a liquid transfer tool including an array of capillary pins for transferring controlled volumes of liquid from tips thereof to a substrate, the method including inserting the tips of the pins into respective counterbores connected to a vacuum pump, each counterbore provided with a sealing ring, wherein the sealing rings have an outer diameter less than that of the counterbores and are mounted on the base of the counterbores such that they are free to move radially thereon so as to allow for mis-alignments between the pins and the centre axes of the counterbores whilst ensuring a good seal between each counterbore and the respective pin.
PCT/GB2004/000383 2003-01-31 2004-01-30 Liquid transfer system WO2004067700A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04706726A EP1594951A2 (en) 2003-01-31 2004-01-30 Liquid transfer system

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0302281.1 2003-01-31
GBGB0302281.1A GB0302281D0 (en) 2003-01-31 2003-01-31 Liquid transfer system
US10/655,714 US20050079621A1 (en) 2003-01-31 2003-09-05 Liquid transfer system
US10/655,714 2003-09-05

Publications (2)

Publication Number Publication Date
WO2004067700A2 WO2004067700A2 (en) 2004-08-12
WO2004067700A3 true WO2004067700A3 (en) 2004-10-21

Family

ID=32827041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/000383 WO2004067700A2 (en) 2003-01-31 2004-01-30 Liquid transfer system

Country Status (2)

Country Link
EP (1) EP1594951A2 (en)
WO (1) WO2004067700A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007289A2 (en) * 2003-07-11 2005-01-27 Genomic Solutions Inc. Apparatus and methods for liquid sample handling based on capillary action
WO2005115619A1 (en) * 2004-05-28 2005-12-08 Tops-Pin Aps A microspotting pin for the production of microarrays
US20210229086A1 (en) * 2018-04-18 2021-07-29 Biosurfit, S.A. Sample transfer device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
WO2000001798A2 (en) * 1998-07-07 2000-01-13 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
WO2001066251A2 (en) * 2000-03-07 2001-09-13 Biotage, Inc. Liquid transfer device
WO2002063272A2 (en) * 2001-02-06 2002-08-15 Parallel Synthesis Technologies Microfabricated spotting apparatus for producing low cost microarrays

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
WO2000001798A2 (en) * 1998-07-07 2000-01-13 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
WO2001066251A2 (en) * 2000-03-07 2001-09-13 Biotage, Inc. Liquid transfer device
WO2002063272A2 (en) * 2001-02-06 2002-08-15 Parallel Synthesis Technologies Microfabricated spotting apparatus for producing low cost microarrays

Also Published As

Publication number Publication date
WO2004067700A2 (en) 2004-08-12
EP1594951A2 (en) 2005-11-16

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