WO2004072606B1 - Polymeric membranes for use in electrochemical sensors - Google Patents

Polymeric membranes for use in electrochemical sensors

Info

Publication number
WO2004072606B1
WO2004072606B1 PCT/US2004/002221 US2004002221W WO2004072606B1 WO 2004072606 B1 WO2004072606 B1 WO 2004072606B1 US 2004002221 W US2004002221 W US 2004002221W WO 2004072606 B1 WO2004072606 B1 WO 2004072606B1
Authority
WO
WIPO (PCT)
Prior art keywords
biological sample
analyte
inorganic cation
contaminant
anionic species
Prior art date
Application number
PCT/US2004/002221
Other languages
French (fr)
Other versions
WO2004072606A3 (en
WO2004072606A2 (en
Inventor
Vasile V Cosofret
Original Assignee
Instrumentation Lab Co
Vasile V Cosofret
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instrumentation Lab Co, Vasile V Cosofret filed Critical Instrumentation Lab Co
Priority to ES04705979T priority Critical patent/ES2384382T3/en
Priority to CA002515425A priority patent/CA2515425A1/en
Priority to EP04705979A priority patent/EP1592802B1/en
Priority to JP2005518474A priority patent/JP2006514307A/en
Priority to AT04705979T priority patent/ATE551428T1/en
Publication of WO2004072606A2 publication Critical patent/WO2004072606A2/en
Publication of WO2004072606A3 publication Critical patent/WO2004072606A3/en
Publication of WO2004072606B1 publication Critical patent/WO2004072606B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes

Abstract

A method for reducing interference caused by contaminants on the detection and/or measurement of an analyte in a biological sample includes providing a chemical sensor that contains carboxylated polyvinyl chloride (PVC-COOH) as a polymer component of the sensor’s polymeric membrane. A biological sample containing the analyte of interest and a contaminant is placed in contact with the chemical sensor that includes PVC-COOH as a polymer component of the sensor’s polymeric membrane. The analyte of interest in the biological sample is then measured and/or detected by the chemical sensor without interference by the contaminant.

Claims

AMENDED CLAIMS [received by the International Bureau on 27 January 2005 (27.01.05); original claims 1-24 replaced by new claims 1-24 (2 pages)]
1. A method for reducing interference caused by at least one contaminant while detecting or measuring at least one analyte in a biological sample, comprising: providing an electrode comprising a sensor and a polymeric membrane, the polymeric membrane comprising carboxylated polyvinyl chloride; contacting the electrode with the biological sample containing at least one contaminant and at least one analyte; and detecting or measuring the at least one analyte in the biological sample, wherein the detection or measurement of the at least one analyte is substantially free from interference caused by the at least one contaminant in the biological sample, wherein the at least one contaminant comprises a lipophilic anionic species.
2. The method according to claim 1, wherein the polymeric membrane is positioned between the chemical sensor and the biological sample.
3. (Cancelled)
4. The method according to claim 1, wherein the lipophilic anionic species comprises an anesthetic.
5. The method according to claim 1, wherein the lipophilic anionic species comprises an analgesic.
6. The method according to claim 1, wherein the lipophilic anionic species comprises thiopental sodium.
7. The method according to claim 1, wherein the lipophilic anionic species comprises a member of the group consisting of phenytoin, ibuprofen, fenoprofen, salicylate, valproate, and ε- amino-caproate.
8. The method according to claim 1, wherein the analyte comprises an inorganic cation.
9. The method according to claim 8, wherein the inorganic cation comprises sodium.
10. The method according to claim 8, wherein the inorganic cation comprises potassium.
11 The method according to claim 8, wherein the inorganic cation comprises calcium.
12 The method according to claim 8, wherein the inorganic cation comprises hydrogen.
13 The method according to claim 8, wherein the inorganic cation comprises lithium.
14 The method according to claim 8, wherein the inorganic cation comprises ammonium.
15 The method according to claim 8, wherein the inorganic cation comprises magnesium.
16 The method according to claim 1 wherein the analyte comprises a dissolved gas.
17 The method according to claim 16, wherein the dissolved gas comprises carbon dioxide. 18
18. The method according to claim 1 wherein the analyte comprises a biological metabolite.
19. The method according to claim 18, wherein the biological metabolite comprises urea.
20. The method according to claim 18, wherein the biological metabolite comprises a member of the group consisting of carbohydrates, peptides, lipids, and nucleotides.
21. The method according to claim 1 wherein the carboxylated polyvinyl chloride contains 0.1 to 5 % carboxyl groups by weight.
22. The method according to claim 1 wherein the biological sample comprises a body fluid.
23. The method according to claim 22 wherein the biological sample comprises blood.
24. The method according to claim 22 wherein the biological sample comprises urine
PCT/US2004/002221 2003-02-11 2004-01-28 Polymeric membranes for use in electrochemical sensors WO2004072606A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES04705979T ES2384382T3 (en) 2003-02-11 2004-01-28 Polymeric membranes for use in electrochemical sensors
CA002515425A CA2515425A1 (en) 2003-02-11 2004-01-28 Polymeric membranes for use in electrochemical sensors
EP04705979A EP1592802B1 (en) 2003-02-11 2004-01-28 Polymeric membranes for use in electrochemical sensors
JP2005518474A JP2006514307A (en) 2003-02-11 2004-01-28 Polymer membranes for use in electrochemical sensors
AT04705979T ATE551428T1 (en) 2003-02-11 2004-01-28 POLYMER MEMBRANES FOR USE IN ELECTROCHEMICAL SENSORS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/364,840 US20040154933A1 (en) 2003-02-11 2003-02-11 Polymeric membranes for use in electrochemical sensors
US10/364,840 2003-02-11

Publications (3)

Publication Number Publication Date
WO2004072606A2 WO2004072606A2 (en) 2004-08-26
WO2004072606A3 WO2004072606A3 (en) 2005-01-13
WO2004072606B1 true WO2004072606B1 (en) 2005-04-28

Family

ID=32824507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002221 WO2004072606A2 (en) 2003-02-11 2004-01-28 Polymeric membranes for use in electrochemical sensors

Country Status (7)

Country Link
US (1) US20040154933A1 (en)
EP (1) EP1592802B1 (en)
JP (1) JP2006514307A (en)
AT (1) ATE551428T1 (en)
CA (1) CA2515425A1 (en)
ES (1) ES2384382T3 (en)
WO (1) WO2004072606A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071051B2 (en) 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
US7242474B2 (en) 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
US8383043B2 (en) * 2004-05-14 2013-02-26 Honeywell International Inc. Analyzer system
US8329118B2 (en) 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
AU2003296492A1 (en) 2002-12-11 2004-06-30 Instrumentation Laboratory Company Multi-analyte reference solutions
US8323564B2 (en) 2004-05-14 2012-12-04 Honeywell International Inc. Portable sample analyzer system
US7373195B2 (en) * 2004-07-30 2008-05-13 Medtronic, Inc. Ion sensor for long term use in complex medium
US7630075B2 (en) * 2004-09-27 2009-12-08 Honeywell International Inc. Circular polarization illumination based analyzer system
EP1885871B1 (en) 2005-05-17 2012-05-30 Radiometer Medical ApS Enzyme sensor with a cover membrane layer covered by a hydrophilic polymer
US7806604B2 (en) * 2005-10-20 2010-10-05 Honeywell International Inc. Face detection and tracking in a wide field of view
EP1963817A2 (en) * 2005-12-22 2008-09-03 Honeywell International Inc. Portable sample analyzer cartridge
JP5431732B2 (en) 2005-12-29 2014-03-05 ハネウェル・インターナショナル・インコーポレーテッド Assay implementation in microfluidic format
US7736478B2 (en) * 2006-09-06 2010-06-15 Chung Yuan Christian University Ion solution concentration-detecting device
US20100034704A1 (en) * 2008-08-06 2010-02-11 Honeywell International Inc. Microfluidic cartridge channel with reduced bubble formation
DE102008050092A1 (en) * 2008-10-06 2010-04-08 Hach Lange Gmbh Mobile water analysis arrangement
US8663583B2 (en) * 2011-12-27 2014-03-04 Honeywell International Inc. Disposable cartridge for fluid analysis
US8741234B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
US8741233B2 (en) 2011-12-27 2014-06-03 Honeywell International Inc. Disposable cartridge for fluid analysis
US8741235B2 (en) * 2011-12-27 2014-06-03 Honeywell International Inc. Two step sample loading of a fluid analysis cartridge
JP6554272B2 (en) * 2013-08-27 2019-07-31 オルガノ株式会社 Hydrogen ion selective electrode, pH measuring method and sensitive membrane
WO2018204627A1 (en) 2017-05-04 2018-11-08 Siemens Healthcare Diagnostics Inc. Biosensors produced from enzymes with reduced solubility and methods of production and use thereof
US20210255133A1 (en) * 2019-04-30 2021-08-19 Microtech Medical (Hangzhou) Co.,Ltd. Biosensing systems having biosensors coated with co-polymers and uses thereof

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3796634A (en) * 1970-03-19 1974-03-12 Us Health Education & Welfare Insolubilized biologically active enzymes
US3672843A (en) * 1970-04-07 1972-06-27 Instrumentation Labor Inc Fluid analyzing apparatus
US3723281A (en) * 1972-01-31 1973-03-27 Corning Glass Works Bicarbonate ion sensitive electrode
US3915829A (en) * 1972-10-10 1975-10-28 Instrumentation Labor Inc Electrochemical structure
US3977995A (en) * 1974-10-17 1976-08-31 Baxter Laboratories, Inc. Calibrating fluid for blood cell counting and hemoglobin determination
DE2612726C3 (en) * 1976-03-25 1979-03-15 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilized urease
US4214968A (en) * 1978-04-05 1980-07-29 Eastman Kodak Company Ion-selective electrode
US4219440A (en) * 1979-06-06 1980-08-26 Coulter Electronics, Inc. Multiple analysis hematology reference control reagent and method of making the same
CA1112474A (en) * 1978-09-18 1981-11-17 Guy Belanger Apparatus for the detection and the measurement of hydrogen concentration in a liquid
US4179349A (en) * 1978-09-26 1979-12-18 The United States Of America As Represented By The United States Department Of Energy Portable probe to measure sensitization of stainless steel
US4361539A (en) * 1980-05-05 1982-11-30 Instrumentation Laboratory Inc. Analysis system
JPS57118152A (en) * 1981-01-14 1982-07-22 Matsushita Electric Ind Co Ltd Enzyme electrode
US4401548A (en) * 1981-02-12 1983-08-30 Corning Glass Works Reference electrode with internal diffusion barrier
US4355105A (en) * 1981-03-30 1982-10-19 Miles Laboratories, Inc. Glutaraldehyde/polyethylenimine immobilization of whole microbial cells
EP0074498B1 (en) * 1981-09-04 1985-12-04 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Method and apparatus for the calibration of sensors
US4390627A (en) * 1981-10-26 1983-06-28 Miles Laboratories, Inc. Immobilization of the sucrose mutase in whole cells of protaminobacter rubrum
DE3223885A1 (en) * 1982-06-26 1983-12-29 Basf Ag, 6700 Ludwigshafen MACROPOROISE, HYDROPHILE CARRIER FOR ENZYME
US4760024A (en) * 1983-08-10 1988-07-26 Miles Inc. Immobilization of enzymes
EP0138150A3 (en) * 1983-10-05 1988-06-01 E.I. Du Pont De Nemours And Company Diagnostic electrode membranes utilizing specific enzyme/ionophore pairs
US4654127A (en) * 1984-04-11 1987-03-31 Sentech Medical Corporation Self-calibrating single-use sensing device for clinical chemistry and method of use
AT380741B (en) * 1985-01-31 1986-06-25 Avl Ges F R Verbrennungskraftm ION-SENSITIVE MEMBRANE ELECTRODE
US4686479A (en) * 1985-07-22 1987-08-11 Young Chung C Apparatus and control kit for analyzing blood sample values including hematocrit
US4734184A (en) * 1985-08-29 1988-03-29 Diamond Sensor Systems, Inc. Self-activating hydratable solid-state electrode apparatus
US4755461A (en) * 1986-04-17 1988-07-05 Bio/Data Corporation Tableted blood plasma microconcentrated thromboplastin coagulation reagent
US4713165A (en) * 1986-07-02 1987-12-15 Ilex Corporation Sensor having ion-selective electrodes
US4810351A (en) * 1986-09-18 1989-03-07 Technicon Instruments Corporation Carbonate selective membrane and electrode
US4818365A (en) * 1986-10-14 1989-04-04 Monsanto Company Solid state indicator electrode and method of making same
US4908117A (en) * 1986-11-13 1990-03-13 Monsanto Company Solid state reference electrode
US4818361A (en) * 1986-12-10 1989-04-04 Diamond Sensor Systems Combined pH and dissolved carbon dioxide gas sensor
US4871439A (en) * 1987-02-05 1989-10-03 Steven Enzer Disposable self-calibratable electrode package
US4975647A (en) * 1987-06-01 1990-12-04 Nova Biomedical Corporation Controlling machine operation with respect to consumable accessory units
US5540828A (en) * 1987-06-08 1996-07-30 Yacynych; Alexander Method for making electrochemical sensors and biosensors having a polymer modified surface
US5286364A (en) * 1987-06-08 1994-02-15 Rutgers University Surface-modified electochemical biosensor
JPS6423155A (en) * 1987-07-17 1989-01-25 Daikin Ind Ltd Electrode refreshing device for biosensor
JPS6423151A (en) * 1987-07-20 1989-01-25 Hitachi Ltd Chlorine ion selective electrode
US5013666A (en) * 1988-06-15 1991-05-07 Bionostics, Incorporated Control for blood gas/calcium analysis instrumentation
US4945062A (en) * 1988-06-15 1990-07-31 Bionostics Incorporated Control for blood gas/calcium analysis instrumentation
US5061631A (en) * 1988-10-14 1991-10-29 Fisher Scientific Company Method, apparatus and solution for calibration of partial pressure value
US4973394A (en) * 1988-09-02 1990-11-27 Sri International Immobilized valinomycin molecule for K+ sensor
US5212050A (en) * 1988-11-14 1993-05-18 Mier Randall M Method of forming a permselective layer
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5558985A (en) * 1989-03-27 1996-09-24 Bionostics Incorporated Stable hemoglobin reference solution
US5352349A (en) * 1989-08-30 1994-10-04 Daikin Industries, Ltd. Method for reviving an electrode of a biosensor
FR2651827A1 (en) * 1989-09-08 1991-03-15 Clera Sa MANUAL DEVICE FOR OPENING AND CLOSING A TANK DOOR.
US5067093A (en) * 1990-01-24 1991-11-19 Eastman Kodak Company Reference reading in an analyzer
US5103179A (en) * 1990-03-05 1992-04-07 Industrial Chemical Measurement, Inc. Water analyzer with multiple electrodes
US5132345A (en) * 1990-12-10 1992-07-21 Harris Stephen J Ion-selective electrodes
US5162077A (en) * 1990-12-10 1992-11-10 Bryan Avron I Device for in situ cleaning a fouled sensor membrane of deposits
US5262305A (en) * 1991-03-04 1993-11-16 E. Heller & Company Interferant eliminating biosensors
ES2099182T3 (en) * 1991-06-26 1997-05-16 Ppg Industries Inc ELECTROCHEMICAL SENSOR ASSEMBLY.
US5342498A (en) * 1991-06-26 1994-08-30 Graves Jeffrey A Electronic wiring substrate
US5370783A (en) * 1991-08-01 1994-12-06 Corrpro Companies, Inc. Electrode
DE4132441C2 (en) * 1991-09-28 1993-10-07 Biotechnolog Forschung Gmbh Thick-film conductivity electrodes as a biosensor
WO1993013408A1 (en) * 1991-12-31 1993-07-08 Abbott Laboratories Composite membrane
US5405510A (en) * 1992-05-18 1995-04-11 Ppg Industries, Inc. Portable analyte measuring system for multiple fluid samples
US5330634A (en) * 1992-08-28 1994-07-19 Via Medical Corporation Calibration solutions useful for analyses of biological fluids and methods employing same
ZA938555B (en) * 1992-11-23 1994-08-02 Lilly Co Eli Technique to improve the performance of electrochemical sensors
JPH08505476A (en) * 1993-03-05 1996-06-11 ユニヴァーシティー オブ ウーロンゴング Pulsed electrochemical detection method using electroactive polymer electrode
US5387329A (en) * 1993-04-09 1995-02-07 Ciba Corning Diagnostics Corp. Extended use planar sensors
DE69433398T2 (en) * 1993-09-01 2004-06-09 Genencor International, Inc., Palo Alto Process for the preparation of immobilized enzyme conjugates and immobilized enzyme conjugates thus obtained
GB9320782D0 (en) * 1993-10-08 1993-12-01 Univ Leeds Innovations Ltd Stabilising of proteins on solution
US5522978A (en) * 1993-11-18 1996-06-04 E. I. Du Pont De Nemours And Company Monensin amides for sodium-selective electrodes
JP3027306B2 (en) * 1994-06-02 2000-04-04 松下電器産業株式会社 Biosensor and manufacturing method thereof
US5705482A (en) * 1995-01-13 1998-01-06 Novo Nordisk A/S Pharmaceutical formulation
JPH08247987A (en) * 1995-03-15 1996-09-27 Omron Corp Portable measuring instrument
US5798030A (en) * 1995-05-17 1998-08-25 Australian Membrane And Biotechnology Research Institute Biosensor membranes
US5972199A (en) * 1995-10-11 1999-10-26 E. Heller & Company Electrochemical analyte sensors using thermostable peroxidase
US6136607A (en) * 1995-11-02 2000-10-24 Bayer Corporation Multi-analyte reference solutions with stable pO2 in zero headspace containers
US5780302A (en) * 1995-11-02 1998-07-14 Chiron Diagnostics Corporation Method of packaging oxygen reference solution using flexile package with inside valve
US5605837A (en) * 1996-02-14 1997-02-25 Lifescan, Inc. Control solution for a blood glucose monitor
US5653862A (en) * 1996-04-15 1997-08-05 Dade Chemistry Systems Inc. Biochemical sensor device and method
DE69735127T2 (en) * 1996-11-14 2006-08-31 Radiometer Medical Aps ENZYME SENSOR
US6103505A (en) * 1996-12-09 2000-08-15 Novo Nordisk A/S Method for reducing phosphorus content of edible oils
AT404992B (en) * 1997-04-17 1999-04-26 Avl List Gmbh SENSOR FOR DETERMINING AN ENZYME SUBSTRATE
AU1628599A (en) * 1997-12-05 1999-06-28 Medical College Of Georgia Research Institute, Inc. Regulation of t cell-mediated immunity by tryptophan
US6030827A (en) * 1998-01-23 2000-02-29 I-Stat Corporation Microfabricated aperture-based sensor
US6174728B1 (en) * 1998-04-03 2001-01-16 Avl Medical Instruments Ag Control or calibration standard for use with instruments for optical measurement of hemoglobin concentration in blood samples
GB9808517D0 (en) * 1998-04-23 1998-06-17 Aea Technology Plc Electrical sensor
US6123820A (en) * 1998-06-05 2000-09-26 Grupo Ch-Werfen, S.A. Sensor cartridges
KR20000053521A (en) * 1999-01-20 2000-08-25 고사이 아끼오 Metal-corrosion inhibitor and cleaning liquid
KR100360774B1 (en) * 1999-12-27 2002-11-13 한국전자통신연구원 Enzyme electrode sensor and manufacturing method thereof
US6652720B1 (en) * 2001-05-31 2003-11-25 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6872297B2 (en) * 2001-05-31 2005-03-29 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
AU2002327513B2 (en) * 2001-08-22 2007-07-26 Instrumentation Laboratory Company Method and apparatus for calibrating electrochemical sensors

Also Published As

Publication number Publication date
JP2006514307A (en) 2006-04-27
WO2004072606A3 (en) 2005-01-13
ES2384382T3 (en) 2012-07-04
ATE551428T1 (en) 2012-04-15
WO2004072606A2 (en) 2004-08-26
EP1592802A2 (en) 2005-11-09
EP1592802B1 (en) 2012-03-28
CA2515425A1 (en) 2004-08-26
US20040154933A1 (en) 2004-08-12

Similar Documents

Publication Publication Date Title
WO2004072606B1 (en) Polymeric membranes for use in electrochemical sensors
WO2006138226A3 (en) Analyte detection devices and methods with hematocrit/volume correction and feedback control
Radomska et al. Creatinine biosensor based on ammonium ion selective electrode and its application in flow-injection analysis
AU2003238869A8 (en) Hybrid microcantilever sensors
ATE532063T1 (en) ELECTROCHEMICAL BIOSENSOR
TW200613729A (en) Diagnostic test strip for collecting and detecting an analyte in a fluid sample and method for using same
JP2018515745A (en) Apparatus and method for detecting creatinine and albumin / creatinine ratio
Ribeiro et al. Electrochemical sensing of ammonium ion at the water/1, 6-dichlorohexane interface
Luo et al. Selective and sensitive determination of uric acid at DNA-modified graphite powder microelectrodes
RU2008129056A (en) DEVICE WITH TWO TRANSDERMAL ANALYTIC SENSORS AND WAYS OF ITS APPLICATION
Campanella et al. New enzyme sensor for sulfite analysis in sea and river water samples
Ping et al. Screen-printed potentiometric strip for calcium ion determination in water and milk
Ikeda et al. Development of long-term stable ammonium ion sensor in conjunction with a microbial membrane
Wang Application of electrochemical biosensors for chemical hazards detection
RU87260U1 (en) POTENTIOMETRIC MEASURING COMPLEX FOR DETERMINING ORGANIC ELECTROLYTES IN AQUEOUS SOLUTIONS CONTAINING POTASSIUM CHLORIDE AND SODIUM
TRAMMELL et al. NRL NISE–Towards the Reagent-Less Electrochemical Detection of Polyfluoroalkyl-Compounds in Water
JP4413060B2 (en) Chemical sensor and method for measuring concentration of chemical substance using the same
WO2002084279A2 (en) Acetate detecting sensor
Cheng et al. Performance Testing of Paper-based Electrochemical Sensor for Blood pH Measurements
Naudin Embryo-larval development of the zebra danio(Brachydanio rerio)): relevance of this model for effluent and sediment toxicity measurement. Contribution of image analysis for biometrics measures of the embryo-larval stage test
JP2014097027A (en) Viable cell count measuring method and viable cell count measuring kit
UA149621U (en) SYSTEM FOR DIAGNOSIS OF IRRITANT GASES O <sub> 3 </sub> AND C <sub> 2 </sub> H <sub> 5 </sub> IT ON THE BASIS OF NANOSTRUCTURAL SENSORS SmFeO <sub> Fe <sub> 3 </sub sub> 2 </sub> O <sub> 3 </sub>
RU30994U1 (en) Thios diglycol biosensor
Tarsiche et al. Permeability of PTFE studied with a potentiometric SO2-sensitive sensor
UA149752U (en) SYSTEM FOR DIAGNOSIS OF IRRITANT GASES H <sub> 2 </sub> S AND C <sub> 2 </sub> H <sub> 5 </sub> ON ON THE BASIS OF NANOSTRUCTURAL SENSORS ZnSnO <sub> 3 </s

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
B Later publication of amended claims

Effective date: 20050127

WWE Wipo information: entry into national phase

Ref document number: 2005518474

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2515425

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004705979

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004705979

Country of ref document: EP