WO2004080501B1 - Decellularized liver for repair of tissue and treatment of organ deficiency - Google Patents

Decellularized liver for repair of tissue and treatment of organ deficiency

Info

Publication number
WO2004080501B1
WO2004080501B1 PCT/US2004/006501 US2004006501W WO2004080501B1 WO 2004080501 B1 WO2004080501 B1 WO 2004080501B1 US 2004006501 W US2004006501 W US 2004006501W WO 2004080501 B1 WO2004080501 B1 WO 2004080501B1
Authority
WO
WIPO (PCT)
Prior art keywords
scaffold
tissue
mammalian
devitalized
cells
Prior art date
Application number
PCT/US2004/006501
Other languages
French (fr)
Other versions
WO2004080501A1 (en
Inventor
Stephen F Badylak
Original Assignee
Acell Inc
Stephen F Badylak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acell Inc, Stephen F Badylak filed Critical Acell Inc
Priority to CA002518229A priority Critical patent/CA2518229A1/en
Priority to AU2004220664A priority patent/AU2004220664A1/en
Priority to EP04717383A priority patent/EP1603602A1/en
Priority to JP2006509040A priority patent/JP2006519865A/en
Publication of WO2004080501A1 publication Critical patent/WO2004080501A1/en
Publication of WO2004080501B1 publication Critical patent/WO2004080501B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

The present invention provides a liver-derived devitalized mammalian parenchymatous tissue composition which includes an interstitial structure of connective tissue which can serve as a scaffold for tissue repair or regeneration. The devitalized mammalian parenchymatous tissue composition can further include the basement membrane of the tissue.

Claims

AMENDED CLAIMS
[Received by the International Bureau on 05 October 2004 (05.10.2004): original claims 1-26 replaced by amended claims 1-26 (2 pages)] 1. A scaffold for promoting restoration of a tissue when implanted at an anatomical site in a patient, comprising: at least a portion of a liver-derived devitalized mammalian parenchymatous tissue combined with a target mammalian cell population, wherein the combined tissue and cell population is sized and shaped for implantation in the patient at the anatomical site remote from the tissue requiring restoration.
2. The scaffold of claim 1 wherein the devitalized mammalian liver tissue further comprises a basement membrane.
3. The scaffold of claim 1 wherein the devitalized tissue comprises allogeneic tissue.
4. The scaffold of claim 1 wherein the devitalized tissue comprises autogeneic tissue.
5. The scaffold of claim 1 wherein the devitalized tissue comprises xenogeneic tissue.
6. The scaffold of claim 1 wherein the cell population is a population of stem cells introduced into the tissue.
7. The scaffold of claim 6 wherein the stem cells are autogeneic.
8. The scaffold of claim 6 wherein the stem cells are allogeneic.
9. The scaffold of claim 6 wherein the stem are xenogeneic.
10. The scaffold according to claim 1 wherein the tissue undergoing restoration comprises an endocrine tissue.
11. The scaffold of claim 1 wherein the target cell population comprises mammalian endocrine cells.
12. The scaffold of claim 11 wherein the mammalian endocrine cells comprise pancreatic islet cells.
13. The scaffold of claim 11 wherein the mammalian endocrine cells comprise pituitary cells.
14. The scaffold of claim 11 wherein the mammalian endocrine cells comprise thyroid cells.
15. The scaffold of claim 11 wherein the mammalian endocrine cells comprise cells from the adrenal gland.
16. The scaffold of claim 10 wherein the devitalized parenchymatous mammalian tissue is autogeneic.
17. The scaffold of claim 10 wherein the devitalized parenchymatous mammalian tissue is allogeneic.
18. The scaffold of claim 10 wherein the devitalized parenchymatous mammalian tissue is xenogeneic. '
19. The scaffold of claim 10 wherein the mammalian endocrine cells are autogeneic.
20. The scaffold of claim 10 wherein the mammalian endocrine cells are allogeneic. 17
21. The scaffold of claim 10 wherein the mammalian endocrine cells are xenogeneic.
22. A method for promoting restoration of a tissue when implanted at an anatomical site in a patient, comprising: providing at least a portion of a liver-derived devitalized mammalian parenchymatous tissue combined with a target mammalian cell population, wherein the combined tissue and cell population is sized and shaped for implantation at the anatomical site in the patient; and implanting the combined tissue and cell population into a site remote from the tissue requiring restoration.
23. The method of claim 22, wherein the scaffold is implanted subcutaneously.
24. The method of claim 22, wherein the scaffold is implanted into the abdominal cavity.
25. The method of claim 22, wherein the scaffold is implanted into the thoracic cavity.
26. The method of claim 22, wherein the scaffold is implanted intracranialy.
PCT/US2004/006501 2003-03-07 2004-03-04 Decellularized liver for repair of tissue and treatment of organ deficiency WO2004080501A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002518229A CA2518229A1 (en) 2003-03-07 2004-03-04 Decellularized liver for repair of tissue and treatment of organ deficiency
AU2004220664A AU2004220664A1 (en) 2003-03-07 2004-03-04 Decellularized liver for repair of tissue and treatment of organ deficiency
EP04717383A EP1603602A1 (en) 2003-03-07 2004-03-04 Decellularized liver for repair of tissue and treatment of organ deficiency
JP2006509040A JP2006519865A (en) 2003-03-07 2004-03-04 Decellularized liver for tissue repair and treatment of organ defects

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/384,213 2003-03-07
US10/384,213 US20040176855A1 (en) 2003-03-07 2003-03-07 Decellularized liver for repair of tissue and treatment of organ deficiency

Publications (2)

Publication Number Publication Date
WO2004080501A1 WO2004080501A1 (en) 2004-09-23
WO2004080501B1 true WO2004080501B1 (en) 2004-11-18

Family

ID=32927215

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/006501 WO2004080501A1 (en) 2003-03-07 2004-03-04 Decellularized liver for repair of tissue and treatment of organ deficiency

Country Status (6)

Country Link
US (4) US20040176855A1 (en)
EP (1) EP1603602A1 (en)
JP (1) JP2006519865A (en)
AU (1) AU2004220664A1 (en)
CA (1) CA2518229A1 (en)
WO (1) WO2004080501A1 (en)

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US20080058956A1 (en) 2008-03-06
EP1603602A1 (en) 2005-12-14
US20040176855A1 (en) 2004-09-09
CA2518229A1 (en) 2004-09-23
AU2004220664A1 (en) 2004-09-23
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JP2006519865A (en) 2006-08-31
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