WO2004083399A3 - Aberrantly methylated genes in pancreatic cancer - Google Patents

Aberrantly methylated genes in pancreatic cancer Download PDF

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Publication number
WO2004083399A3
WO2004083399A3 PCT/US2004/008061 US2004008061W WO2004083399A3 WO 2004083399 A3 WO2004083399 A3 WO 2004083399A3 US 2004008061 W US2004008061 W US 2004008061W WO 2004083399 A3 WO2004083399 A3 WO 2004083399A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
subject
pancreatic cancer
regulatory region
pancreatic carcinoma
Prior art date
Application number
PCT/US2004/008061
Other languages
French (fr)
Other versions
WO2004083399A2 (en
Inventor
Michael G Goggins
Norihiro Sato
Original Assignee
Univ Johns Hopkins
Michael G Goggins
Norihiro Sato
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Michael G Goggins, Norihiro Sato filed Critical Univ Johns Hopkins
Priority to EP04757526A priority Critical patent/EP1604013A4/en
Priority to CA002519456A priority patent/CA2519456A1/en
Priority to US10/548,976 priority patent/US7485418B2/en
Priority to AU2004221394A priority patent/AU2004221394A1/en
Priority to JP2006507248A priority patent/JP2007524369A/en
Publication of WO2004083399A2 publication Critical patent/WO2004083399A2/en
Publication of WO2004083399A3 publication Critical patent/WO2004083399A3/en
Priority to US12/351,709 priority patent/US8785614B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Abstract

The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having the pancreatic carcinoma, thereby detecting pancreatic carcinoma in the subject.
PCT/US2004/008061 2003-03-17 2004-03-17 Aberrantly methylated genes in pancreatic cancer WO2004083399A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP04757526A EP1604013A4 (en) 2003-03-17 2004-03-17 Aberrantly methylated genes in pancreatic cancer
CA002519456A CA2519456A1 (en) 2003-03-17 2004-03-17 Aberrantly methylated genes in pancreatic cancer
US10/548,976 US7485418B2 (en) 2003-03-17 2004-03-17 Aberrantly methylated genes in pancreatic cancer
AU2004221394A AU2004221394A1 (en) 2003-03-17 2004-03-17 Aberrantly methylated genes in pancreatic cancer
JP2006507248A JP2007524369A (en) 2003-03-17 2004-03-17 Abnormal methylation genes in pancreatic cancer
US12/351,709 US8785614B2 (en) 2003-03-17 2009-01-09 Aberrantly methylated genes in pancreatic cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45461403P 2003-03-17 2003-03-17
US60/454,614 2003-03-17

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/548,976 A-371-Of-International US7485418B2 (en) 2003-03-17 2004-03-17 Aberrantly methylated genes in pancreatic cancer
US12/351,709 Division US8785614B2 (en) 2003-03-17 2009-01-09 Aberrantly methylated genes in pancreatic cancer

Publications (2)

Publication Number Publication Date
WO2004083399A2 WO2004083399A2 (en) 2004-09-30
WO2004083399A3 true WO2004083399A3 (en) 2007-10-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/008061 WO2004083399A2 (en) 2003-03-17 2004-03-17 Aberrantly methylated genes in pancreatic cancer

Country Status (6)

Country Link
US (2) US7485418B2 (en)
EP (1) EP1604013A4 (en)
JP (1) JP2007524369A (en)
AU (1) AU2004221394A1 (en)
CA (1) CA2519456A1 (en)
WO (1) WO2004083399A2 (en)

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WO2006113671A2 (en) * 2005-04-15 2006-10-26 Oncomethylome Sciences, S.A. Methylation markers for diagnosis and treatment of cancers
CA2656807A1 (en) * 2006-07-14 2008-01-24 Oncomethylome Sciences, S.A. Early detection and prognosis of colon cancers
JP2008136404A (en) * 2006-11-30 2008-06-19 Sysmex Corp Method for confirming amount of dna after conversion treatment of non-methylated cytosine in dna methylation detection
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JP5211790B2 (en) * 2007-03-26 2013-06-12 住友化学株式会社 DNA methylation measurement method
AU2008290060B2 (en) * 2007-08-20 2014-04-24 Oncotherapy Science, Inc. CDH3 peptide and medicinal agent comprising the same
DK2394170T3 (en) * 2009-02-03 2015-07-13 Mdxhealth Sa Methods for detecting colorectal cancer
US9187786B2 (en) * 2009-02-27 2015-11-17 The Johns Hopkins University Ovarian cancer methylome
EP2540839B1 (en) 2010-02-26 2015-07-01 Sysmex Corporation Method for determining presence or absence of cancer cell in biological sample, and molecular marker and kit for determination
WO2011119934A2 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
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US8529547B2 (en) * 2011-04-05 2013-09-10 Olympus Corporation Method of collecting specimen and method of diagnosing subject to detect upper digestive system disease
US8586384B2 (en) * 2011-04-05 2013-11-19 Olympus Corporation Method of collecting duodenal specimen to detect upper digestive system disease without using pancreatic or bile stimulant
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CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
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US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
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Publication number Priority date Publication date Assignee Title
US11970746B2 (en) 2010-02-03 2024-04-30 Exact Sciences Corporation Fecal sample processing and analysis comprising detection of blood

Also Published As

Publication number Publication date
WO2004083399A2 (en) 2004-09-30
EP1604013A2 (en) 2005-12-14
US20110003284A1 (en) 2011-01-06
CA2519456A1 (en) 2004-09-30
US7485418B2 (en) 2009-02-03
AU2004221394A1 (en) 2004-09-30
JP2007524369A (en) 2007-08-30
US8785614B2 (en) 2014-07-22
US20070015156A1 (en) 2007-01-18
EP1604013A4 (en) 2009-02-11

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