WO2004083811A3 - Method and apparatus for controlling position of a laser of a maldi mass spectrometer - Google Patents
Method and apparatus for controlling position of a laser of a maldi mass spectrometer Download PDFInfo
- Publication number
- WO2004083811A3 WO2004083811A3 PCT/US2004/006822 US2004006822W WO2004083811A3 WO 2004083811 A3 WO2004083811 A3 WO 2004083811A3 US 2004006822 W US2004006822 W US 2004006822W WO 2004083811 A3 WO2004083811 A3 WO 2004083811A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mass spectrometer
- maldi
- laser
- sample
- maldi mass
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
- H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0004—Imaging particle spectrometry
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04718066A EP1604383A2 (en) | 2003-03-17 | 2004-03-05 | Method and apparatus for controlling position of a laser of a maldi mass spectrometer |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45550503P | 2003-03-17 | 2003-03-17 | |
US45571403P | 2003-03-17 | 2003-03-17 | |
US60/455,714 | 2003-03-17 | ||
US60/455,505 | 2003-03-17 | ||
US10/603,488 | 2003-06-25 | ||
US10/603,488 US6956208B2 (en) | 2003-03-17 | 2003-06-25 | Method and apparatus for controlling position of a laser of a MALDI mass spectrometer |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004083811A2 WO2004083811A2 (en) | 2004-09-30 |
WO2004083811A3 true WO2004083811A3 (en) | 2005-04-28 |
Family
ID=33033152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/006822 WO2004083811A2 (en) | 2003-03-17 | 2004-03-05 | Method and apparatus for controlling position of a laser of a maldi mass spectrometer |
Country Status (3)
Country | Link |
---|---|
US (1) | US6956208B2 (en) |
EP (1) | EP1604383A2 (en) |
WO (1) | WO2004083811A2 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6982413B2 (en) * | 2003-09-05 | 2006-01-03 | Griffin Analytical Technologies, Inc. | Method of automatically calibrating electronic controls in a mass spectrometer |
DE102004044196B4 (en) * | 2004-09-14 | 2019-03-07 | Bruker Daltonik Gmbh | Mass spectrometer with a laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis |
US7262841B2 (en) * | 2005-03-17 | 2007-08-28 | Agilent Technologies, Inc. | Laser alignment for ion source |
US20060247863A1 (en) * | 2005-04-28 | 2006-11-02 | Bui Huy A | Optimizing maldi mass spectrometer operation by sample plate image analysis |
US7655476B2 (en) * | 2005-12-19 | 2010-02-02 | Thermo Finnigan Llc | Reduction of scan time in imaging mass spectrometry |
JP4765667B2 (en) * | 2006-02-27 | 2011-09-07 | ブラザー工業株式会社 | Image processing program and image processing apparatus |
JP4614000B2 (en) * | 2006-04-07 | 2011-01-19 | 株式会社島津製作所 | Mass spectrometer |
JP5377302B2 (en) * | 2006-07-19 | 2013-12-25 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | Dynamic pixel scanning using MALDI-MS |
GB2452239B (en) * | 2007-06-01 | 2012-08-29 | Kratos Analytical Ltd | Method and apparatus useful for imaging |
WO2011081180A1 (en) * | 2009-12-30 | 2011-07-07 | 公益財団法人野口研究所 | Maldi mass analysis method |
DE102010052975A1 (en) * | 2010-11-30 | 2012-05-31 | Bruker Daltonik Gmbh | Method and specimen support for assisting the manual preparation of samples for ionization with matrix-assisted laser desorption |
DE102010052976A1 (en) | 2010-11-30 | 2012-05-31 | Bruker Daltonik Gmbh | Support for the manual preparation of samples on a sample carrier for ionization with matrix-assisted laser desorption |
DE102011112649B4 (en) * | 2011-09-06 | 2014-02-27 | Bruker Daltonik Gmbh | Laser spot control in MALDI mass spectrometers |
KR20150015531A (en) | 2012-05-29 | 2015-02-10 | 바이오디식스, 인크. | Deep-MALDI TOF mass spectrometry of complex biological samples, e.g., serum, and uses thereof |
DE102012025046B4 (en) * | 2012-12-20 | 2015-03-05 | Bruker Daltonik Gmbh | Method for detecting a misuse on a MALDI sample carrier |
GB201304757D0 (en) * | 2013-03-15 | 2013-05-01 | Micromass Ltd | Method for resuction in acquisition time for MALSDI imaging by targeted acquisition |
WO2014140627A1 (en) | 2013-03-15 | 2014-09-18 | Micromass Uk Limited | Data directed storage of imaging mass spectra |
GB201304751D0 (en) * | 2013-03-15 | 2013-05-01 | Micromass Ltd | Data directed storage of imaging mass spectra |
CA2905318A1 (en) | 2013-03-15 | 2014-09-18 | Micromass Uk Limited | Automated tuning for maldi ion imaging |
US9390896B2 (en) | 2013-03-15 | 2016-07-12 | Micromass Uk Limited | Data directed acquisition of imaging mass |
JP6291972B2 (en) * | 2014-03-31 | 2018-03-14 | 三菱マテリアル株式会社 | Sampling position display device and sampling method |
CA3090811A1 (en) | 2018-03-14 | 2019-09-19 | Biomerieux, Inc. | Methods for aligning a light source of an instrument, and related instruments |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965884A (en) * | 1998-06-04 | 1999-10-12 | The Regents Of The University Of California | Atmospheric pressure matrix assisted laser desorption |
US20020120404A1 (en) * | 2000-12-21 | 2002-08-29 | Parker Kenneth C. | Methods and apparatus for mass fingerprinting of biomolecules |
Family Cites Families (26)
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JPH067471B2 (en) | 1986-03-26 | 1994-01-26 | 株式会社日立製作所 | Mass spectrometer |
US4867947A (en) | 1986-09-08 | 1989-09-19 | Sepragen Corporation | Interface for liquid chromatograph-mass spectrometer |
US4740298A (en) | 1986-09-08 | 1988-04-26 | Sepragen Corporation | Chromatography column/moving belt interface |
US5037611A (en) | 1988-11-29 | 1991-08-06 | Icr Research Associates, Inc. | Sample handling technique |
US5763875A (en) | 1991-11-12 | 1998-06-09 | Max Planck Gesellschaft | Method and apparatus for quantitative, non-resonant photoionization of neutral particles |
US5372862A (en) | 1993-10-14 | 1994-12-13 | Krishnaswamy; Jayaram | Coating technique for synchrotron beam tubes |
US5612887A (en) | 1995-02-09 | 1997-03-18 | The United States Of America As Represented By The Secretary Of The Air Force | Automation of pulsed laser deposition |
US5624722A (en) | 1995-03-07 | 1997-04-29 | Sumitomo Electric Industries, Ltd. | Apparatus and method for depositing films on substrate via on-axis laser ablation |
US5572025A (en) | 1995-05-25 | 1996-11-05 | The Johns Hopkins University, School Of Medicine | Method and apparatus for scanning an ion trap mass spectrometer in the resonance ejection mode |
DE19534590A1 (en) | 1995-09-11 | 1997-03-13 | Laser & Med Tech Gmbh | Scanning ablation of ceramic materials, plastics and biological hydroxyapatite materials, especially hard tooth substance |
US5696376A (en) | 1996-05-20 | 1997-12-09 | The Johns Hopkins University | Method and apparatus for isolating ions in an ion trap with increased resolving power |
DE19628112A1 (en) | 1996-07-12 | 1998-01-22 | Bruker Franzen Analytik Gmbh | Device and method for introducing sample carriers into a mass spectrometer |
GB9624927D0 (en) | 1996-11-29 | 1997-01-15 | Oxford Glycosciences Uk Ltd | Gels and their use |
US6674070B2 (en) | 1997-05-23 | 2004-01-06 | Northeastern University | On-line and off-line deposition of liquid samples for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy |
US6175112B1 (en) | 1998-05-22 | 2001-01-16 | Northeastern University | On-line liquid sample deposition interface for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy |
US5917185A (en) | 1997-06-26 | 1999-06-29 | Iowa State University Research Foundation, Inc. | Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry |
US6348688B1 (en) | 1998-02-06 | 2002-02-19 | Perseptive Biosystems | Tandem time-of-flight mass spectrometer with delayed extraction and method for use |
GB9807915D0 (en) | 1998-04-14 | 1998-06-10 | Shimadzu Res Lab Europe Ltd | Apparatus for production and extraction of charged particles |
US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
US6282213B1 (en) | 1998-09-14 | 2001-08-28 | Interscience, Inc. | Tunable diode laser with fast digital line selection |
DE19937438C2 (en) | 1999-08-07 | 2001-09-13 | Bruker Daltonik Gmbh | Coupling thin layer chromatography and mass spectrometry (TLC / MS) |
EP1314186A2 (en) | 2000-08-24 | 2003-05-28 | Newton Scientific, Inc. | Sample introduction interface for analytical processing |
US6617577B2 (en) | 2001-04-16 | 2003-09-09 | The Rockefeller University | Method and system for mass spectroscopy |
US6825466B2 (en) * | 2002-08-01 | 2004-11-30 | Automated Biotechnology, Inc. | Apparatus and method for automated sample analysis by atmospheric pressure matrix assisted laser desorption ionization mass spectrometry |
US20040023410A1 (en) | 2002-08-05 | 2004-02-05 | Catherine Stacey | Method and apparatus for continuous sample deposition on sample support plates for liquid chromatography-matrix-assisted laser desorption/ionization mass spectrometry |
US6707039B1 (en) * | 2002-09-19 | 2004-03-16 | Agilent Technologies, Inc. | AP-MALDI target illumination device and method for using an AP-MALDI target illumination device |
-
2003
- 2003-06-25 US US10/603,488 patent/US6956208B2/en not_active Expired - Fee Related
-
2004
- 2004-03-05 EP EP04718066A patent/EP1604383A2/en not_active Withdrawn
- 2004-03-05 WO PCT/US2004/006822 patent/WO2004083811A2/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965884A (en) * | 1998-06-04 | 1999-10-12 | The Regents Of The University Of California | Atmospheric pressure matrix assisted laser desorption |
US20020120404A1 (en) * | 2000-12-21 | 2002-08-29 | Parker Kenneth C. | Methods and apparatus for mass fingerprinting of biomolecules |
Also Published As
Publication number | Publication date |
---|---|
US20040183006A1 (en) | 2004-09-23 |
WO2004083811A2 (en) | 2004-09-30 |
US6956208B2 (en) | 2005-10-18 |
EP1604383A2 (en) | 2005-12-14 |
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