WO2004083944A3 - Polarized light devices and methods - Google Patents

Polarized light devices and methods Download PDF

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Publication number
WO2004083944A3
WO2004083944A3 PCT/US2004/008251 US2004008251W WO2004083944A3 WO 2004083944 A3 WO2004083944 A3 WO 2004083944A3 US 2004008251 W US2004008251 W US 2004008251W WO 2004083944 A3 WO2004083944 A3 WO 2004083944A3
Authority
WO
WIPO (PCT)
Prior art keywords
polarized light
methods
light devices
incident
directed
Prior art date
Application number
PCT/US2004/008251
Other languages
French (fr)
Other versions
WO2004083944A2 (en
Inventor
Anna M Yaroslavsky
Rox R Anderson
Original Assignee
Gen Hospital Corp
Anna M Yaroslavsky
Rox R Anderson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Anna M Yaroslavsky, Rox R Anderson filed Critical Gen Hospital Corp
Priority to AU2004220870A priority Critical patent/AU2004220870B2/en
Priority to EP04757597.2A priority patent/EP1610671B1/en
Publication of WO2004083944A2 publication Critical patent/WO2004083944A2/en
Publication of WO2004083944A3 publication Critical patent/WO2004083944A3/en
Priority to HK06107544.0A priority patent/HK1090820A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence

Abstract

The present invention is directed to a novel multi-spectral contrast agent-enhanced polarized light technique that enables rapid imaging of large tissue fields. The imaging device includes a tunable monochromatic light source (2, 3, 4, 5) and a CCD camera (15). Linear polarizers (9, 13) are placed into both the incident and collected light pathways in order to limit the measurement volume to the superficial tissue layers.
PCT/US2004/008251 2003-03-18 2004-03-18 Polarized light devices and methods WO2004083944A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2004220870A AU2004220870B2 (en) 2003-03-18 2004-03-18 Polarized light devices and methods
EP04757597.2A EP1610671B1 (en) 2003-03-18 2004-03-18 Polarized light devices and methods
HK06107544.0A HK1090820A1 (en) 2003-03-18 2006-07-04 Polarized light devices and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45561403P 2003-03-18 2003-03-18
US60/455,614 2003-03-18

Publications (2)

Publication Number Publication Date
WO2004083944A2 WO2004083944A2 (en) 2004-09-30
WO2004083944A3 true WO2004083944A3 (en) 2005-01-20

Family

ID=33030031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/008251 WO2004083944A2 (en) 2003-03-18 2004-03-18 Polarized light devices and methods

Country Status (5)

Country Link
US (1) US7627363B2 (en)
EP (1) EP1610671B1 (en)
AU (1) AU2004220870B2 (en)
HK (1) HK1090820A1 (en)
WO (1) WO2004083944A2 (en)

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US7289205B2 (en) * 2003-09-19 2007-10-30 The General Hospital Corporation Fluorescence polarization imaging devices and methods
US7532325B2 (en) * 2003-09-23 2009-05-12 Research Foundation Of The City University Of New York Method and apparatus for the separation of fluoroscence and elastic scattering produced by broadband illumination using polarization discrimination techniques
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Also Published As

Publication number Publication date
AU2004220870B2 (en) 2011-03-17
EP1610671A4 (en) 2007-04-25
EP1610671B1 (en) 2013-08-21
HK1090820A1 (en) 2007-01-05
WO2004083944A2 (en) 2004-09-30
EP1610671A2 (en) 2006-01-04
AU2004220870A1 (en) 2004-09-30
US7627363B2 (en) 2009-12-01
US20040249274A1 (en) 2004-12-09

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