WO2004087281A3 - Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system - Google Patents

Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system Download PDF

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Publication number
WO2004087281A3
WO2004087281A3 PCT/US2004/010163 US2004010163W WO2004087281A3 WO 2004087281 A3 WO2004087281 A3 WO 2004087281A3 US 2004010163 W US2004010163 W US 2004010163W WO 2004087281 A3 WO2004087281 A3 WO 2004087281A3
Authority
WO
WIPO (PCT)
Prior art keywords
microfluidic
implementation
components
including molecular
molecular fractionation
Prior art date
Application number
PCT/US2004/010163
Other languages
French (fr)
Other versions
WO2004087281A9 (en
WO2004087281A2 (en
Inventor
John R Gilbert
Manish Deshpande
Jaishree Trikha
Original Assignee
Cytonome Inc
John R Gilbert
Manish Deshpande
Jaishree Trikha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytonome Inc, John R Gilbert, Manish Deshpande, Jaishree Trikha filed Critical Cytonome Inc
Priority to EP04749668A priority Critical patent/EP1616189A4/en
Publication of WO2004087281A2 publication Critical patent/WO2004087281A2/en
Publication of WO2004087281A9 publication Critical patent/WO2004087281A9/en
Publication of WO2004087281A3 publication Critical patent/WO2004087281A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8411—Intermediate storage of effluent, including condensation on surface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors

Abstract

A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.
PCT/US2004/010163 2003-03-31 2004-03-31 Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system WO2004087281A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04749668A EP1616189A4 (en) 2003-03-31 2004-03-31 Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45902803P 2003-03-31 2003-03-31
US60/459,028 2003-03-31
US50173403P 2003-09-09 2003-09-09
US60/501,734 2003-09-09

Publications (3)

Publication Number Publication Date
WO2004087281A2 WO2004087281A2 (en) 2004-10-14
WO2004087281A9 WO2004087281A9 (en) 2004-11-18
WO2004087281A3 true WO2004087281A3 (en) 2005-06-16

Family

ID=33135123

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/010163 WO2004087281A2 (en) 2003-03-31 2004-03-31 Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system

Country Status (2)

Country Link
EP (1) EP1616189A4 (en)
WO (1) WO2004087281A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10753927B2 (en) 2006-09-22 2020-08-25 ALERE TECHNOLOGIES GmbH Methods for detecting an analyte
CN101743063B (en) * 2007-05-03 2012-12-12 科隆迪亚戈有限公司 Assays
CN102026725B (en) 2008-03-14 2014-10-29 科隆迪亚戈有限公司 Device for detecting analyte of sample and its detecting method
DE102012220250A1 (en) * 2012-11-07 2014-05-08 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. FLUIDIKMODUL FOR A CENTRIFUGAL FILTRATION AND METHOD FOR FILTERING A SAMPLE

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5962081A (en) * 1995-06-21 1999-10-05 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US20010041357A1 (en) * 1999-07-28 2001-11-15 Yves Fouillet Method for carrying out a biochemical protocol in continuous flow in a microreactor
US20020106786A1 (en) * 2000-05-15 2002-08-08 Carvalho Bruce L. Microfluidics devices and methods for performing cell based assays
US20030027354A1 (en) * 2001-06-08 2003-02-06 Francois Geli Device for the analysis of chemical or biochemical specimens, comparative analysis, and associated analysis process

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147606A (en) * 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US20020155010A1 (en) * 2001-04-24 2002-10-24 Karp Christoph D. Microfluidic valve with partially restrained element

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5962081A (en) * 1995-06-21 1999-10-05 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US20010041357A1 (en) * 1999-07-28 2001-11-15 Yves Fouillet Method for carrying out a biochemical protocol in continuous flow in a microreactor
US20020106786A1 (en) * 2000-05-15 2002-08-08 Carvalho Bruce L. Microfluidics devices and methods for performing cell based assays
US20030027354A1 (en) * 2001-06-08 2003-02-06 Francois Geli Device for the analysis of chemical or biochemical specimens, comparative analysis, and associated analysis process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1616189A4 *

Also Published As

Publication number Publication date
EP1616189A2 (en) 2006-01-18
WO2004087281A9 (en) 2004-11-18
WO2004087281A2 (en) 2004-10-14
EP1616189A4 (en) 2007-10-17

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