WO2004094671A3 - Methods and products for identification and assessment of tlr ligands - Google Patents

Methods and products for identification and assessment of tlr ligands Download PDF

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Publication number
WO2004094671A3
WO2004094671A3 PCT/US2004/012788 US2004012788W WO2004094671A3 WO 2004094671 A3 WO2004094671 A3 WO 2004094671A3 US 2004012788 W US2004012788 W US 2004012788W WO 2004094671 A3 WO2004094671 A3 WO 2004094671A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
assessment
products
identification
tlr ligands
Prior art date
Application number
PCT/US2004/012788
Other languages
French (fr)
Other versions
WO2004094671A9 (en
WO2004094671A2 (en
Inventor
Joerg Vollmer
Marion Jurk
Grayson B Lipford
Christian Schetter
Alexandra Forsbach
Arthur M Krieg
Original Assignee
Coley Pharm Gmbh
Coley Pharm Group Inc
Joerg Vollmer
Marion Jurk
Grayson B Lipford
Christian Schetter
Alexandra Forsbach
Arthur M Krieg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Gmbh, Coley Pharm Group Inc, Joerg Vollmer, Marion Jurk, Grayson B Lipford, Christian Schetter, Alexandra Forsbach, Arthur M Krieg filed Critical Coley Pharm Gmbh
Priority to EP04760178A priority Critical patent/EP1631687A2/en
Publication of WO2004094671A2 publication Critical patent/WO2004094671A2/en
Publication of WO2004094671A9 publication Critical patent/WO2004094671A9/en
Publication of WO2004094671A3 publication Critical patent/WO2004094671A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Abstract

The invention provides in part novel screening methods and compositions for identifying and distinguishing between candidate immunomodulatory compounds. The invention further provides methods for assessing biological activity of composition containing a known TLR ligand. These latter methods can be used for quality assessment and selection of various lots of test compositions, including pharmaceutical products for clinical use.
PCT/US2004/012788 2003-04-22 2004-04-22 Methods and products for identification and assessment of tlr ligands WO2004094671A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04760178A EP1631687A2 (en) 2003-04-22 2004-04-22 Methods and products for identification and assessment of tlr ligands

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46458803P 2003-04-22 2003-04-22
US46458603P 2003-04-22 2003-04-22
US60/464,588 2003-04-22
US60/464,586 2003-04-22

Publications (3)

Publication Number Publication Date
WO2004094671A2 WO2004094671A2 (en) 2004-11-04
WO2004094671A9 WO2004094671A9 (en) 2005-01-27
WO2004094671A3 true WO2004094671A3 (en) 2005-09-22

Family

ID=33313485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/012788 WO2004094671A2 (en) 2003-04-22 2004-04-22 Methods and products for identification and assessment of tlr ligands

Country Status (2)

Country Link
EP (1) EP1631687A2 (en)
WO (1) WO2004094671A2 (en)

Families Citing this family (35)

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US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
EP1733735B1 (en) 1998-05-22 2017-03-22 Ottawa Hospital Research Institute Methods and products for inducing mucosal immunity
EP2204186B1 (en) 1999-02-17 2016-04-06 CSL Limited Immunogenic complexes and methods relating thereto
AP1775A (en) 1999-09-25 2007-08-28 Univ Iowa Res Found Immunostimulatory nucleic acids.
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
WO2002022809A2 (en) 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST
SG177000A1 (en) 2001-08-17 2012-01-30 Coley Pharm Gmbh Combination motif immune stimulatory oligonucleotides with improved activity
EP3006043B1 (en) 2002-04-04 2019-05-29 Zoetis Belgium S.A. Immunostimulatory g,u-containing oligoribonucleotides
SG167667A1 (en) * 2002-07-03 2011-01-28 Coley Pharm Group Inc Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AR040996A1 (en) 2002-08-19 2005-04-27 Coley Pharm Group Inc IMMUNE STIMULATING NUCLEIC ACIDS
ZA200503511B (en) 2002-10-29 2006-10-25 Coley Pharmaceutical Group Ltd Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
US7956043B2 (en) 2002-12-11 2011-06-07 Coley Pharmaceutical Group, Inc. 5′ CpG nucleic acids and methods of use
CN101454451A (en) 2003-10-30 2009-06-10 科勒制药有限公司 C-class oligonucleotide analogs with enhanced immunostimulatory potency
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
WO2006054129A1 (en) 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
WO2007088423A2 (en) * 2005-09-16 2007-08-09 Coley Pharmaceutical Gmbh Immunostimulatory single-stranded ribonucleic acid with phosphodiester backbone
US8426375B2 (en) 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8399423B2 (en) 2005-10-12 2013-03-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8383598B2 (en) 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
KR101455081B1 (en) * 2005-10-12 2014-10-27 이데라 파마슈티칼즈, 인코포레이티드 Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
KR20080072934A (en) 2005-11-25 2008-08-07 콜리 파마슈티칼 게엠베하 Immunostimulatory oligoribonucleotides
MX2009003398A (en) 2006-09-27 2009-08-12 Coley Pharm Gmbh Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity.
US8377898B2 (en) 2006-10-12 2013-02-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US20110076296A1 (en) 2008-04-25 2011-03-31 Innate Pharma S.A. TLR3 Agonist Compositions
US8853177B2 (en) 2008-10-06 2014-10-07 Idera Pharmaceuticals, Inc. Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
SG194005A1 (en) 2011-04-08 2013-11-29 Roquette Freres Methods for detecting contaminants in solutions containing glucose polymers
CN110248668B (en) 2016-12-15 2023-05-30 杜克大学 Antibodies and methods for depleting regulatory B10 cells and combination with immune checkpoint inhibitors
US20220170042A1 (en) * 2020-11-27 2022-06-02 Wyvern Pharmaceuticals Inc. Compositions and methods for regulating production of a precursor protein
CA3213217A1 (en) 2021-04-28 2022-11-03 Raphael Darteil Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment

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WO1998050547A2 (en) * 1997-05-07 1998-11-12 Schering Corporation Human toll-like receptor proteins, related reagents and methods
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WO2002085933A1 (en) * 2001-04-20 2002-10-31 The Institute For Systems Biology Toll-like receptor 5 ligands and methods of use
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WO1998050547A2 (en) * 1997-05-07 1998-11-12 Schering Corporation Human toll-like receptor proteins, related reagents and methods
US20030032090A1 (en) * 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
WO1999020756A2 (en) * 1997-10-17 1999-04-29 Genentech, Inc. Human toll homologues
WO2000067023A1 (en) * 1999-04-29 2000-11-09 Coley Pharmaceutical Gmbh Screening for immunostimulatory dna functional modifyers
WO2001055386A1 (en) * 2000-01-25 2001-08-02 Glaxosmithkline Toll-like receptor
WO2002022809A2 (en) * 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST
WO2002085933A1 (en) * 2001-04-20 2002-10-31 The Institute For Systems Biology Toll-like receptor 5 ligands and methods of use
WO2003031573A2 (en) * 2001-10-05 2003-04-17 Coley Pharmaceutical Gmbh Toll-like receptor 3 signaling agonists and antagonists

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Title
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JURK M ET AL: "HUMAN TLR7 OR TLR8 INDEPENDENTLY CONFER RESPONSIVENESS TO THE ANTIVIRAL COMPOUND R-848", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP,, GB, vol. 3, no. 6, June 2002 (2002-06-01), pages 499, XP009000821, ISSN: 1529-2908 *
ROTHENFUSSER SIMON ET AL: "Recent advances in immunostimulatory CpG oligonucleotides.", CURRENT OPINION IN MOLECULAR THERAPEUTICS. APR 2003, vol. 5, no. 2, April 2003 (2003-04-01), pages 98 - 106, XP009037365, ISSN: 1464-8431 *
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VERTHELYI D ET AL: "Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 FEB 2001, vol. 166, no. 4, 15 February 2001 (2001-02-15), pages 2372 - 2377, XP002299044, ISSN: 0022-1767 *
VOLLMER J ET AL: "IMMUNOPHARMACOLOGY OF CPG OLIGODEOXYNUCLEOTIDE AND RIBAVIRIN", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 48, no. 6, June 2004 (2004-06-01), pages 2314 - 2317, XP009032686, ISSN: 0066-4804 *
YOSHIOKA T ET AL: "Bacterial lipopolysaccharide induces transforming growth factor beta and hepatocyte growth factor through toll-like receptor 2 in cultured human colon cancer cells.", THE JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. 2001 SEP-OCT, vol. 29, no. 5, September 2001 (2001-09-01), pages 409 - 420, XP009037464, ISSN: 0300-0605 *

Also Published As

Publication number Publication date
WO2004094671A9 (en) 2005-01-27
EP1631687A2 (en) 2006-03-08
WO2004094671A2 (en) 2004-11-04

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