WO2004098567A3 - Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer - Google Patents

Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer Download PDF

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Publication number
WO2004098567A3
WO2004098567A3 PCT/US2004/013810 US2004013810W WO2004098567A3 WO 2004098567 A3 WO2004098567 A3 WO 2004098567A3 US 2004013810 W US2004013810 W US 2004013810W WO 2004098567 A3 WO2004098567 A3 WO 2004098567A3
Authority
WO
WIPO (PCT)
Prior art keywords
active agent
agent component
dosage form
tamper
adverse
Prior art date
Application number
PCT/US2004/013810
Other languages
French (fr)
Other versions
WO2004098567A2 (en
Inventor
Stephen A Howard
Bruce Reidenberg
Original Assignee
Purdue Pharma Lp
Stephen A Howard
Bruce Reidenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33436723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004098567(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to NZ542969A priority Critical patent/NZ542969A/en
Priority to AU2004235794A priority patent/AU2004235794B8/en
Priority to CN200480011691.XA priority patent/CN1780611B/en
Priority to CA2522529A priority patent/CA2522529C/en
Priority to EP04751268.6A priority patent/EP1641441B1/en
Priority to YUP-2005/0812A priority patent/RS20050812A/en
Priority to MEP-2008-492A priority patent/ME00276B/en
Priority to KR1020057020592A priority patent/KR101159828B1/en
Priority to MXPA05011703A priority patent/MXPA05011703A/en
Priority to JP2006514265A priority patent/JP5048324B2/en
Application filed by Purdue Pharma Lp, Stephen A Howard, Bruce Reidenberg filed Critical Purdue Pharma Lp
Priority to BRPI0409945-1A priority patent/BRPI0409945A/en
Priority to EA200501702A priority patent/EA009623B1/en
Publication of WO2004098567A2 publication Critical patent/WO2004098567A2/en
Publication of WO2004098567A3 publication Critical patent/WO2004098567A3/en
Priority to IS8060A priority patent/IS2935B/en
Priority to NO20054682A priority patent/NO332157B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Abstract

The invention comprises a transdermal dosage form comprising an active agent component comprising an active agent and an adverse agent component comprising an adverse agent, wherein the active agent component defines at least one channel extending substantially there through.
PCT/US2004/013810 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer WO2004098567A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
EA200501702A EA009623B1 (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form
JP2006514265A JP5048324B2 (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active substance element and a side-effect substance element distal to the active substance layer
MXPA05011703A MXPA05011703A (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer.
CA2522529A CA2522529C (en) 2003-04-30 2004-04-30 Tamper resistant transdermal dosage form
AU2004235794A AU2004235794B8 (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
YUP-2005/0812A RS20050812A (en) 2003-04-30 2004-04-30 Tamper resistant transdermal dosage form
MEP-2008-492A ME00276B (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
NZ542969A NZ542969A (en) 2003-04-30 2004-04-30 Tamper resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
CN200480011691.XA CN1780611B (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
EP04751268.6A EP1641441B1 (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
KR1020057020592A KR101159828B1 (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
BRPI0409945-1A BRPI0409945A (en) 2003-04-30 2004-04-30 change resistant dosage form
IS8060A IS2935B (en) 2003-04-30 2005-10-04 Anti-doping dosage forms
NO20054682A NO332157B1 (en) 2003-04-30 2005-10-12 Manipulation-safe transdermal dosage form comprising an active substance component and a counteracting drug component at the distal region of the active drug layer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46723503P 2003-04-30 2003-04-30
US46724303P 2003-04-30 2003-04-30
US60/467,235 2003-04-30
US60/467,243 2003-04-30

Publications (2)

Publication Number Publication Date
WO2004098567A2 WO2004098567A2 (en) 2004-11-18
WO2004098567A3 true WO2004098567A3 (en) 2005-01-13

Family

ID=33436723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/013810 WO2004098567A2 (en) 2003-04-30 2004-04-30 Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer

Country Status (22)

Country Link
US (1) US8778382B2 (en)
EP (3) EP2319505A1 (en)
JP (1) JP5048324B2 (en)
KR (1) KR101159828B1 (en)
AR (1) AR047936A1 (en)
AU (1) AU2004235794B8 (en)
BR (1) BRPI0409945A (en)
CA (1) CA2522529C (en)
CL (1) CL2004000927A1 (en)
EA (1) EA009623B1 (en)
EC (1) ECSP056191A (en)
IS (1) IS2935B (en)
ME (1) ME00276B (en)
MX (1) MXPA05011703A (en)
MY (1) MY141815A (en)
NO (1) NO332157B1 (en)
NZ (1) NZ542969A (en)
PE (2) PE20050146A1 (en)
RS (1) RS20050812A (en)
TW (1) TWI350186B (en)
UA (1) UA82880C2 (en)
WO (1) WO2004098567A2 (en)

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