WO2004101809A3 - Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture - Google Patents

Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture Download PDF

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Publication number
WO2004101809A3
WO2004101809A3 PCT/US2004/015196 US2004015196W WO2004101809A3 WO 2004101809 A3 WO2004101809 A3 WO 2004101809A3 US 2004015196 W US2004015196 W US 2004015196W WO 2004101809 A3 WO2004101809 A3 WO 2004101809A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
mass spectrometry
methods
subsequent analysis
solution capture
Prior art date
Application number
PCT/US2004/015196
Other languages
French (fr)
Other versions
WO2004101809A2 (en
Inventor
Steven A Hofstadler
Lendell L Cummins
Original Assignee
Isis Pharmaceuticals Inc
Steven A Hofstadler
Lendell L Cummins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Steven A Hofstadler, Lendell L Cummins filed Critical Isis Pharmaceuticals Inc
Priority to CA2525498A priority Critical patent/CA2525498C/en
Priority to CN2004800161879A priority patent/CN1806050B/en
Priority to JP2006533082A priority patent/JP2007516425A/en
Priority to EP04752257A priority patent/EP1623039B1/en
Priority to AU2004239340A priority patent/AU2004239340A1/en
Publication of WO2004101809A2 publication Critical patent/WO2004101809A2/en
Publication of WO2004101809A3 publication Critical patent/WO2004101809A3/en
Priority to AU2008205432A priority patent/AU2008205432B8/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides methods for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides for kits useful for practicing rapid solution capture of nucleic acids so that purified samples are in condition for analysis by electrospray mass spectrometry.
PCT/US2004/015196 2003-05-13 2004-05-13 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture WO2004101809A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2525498A CA2525498C (en) 2003-05-13 2004-05-13 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
CN2004800161879A CN1806050B (en) 2003-05-13 2004-05-13 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
JP2006533082A JP2007516425A (en) 2003-05-13 2004-05-13 Rapid purification of nucleic acids by solution capture for later analysis using mass spectrometry
EP04752257A EP1623039B1 (en) 2003-05-13 2004-05-13 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
AU2004239340A AU2004239340A1 (en) 2003-05-13 2004-05-13 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
AU2008205432A AU2008205432B8 (en) 2003-05-13 2008-08-14 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47054703P 2003-05-13 2003-05-13
US60/470,547 2003-05-13

Publications (2)

Publication Number Publication Date
WO2004101809A2 WO2004101809A2 (en) 2004-11-25
WO2004101809A3 true WO2004101809A3 (en) 2005-09-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/015196 WO2004101809A2 (en) 2003-05-13 2004-05-13 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture

Country Status (8)

Country Link
US (1) US7964343B2 (en)
EP (1) EP1623039B1 (en)
JP (2) JP2007516425A (en)
KR (1) KR100779138B1 (en)
CN (1) CN1806050B (en)
AU (2) AU2004239340A1 (en)
CA (1) CA2525498C (en)
WO (1) WO2004101809A2 (en)

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