WO2004102193A3 - Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers - Google Patents

Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers Download PDF

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Publication number
WO2004102193A3
WO2004102193A3 PCT/US2004/014262 US2004014262W WO2004102193A3 WO 2004102193 A3 WO2004102193 A3 WO 2004102193A3 US 2004014262 W US2004014262 W US 2004014262W WO 2004102193 A3 WO2004102193 A3 WO 2004102193A3
Authority
WO
WIPO (PCT)
Prior art keywords
tunable
biosensor
light
reflected
detection
Prior art date
Application number
PCT/US2004/014262
Other languages
French (fr)
Other versions
WO2004102193A2 (en
Inventor
Brian T Cunningham
Peter Y Li
Constance Chang-Hasnain
Carlos Mateus
Original Assignee
Sru Biosystems Llc
Univ California
Brian T Cunningham
Peter Y Li
Constance Chang-Hasnain
Carlos Mateus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sru Biosystems Llc, Univ California, Brian T Cunningham, Peter Y Li, Constance Chang-Hasnain, Carlos Mateus filed Critical Sru Biosystems Llc
Priority to EP04751596A priority Critical patent/EP1623220B1/en
Priority to CA2525240A priority patent/CA2525240C/en
Priority to AT04751596T priority patent/ATE485511T1/en
Priority to AU2004239726A priority patent/AU2004239726B2/en
Priority to DE602004029665T priority patent/DE602004029665D1/en
Priority to NZ543982A priority patent/NZ543982A/en
Publication of WO2004102193A2 publication Critical patent/WO2004102193A2/en
Publication of WO2004102193A3 publication Critical patent/WO2004102193A3/en
Priority to HK06103657.2A priority patent/HK1081271A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide

Abstract

An apparatus and method for detection of peak wavelength values of colorimetric resonant optical biosensors using tunable filters and tunable lasers is provided. Biomolecular interactions may be detected on a biosensor by directing collimated white light towards a surface of the biosensor. Molecular binding on the surface of the biosensor is indicated by a shift in the peak wavelength value of reflected or transmitted light from the biosensor, while an increase in the wavelength corresponds to an increase in molecular absorption. A tunable laser light source may generate the collimated white light and a tunable filter may receive the reflected or transmitted light and pass the light to a photodiode sensor. The photodiode sensor then quantifies an amount of the light reflected or transmitted through the tunable filter as a function of the tuning voltage of the tunable filter.
PCT/US2004/014262 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers WO2004102193A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP04751596A EP1623220B1 (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
CA2525240A CA2525240C (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
AT04751596T ATE485511T1 (en) 2003-05-08 2004-05-07 DETECTION OF BIOCHEMICAL INTERACTIONS ON A BIOSENSOR USING TUNABLE FILTERS AND TUNABLE LASERS
AU2004239726A AU2004239726B2 (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
DE602004029665T DE602004029665D1 (en) 2003-05-08 2004-05-07 DETECTION OF BIOCHEMICAL INTERACTIONS ON A BIOSENSOR USING TUNABLE FILTERS AND TUNABLE LASERS
NZ543982A NZ543982A (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
HK06103657.2A HK1081271A1 (en) 2003-05-08 2006-03-23 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/434,015 US7497992B2 (en) 2003-05-08 2003-05-08 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US10/434,015 2003-05-08

Publications (2)

Publication Number Publication Date
WO2004102193A2 WO2004102193A2 (en) 2004-11-25
WO2004102193A3 true WO2004102193A3 (en) 2005-03-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/014262 WO2004102193A2 (en) 2003-05-08 2004-05-07 Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers

Country Status (9)

Country Link
US (2) US7497992B2 (en)
EP (1) EP1623220B1 (en)
AT (1) ATE485511T1 (en)
AU (1) AU2004239726B2 (en)
CA (2) CA2723087A1 (en)
DE (1) DE602004029665D1 (en)
HK (1) HK1081271A1 (en)
NZ (1) NZ543982A (en)
WO (1) WO2004102193A2 (en)

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