WO2004105649A1

WO2004105649A1 - Injector cartridge for inserting intraocular lens and intraocular lens inserting device

Info

Publication number: WO2004105649A1
Application number: PCT/JP2004/007913
Authority: WO
Inventors: Hidetoshi Iwamoto
Original assignee: Hoya Healthcare Corporation
Priority date: 2003-06-02
Filing date: 2004-06-01
Publication date: 2004-12-09
Also published as: JPWO2004105649A1

Abstract

An intraocular lens inserting device used when a soft intraocular lens is inserted from an incision cut into an eye ball and implanted therein, comprising a slidable resin cartridge for inserting an intraocular lens which is installed in an injector body having an extruding mechanism, storably setting the lens to be transplanted in the eye ball, and formed in a hollow structure for extruding the lens in the eye ball. The inside wall surface of the hollow tube of the cartridge is roughly processed, and the sliding resin forming the cartridge has a coefficient of friction of 0.4 or less.

Description

Description Intraocular lens introduction injector force cartridge and intraocular lens introduction device

The present invention relates to an intraocular lens introduction injector and a cartridge, and an intraocular lens introduction device. More specifically, the present invention relates to an intraocular lens, an injector cartridge for use in inserting the intraocular lens from a relatively small incision wound, and an intraocular lens insertion device using the injector cartridge. is there.

Background art

In recent years, the number of senile cataract patients has been increasing with the increase of the elderly population. Cataract treatment removes cloudy lens nuclei and cortex, and is done by either correcting the eyesight with eyeglasses or contact lenses, or by inserting an intraocular lens. Later, a method of fixing the intraocular lens is widely practiced. The intraocular lens includes a polymethyl methacrylate lens made of a hard material with a glass transition ¾S of 10 o ° c or more, and a soft intraocular material made of a silicone-based acrylic material developed as a lens for small incision surgery. The lens has been raised.

At present, there are many small incision surgical procedures aimed at the simplicity of surgery, the reduction of postoperative astigmatism, and the quick recovery, and the demand for flexible intraocular lenses is growing significantly. In general, the method of inserting the lens into the eye was to insert the lens with tweezers and then insert it from the small incision wound. A special injector system has been developed for introducing flexible lenses. By adopting this system, the lens can be safely introduced into the eye with a 3.0 to 3.5 mm incision. There are various designs of the intraocular lens introduction device, but they are basically divided into a cartridge portion and an injector body. Cartridges This is a hollow tube having a lens insertion port and an extrusion port, and is made of a polymer material. The surgeon holds the injector body in his hand, pushes the lens installed in the cartridge while pushing the plunger forward, and inserts the lens into the eye. Generally, there are a push type and a screw type as a mechanism for pushing out the plunger. The injector body does not touch the eyeball tissue, but the tip of the cartridge is inserted into the eyeball.

With respect to the cartridge, for example, a glycerol ester of a carboxylic acid having about 10 to 30 carbon atoms per molecule as a lubricating component, for example, a polypropylene resin, a glycerol ester of a carboxylic acid having, for example, glycerol monostearate, monopalmitic acid Glycerol and glycerol monooleate are added and molded. After plasma treatment and blooming process, the lubricity improving component is bleeded to the surface, and the inner surface is coated with a hydrophilic component such as hydroxymethylcellulose. There is known a technique for producing the same (for example, see Japanese Patent Application Laid-Open No. 2000-51043333). By using this cartridge, the lens bent small inside the hollow tube can be smoothly slid and moved inside the tube by the lubricity improving component bleeding on the inner surface of the hollow tube, and inserted into the eyeball. it can. With this method, the lens can be pushed out from a fairly small hollow tube with a moderate force.

Also, a technique is known in which the inner wall of a cartridge is coated with a covalently bonded lubricity improving component, for example, polybutylpyrrolidone or polyethylene render glycol (see, for example, Japanese Patent Application Laid-Open No. 2001-504704). ).

However, in these techniques, although a large pushing load is not required for the lens to slide smoothly, there is a problem that the lubricity improving component is inevitably attached to the lens. For example, when the technique disclosed in JP-T-2000-0 514 33 33 is described in detail, the intraocular lens has a lubricity improving component bleeding on the inner surface of the cartridge. When slipping out of the lens, the lubricity improving component adheres to the surface of the optical part or the loop of the lens, and as a result, the lubricity improving component stays in the eye, which is a very serious problem in terms of safety. In addition, since the amount of the lubricating component varies depending on the temperature and humidity, it is extremely difficult to control the amount of bleed and maintain quality. Furthermore, in the production of the cartridge, the technique disclosed in JP-T-200-501-433 requires an oxygen plasma treatment step and a blooming step. The technique disclosed in Japanese Patent Publication No. 40 has a problem that the process is complicated, such as irradiating the coating on the inner wall with ultraviolet rays, and the cost is inevitably increased.

Also, there is known a technique of inserting an intraocular lens into an eye using an intraocular lens insertion device in which the inner wall of a hollow tube constituting the intraocular lens insertion device has a roughened surface (for example, Japanese Patent Application Laid-Open Publication No. 2002-54092). Japanese Patent Application Laid-Open Publication No. 2002-54028 884 discloses that polypropylene resin is preferably used as a material of a hollow tube constituting an intraocular lens insertion device.

Disclosure of the invention

However, when an injector and a cartridge for inserting an intraocular lens are made of polypropylene resin in the same manner as in the intraocular lens insertion device described in Japanese Patent Application Laid-Open No. 2002-54028,84, the hollow tube of the cartridge is In spite of the fact that the inner wall is roughened, according to the study of the present inventor, when the intraocular lens is set and pushed out in this case, the intraocular lens stops in the middle of the cartridge, It became clear that the support of the intraocular lens was damaged (see Comparative Examples 2 and 3 described later). In order to solve this problem, a cartridge was prepared by adding glycerol monostearate as a lubricity improving component to a polypropylene resin, followed by oxygen plasma treatment and bridging treatment. Although the extruded state was improved, it became clear that the lubricity improving component was attached to the optical part of the intraocular lens (see Comparative Example 4 described later).

The present invention is directed to an injector cartridge which is used when an intraocular lens is bent from a relatively small incision and is introduced into the eye under such circumstances, and an excessive force is applied when the lens is inserted. In addition to the conventional cartridge, various compounds present as lubricity improving components on the inner surface of the cartridge do not adhere to the lens, making it extremely safe and easy to manufacture. The primary object of the present invention is to provide a lens introduction injector.

The present invention also provides an injector for inserting an intraocular lens which achieves the first object. A second object is to provide an intraocular lens insertion device using a cartridge. The inventor of the present invention has conducted intensive studies to develop an intraocular lens having the above-mentioned excellent functions, an injector and a cartridge for insertion and an intraocular lens insertion device. As a result, the lens of a cartridge made of a slidable resin was obtained. If the inner wall surface of the hollow tube from the inlet to the outlet is roughened and the slidable resin that composes the cartridge has a coefficient of friction less than a certain value, the purpose can be achieved. The present inventors have completed the present invention based on these findings.

That is, the present invention

(1) In an intraocular lens insertion device used for implanting and implanting a soft intraocular lens from the incision into the eyeball, a lens attached to the injector body having an extrusion mechanism and implanted into the eye A cartridge made of a slidable resin having a hollow structure for installing and housing and extruding the lens into the eye, wherein the inner wall surface of the hollow tube of the cartridge is roughened, and the slide forming the cartridge is provided. Wherein the conductive resin is a resin having a friction coefficient of 0.5 or less,

(2) The injector cartridge for introducing an intraocular lens according to claim 1, wherein the average surface roughness Ra of the inner wall surface of the hollow tube having the roughened surface is 0.5 to 5.0 μm.

(3) The slidable resin having a friction coefficient of 0.5 or less is at least one selected from a high-molecular-weight polyethylene resin, a fluorine-based resin, a polyamide-based resin, a polyacetal resin, and a polyphenylene phenol resin. Injection cartridge for intraocular lens according to 1,

(4) The injector cartridge according to any one of claims 1 to 3, wherein the injector cartridge molding die is formed by using a roughened surface of a die pin portion surface for forming a hollow tube. The described injector cartridge for introducing an intraocular lens.

(5) The injector cartridge for introducing an intraocular lens according to any one of claims 1 to 3, wherein the inner wall surface of the hollow tube of the cartridge is roughened by using a cylindrical file or sandblast.

(6) An intraocular lens insertion device including an injector body and the intraocular lens insertion injector cartridge according to any one of claims 1 to 5, and (7) The intraocular lens insertion device according to claim 6, wherein the injector cartridge for introducing the intraocular lens and the injector body are integrated or separable.

The intraocular lens introduction injector force cartridge of the present invention can safely insert the lens into the eye with an appropriate force without damaging the supporting portion and the optical portion of the lens. Since there is no need for an improving component, it has an effect of being excellent in safety. By using this injector cartridge, an intraocular lens insertion device useful in ophthalmic surgery can be obtained.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a partially transparent perspective view of an example of an injector power cartridge according to the present invention. FIG. 2 is a perspective view of an example of an injector main body used to mount the injector cartridge of the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION

The intraocular lens insertion injector force cartridge of the present invention has an extrusion mechanism in an intraocular lens insertion device used when implanting and implanting a soft intraocular lens into the eyeball from a relatively small incision. This is a cartridge made of a slidable resin having a hollow structure for mounting and storing a lens to be implanted into the eye, mounted on the injector body, and for pushing the lens into the eye.

As the slidable resin constituting the cartridge of the present invention, in order to improve the slip of the lens in the cartridge hollow tube, the coefficient of friction measured by the following method is 0.5 or less, preferably 0.4 or less, more preferably Use 0.2 or less resin.

The coefficient of friction can be measured in accordance with ASTM D1884.For example, using a thrust type testing machine, select SUS304 as the mating material, place the test piece on it, and at room temperature. Measure.

Examples of such resins include high molecular weight polyethylene resins, fluorine resins, polyamide resins, polyacetal resins, and polyphenylene sulfide. Here, high molecular weight polyethylene resin (HMW-PE) is manufactured by Ziegler polymerization technology, and the average molecular weight is 100,000 to 6 It is a polyethylene resin of about 100,000, and has properties such as excellent wear resistance and impact strength, low friction coefficient, excellent self-lubricating properties, and extremely low water absorption. Fluorocarbon resins have excellent properties such as excellent heat resistance, chemical resistance, and electrical insulation as well as unique non-adhesiveness and low friction. Examples of the fluorine-based resin include tetrafluoroethylene resin, tetrafluoroethylene-hexafluoropropylene copolymer resin, tetrafluoroethylene-perfluoroalkoxyethylene copolymer resin, trifluoroethylene chloride resin, and tetrafluoroethylene resin. Some powers such as fluorinated ethylene-ethylene copolymer resin and vinylidene fluoride resin are among these. Polyamide resins have, as common properties, excellent impact resistance, oil resistance, chemical resistance, and heat resistance, as well as a low coefficient of friction, excellent wear resistance, and self-lubricating properties. Examples of the polyamide system include nylon 6, nylon 66, nylon 610, nylon 612, nylon 11, nylon 12, and the like.Nylon 6, nylon 66, nylon 1 2 is preferred. Polyacetal resin has excellent properties such as excellent creep resistance, fatigue resistance, and toughness, excellent friction and wear properties, self-lubricating properties, and the ability to be used as a sliding member without lubrication. are doing . Polyphenylene sulfide resin has excellent heat resistance, flame retardancy, chemical resistance, mechanical properties, and dimensional stability, and has a low friction coefficient. Used as advanced sliding material.

In the present invention, one of these slidable resins may be used alone, or two or more thereof may be used in combination.In addition, for the purpose of further improving the slidability, if desired, An appropriate amount of the third component can be added. Further, as the slidable resin, it is desirable that the state in which the lens is installed and stored in the cartridge and the state in which the lens is pushed out can be confirmed from the outside, and therefore, a resin having transparency is preferable. Among the above-mentioned slidable resins, a high molecular weight polyethylene resin is particularly preferable in terms of balance between slidability, transparency, and moldability.

In the cartridge of the present invention, it is necessary that the inner wall surface of the hollow tube is roughened. This roughening reduces the contact area between the lens surface and the inner surface of the hollow tube, and also allows a viscous substance, such as hyaluronic acid, used when penetrating the lens into the eye to make the contact between the lens surface and the inner surface of the hollow tube. It is applied so that it is not completely removed from the gap This further improves the slip of the lens.

The roughening is preferably performed so as to form streaks in the longitudinal direction on the inner wall surface of the hollow tube of the cartridge, and is preferably performed on the entire inner wall surface of the hollow tube from the intraocular lens to the entrance to the exit. .

The average surface roughness Ra of the inner wall surface of the roughened hollow tube is usually about 0.5 to 5.5 μμη in order to push the lens into the eye smoothly with a small force. If this Ra is less than 0.5 μπι, a large force may be required to push out the lens, and it is difficult to achieve the object of the present invention. On the other hand, if it exceeds 5.0 O / m, the resistance becomes large. It is not preferable. The preferred value of Ra is 0.7 to 3.3. Incidentally, the average surface roughness R a is Taylor Hobson Ne ring form Talysurf (scanning distance:. 0 5 mm _s approximate shape: Conca V e, stylus: diamond) is a value measured using a.

The method for roughening the inner wall surface of the cartridge hollow tube is not particularly limited as long as the inner wall surface can be easily roughened. For example, the following method can be employed. Specifically, a method is used in which a cartridge is formed using a mold for forming a hollow tube having a roughened surface of a mold pin portion for forming a hollow tube. In this case, in order to roughen the mold pin surface, sandpaper surface polishing, sandplasting and chemical etching, such as sipo processing, should be used with warworms or in combination. Can be. Since the surface shape of the mold pin portion is transferred to the inner wall surface of the cartridge hollow tube, it is preferable that the surface of the mold pin portion is roughened in the longitudinal direction into a stripe shape. Also, a method of roughening the inner wall surface of the hollow tube of a cartridge formed by using a normal mold with a cylindrical file or sandplast having the same inner diameter, or a method of performing plasma processing can be used. When roughing is performed using a cylindrical file, it is preferable to extrude the file in the longitudinal direction of the cartridge.

The ophthalmic lens insertion device of the present invention includes an injector main body and an intraocular lens inserting injector.

The injector main body constituting the intraocular lens insertion device may be a known injector body. Examples of the material include metal, ceramics, and plastics. In the intraocular lens insertion device, the above-described injector cartridge of the present invention is used as an injector cartridge for inserting an intraocular lens adapted to the injector body.

In the intraocular lens insertion device of the present invention, the injector body and the injector cartridge may be integrated or may be separable.

When the injector main body and the injector cartridge are integrated, it is preferable to use the same material as the injector main body (slidable resin) as the material of the injector main body. When the cartridge is separable, the above various materials can be used as the material of the injector body.

FIG. 1 is a partially transparent perspective view of an example of an injector force cartridge according to the present invention. A cartridge 10 includes a hollow tube 1 having a distal end portion 2 inserted into an eye, and a cartridge. And a plate-shaped body 3 and 3 'for holding by hand when attached to the main body. FIG. 1 shows a state in which the soft intraocular lens 4 is installed and housed in a cartridge (not shown) filled with a viscoelastic substance such as hyanoleronic acid. At least the tapered portion 6 of the cartridge 10 to the outlet of the distal end portion 2 is roughened in a longitudinal direction in a stripe shape.

FIG. 2 is a perspective view of an example of the injector main body. The injector main body 20 includes a hand member 11 having a cartridge mounting portion 13 and a plunger 12. After the cartridge 10 in which the lens 4 is installed and stored is mounted on the cartridge mounting portion 13 of the hand member 11, the plunger 12 is pressed, whereby the lens 4 is moved into the hollow space 5 in the cartridge. Through the cartridge, it is extruded into the eye from the tip 2 of the cartridge together with a viscoelastic substance such as hyal valerate. Since the injector cartridge of the present invention is made of a slidable resin and the inner wall surface of the hollow tube is roughened, no excessive force is required when inserting the lens into the eye. Also, unlike conventional cartridges, various compounds present as lubricity-improving components on the inner surface do not adhere to the lens, and are extremely safe. In addition, in the production of conventional cartridges, a lubricity improving component is mixed with resin. In order to bleed the surface, it is necessary to perform a complicated operation such as oxygen plasma treatment, and to coat the inner surface of the hollow tube of the cartridge with a lubricity-improving component, it is difficult to apply ultraviolet light. Although an operation is required, the present invention can extremely easily produce a desired cartridge only by roughening the mold pin portion with sandpaper or the like.

【Example】

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

The coefficient of friction of the resin in the following Examples and Comparative Examples was as follows: SUS304 was selected as the mating material in accordance with ASTMD1894, and a test piece was placed on top of it, at a temperature of 23 ± 2 ° C and a humidity of 50 ± 10%. Measured in RH.

Example 1

As a resin molding die, the surface of the die pin portion forming the hollow tube of the cartridge was polished with a paper file (# 120) in the longitudinal direction of the die pin portion, and the surface was subjected to a line-shaped roughening process. The outer diameter of this pin is 2.1 mm.

Using this mold, a high molecular weight polyethylene resin [Mitsui Chemicals Co., Ltd., product name “Rubmer L5000”, average molecular weight of about 500,000, coefficient of friction 0.09] is formed, and the inner wall surface of the hollow tube extends in the longitudinal direction. A cartridge having a streak-like roughened surface was produced. Thereafter, the cartridge was washed with water and dried. The average surface roughness Ra of the inner wall surface of the hollow tube of this cartridge was 2.O m.

The hollow interior of this cartridge is filled with hyaluronic acid as a viscoelastic substance, a soft intraocular lens [HOY A Healthcare Co., Ltd., trade name "Acrifold (20D) J"] is folded and set. After mounting on the injector body as shown in the figure, the plunger was pushed in using an universal testing machine manufactured by Instron Japan Co., Ltd., and the maximum load required at that time was recorded. The presence or absence of the deposits was observed and confirmed with a stereoscopic microscope (X60). The results are shown in Table 1.

The maximum load is extremely low at 2.45 N, and there is no lens damage or attachment to the lens. Example 2

Using the cartridge prepared in Example 1, an extrusion test of a 30D soft 1 "raw ocular lens [HOY A Healthcare Co., Ltd., trade name" Acrifold (30D) "] was carried out in Example 1. Was carried out similarly to The results are shown in Table 1.

The maximum load was good at 4.42N, and there was no lens breakage or lens attachment. Example 3

Using the mold prepared in Example 1, high-molecular-weight polyethylene resin [Mitsui Chemicals Co., Ltd., product name "Lupmer L4000", average molecular weight of about 400,000, coefficient of friction 0.10] to form a cartridge to produce a cartridge did. Thereafter, the cartridge was washed with water and dried. The average surface roughness Ra of the inner wall surface of the hollow tube of this cartridge was 1.5 μπι.

Using this cartridge, an extrusion test of a soft 14 intraocular lens acrylic foam (20D) (described above) was performed in the same manner as in Example 1. The results are shown in Table 1. The maximum load was as low as 3.43 mm, and there was no lens damage or attachment to the lens. Example 4

Using the mold prepared in Example 1, a cartridge was formed by molding a fluororesin [trade name “AFLON COP88AXP”, manufactured by Asahi Glass Co., Ltd., with a coefficient of friction of about 0.1]. Thereafter, the cartridge was washed with water and dried. The average surface roughness Ra of the inner wall surface of the hollow tube of this cartridge was 1.5 / in.

Using this cartridge, an extrusion test was performed on a soft 1 "intraocular lens acryl (20D) (described above) in the same manner as in Example 1. The results are shown in Table 1. The maximum load was 2.65N. Example 5 There was no lens damage or attachment to the lens.

Using the mold prepared in Example 1, nylon 66 resin [manufactured by Toray Industries, Inc., trade name “CM3001NJ, coefficient of friction about 0.2”] was molded to produce a cartridge. The cartridge was washed and dried, and the average surface roughness Ra of the inner wall surface of the hollow tube of this cartridge was 2.Ομπι.

Using this cartridge, an extrusion test of a soft 1 "intraocular lens acrylic foam (20D) (described above) was carried out in the same manner as in Example 1. The results are shown in Table 1. The maximum load was as low as 3.24 N, and there was no lens damage or attachment to the lens.

table 1

Comparative Example 1

Example 1 was carried out in the same manner as in Example 1, except that the mold for resin molding had a mirror-finished pin portion surface. The results are shown in Table 2. The maximum load was extremely high, 14.7 N, and the lens support was damaged.

The average surface roughness Ra of the inner wall surface of the hollow tube of the cartridge was 0.1 μΐη Comparative Example 2

Using the mold prepared in Comparative Example 1, a cartridge was formed by molding a polypropylene resin [manufactured by San-Alomer Co., Ltd., trade name “San-Alomer ΡΜ 921 Υ”, coefficient of friction about 0.6]. Thereafter, the cartridge was washed with water and dried.

Using this cartridge, an extrusion test of a flexible intraocular lens acrylic (20 D) (described above) was carried out in the same manner as in Example 1. The results are shown in Table 2. The lens stopped in the middle of the cartridge and could not be moved out.

Comparative Example 3

Using the mold prepared in Example 1, a polypropylene resin [manufactured by San-Alomer Co., Ltd.]

The product was molded into a cartridge by molding “Salomar ΡΜ 921 Yj, coefficient of friction about 0.6”. Thereafter, the cartridge was washed with water and dried. The surface roughness Ra was 1.5 μπι.

Using this cartridge, an extrusion test of a soft intraocular lens acrylic (20 D) (described above) was carried out in the same manner as in Example 1. The results are shown in Table 2. The maximum load was extremely high, 24.5 mm, and the lens support was damaged. Comparative Example 4

Polypropylene resin pellets [Sanaroma Co., Ltd., trade name "Sanaroma PM 9 2 1 Y] and the glycerol monostearate is a lubricant to 0. 2 5 mass ^_0/0 by forming a pressurized forte cartridge. Then, oxygen plasma treatment ( (40 cm ³ , 13 Pa for 90 minutes), followed by a bridging treatment at 50 for 2 days.

Using this cartridge, an extrusion test of a soft intraocular lens acrylic foam (20 D) (described above) was carried out in the same manner as in Example 1. The results are shown in Table 2. Although the maximum load was as good as 3.43 N, adhesion of the lubricant to the lens optical portion was observed in a streak shape.

Comparative Example 5

In Comparative Example 4, the same procedure was performed as in Comparative Example 4, except that the bleeding treatment was changed to 50 ° C. for 4 days. The results are shown in Table 2.

Although the maximum load was as good as 2.45 N, adhesion of the lubricant to the lens optics was observed in a strip shape.

Comparative Example 6

Comparative Example 4 was carried out in the same manner as in Comparative Example 4, except that glycerol monostearate was added in an amount of 0.1% by mass and bleeding was performed at 50 ° C for 10 days. The results are shown in Table 2.

Although the maximum load was as good as 3.24 N, the adhesion of the lubricant to the lens optical portion was observed in a dot-like manner.

Table 2

As shown in Table 2, in Comparative Examples: ~ 6, the lens was extruded extremely smoothly However, adhesion of the lubricant to the lens occurred. As shown in Comparative Examples 1 and 2, if the surface of the mold pin is slippery, not only polypropylene resin but also L500, which has good slidability, the extrusion load of the lens is high, and lens breakage occurs. This indicates that the inner wall of the cartridge hollow tube needs to be roughened. Even if the inner wall of the cartridge hollow tube is roughened, if the slidability of the resin is poor, the extrusion load of the lens will be high and the lens will be damaged, making it unusable (Comparative Example 3). On the other hand, as shown in Table 1, in Examples 1 to 5, the lenses were extruded smoothly, and the lenses were extremely good with no damage or adhesion.

Industrial potential

The intraocular lens insertion injector force cartridge of the present invention can safely insert the lens into the eye with an appropriate force without damaging the supporting portion and the optical portion of the lens, and improves lubricity. It has the effect of being excellent in safety because it does not require any components. By using this injector cartridge, it is possible to obtain an intraocular lens insertion device useful in ophthalmic surgery.

Claims

The scope of the claims

1. In an intraocular lens insertion device used to implant and implant a soft intraocular lens from the incision into the eyeball, a lens that is attached to the injector body with an extrusion mechanism and is implanted into the eye A cartridge made of a slidable resin having a hollow structure for storing and extruding the lens into the eye, wherein the inner wall surface of the hollow tube of the cartridge is roughened, and the slide constituting the cartridge is provided. An injector for introducing an ophthalmic lens, wherein the conductive resin is a resin having a friction coefficient of 0.5 or less.

2. The injector cartridge for inserting an intraocular lens according to claim 1, wherein the average surface roughness Ra of the inner wall surface of the hollow tube having the roughened surface is 0.5 to 5.0 O / im.

3. The slidable resin having a friction coefficient of 0.5 or less is at least one kind selected from high molecular weight polyethylene resin, fluorine resin, polyamide resin, polyacetal resin and polyphenylene sulfide resin. Item 4. An injector for inserting an intraocular lens according to item 1.

4. The mold according to any one of claims 1 to 3, wherein the mold for molding the injector cartridge is formed by using a roughened surface of a mold pin portion surface for forming a hollow tube. Injector cartridge for introducing intraocular lens.

5. The ink for inserting an intraocular lens according to any one of claims 1 to 3, wherein the inner wall surface of the hollow tube of the cartridge is roughened by a cylindrical file or sand blast.

6. An intraocular lens insertion device including an injector body and the injector cartridge for introducing an intraocular lens according to any one of claims 1 to 5.

7. The intraocular lens introduction device according to claim 6, wherein the intraocular lens introduction injector cartridge and the injector main body are integrated or separable.