WO2004110414A1 - Preparation-at-use device comprising pre-formed hydrogel product - Google Patents
Preparation-at-use device comprising pre-formed hydrogel product Download PDFInfo
- Publication number
- WO2004110414A1 WO2004110414A1 PCT/US2004/017985 US2004017985W WO2004110414A1 WO 2004110414 A1 WO2004110414 A1 WO 2004110414A1 US 2004017985 W US2004017985 W US 2004017985W WO 2004110414 A1 WO2004110414 A1 WO 2004110414A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- component
- formed hydrogel
- benefit
- skin
- compartment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Definitions
- the present invention relates to a preparation-at-use device which comprises at least 2 separate compartments comprising interim components which are contacted with each other at- use.
- the interim components are a pre-formed hydrogel component and a benefit component.
- the device is suitable for delivering components which are unstable when contacted with the preformed hydrogel component, and also for preparing the final pre-formed hydrogel product at-use in a suitable manner.
- Pre-formed hydrogels made of gelling agents provide unique benefits to various consumer products due to its formed, yet flexible physical characteristics.
- Pre-formed hydrogel patch and mask devices are useful for cosmetic and dermatological treatment products such as for delivering skin care actives, percutaneously deliverable pharmaceuticals, and for promoting healing of burns or wounds.
- Edible pre-formed hydrogel sheets and objects provide nutritional products and snacks having distinctive appearance, taste, and oral texture; and oral administrative pharmaceuticals.
- pre-formed hydrogel products are suitable for delivering a variety of skin benefit agents to the skin
- certain skin benefit agents and other chemical compounds that cannot be formulated with the product, as being unstable with the pre-formed hydrogel.
- certain compounds react with the pre-formed hydrogel and enhance synerisis, enhance stiffening, or produce unaesthetic color and/or odor. All of these results may significantly affect product performance and/or aesthetics. Such factors limit the scope of compounds that can be formulated with the pre-formed hydrogel products.
- a pre-formed hydrogel component packaged in a first compartment; the pre-formed hydrogel component comprising a gelling agent and a solvent;
- a benefit component packaged in a second compartment comprising at least one compound that is unstable when contacted with the pre-formed hydrogel component; wherein the first and second compartments are separately packaged prior to use, and wherein the package comprises means for contacting the pre-formed hydrogel component and benefit component at-use.
- the present invention is further directed to a device wherein the pre-formed hydrogel component has a first surface having a specified texture, and the benefit component has a specified viscosity.
- Fig. 1 is a sectional view of a preferred embodiment of the device of the present invention with the thickness of a packaging material being inflated.
- Fig. 2 is a perspective view of a preferred embodiment of the device of the present invention with a seal liner freshly removed.
- Fig. 3 is a perspective view of a preferred embodiment of the package of the present invention.
- Fig. 4 is a sectional view of a preferred embodiment of the device of the present invention during preparation.
- Fig. 5 is another sectional view of a preferred embodiment of the device of the present invention wherein preparation of a final product is completed.
- Fig. 6 is a perspective view of a preferred embodiment of the device of the present invention in a series of units.
- ingredients such as actives and other ingredients useful herein may be categorized or described by their cosmetic and/or therapeutic benefit or their postulated mode of action. However, it is to be understood that the active and other ingredients useful herein can, in some instances, provide more than one cosmetic and/or therapeutic benefit or operate via more than one mode of action. Therefore, classifications herein are made for the sake of convenience and are not intended to limit an ingredient to the particularly stated application or applications listed.
- the present invention relates to a device that is specifically designed to prepare final products at-use, typically within about 60 minutes, preferably within about 10 minutes prior to use, suitably referred to as products for "preparation-at-use".
- Preparation-at-use devices are known in the art, and comprise at least 2 separate compartments comprising interim components which are contacted with each other upon use.
- a preparation-at-use device is designed so that the interim components are not contacted with each other during storage.
- the packaging for a preparation-at-use device is preferably designed so that the preparation of the final product, such as mixing of the interim products, can be done by utilizing one of the compartments of the package.
- the present invention relates to such preparation-at-use device which is suitable for delivering to the user at least two interim components, the interim components being at least a pre-formed hydrogel component and a benefit component, the benefit component being unstable when contacted with the pre-formed hydrogel component.
- the present device (10) comprises at least two compartments for separately packaging the interna component, namely the pre-formed hydrogel component (21) in a first compartment (20) and the benefit component (31) in a second compartment (30).
- the pre-formed hydrogel components herein are typically relatively vulnerable to change of humidity, particularly excessive or rapid drying. Drying beyond a certain extent, depending on the composition, will decompose or deform the preformed hydrogel by destroying its gel structure.
- Such notch area is for slightly weakening the material such that it can be folded without complete rupture by the user as depicted in Fig. 4. By such folding, the user may bring the pre-formed hydrogel component and benefit component in contact with each other without touching either the pre-formed hydrogel component or the benefit component.
- Such preparation is suitable from a hygiene point of view, as avoiding contamination from the hands.
- the overall configuration of the package is also suitable from a manufacturing cost point of view, as the package may be made with commonly used material and conventional thermoforming technology.
- the pre-formed hydrogel component is transferred from the first compartment to the second compartment as depicted in Fig. 4 and Fig. 5.
- the preformed hydrogel component thus transferred to the second compartment contacts the benefit component for providing the final hydrogel product, which may be retrieved by the user.
- the user may further engage or soak the pre-formed hydrogel component into the benefit component for better retrieval of the benefit component.
- the interior surface (22) of the first compartment may comprise embossing (23) for facilitating release of the pre-formed hydrogel component upon transferring into the second compartment.
- the interior surface (32) of the second compartment may also comprise embossing for facilitating preparation of the final product, for example, avoiding the hydrogel to slip out of the second compartment when the user engages the hydrogel component in the benefit component.
- the device of the present invention may be provided in individual units, or in a series of units as depicted in Fig 6.
- the series of devices in Fig. 6 are provided in 4 doses/servings, wherein each unit can be separated away by breaking perforated areas (60).
- Providing a series of devices can be beneficial for providing doses designed to be administered in a fixed period of time, such as a day, and/or for simply reducing secondary packaging material.
- the device of the present invention comprises a pre-formed hydrogel component.
- the pre-formed hydrogel component of the present invention provides structure and shape, allowing it to be handled and to suit treatment of a specific target area of the skin, hair or nails, fabric or hard surface, or to be orally administered or consumed. Physical characteristics such as strength, flexibility, and surface texture are designed to meet the function for which the pre-formed hydrogel component is intended to achieve.
- the pre-formed hydrogels of the present invention comprises a gelling agent that provides structure and shape.
- the type and amount of gelling agent to be included in the preformed hydrogel is selected according to the desired characteristic and purpose of the product, depending on the properties of the gelling agent. Generally, more gelling agent will provide a more rigid pre-formed hydrogel. For providing food products or orally administrative products, the gelling agent must be edible and acceptable in taste and flavor. Many types of gelling agents are known in the art, including polymeric gellants and particulate based gellants such as various types of clays or other silicate based materials. Highly preferred herein are polymeric gelling agents that form 3-dimensional gel networks in combination with water.
- the pre-formed hydrogel preferably comprises from about 0.5% to about 20%, more preferably from about 1% to about 10%, of gelling agent.
- the gelling agents herein may be water soluble or water insoluble, and selected according to the solvent.
- the solvent is water or water-based, preferably the gelling agent is water soluble.
- Water insoluble polymeric gellants such as silicone materials e.g. organopolysiloxane resins, or block co-polymer thermoplastic elastomers, may be used in an appropriate solvent.
- the water-soluble polymeric gellants for use in the present invention are selected from synthetic or natural polymers, and mixtures thereof.
- Preferred polymers for use herein are natural polymers, including gelatin, polysaccharides, and mixtures thereof. Preferred are polysaccharides.
- the term "polysaccharide” herein means a naturally occurring or synthetically produced, linear, branched or cross-linked polymer of monosaccharide units, which swells when dispersed in water at low concentrations and thickens the aqueous phase.
- the polysaccharides for use in the pre-formed hydrogels herein are preferably selected from red seaweed polysaccharides; glucomannans; galactomannans; fermentation polysaccharides, or derivatives thereof; brown seaweed polysaccharides; extracts of marine invertebrates; starch, or derivatives thereof; natural fruit extracts; plant fiber derivatives; kelp; natural plant exudates; and resinous gums; or mixtures thereof.
- the total polysaccharide level is controlled so that other optional components of the pre-formed hydrogel are not as tightly bound within the gel network and are available for diffusion.
- gelatin When gelatin is used in the pre-formed hydrogels herein, a high-molecular weight gelatin is combined with a low-molecular weight one to control the solubility.
- a gelatin having a low molecular weight of 20,000 or less has weaker gelling ability when used as the sole gelling agent.
- Brown seaweed polysaccharides are isolated by extraction from various species of Phaebophyceae. Suitable brown seaweed polysaccharides for use herein include algin, alginic acid, ammonium alginate, calcium alginate, potassium alginate, sodium alginate, propylene glycol alginate, and mixtures thereof.
- Red seaweed polysaccharides are isolated from marine plant species belonging to the class of Rhodophyceae. Red seaweed polysaccharides provide mechanical strength to the preformed hydrogel. Suitable red seaweed polysaccharides for use in the present invention include agar known in the industry under the (CTFA) trade designation as agar agar flake derived from various Gelidium plant species or closely related red algae commercially available as "Agar Agar 100" or "Agar Agar 150" from TIC Gums (Belcamp, MD, USA) or "Agar Agar K-100" from Gumix International Inc.
- CTFA agar known in the industry under the (CTFA) trade designation as agar agar flake derived from various Gelidium plant species or closely related red algae commercially available as "Agar Agar 100" or "Agar Agar 150" from TIC Gums (Belcamp, MD, USA) or "Agar Agar K-100" from Gumix International Inc.
- the red seaweed polysaccharide for use herein is selected from agar, agarose, kappa- carrageenan and furcellaran, or mixtures thereof.
- Glucomannans are polysaccharides which comprise an essentially linear backbone of glucose and mannose residues. Glucomannans have short side branches attached to the linear backbone and acetyl groups are randomly present at the C-6 position of a sugar unit. The acetyl groups are generally found on one per six sugar units to one per twenty sugar units. Suitable glucomannans or derivatives thereof for use herein have a ratio of mannose to glucose of from about 0.2 to about 3.
- Preferred glucomannans for use herein include ko ⁇ jac mannan, which is the generic name for the flour formed from grinding the tuber root of the Amorphophallus konjac plant (elephant yam), commercially available under the trade name "Nutricol® konjac flour” from FMC (Philadelphia, PA, USA); and deacetylated konjac mannan; or mixtures thereof.
- ko ⁇ jac mannan is the generic name for the flour formed from grinding the tuber root of the Amorphophallus konjac plant (elephant yam), commercially available under the trade name "Nutricol® konjac flour” from FMC (Philadelphia, PA, USA); and deacetylated konjac mannan; or mixtures thereof.
- Galactomannans are vegetable reserve polysaccharides which occur in the endosperm cells of numerous seeds of Leguminosae.
- the collective term "galactomannan” comprises all polysaccharides which are built up of galactose and mannose residues.
- Galactomannans comprise a linear backbone of (l->4)-linked ⁇ -D-mannopyranosyl units. To these rings are attached as branches, isolated galactopyranose residues by ⁇ -(l,6)-glucoside bonds.
- Galactomannans may in addition also contain minor amounts of other sugar residues.
- Suitable galactomannans for use herein are fenugreek gum; lucern; clover; locust bean gum known for example in the industry under the (CTFA) trade designation as carob bean gum, commercially available as "Seagul L” from FMC (Philadelphia, PA, USA); tara gum commercially available from Starlight Products (Rouen, France) or Bunge Foods (Atlanta, GA, USA); guar gum derived from the ground endosperms of Cyamopsis tetragonolobus, commercially available as "Burtonite V7E” from TIC Gums (Belcamp, MD, USA), “Jaguar C” from Rhone-Poulenc (Marietta, GA, USA), or “Supercol” from Aqualon (Wilmington, DE, USA); and cassia gum commercially available from Starlight Products (Rouen, France), or mixtures thereof.
- the galactomannans for use herein have an average one of every 1 to about 5 mannosyl units substituted with a (l->6)-linked- ⁇ -D-galactopyranosyl unit and are selected from guar gum, locust bean gum and cassia gum, or mixtures thereof.
- Fermentation polysaccharides are polysaccharides which are commercially produced by the fermentation of micro-organisms in a medium containing a carbon and nitrogen source, buffering agent, and trace elements.
- Suitable fermentation polysaccharides or derivatives thereof, for use in the present invention include gellan gum known in the industry under the (CTFA) trade designation as gum gellan, a high molecular weight hetero polysaccharide gum produced by a pure-culture fermentation of a carbohydrate with Pseudomonas elodea, commercially available as "Kelcogel” from Kelco (San Diego, CA, USA); xanthan gum which is a high molecular weight hetero polysaccharide gum produced by a pure-culture fermentation of a carbohydrate with Xanihomonas campestris, known in the industry under the (CTFA) trade designation as xanthan, commercially available for example as "Keltrol CG 1000/BT/F/GM/RD/SF/T/TF
- Extracts of marine invertebrates can also be used.
- Examples of such polysaccharides suitable for use herein include chitosan, commercially available for example as “Marine Dew” from Ajinomoto (Teakneck, NJ, USA); and hydroxypropyl chitosan commercially available for example as "HPCH Liquid” from Ichimaru Pharcos (Yamagata Gun Gifu-Pref, Japan) and derivatives; or mixtures thereof.
- Starches are polysaccharides which consist of various proportions of two glucose polymers, amylose and amylopectin. Suitable materials for use herein include starch, amylopectin and dextrin, commercially available as "Nadex 360" from National Starch (Bridgewater, NJ, USA), and derivatives or mixtures thereof. Examples of natural fruit extracts suitable for use herein include pectin, arabian and mixtures thereof. A suitable example of a plant fiber derivative for use herein is cellulose. Suitable polysaccharides obtained from natural plant exudates for use herein include karaya, tragacanth, arabic, tamarind, and ghatty gums, or mixtures thereof. Examples of resinous gums suitable for use herein include shellac gum, which is obtained from the resinous secretion of the insect Laccifer (Tachardia) lacca, damar gum; copal gum and rosin gum; or mixtures thereof.
- Natural and synthetic polymeric gelling agents that form gels in combination with other substances may also be used as a gelling agent in combination with other thermo-forming gelling agents, so long as the gel phase forming can been synchronized. They may be chemically cross linked. Some gelling agents form gels in combination with substances such as sugar, alcohol, or mono- or multi-valent salts. Mono- or multi-valent salts may additionally act as gel strengthening agents imparting added strength to the pre-formed hydrogels herein. Suitable cations for such salts can be selected from potassium, sodium, ammonium, zinc, aluminium, calcium and magnesium ions, or mixtures thereof. Suitable anions associated with the aforementioned cations may be selected from chloride, citrates, sulfate, carbonate, borate and phosphate anions, or mixtures thereof.
- the water-soluble polymeric gellants for use in the present invention are selected from synthetic or natural polymers, and mixtures thereof.
- the pre-formed, gel sheets of the present invention comprise less than 50%, more preferably less than 30% and especially less than 20% by total weight of a water-soluble polymeric gellant.
- Suitable synthetic polymers for use herein include non-ionic water-soluble polymers, acrylic acid based polymers, cellulose derivatives, and mixtures thereof.
- a particularly preferred synthetic polymer system is disclosed in WO 00/06215, incorporated herein by reference, which describes a product suitable for attaching biomedical devices to the skin.
- a bioadhesive, hydrogel composition comprising an aqueous plasticiser, a polymer of one or more monomers comprising a hydrophilic unsaturated water soluble acrylamido monomer, particularly NaAMPS, and a hydrophobic polymer, such as an ethylene / vinyl acetate copolymer.
- Physical cross linking refers to polymers having cross links which are not chemical covalent bonds but are of a physical nature such that there are areas having high crystallinity or areas having a high glass transition temperature. Such cross linked polymers may also be used. Preferably, the polymer is chemically cross linked thermally. In addition when chemical cross links are formed in the system, a polyfunctional cross linker and/or a free radical initiator may be present in the premix to initiate the cross linking upon irradiation.
- the pre-formed hydrogels herein comprise a mixture of water-soluble polymeric gelling agents of natural origin.
- a preferred water-soluble polymeric gelling agent mixture herein may comprise a polysaccharide and a non-ionic water-soluble polymer or, alternatively, it may comprise two polysaccharides.
- the water-soluble polymeric gel forming agent is a polysaccharide mixture, wherein the polysaccharide mixture comprises (1) at least one red seaweed polysaccharide; brown seaweed polysaccharide; or mixtures thereof; and (2) at least one fermentation polysaccharide; galactomannan; glucomannan; natural plant exudate; or natural fruit extract; and derivatives or mixtures thereof.
- the water-soluble polymeric gel forming agent of the pre-formed hydrogels of the present invention is a polysaccharide mixture comprising (1) at least one red seaweed polysaccharide; and (2) at least one fermentation polysaccharide; glucomannan; or galactomannan; and derivatives or mixtures thereof.
- the water-soluble polymeric gel forming agent of the present invention is a polysaccharide mixture, comprising a red seaweed polysaccharide and a glucomannan or a galactomannan.
- the ratio of red seaweed polysaccharide to glucomannan or galactomannan in the polysaccharide mixture is preferably from about 20:1 to about 1:5 and more preferably from about 10:1 to about 1:2. Without being limited by theory, it is believed that gel compositions herein form 3 -dimensional networks or matrices which bind or encapsulate other ingredients of the composition.
- the pre-formed hydrogels of the present invention comprise a solvent for the gelling agent, which may be water, water solutions, or water dispersions.
- the gelling agent is at least miscible in the solvent at sol phase state for eventually providing a uniform unilamellar pre-formed hydrogel.
- the amount and type of solvent is determined to provide a stable gel phase with the gelling agent, in view of the desired mechanical properties, particularly gel strength and flexibility, and also in view of the desired characteristic of the obtained product.
- the solvent further acts as a plasticiser or softener for the pre-formed hydrogel.
- the pre-formed hydrogel comprises a hydrophilic solvent.
- hydrophilic as used in reference to solvents herein, means that the solvent is miscible with water, at least in a solvent to water ratio of 1 to 10, preferably 1 to 5.
- a topical acceptable, hydrophilic solvent is one which can be used in a pre-formed hydrogel to be applied against the skin without causing irritation and which is miscible with water.
- Suitable hydrophilic solvents include lower alcohols such as ethanol, and polyhydric alcohols such as propylene glycol, butylene glycol, hexylene glycol, glycerin, sorbitol; polyethylene glycols of MW less than 30,000, preferably less than 10,000; and polypropylene glycols of MW less than 5,000, preferably less than 1,000.
- many of the polyhydric alcohols useful as hydrophilic solvents herein also function as humectants for the skin.
- the hydrophilic solvent can assist in diffusion of skin benefit agents to the skin and, by evaporation from the pre-formed hydrogel, can also provide cooling, making the pre-formed hydrogel more comfortable to wear.
- the solvent comprises water and at least one polyhydric alcohol, more preferably, the solvent consists essentially of water and polyhydric alcohol.
- the pre-formed hydrogel comprises from about 10% to about 99.5% of water, more preferably from about 20% to about 95%, and yet more preferably from about 30% to about 90% of water. Still preferably, the pre-formed hydrogel further comprises from about 1.0% to about 50%, preferably from about 5% to about 45%, more preferably from about 10% to about 40% of polyhydric alcohol.
- the solvent is selected from the group hereinabove that are safe, and preferably pleasing, for oral consumption.
- the device of the present invention comprises a benefit component.
- the benefit component of the present invention provides additional benefit to the pre-formed hydrogel component when contacted upon use, however comprises at least one compound that is unstable when brought in contact with the pre-formed hydrogel component.
- the final hydrogel product is prepared at-use.
- the benefit component may be in the form of liquid, powder, or solid, preferably liquid or powder.
- the benefit component may comprise a compound that enhances synerisis, enhances stiffening, or produces unaesthetic color, taste, flavor, and/or odor when contacted with the pre-formed hydrogel component.
- the benefit component may comprise an interim compound or catalyst which reacts with water encompassed in the pre-formed hydrogel component.
- the benefit component may comprise a compound that quickly alters its physical properties or decreases its performance by being easily dissolved/absorbed in the pre-formed hydrogel component, or absorbing the solvent from the pre-formed hydrogel component.
- Compounds which are known to be unstable with the pre-formed hydrogel component, particularly with water, and thus suitable for comprising in the benefit component are, for example, easily oxidated water-soluble compounds, heat generating compounds, powder compounds, electrically charged compounds, gas forming compounds, and mixtures thereof.
- the unstable compounds herein may be categorized or described by their chemical/physical property or their postulated mode of action. However, it is to be understood that the unstable compound herein can, in some instances, provide more than one benefit or operate via more than one mode of action. Therefore, classifications herein are made for the sake of convenience and are not intended to limit a compound to the particularly stated characteristic.
- Easily oxidated water-soluble compounds herein include ascorbic acid compounds. While ascorbic acid compounds are useful for topical use and oral consumption, they may provide visible yellowness to the pre-formed hydrogel when in contact for over about 5 days. Ascorbic acid compounds provide skin lightening benefit when used topically, and provide distinctive flavor when taken orally. Ascorbic acid compounds useful herein include, ascorbic acid per se in the L-form, ascorbic acid salt, and derivatives thereof. Ascorbic acid salts useful herein include, sodium, potassium, lithium, calcium, magnesium, barium, ammonium and protamine salts. Ascorbic acid derivatives useful herein includes, for example, esters of ascorbic acid, and ester salts of ascorbic acid.
- Particularly preferred ascorbic acid compounds include 2-o-D- glucopyranosyl-L-ascorbic acid, which is an ester of ascorbic acid and glucose and usually referred to as L-ascorbic acid 2-glucoside or ascorbyl glucoside, and its metal salts, and L- ascorbic acid phosphate ester salts such as sodium ascorbyl phosphate, potassium ascorbyl phosphate, magnesium ascorbyl phosphate, and calcium ascorbyl phosphate.
- 2-o-D- glucopyranosyl-L-ascorbic acid which is an ester of ascorbic acid and glucose and usually referred to as L-ascorbic acid 2-glucoside or ascorbyl glucoside, and its metal salts
- L- ascorbic acid phosphate ester salts such as sodium ascorbyl phosphate, potassium ascorbyl phosphate, magnesium ascorbyl phosphate, and calcium ascorbyl phosphate.
- ascorbic compounds include magnesium ascorbyl phosphate available from Showa Denko, 2-o-D-glucopyranosyl-L-ascorbic acid available from Hayashibara and sodium L-ascorbyl phosphate with tradename STAY C available from Roche.
- Heat generating compounds herein include those which generate heat upon contact with abundant air when breaking the seal for preparation, and/or upon contact with water included in the hydrogel component. Generation of heat may provide a pleasant warm feeling when used topically, and may further enhance penetration of active ingredients included in the hydrogel component and/or the benefit component.
- Suitable heat generating compounds include, for example, chlorides such as calcium chloride (CaCl 2 , CaCl 2 -H 2 O, CaCl 2 -2H 2 O), magnesium chloride (MgCl 2 , MgCl 2 -2H 2 O, MgCl 2 4H 2 O), aluminum chloride (AlCl 3 , AlCl 3 -OH 2 O), ferric chloride (FeCl 3 , FeCl 3 -2H 2 O), and zinc chloride (ZnCl 2 ); sulfates such as magnesium sulfate (MgSO 4 , MgSO 4 -H 2 O, MgSO 4 -4H 2 O), zinc sulfate (ZnSO 4 -H 2 O), ferrous sulfate (FeSO 4 , FeSO 4 -H 2 O), aluminum sulfate (A1(SO 4 ) 3 ), calcium sulfate (CaSO 4 , CaSO 4 - 1/2H 2 O, Ca
- anhydrous inorganic salts such as sodium sulfate (Na 2 SO 4 ), calcium sulfate (CaSO 4 ), magnesium sulfate (MgSO 4 ), aluminum sulfate (A1(SO 4 ) 3 ), calcium chloride (CaCl 2 ), magnesium chloride(MgCl 2 ), calcium oxide (CaO), and mixtures thereof, in view of their effective heat generation, mildness to hair and/or skin, and easy handling. More preferred is anhydrous magnesium sulfate (MgSO 4 ).
- the heat generating compounds useful herein have an average diameter of, preferably from about O.Ol ⁇ m to about 40 ⁇ m, more preferably from about 0.05 ⁇ m to about 30 ⁇ m, still more preferably from about O.l ⁇ m to about 20 ⁇ m, in view of preventing gritty feel upon handling or when topically applied.
- Powder compounds herein typically quickly alters its physical properties or decreases its performance by being easily dissolved/absorbed in the pre-formed hydrogel component, or absorbing the solvent from the pre-formed hydrogel component.
- Powder compounds may be any that provide a topical benefit or are pleasing for oral consumption.
- Powder compounds for topical use herein include those which provide a distinctive skin feel, such as titanium dioxide, talc, cellulose powder, iron oxide, silicone resins, ferric oxide, zinc oxide, and others.
- Powder compounds for oral consumption herein include, for example, salt, sugar, pepper, rice powder, cellulose powder, starch powder, cocoa powder, soya bean powder, wheat flour, and others.
- Electrically charged compounds such as electrolytes and ionic surfactants are useful compounds for detersive purposes, however, may enhance synerisis or even decompose the preformed hydrogel when in contact.
- Electrically charged compounds herein include, for example, any electrolyte which provides alkali metal or alkali earth metal ions, anionic surfactants, cationic surfactants, anionic polymers, cationic polymers, and others.
- Gas forming compounds useful herein are those which provide any kind of effervescent effect when contacted with solvent, typically water. Gas forming compounds may be suitable for any product to provide a visible, audible, or olfactory signal that a final product is being made. The gas forming compounds may enhance taste and flavor, enhance topical absorbance, or enhance detersive effect.
- Useful herein are alkaline salts which generate carbon dioxide upon dissolution with water, including sodium carbonate, sodium hydrogen carbonate, sodium sesquicarbonate, potassium carbonate, potassium hydrogen carbonate, potassium sesquicarbonate, and mixtures thereof. When such alkaline salts are used, it is preferable to further comprise organic acids or its salts to regulate the pH of the final hydrogel product.
- Suitable organic acids for this use include aliphatic carboxylic acids such as citric acid, tartaric acid, malic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, fumaric acid, and maleic acid, aromatic carboxylic acids such as benzoic acid, phthalic acid, isophthalic acid, terephthalic acid, and cinnamic acid, heterocyclic carboxylic acids such as nicotinic acids, acidic amino acid such as glutamic acid and aspartic acid, and mixtures thereof. Also useful herein are particles which contain pressurized gas trapped within the particles. PRODUCTS FOR TOPICAL USE
- the final pre-formed hydrogel product of the present invention is a sheet-like patch useful for delivering skin benefit agents to the skin, hair, or nails.
- the products are generally of a size such that each surface has an area of from about 0.25 cnP- to about 1,000 cm 2 , preferably from about 1 cm 2 to about 400 cm 2 .
- Surface area refers to that of a flat plane having the same boundary as the surface i.e. ignoring any surface texturing, when present.
- the pre-formed hydrogel herein can be, for example, square, circular, semicircular, rectangular, oval, rings, crescents, teardrops or other more complex shapes which may be composites of these, for covering areas such as the eye area, eye lids, the nose, the mouth area, the forehead, the cheek, the chin, the entire contour of the face, neck, arm, other specific places of the body, or combinations thereof.
- the pre-formed hydrogel should be flexible enough to fit along the surface of the skin on which it is applied. Yet, minimum gel strength is required so that the pre-formed hydrogel does not rupture under its own weight when overhanging, for example, when the user wears the product.
- the present invention further relates to a final pre-formed hydrogel product comprising:
- a pre-formed hydrogel component comprising:
- the pre-formed hydrogel component is free of a supporting substrate, has a thickness of from about 0.1mm to about 5mm, preferably from about 0.5mm to about 2.0mm and a first surface and a second surface, the first surface having a repeating texture having a depth of from about lO ⁇ m to about 500 ⁇ m, preferably from about 50 ⁇ m to about 200 ⁇ m at a frequency of from about 0.2 to about 1 per mm, preferably from about 0.3 to about 0.7 per mm; wherein the depth of the texture is at least about 10% of the thickness of the pre-formed hydrogel component; and
- a benefit component comprising a skin benefit agent and having a viscosity of from about 100OmPa-S to about 100,00OmPa-S, preferably from about 500OmPa-S to about 300,000mPa-s; wherein the repeating texture is so designed to provide a network of channels that allows fluid communication of the benefit component when the first surface is worn on the skin.
- first surface means a surface of the pre-formed hydrogel to be worn on the skin, and which faces the seal when packaged in the first compartment.
- thickness means a thickness of a pre-formed hydrogel component, wherein when the sheet is textured, the peaks of the texture are used for measuring the thickness.
- depth as used herein, relates to a length in the thickness direction of a texture provided on the surface of a pre-formed hydrogel component.
- frequency as used herein, relates to the number of repeating non-planar topography per mm, the repetition of the non-planer topography providing a texture to the surface of a pre-formed sheet.
- the pre-formed hydrogel component of the present invention having a certain thickness and texture of certain depth and frequency to the first surface provides various benefits for the user.
- the first surface is positioned to face the seal when packaged in the first compartment, so that when the pre-formed hydrogel component is transferred into the second compartment, the first surface contacts directly with the benefit component, and thus the user is derived to apply such surface on the skin.
- the benefit component is in such amount and viscosity that it covers only the first surface of the pre-formed hydrogel, as depicted in Fig. 5.
- the final pre-formed hydrogel product comprises a benefit component which facilitates convenient adhesion of the product to the skin by applying the first surface to the skin.
- the benefit component immediately evenly distributes throughout the area on which the product is worn, leaving the discontinuous, spaced wearer contacting areas more or less vacuum. Thus, the product is sucked onto the skin.
- the pre-formed hydrogel component is preferably uniform in thickness.
- the channels further provide a reservoir of the benefit component between the pre-formed hydrogel component and the skin, thus allowing continuous contact of the benefit component to the skin.
- the benefit component may be aqueous solutions, including gels, or emulsions such as oil-in-water emulsions, water-in-oil emulsions or multiple emulsions having aqueous or oily external phases, all of which have a viscosity of between about 1000 mPa-s and about 100,000 mPa-s.
- the viscosity of the coating composition is measured on a Brookf ⁇ eld viscometer using a heliopath T-bar C spindle at 5 rpm.
- the weight ratio of the benefit component to the pre-formed hydrogel component is generally more than about 1:50, preferably from about 1:25, more preferably from about 1:15 to about 10:1.
- the pre-formed hydrogel component herein can be made by any suitable process, preferably, by a cooling process utilizing the gel transition point of the gelling agent.
- Other processes include injection molding.
- the benefit component comprises a safe and effective amount, preferably from about 0.1% to about 10% ascorbic acid compound for providing chronic skin lightening benefit to the skin.
- Skin Benefit Agents preferably from about 0.1% to about 10% ascorbic acid compound for providing chronic skin lightening benefit to the skin.
- the benefit component is a liquid composition comprising at least one skin benefit agent for the skin, hair or nails.
- the pre-formed hydrogel component and the benefit component each comprise at least one skin benefit agent in common.
- the skin benefit agents discussed in this section herein exclude those compounds that are unstable with the pre-formed hydrogel component.
- the benefit component can rapidly provide a skin benefit agent to the target area upon use, while the pre-formed hydrogel can act as a reservoir for the skin benefit agent or inhibit the pre-formed hydrogel from absorbing the skin benefit agent from the benefit component.
- skin benefit agent means an active ingredient which provides a cosmetic and/or therapeutic effect to the area of application on the skin, hair, or nails.
- the skin benefit agents useful herein include anti-acne agents, emollients, non-steroidal anti-inflammatory agents, topical anaesthetics, artificial tanning agents, antiseptics, anti-microbial and anti-fungal actives, skin soothing agents, sunscreening agents, skin barrier repair agents, anti-wrinkle agents, anti-skin atrophy actives, lipids, skin lightening agents, sebum inhibitors, sebum inhibitors, skin sensates, protease inhibitors, skin tightening agents, anti-itch agents, hair growth inhibitors, desquamation enzyme enhancers, anti-glycation agents, and mixtures thereof.
- the benefit component of the present invention comprise from about 0.01% to about 60%, preferably from about 0.1% to about 40% and most preferably from about 0.5% to about 30% by weight of the benefit component of at least one skin benefit agent, or mixtures thereof.
- Preferred examples of skin benefit agents useful herein include those selected from the group consisting of: salicylic acid, niacinamide, panthenol, tocopheryl nicotinate, benzoyl peroxide, 3-hydroxy benzoic acid, flavonoids (e.g., flavanone, chalcone), farnesol, phytantriol, glycolic acid, lactic acid, 4-hydroxy benzoic acid, acetyl salicylic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, cis-retinoic acid, trans-retinoic acid, retinol, retinyl esters (e.g., retinyl propionate), phytic acid, N-acetyl-L-cysteine, lipoic acid, tocopherol and its esters (e.g., tocopheryl acetate), azelaic acid, arachidonic acid, tetracycline, i
- the cosmetic skin benefit agent is preferably selected from anti-wrinkle and anti-skin atrophy actives, anti-acne actives, artificial tanning agents and accelerators, emollients, humectants, skin repair actives, skin barrier repair aids, skin lightening agents, skin sensates, skin soothing agents, lipids, sebum inhibitors, sebum stimulators, sunscreening agents, protease inhibitors, skin tightening agents, anti-itch ingredients, and desquamation enzyme enhancers, or mixtures thereof.
- the pH of the pre-formed hydrogel component and the benefit component herein is preferably from about 3 to about 9, more preferably from about 4 to about 8. The pH may be selected depending on the activity of the skin benefit agent.
- the final pre-formed hydrogel product of the present invention may have at least one of the following uses; hydrating the skin, hair or nails, smoothing fine lines and wrinkles; cosmetically treating acne; firming or softening the skin, strengthening; softening; exfoliating; improving and/or evening skin tone and/or texture; skin, hair or nail lightening; tanning; reducing the appearance of pores; absorbing or controlling secretions; protecting and/or soothing the skin, hair or nails, muscles, aches or pains; reducing puffiness, and/or dark circles; stimulating wound healing; warming, refreshing or cooling the skin, hair or nails; relieving inflammation; brightening the complexion; decongesting; reducing swelling; treating dermatological conditions; cushioning; purifying; fragrancing; reducing bacterial or micro-organism growth; healing; repelling insects; removing unwanted hair, dirt, or make-up; and coloring or bleaching the target area to which the final pre-formed hydrogel product is applied.
- the final hydrogel product of the present invention is prepared shortly prior to wearing on the skin, preferably within about 10 minutes, according to the preparation steps as described above.
- the first surface of the final hydrogel product is worn on the skin so that a network of channels provided by the surface texture allows fluid communication of the benefit component.
- the final hydrogel product thus obtained is applied to a target area of the skin, hair or nails, and will generally be left on the target area for about 1 minute to about 12 hours, preferably about 5 to about 60 minutes.
- the preparation-at-use devices are made of components having the following compositions and formed by the process described herein: Table 1 - Compositions 1-6 for Hydrogel Component For providing a formed structure, Examples 4-6 further comprise a supportive layer.
- Kelgum and Keltrol T are, respectively, a 1 : 1 mixture of xanthan gum and locust bean gum; and xanthan gum, supplied by Kelco, San Diego, CA, USA.
- the preparation-at-use device herein is made by any suitable process known in the art.
- the hydrogel components of Examples 1-6 may be combined with any benefit components of Examples 7-12 for providing a product for topical use.
- Products comprising Examples 7-11 as the benefit component are particularly useful for skin care products.
- Products comprising Examples 12 as the benefit component are particularly useful as a powder foundation product.
- the present device is made by a continuous line process, wherein the preformed hydrogel component is made comprising the steps of:
- Packaging made by polypropylene having configurations shown in Fig. 3 and a seal component made by aluminum laminated with polyethyleneterephthalate on the outside and polypropylene on the inside are provided.
- the preformed hydrogel component as obtained above is further transferred to a process for providing the present device comprising the steps of: (6) providing a series of unsealed packages, each package unit having a first compartment and a second compartment;
- the final pre-formed hydrogel product is obtained by opening the seal, folding the packaging at the notch, and transferring the pre-formed hydrogel component into the second compartment to contact the benefit component.
- the product thus obtained is applied to a target area of the skin.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006533583A JP4223531B2 (en) | 2003-06-11 | 2004-06-07 | Ready-to-use devices containing preformed hydrogel products |
MXPA05013213A MXPA05013213A (en) | 2003-06-11 | 2004-06-07 | Preparation-at-use device comprising pre-formed hydrogel product. |
BRPI0411333-0A BRPI0411333A (en) | 2003-06-11 | 2004-06-07 | preparation device for use comprising a preformed hydrogel product |
AU2004247102A AU2004247102A1 (en) | 2003-06-11 | 2004-06-07 | Preparation-at-use device comprising pre-formed hydrogel product |
CA002525786A CA2525786A1 (en) | 2003-06-11 | 2004-06-07 | Preparation-at-use device comprising pre-formed hydrogel product |
EP04754556A EP1633332A1 (en) | 2003-06-11 | 2004-06-07 | Preparation-at-use device comprising pre-formed hydrogel product |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47754603P | 2003-06-11 | 2003-06-11 | |
US60/477,546 | 2003-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004110414A1 true WO2004110414A1 (en) | 2004-12-23 |
Family
ID=33551729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/017985 WO2004110414A1 (en) | 2003-06-11 | 2004-06-07 | Preparation-at-use device comprising pre-formed hydrogel product |
Country Status (10)
Country | Link |
---|---|
US (3) | US7854938B2 (en) |
EP (1) | EP1633332A1 (en) |
JP (1) | JP4223531B2 (en) |
KR (1) | KR100738264B1 (en) |
CN (1) | CN100418516C (en) |
AU (1) | AU2004247102A1 (en) |
BR (1) | BRPI0411333A (en) |
CA (1) | CA2525786A1 (en) |
MX (1) | MXPA05013213A (en) |
WO (1) | WO2004110414A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007142054A1 (en) | 2006-06-06 | 2007-12-13 | Taiki Corp., Ltd. | Sheathlike applicator and process for producing the same |
EP1870078A2 (en) * | 2006-06-19 | 2007-12-26 | Beiersdorf AG | Combi set for decorative skin treatment |
WO2008120113A2 (en) * | 2007-03-30 | 2008-10-09 | Kimberly-Clark Worldwide, Inc. | Cosmetic skin care articles and skin care system |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009541301A (en) * | 2006-07-14 | 2009-11-26 | ザ プロクター アンド ギャンブル カンパニー | Treatment article capable of delivering intensive care and overall treatment simultaneously |
DE102007039229A1 (en) * | 2007-08-20 | 2009-02-26 | Ics Innovative Care Systems Andernach Gmbh | Water and medicated gel |
FR2940115B1 (en) * | 2008-12-19 | 2012-06-15 | Oreal | KERATINIC MATERIAL COATING KIT COMPRISING A POLYSACCHARIDE AND A CHEMICAL CROSSLINKING AGENT |
FR2940111B1 (en) * | 2008-12-19 | 2012-06-01 | Oreal | KERATINIC MATERIAL COATING KIT COMPRISING A POLYSACCHARIDE AND A IONIC OR DATIVE COMPLEXATION AGENT |
FR2955252B1 (en) * | 2010-01-21 | 2012-03-23 | Patrick Lesage | INSERTION MATERIAL FOR EXTENDING THE GINGIVAL BRIDGE |
JP2012092022A (en) * | 2010-10-25 | 2012-05-17 | Tokuhon Corp | External skin patch |
EP2692335B1 (en) * | 2011-03-31 | 2017-07-12 | Nissan Chemical Industries, Ltd. | Method for producing cosmetic, method for preparing gel for cosmetics, and method for reducing quantity of high-molecular thickener added to starting materials of cosmetic |
US20120283668A1 (en) * | 2011-05-04 | 2012-11-08 | Pinchas Shalev | Apparatus and method for using effervescent tablets for cosmetic care |
PT106679B (en) | 2012-11-27 | 2015-03-25 | Hovione Farmaciencia Sa | TOPICAL FORMULATIONS OF TETRACYCLINES, THEIR PREPARATION AND USES |
JP2016516778A (en) | 2013-04-10 | 2016-06-09 | ザ プロクター アンド ギャンブル カンパニー | Oral care composition containing polyorganosilsesquioxane particles |
BR112015024772A2 (en) * | 2013-04-10 | 2017-07-18 | Procter & Gamble | mouthwash compositions containing polyorganosilesquioxane particles |
BR112015025484A2 (en) | 2013-04-10 | 2017-07-18 | Procter & Gamble | buccal treatment compositions containing polyorganosilsesquioxane particles |
CN107148261A (en) | 2014-10-21 | 2017-09-08 | 宝洁公司 | Improve the method for skin appearance |
CN107108837B (en) | 2014-10-31 | 2021-04-13 | 路博润先进材料公司 | Thermoplastic polyurethane films for delivering active agents to skin surfaces |
US20160200500A1 (en) * | 2015-01-07 | 2016-07-14 | Lavico Inc. | L-Ascorbic Acid Formulations and Methods of Use for Skin Care |
GB2543495B (en) * | 2015-10-16 | 2019-06-12 | Gr8 Eng Ltd | Container with frangible weakened portion and manufacture thereof |
EP3364936B1 (en) | 2015-10-22 | 2019-11-20 | The Procter and Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
CN108136230B (en) | 2015-10-22 | 2022-05-13 | 宝洁公司 | Barrier patches for foamed films and methods of improving the appearance of skin |
WO2017107175A1 (en) * | 2015-12-25 | 2017-06-29 | Henkel (China) Investment Co., Ltd. | A sprayable gel composition and use thereof |
FR3053247B1 (en) * | 2016-07-01 | 2020-04-24 | L'oreal | COSMETIC PROCESS FOR TREATING KERATINIC MATERIALS USING A COMPOSITION COMPRISING ASCORBIC ACID |
WO2018066466A1 (en) * | 2016-10-04 | 2018-04-12 | 隆 竹原 | Hydrogen-generating facial sheet |
US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
CN110167642B (en) | 2017-01-09 | 2022-06-07 | 宝洁公司 | Barrier patch with dissolvable film and method of improving the appearance of skin |
US10751265B2 (en) | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
US10959918B2 (en) | 2017-06-22 | 2021-03-30 | The Procter & Gamble Company | Films including a water-soluble layer and a vapor-deposited coating |
KR101891514B1 (en) * | 2017-09-25 | 2018-09-28 | (주)아모레퍼시픽 | Apparatus for manufacturing hydrogel pack for skin care and contorl method thereof |
DE102018203223A1 (en) * | 2018-03-05 | 2019-09-05 | Beiersdorf Ag | Fruit acid-containing, cosmetic gel |
EP3768249B1 (en) | 2018-03-19 | 2024-04-17 | The Procter & Gamble Company | Method of making a barrier patch with soluble film |
US10918514B2 (en) * | 2018-08-12 | 2021-02-16 | Eric Vélez Justiniano | Tamper evident packaging |
US11135336B2 (en) | 2019-09-30 | 2021-10-05 | L'oreal | Thin-film vehicles that stabilize highly reactive active ingredients |
FR3127878B1 (en) * | 2021-10-12 | 2024-04-05 | Oreal | hair treatment compositions providing luminosity and shine |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4927408A (en) * | 1988-10-03 | 1990-05-22 | Alza Corporation | Electrotransport transdermal system |
US5084008A (en) * | 1989-12-22 | 1992-01-28 | Medtronic, Inc. | Iontophoresis electrode |
EP0904779A2 (en) * | 1997-09-30 | 1999-03-31 | Becton, Dickinson and Company | Iontophoretic patch with hydrogel reservoir |
US5935593A (en) * | 1995-06-07 | 1999-08-10 | Medlogic Global Corporation | Chemo-mechanical expansion delivery system |
EP0976396A1 (en) * | 1998-07-30 | 2000-02-02 | L'oreal | Cosmetic or pharmaceutical patch and packaging |
US6510561B1 (en) * | 1998-10-21 | 2003-01-28 | Reckitt Benckiser (Uk) Limited | Dispensing device |
WO2003049722A1 (en) * | 2001-12-11 | 2003-06-19 | The Procter & Gamble Company | Process for making pre-formed objects |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US76711A (en) * | 1868-04-14 | Improvement in shifting-bucket propellers | ||
JPH06336413A (en) | 1993-03-31 | 1994-12-06 | Shiseido Co Ltd | Heat-generating pack cosmetic |
US5393305A (en) | 1993-08-26 | 1995-02-28 | Bristol-Myers Squibb Company | Two-part aqueous composition for coloring hair, which forms a gel on mixing of the two parts |
FR2718018B1 (en) | 1994-04-05 | 1996-04-26 | Oreal | Cosmetic and / or dermatological composition with hydrophilic support and vitamin C mixable extemporaneously. |
US5984953A (en) * | 1998-05-21 | 1999-11-16 | Tempra Technology, Inc. | Self-regulating heat pack |
US6419935B1 (en) * | 1998-07-30 | 2002-07-16 | L'oreal S.A. | Cosmetic skin treatment method and cleansing treatment patch |
DE29814215U1 (en) | 1998-08-12 | 1998-10-15 | Klocke Verpackungs Service | Multi-chamber container |
US6138312A (en) * | 1999-03-26 | 2000-10-31 | Cummings; Eugene M. | Single-use contact lens treatment apparatus |
JP2000297008A (en) | 1999-04-12 | 2000-10-24 | Pola Chem Ind Inc | Foaming cosmetic |
US7658942B2 (en) | 2000-04-12 | 2010-02-09 | The Procter & Gamble Company | Cosmetic devices |
ES2278603T3 (en) | 2000-04-12 | 2007-08-16 | THE PROCTER & GAMBLE COMPANY | SHAPED SHAPED DEVICES PREVIOUSLY SUITABLE FOR TOPICAL APPLICATION. |
-
2004
- 2004-06-07 JP JP2006533583A patent/JP4223531B2/en active Active
- 2004-06-07 AU AU2004247102A patent/AU2004247102A1/en not_active Abandoned
- 2004-06-07 CN CNB2004800161900A patent/CN100418516C/en active Active
- 2004-06-07 WO PCT/US2004/017985 patent/WO2004110414A1/en active Application Filing
- 2004-06-07 MX MXPA05013213A patent/MXPA05013213A/en unknown
- 2004-06-07 BR BRPI0411333-0A patent/BRPI0411333A/en not_active Application Discontinuation
- 2004-06-07 CA CA002525786A patent/CA2525786A1/en not_active Abandoned
- 2004-06-07 EP EP04754556A patent/EP1633332A1/en not_active Withdrawn
- 2004-06-07 KR KR1020057023662A patent/KR100738264B1/en active IP Right Grant
- 2004-06-09 US US10/864,564 patent/US7854938B2/en not_active Expired - Fee Related
-
2010
- 2010-11-11 US US12/944,047 patent/US8066117B2/en not_active Expired - Fee Related
-
2011
- 2011-10-27 US US13/282,568 patent/US8353399B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4927408A (en) * | 1988-10-03 | 1990-05-22 | Alza Corporation | Electrotransport transdermal system |
US5084008A (en) * | 1989-12-22 | 1992-01-28 | Medtronic, Inc. | Iontophoresis electrode |
US5935593A (en) * | 1995-06-07 | 1999-08-10 | Medlogic Global Corporation | Chemo-mechanical expansion delivery system |
EP0904779A2 (en) * | 1997-09-30 | 1999-03-31 | Becton, Dickinson and Company | Iontophoretic patch with hydrogel reservoir |
EP0976396A1 (en) * | 1998-07-30 | 2000-02-02 | L'oreal | Cosmetic or pharmaceutical patch and packaging |
US6510561B1 (en) * | 1998-10-21 | 2003-01-28 | Reckitt Benckiser (Uk) Limited | Dispensing device |
WO2003049722A1 (en) * | 2001-12-11 | 2003-06-19 | The Procter & Gamble Company | Process for making pre-formed objects |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007142054A1 (en) | 2006-06-06 | 2007-12-13 | Taiki Corp., Ltd. | Sheathlike applicator and process for producing the same |
EP1870078A2 (en) * | 2006-06-19 | 2007-12-26 | Beiersdorf AG | Combi set for decorative skin treatment |
EP1870078A3 (en) * | 2006-06-19 | 2009-12-30 | Beiersdorf AG | Combi set for decorative skin treatment |
WO2008120113A2 (en) * | 2007-03-30 | 2008-10-09 | Kimberly-Clark Worldwide, Inc. | Cosmetic skin care articles and skin care system |
WO2008120113A3 (en) * | 2007-03-30 | 2009-08-13 | Kimberly Clark Co | Cosmetic skin care articles and skin care system |
Also Published As
Publication number | Publication date |
---|---|
CA2525786A1 (en) | 2004-12-23 |
AU2004247102A1 (en) | 2004-12-23 |
KR100738264B1 (en) | 2007-07-12 |
JP4223531B2 (en) | 2009-02-12 |
CN100418516C (en) | 2008-09-17 |
KR20060016807A (en) | 2006-02-22 |
EP1633332A1 (en) | 2006-03-15 |
US8353399B2 (en) | 2013-01-15 |
US20110056943A1 (en) | 2011-03-10 |
BRPI0411333A (en) | 2006-07-25 |
US7854938B2 (en) | 2010-12-21 |
US20120041396A1 (en) | 2012-02-16 |
JP2007501286A (en) | 2007-01-25 |
CN1805736A (en) | 2006-07-19 |
MXPA05013213A (en) | 2006-03-09 |
US8066117B2 (en) | 2011-11-29 |
US20040253313A1 (en) | 2004-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8353399B2 (en) | Preparation-at-use device comprising pre-formed hydrogel product | |
US7021031B2 (en) | Process for making pre-formed objects | |
US7658942B2 (en) | Cosmetic devices | |
EP1289487B1 (en) | Pre-formed sheet devices suitable for topical application | |
AU2000242314A1 (en) | Pre-formed sheet devices suitable for topical application | |
US20060018862A1 (en) | Substrate based skin care device | |
US20060198805A1 (en) | Cosmetic and Pharmaceutical Masks for Skin Improvement | |
KR100511188B1 (en) | Pre-formed sheet devices suitable for topical application |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2525786 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004754556 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2005/013213 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004247102 Country of ref document: AU Ref document number: 1020057023662 Country of ref document: KR Ref document number: 20048161900 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006533583 Country of ref document: JP |
|
WWP | Wipo information: published in national office |
Ref document number: 2004247102 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 1020057023662 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2004754556 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: PI0411333 Country of ref document: BR |