WO2005003290A3 - Methods and devices for determining a cell characteristic, and applications employing same - Google Patents

Methods and devices for determining a cell characteristic, and applications employing same Download PDF

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Publication number
WO2005003290A3
WO2005003290A3 PCT/US2003/028066 US0328066W WO2005003290A3 WO 2005003290 A3 WO2005003290 A3 WO 2005003290A3 US 0328066 W US0328066 W US 0328066W WO 2005003290 A3 WO2005003290 A3 WO 2005003290A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
methods
determining
characteristic
devices
Prior art date
Application number
PCT/US2003/028066
Other languages
French (fr)
Other versions
WO2005003290A2 (en
Inventor
James K Gimzewski
Andrew E Pelling
Original Assignee
Univ California
James K Gimzewski
Andrew E Pelling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, James K Gimzewski, Andrew E Pelling filed Critical Univ California
Priority to AU2003304276A priority Critical patent/AU2003304276A1/en
Publication of WO2005003290A2 publication Critical patent/WO2005003290A2/en
Priority to US11/077,266 priority patent/US8524488B2/en
Publication of WO2005003290A3 publication Critical patent/WO2005003290A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q20/00—Monitoring the movement or position of the probe
    • G01Q20/02—Monitoring the movement or position of the probe by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
    • G01Q60/24—AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes

Abstract

The present invention provides methods of determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, and biological state. The method generally involves detecting membrane movement in a cell to determine a characteristic of a cell. The methods of the invention are useful for applications such as drug screening and diagnostics. The invention further provides databases of cell characteristics, as determined by the instant methods. The invention further provides systems for determining the characteristic of a cell.
PCT/US2003/028066 2002-09-10 2003-09-08 Methods and devices for determining a cell characteristic, and applications employing same WO2005003290A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003304276A AU2003304276A1 (en) 2002-09-10 2003-09-08 Methods and devices for determining a cell characteristic, and applications employing same
US11/077,266 US8524488B2 (en) 2002-09-10 2005-03-09 Methods and devices for determining a cell characteristic, and applications employing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41001502P 2002-09-10 2002-09-10
US60/410,015 2002-09-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/077,266 Continuation-In-Part US8524488B2 (en) 2002-09-10 2005-03-09 Methods and devices for determining a cell characteristic, and applications employing the same

Publications (2)

Publication Number Publication Date
WO2005003290A2 WO2005003290A2 (en) 2005-01-13
WO2005003290A3 true WO2005003290A3 (en) 2005-03-10

Family

ID=33563639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/028066 WO2005003290A2 (en) 2002-09-10 2003-09-08 Methods and devices for determining a cell characteristic, and applications employing same

Country Status (2)

Country Link
AU (1) AU2003304276A1 (en)
WO (1) WO2005003290A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103460039A (en) * 2010-12-10 2013-12-18 巴塞尔大学 Method for staging cancer progression by AFM

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016115434A1 (en) 2015-01-16 2016-07-21 The General Hospital Corporation Compounds for improving mrna splicing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620854A (en) * 1993-08-25 1997-04-15 Regents Of The University Of California Method for identifying biochemical and chemical reactions and micromechanical processes using nanomechanical and electronic signal identification
US6238874B1 (en) * 1998-07-28 2001-05-29 Biometric Imaging, Inc. Cell motility assay
US6573063B2 (en) * 1995-10-04 2003-06-03 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical and spectroscopic detection techniques

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620854A (en) * 1993-08-25 1997-04-15 Regents Of The University Of California Method for identifying biochemical and chemical reactions and micromechanical processes using nanomechanical and electronic signal identification
US6573063B2 (en) * 1995-10-04 2003-06-03 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
US6238874B1 (en) * 1998-07-28 2001-05-29 Biometric Imaging, Inc. Cell motility assay

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOWEN W.R. ET AL.: "Atomic force microscopy study of the adhesion of Saccharomyces cerevisiae", J. COLLOID. INTERFACE SCI., vol. 237, May 2001 (2001-05-01), pages 54 - 61, XP002982945 *
DUFRENE Y.F.: "Atomic force microscopy, a powerful tool in microbiology", JOURNAL OF BACTERIOLOGY, vol. 184, no. 19, October 2002 (2002-10-01), pages 5205 - 5213, XP002982943 *
GAD M. ET AL.: "Method for immobilizing microbial cells on gel surface for dynamic AFM studies", BIOPHYSICAL JOURNAL, vol. 69, December 1995 (1995-12-01), pages 2226 - 2233, XP008041727 *
MOSBACHER J. ET AL.: "Voltage-dependent membrane displacements measured by atomic force microscopy", J. GEN. PHYSIOL., vol. 111, January 1998 (1998-01-01), pages 65 - 74, XP002982944 *
RAUCHER D. ET AL.: "Cell spreading and lamellipodial extension rate is regulated by membrane tension", JOURNAL OF CELL BIOLOGY, vol. 148, no. 1, January 2000 (2000-01-01), pages 127 - 136, XP002982942 *
SCHAUS S.S. ET AL.: "Cell viability and probe-cell membrane interactions of XR1 glial cells imaged by atomic force microscopy", BIOPHYSICAL JOURNAL, vol. 73, September 1997 (1997-09-01), pages 1205 - 1214, XP008041726 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103460039A (en) * 2010-12-10 2013-12-18 巴塞尔大学 Method for staging cancer progression by AFM

Also Published As

Publication number Publication date
AU2003304276A1 (en) 2005-01-21
WO2005003290A2 (en) 2005-01-13

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