WO2005005608A3 - Compositions and methods for differentiating adipose stromal cells into pancratic beta cells - Google Patents

Compositions and methods for differentiating adipose stromal cells into pancratic beta cells Download PDF

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Publication number
WO2005005608A3
WO2005005608A3 PCT/US2004/020980 US2004020980W WO2005005608A3 WO 2005005608 A3 WO2005005608 A3 WO 2005005608A3 US 2004020980 W US2004020980 W US 2004020980W WO 2005005608 A3 WO2005005608 A3 WO 2005005608A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
methods
compositions
pancratic
adipose stromal
Prior art date
Application number
PCT/US2004/020980
Other languages
French (fr)
Other versions
WO2005005608A2 (en
Inventor
Alireza Rezania
Original Assignee
Lifescan Inc
Alireza Rezania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifescan Inc, Alireza Rezania filed Critical Lifescan Inc
Publication of WO2005005608A2 publication Critical patent/WO2005005608A2/en
Publication of WO2005005608A3 publication Critical patent/WO2005005608A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/335—Glucagon; Glucagon-like peptide [GLP]; Exendin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

Abstract

This invention relates generally to methods and compositions for the production of cells characteristic of pancreatic beta cell lineage. In particular, the present invention relates to methods and compositions for differentiating adipose stromal cells into cells having at least one marker, preferably two or more markers, characteristic of pancreatic beta cell lineage. The present invention also relates to the cells produced in accordance with the present methods and the use of these cells in the treatment of diseases.
PCT/US2004/020980 2003-06-30 2004-06-29 Compositions and methods for differentiating adipose stromal cells into pancratic beta cells WO2005005608A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48380203P 2003-06-30 2003-06-30
US60/483,802 2003-06-30

Publications (2)

Publication Number Publication Date
WO2005005608A2 WO2005005608A2 (en) 2005-01-20
WO2005005608A3 true WO2005005608A3 (en) 2005-06-23

Family

ID=34061989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/020980 WO2005005608A2 (en) 2003-06-30 2004-06-29 Compositions and methods for differentiating adipose stromal cells into pancratic beta cells

Country Status (1)

Country Link
WO (1) WO2005005608A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013049375A2 (en) * 2011-09-28 2013-04-04 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating beta cell proliferation
WO2014033322A1 (en) 2012-09-03 2014-03-06 Novo Nordisk A/S Generation of pancreatic endoderm from pluripotent stem cells using small molecules
JP2013063088A (en) * 2012-12-14 2013-04-11 Nippon Institute For Biological Science Method for inducing differentiation to neurocyte from adipose tissue stromal cells
WO2016183141A1 (en) 2015-05-11 2016-11-17 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Pancreatic stromal progenitor cells
JP2023534774A (en) * 2019-09-10 2023-08-10 フンダシオ インスティテュート デ バイオエンジニエリア デ カタルーニャ Multilayer cell capsule and its use
CN113736725B (en) * 2020-05-29 2024-04-16 国玺干细胞应用技术股份有限公司 Cell differentiation medium composition, high secretion amount insulin producing cell and preparation thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US6617161B2 (en) * 1997-06-25 2003-09-09 The United States Of America As Represented By The Department Of Health And Human Services Serum-free cell growth medium
US6670180B2 (en) * 1996-03-18 2003-12-30 University Of Pittsburgh Cell culture media for mammalian cells
US6815203B1 (en) * 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US6670180B2 (en) * 1996-03-18 2003-12-30 University Of Pittsburgh Cell culture media for mammalian cells
US6617161B2 (en) * 1997-06-25 2003-09-09 The United States Of America As Represented By The Department Of Health And Human Services Serum-free cell growth medium
US6815203B1 (en) * 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types

Also Published As

Publication number Publication date
WO2005005608A2 (en) 2005-01-20

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