WO2005010207A3 - Methods and compositions for the detection of microbial contaminants - Google Patents

Methods and compositions for the detection of microbial contaminants Download PDF

Info

Publication number
WO2005010207A3
WO2005010207A3 PCT/US2004/008013 US2004008013W WO2005010207A3 WO 2005010207 A3 WO2005010207 A3 WO 2005010207A3 US 2004008013 W US2004008013 W US 2004008013W WO 2005010207 A3 WO2005010207 A3 WO 2005010207A3
Authority
WO
WIPO (PCT)
Prior art keywords
detection
provides
compositions
quantification
sample
Prior art date
Application number
PCT/US2004/008013
Other languages
French (fr)
Other versions
WO2005010207A2 (en
Inventor
Norman R Wainwright
Foster T Jordan
Frank C Rumore
Charles Balas Jr
Original Assignee
Charles River Lab Inc
Norman R Wainwright
Foster T Jordan
Frank C Rumore
Charles Balas Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charles River Lab Inc, Norman R Wainwright, Foster T Jordan, Frank C Rumore, Charles Balas Jr filed Critical Charles River Lab Inc
Priority to DE602004024769T priority Critical patent/DE602004024769D1/en
Priority to AT04775840T priority patent/ATE452986T1/en
Priority to EP04775840A priority patent/EP1606414B1/en
Priority to JP2006532327A priority patent/JP5118849B2/en
Publication of WO2005010207A2 publication Critical patent/WO2005010207A2/en
Publication of WO2005010207A3 publication Critical patent/WO2005010207A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/12—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar
    • G01N2400/24—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar beta-D-Glucans, i.e. having beta 1,n (n=3,4,6) linkages between saccharide units, e.g. xanthan
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS

Abstract

The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides methods of making and using such cartridges. In addition, the invention provides a rapid, sensitive, multi-step kinetic hemocyte lysate-based assay for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides a glucan-specific lysate that can be used in a variety of assay formats, including, for example, a test cartridge, optionally configured to perform a kinetic assay.
PCT/US2004/008013 2003-03-17 2004-03-17 Methods and compositions for the detection of microbial contaminants WO2005010207A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE602004024769T DE602004024769D1 (en) 2003-03-17 2004-03-17 METHODS AND COMPOSITIONS FOR DETECTING MICROBIAL CONTAMINANTS
AT04775840T ATE452986T1 (en) 2003-03-17 2004-03-17 METHODS AND COMPOSITIONS FOR DETECTING MICROBIAL CONTAMINANTS
EP04775840A EP1606414B1 (en) 2003-03-17 2004-03-17 Methods and compositions for the detection of microbial contaminants
JP2006532327A JP5118849B2 (en) 2003-03-17 2004-03-17 Methods and compositions for detection of microbial contaminants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45563203P 2003-03-17 2003-03-17
US60/455,632 2003-03-17

Publications (2)

Publication Number Publication Date
WO2005010207A2 WO2005010207A2 (en) 2005-02-03
WO2005010207A3 true WO2005010207A3 (en) 2005-06-09

Family

ID=34102595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/008013 WO2005010207A2 (en) 2003-03-17 2004-03-17 Methods and compositions for the detection of microbial contaminants

Country Status (6)

Country Link
US (5) US7329538B2 (en)
EP (1) EP1606414B1 (en)
JP (3) JP5118849B2 (en)
AT (1) ATE452986T1 (en)
DE (1) DE602004024769D1 (en)
WO (1) WO2005010207A2 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5118849B2 (en) 2003-03-17 2013-01-16 チャールズ リバー ラボラトリーズ， インコーポレイテッド Methods and compositions for detection of microbial contaminants
CA2563002C (en) 2004-04-07 2011-07-12 Wardlaw Partners Lp Disposable chamber for analyzing biologic fluids
JP2008522640A (en) * 2004-12-02 2008-07-03 チャールズ リバー ラボラトリーズ， インコーポレイテッド Methods and compositions for detection and / or quantification of Gram positive bacteria contaminants
US7479375B2 (en) 2005-01-13 2009-01-20 Charles River Laboratories, Inc. Method for classifying a microorganism in a biological sample
US7731901B2 (en) 2005-10-19 2010-06-08 Abbott Laboratories Apparatus and method for performing counts within a biologic fluid sample
US8097434B2 (en) 2007-10-19 2012-01-17 Becton, Dickinson And Company Methods for the detection of beta-lactamases
WO2009137244A1 (en) * 2008-04-15 2009-11-12 Charles River Laboratories, Inc. Cartridge and method for sample analysis
US9834807B2 (en) 2008-10-20 2017-12-05 Becton, Dickinson And Company Compositions for the detection of intracellular bacterial targets and other intracellular micororganism targets
WO2010120786A1 (en) * 2009-04-13 2010-10-21 Micronics, Inc. Microfluidic clinical analyzer
WO2010151751A2 (en) * 2009-06-26 2010-12-29 Charles River Laboratories, Inc. Heat-treated limulus amebocyte lysates
US20130130309A1 (en) * 2009-09-23 2013-05-23 Abt Molecular Imaging Inc Radiopharmaceutical Production System and Quality Control System Utilizing High Performance Liquid Chromatography
US9579651B2 (en) * 2009-12-18 2017-02-28 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
MY155541A (en) * 2010-10-29 2015-10-30 Universiti Malaysia Terengganu Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab
WO2012078896A1 (en) * 2010-12-09 2012-06-14 Abbott Point Of Care, Inc. Apparatus and method using anti-adsorption agent to facilitate sample mixing and analysis
JP5727218B2 (en) * 2010-12-24 2015-06-03 積水化学工業株式会社 Microfluidic device, microbial contaminant detection system, and microbial contaminant detection method
JP5620257B2 (en) * 2010-12-24 2014-11-05 積水化学工業株式会社 Microbial contaminant detection container, microbial contaminant detection system, and microbial contaminant detection method
CN103282123B (en) 2010-12-30 2015-05-06 艾博特健康公司 Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
USD667022S1 (en) * 2011-02-11 2012-09-11 Charles River Laboratories, Inc. Computer display with a graphical user interface
JP5964555B2 (en) * 2011-05-20 2016-08-03 ローム株式会社 Microchip, and measurement system and measurement method using the same
USD668779S1 (en) * 2011-06-10 2012-10-09 Mbio Diagnostics, Inc. Diagnostic cartridge
EP2748618A1 (en) 2011-08-24 2014-07-02 Abbott Point of Care Inc. Biologic fluid sample analysis cartridge
USD668350S1 (en) * 2012-01-30 2012-10-02 Mbio Diagnostics, Inc. Diagnostic cartridge
US8937287B2 (en) 2012-04-19 2015-01-20 Abt Molecular Imaging, Inc. Self-referencing radiation detector for use with a radiopharmaceutical quality control testing system
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
CN104735980A (en) * 2012-08-14 2015-06-24 中国电力株式会社 Method for stopping attachment-period larvae from swimming or crawling
US9678079B2 (en) * 2012-10-08 2017-06-13 General Electric Company Microfluidic LAL-reactive substances testing method and apparatus
GB201223079D0 (en) * 2012-12-20 2013-02-06 Sepsis Ltd Point of care sepsis assay device and method
US10309947B2 (en) 2013-02-27 2019-06-04 Trace-Ability, Inc. System and method for radiosynthesis, quality control and dose dispensing
CN103235116B (en) * 2013-04-13 2015-06-03 福州大学 Method for amplifying antibody marking signal or nucleic acid probe marking signal
GB201312635D0 (en) * 2013-07-15 2013-08-28 Univ Plymouth Water testing
JP2015021906A (en) * 2013-07-22 2015-02-02 東亜ディーケーケー株式会社 Measuring method, cartridge for measurement, and measuring device
US11002717B2 (en) 2014-02-26 2021-05-11 Trace-Ability, Inc. Systems and methods for characterizing radioactive analytes
US10895563B2 (en) 2014-02-26 2021-01-19 Trace-Ability, Inc. Palette-based systems for analyte characterization
EP3124441B1 (en) 2014-03-24 2020-04-22 The Chugoku Electric Power Co., Inc. Method for killing pteriomorphia and barnacles using light irradiation
US11140893B2 (en) 2014-03-24 2021-10-12 The Chugoku Electric Power Co., Inc. Method for stopping swimming or crawling of adhesion-stage larvae
CN106793769B (en) 2014-12-08 2020-10-23 中国电力株式会社 Method for inhibiting adhesion of ampullaria gigas
US11134671B2 (en) 2015-03-27 2021-10-05 The Chugoku Electric Power Co., Inc. Method for preventing settlement of sessile organisms
USD812766S1 (en) * 2016-07-12 2018-03-13 EMULATE, Inc. Microfluidic chip for use with a fluid perfusion module
USD816861S1 (en) * 2016-09-07 2018-05-01 EMULATE, Inc. Transparent microfluidic chip without pressure features for use with a fluid perfusion module
SG11201906639QA (en) * 2017-01-27 2019-08-27 Lonza Ag Dynamically controlling an automated system
CN110869767A (en) * 2017-06-28 2020-03-06 隆萨沃克斯维尔股份有限公司 Cartridge for endotoxin detection
US11892397B2 (en) * 2017-10-17 2024-02-06 Board Of Regents, The University Of Texas System Endotoxin testing assay and method of same
CN109613250A (en) * 2018-12-25 2019-04-12 中国大冢制药有限公司 The inspection method of pyrophosphoric acid ironic citrate raw material bacterial endotoxin
WO2020185646A1 (en) 2019-03-08 2020-09-17 Bl Technologies, Inc. Method and system for visualization of endotoxins in a fluid sample
KR20220045023A (en) * 2019-08-21 2022-04-12 론자 워커스빌 아이엔씨. Cartridge with mixing zone for endotoxin detection
JP7397343B2 (en) 2021-06-02 2023-12-13 東亜ディーケーケー株式会社 How to measure endotoxin

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717658A (en) * 1985-12-03 1988-01-05 Miles Inc. Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)
US5310657A (en) * 1989-10-30 1994-05-10 Whittaker Bioproducts, Inc. Kinetic assay for endotoxin using limulus amebocyte lysate and chromogenic substrate
US5605806A (en) * 1990-08-22 1997-02-25 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Reagent for assaying endotoxin
WO1999053322A1 (en) * 1998-04-09 1999-10-21 Allied Therapeutics Limited Solid phase test for endotoxin
US6391570B1 (en) * 1997-10-09 2002-05-21 Charles River Laboratories Methods and compositions for the detection of bacterial endotoxins

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915805A (en) 1970-05-25 1975-10-28 Univ Johns Hopkins Quantitative detection of endotoxin in biological fluids
US3954663A (en) 1972-12-18 1976-05-04 Teikoku Horinine Mfg. Co. Ltd. Process for the preparation of Limulina lysate
US3944391A (en) 1974-12-27 1976-03-16 Preventive Systems, Inc. In vitro process for detecting endotoxin in a biological fluid
US4038029A (en) 1976-01-20 1977-07-26 Worthington Biochemical Corporation Limulus lysate turbidity test for pyrogens
US4038147A (en) 1976-06-15 1977-07-26 Becton, Dickinson And Company Method for detecting endotoxins
USD258144S (en) 1977-11-11 1981-02-03 Farrand Optical Co., Inc. Optical cuvette insert for use with differential spectrofluorometer and absorption meter
US4221865A (en) 1978-10-06 1980-09-09 Baxter Travenol Laboratories, Inc. Method for determining endotoxin concentration
US4221866A (en) 1978-10-06 1980-09-09 Baxter Travenol Laboratories, Inc. Method for determining endotoxin concentration
US4245044A (en) 1979-02-01 1981-01-13 Cutter Laboratories, Inc. Fat emulsion pyrogenicity test
US4376819A (en) 1979-09-14 1983-03-15 Baxter Travenol Laboratories, Inc. Biological extracts and method for making same
US4279774A (en) 1979-11-13 1981-07-21 Dynasciences Corporation Method of removing lipid inhibitors from limulus amebocyte lysate
IL59383A (en) 1980-02-14 1983-03-31 Technion Res & Dev Foundation Micromethod for the determination of endotoxins with limulus amebocyte lysate
US4273557A (en) 1980-03-31 1981-06-16 Mallinckrodt, Inc. Limulus lysate procedure for determining endotoxins
US4301245A (en) 1980-05-29 1981-11-17 Dynasciences Corporation Chromogenic method of detecting endotoxins in blood
US4322217A (en) 1980-06-27 1982-03-30 Mallinckrodt, Inc. Process for preparing Limulus lysate
SE431228B (en) 1981-12-17 1984-01-23 Kenneth Soderhell SETTING FOR DETERMINATION OF BACTERIAL ENDOTOXIN MEDIUM PROPHENOLOXIDAS-CONTAINING ANIMAL ANIMAL OR INSECTS AND REAGENTS
USD278182S (en) 1982-04-10 1985-03-26 Olympus Optical Co. Ltd. Cuvette for a sample of liquid serum or the like
JPS608875U (en) * 1983-06-29 1985-01-22 三菱レイヨン株式会社 Endotoxin detection measurement equipment
CA1236396A (en) * 1983-04-01 1988-05-10 Ryozo Numazawa Endotoxin-detecting device
JPS6193958A (en) 1984-10-13 1986-05-12 Daicel Chem Ind Ltd Quantitative determination of endotoxin
US4606824A (en) 1984-10-26 1986-08-19 Chaokang Chu Modified cellulose separation matrix
US4806316A (en) 1987-03-17 1989-02-21 Becton, Dickinson And Company Disposable device for use in chemical, immunochemical and microorganism analysis
DK255887D0 (en) * 1987-05-20 1987-05-20 Claus Koch IMMUNOASSAY
JPH0715474B2 (en) 1988-02-27 1995-02-22 和光純薬工業株式会社 Endotoxin assay
KR0141685B1 (en) * 1988-09-01 1998-07-01 야마따니 와따루 Limulus amoebocyte lysate g-factor activation
CA1328074C (en) 1988-09-01 1994-03-29 Shigenori Tanaka Horseshoe crab amebocyte lysate factor g inhibitor
JPH0375565A (en) * 1989-08-18 1991-03-29 Taiyo Fishery Co Ltd Simplified method for determining quantity of endotoxin and reagent used in the method
USD325090S (en) 1989-11-30 1992-03-31 Akzo N.V. Cuvette
JP2944709B2 (en) 1990-06-21 1999-09-06 生化学工業株式会社 (1 → 3) -β-D-glucan measuring agent
USD330428S (en) 1990-07-20 1992-10-20 Scott Lewis Cuvette for a clinical laboratory analyzer
JP2944721B2 (en) 1990-08-22 1999-09-06 生化学工業株式会社 Agent for measuring endotoxin
USD343905S (en) 1990-08-23 1994-02-01 Olympus Optical Co., Ltd. Cuvette for use in chemical analysis
JP3122454B2 (en) * 1990-09-27 2001-01-09 生化学工業株式会社 Preparation of horseshoe crab, amebosite lysate
US5681710A (en) * 1991-03-14 1997-10-28 Seikagaku Kogyo Kabushiki Kaisha Reagent for determining (1→3)-β-D-glucan
USD342793S (en) 1991-05-07 1993-12-28 Hoffmann-La Roche Inc. Cuvette
JP3034352B2 (en) * 1991-08-08 2000-04-17 生化学工業株式会社 Intramolecular cross-linking (1 → 3) -β-D-glucans having stable single helix structure and method for producing the same
DE69211973T2 (en) * 1991-12-25 1996-12-19 Maruha Corp Reagents and methods for the determination of beta-glucans
JPH05306978A (en) * 1992-05-01 1993-11-19 Meidensha Corp Microorganism measuring instrument
JP3524120B2 (en) * 1992-05-08 2004-05-10 生化学工業株式会社 Pretreatment agent, pretreatment method, measurement method using pretreated sample, measurement kit, and sample determination method
USD353676S (en) 1992-07-16 1994-12-20 Spectrum Systems, Inc. Cuvette for a chemical analyzer
JP3322700B2 (en) * 1992-09-14 2002-09-09 生化学工業株式会社 Endotoxin-specific measuring agent for solid-phase reaction
US5302348A (en) * 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
CA2112776C (en) * 1993-01-21 2002-11-12 Masakazu Tsuchiya Process for inhibiting activity of endotoxin
JP3242733B2 (en) * 1993-02-26 2001-12-25 生化学工業株式会社 Endotoxin-specific measuring agent
CN1063489C (en) * 1993-06-29 2001-03-21 生化学工业株式会社 Novel polypeptide and DNA coding for the same
US5496700A (en) * 1993-08-06 1996-03-05 The United States Of America As Represented By The Secretary Of The Navy Optical immunoassay for microbial analytes using non-specific dyes
JP3429036B2 (en) * 1993-09-30 2003-07-22 生化学工業株式会社 Endotoxin specific assay
US5518006A (en) * 1994-08-09 1996-05-21 International Technidyne Corp. Blood sampling device
USD380555S (en) 1994-08-31 1997-07-01 Toa Medical Electronics Co., Ltd. Sample analysis cuvette
US5504011A (en) * 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
US5637474A (en) * 1994-10-31 1997-06-10 Wako Pure Chemical Industries, Ltd. Process for measuring amount of endotoxin or (1→3)-β-D-glucan by kinetic turbidimetric method
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
US6046021A (en) * 1995-04-12 2000-04-04 Biolog, Inc. Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a multiwell testing device
JPH09131174A (en) * 1995-09-08 1997-05-20 Wako Pure Chem Ind Ltd Plate for detecting microorganism
JP3666621B2 (en) * 1995-10-05 2005-06-29 和光純薬工業株式会社 Microbe-derived component measuring apparatus and measuring method
USD391373S (en) 1996-04-04 1998-02-24 Biometric Imaging, Inc. Cuvette for laboratory sample
US6428971B1 (en) * 1996-05-07 2002-08-06 Pharmacia & Upjohn Company Teichoic acid enzymes and assays
NZ333346A (en) * 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
EP0816513B1 (en) 1996-06-28 2003-01-08 Nitto Denko Corporation Pressure sensitive adhesive sheet for detection of microorganism and method for detection of microorganism
US5820767A (en) * 1996-07-29 1998-10-13 Pall Corporation Method for quantitation of microorganism contamination of liquids
USD390661S (en) 1996-10-04 1998-02-10 International Technidyne Corporation Blood coagulation analyzer
US5836360A (en) * 1997-03-25 1998-11-17 International Technidyne Corporation Volume controlled receptacle
US6235471B1 (en) * 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
EP0991928A2 (en) * 1997-06-27 2000-04-12 Immunetics Rapid flow-through binding assay apparatus and method
JPH11178596A (en) * 1997-12-24 1999-07-06 Nitto Denko Corp Sheet-like article for detecting microorganism, kit containing the same and used for detecting microorganism and detection of microorganism with the same
USD437419S1 (en) 1999-02-04 2001-02-06 Eppendorf Ag Cuvette
US6451610B1 (en) * 1999-04-14 2002-09-17 International Technidyne Corporation Method and apparatus for coagulation based assays
USD445909S1 (en) 1999-11-11 2001-07-31 Hemocue Ab Cuvette
PT2295968E (en) * 1999-12-03 2013-01-09 Baxter Int Pyrogenicity test for use with automated immunoassay systems
USD463570S1 (en) 2001-06-28 2002-09-24 3M Innovative Properties Company Sample processing device
JP3642319B2 (en) * 2002-01-30 2005-04-27 トヨタ自動車株式会社 Control device for vehicle power supply
USD472324S1 (en) 2002-04-05 2003-03-25 Charles River Laboratories, Inc. Cuvette
JP5118849B2 (en) 2003-03-17 2013-01-16 チャールズ リバー ラボラトリーズ， インコーポレイテッド Methods and compositions for detection of microbial contaminants
JP2008522640A (en) * 2004-12-02 2008-07-03 チャールズ リバー ラボラトリーズ， インコーポレイテッド Methods and compositions for detection and / or quantification of Gram positive bacteria contaminants
US7479375B2 (en) 2005-01-13 2009-01-20 Charles River Laboratories, Inc. Method for classifying a microorganism in a biological sample

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717658A (en) * 1985-12-03 1988-01-05 Miles Inc. Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)
US5310657A (en) * 1989-10-30 1994-05-10 Whittaker Bioproducts, Inc. Kinetic assay for endotoxin using limulus amebocyte lysate and chromogenic substrate
US5605806A (en) * 1990-08-22 1997-02-25 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Reagent for assaying endotoxin
US6391570B1 (en) * 1997-10-09 2002-05-21 Charles River Laboratories Methods and compositions for the detection of bacterial endotoxins
WO1999053322A1 (en) * 1998-04-09 1999-10-21 Allied Therapeutics Limited Solid phase test for endotoxin

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DUNER KRISTINA I: "A new kinetic single-stage Limulus amoebocyte lysate method for the detection of endotoxin in water and plasma", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 26, no. 2-3, 1993, pages 131 - 142, XP002305906, ISSN: 0165-022X *
HURLEY JAMES C: "Endotoxemia: Methods of detection and clinical correlates", CLINICAL MICROBIOLOGY REVIEWS, vol. 8, no. 2, 1995, pages 268 - 292, XP002305904, ISSN: 0893-8512 *
IWANAGA ET AL: "The limulus clotting reaction", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, vol. 5, no. 5, 1993, pages 74 - 82, XP002099783, ISSN: 0952-7915 *
IWANAGA S ET AL: "CHROMOGENIC SUBSTRATES FOR HORSESHOE-CRAB CLOTTING ENZYME ITS APPLICATION FOR THE ASSAY OF BACTERIAL ENDO TOXINS", HAEMOSTASIS, vol. 7, no. 2/3, 1978, pages 183 - 188, XP009039832, ISSN: 0301-0147 *
MUTA ET AL: "Limulus factor C", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 266, no. 10, 5 April 1991 (1991-04-05), pages 6554 - 6561, XP002099782, ISSN: 0021-9258 *
TSUJI K ET AL: "AUTOMATION OF CHROMOGENIC SUBSTRATE LIMULUS AMEBOCYTE LYSATE ASSAY METHOD FOR ENDOTOXIN BY ROBOTIC SYSTEM", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 48, no. 3, 1984, pages 550 - 555, XP002305905, ISSN: 0099-2240 *

Also Published As

Publication number Publication date
US20080020422A1 (en) 2008-01-24
US7939291B2 (en) 2011-05-10
JP2007501020A (en) 2007-01-25
US20110201049A1 (en) 2011-08-18
EP1606414B1 (en) 2009-12-23
US20190271699A1 (en) 2019-09-05
DE602004024769D1 (en) 2010-02-04
US10119969B2 (en) 2018-11-06
WO2005010207A2 (en) 2005-02-03
JP5118849B2 (en) 2013-01-16
ATE452986T1 (en) 2010-01-15
US7329538B2 (en) 2008-02-12
US20100047851A1 (en) 2010-02-25
JP5738543B2 (en) 2015-06-24
EP1606414A2 (en) 2005-12-21
JP2010200766A (en) 2010-09-16
JP2014110806A (en) 2014-06-19
US20040241788A1 (en) 2004-12-02

Similar Documents

Publication Publication Date Title
WO2005010207A3 (en) Methods and compositions for the detection of microbial contaminants
WO2007149065A3 (en) Methods and apparatuses for detecting chemical or biological agents
WO2004036177A3 (en) Assays to detect or quantify bacterial or viral pathogens and contaminants
WO2006079049A3 (en) Methods and compositions for increased dynamic range detection of nucleic acid molecules
WO2005111212A3 (en) Biological bar code
WO2002079490A3 (en) Bio-barcodes based on oligonucleotide-modified particles
WO2006083305A8 (en) Methods and compositions for the detection of biological molecules using a two particle complex
WO2008105896A3 (en) Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
WO2005045075A3 (en) Sample preparation methods and devices
WO2006020579A3 (en) Method for rapid identification of microorganisms
WO2004041061A3 (en) Substrates, devices, and methods for cellular assays
WO2007098279A3 (en) Analyte detection using barcoded polymers
WO2008057111A3 (en) Assay apparatuses, methods and reagents
WO2003064993A3 (en) Methods and materials for detecting genetic material
WO2007086900A3 (en) Stilbazium research assays
EP2266996A3 (en) New labelling strategies for the sensitive detection of analytes
WO2006110561A3 (en) Methods and compositions for identifying chemical or biological agents using multiplexed labeling and colocalization detection
WO2008020823A3 (en) Cooperative reporter systems, components, and methods for analyte detection
WO2008124091A3 (en) Compositions and methods of detection
WO2007044903A3 (en) Binary signal detection assays
WO2005008252A3 (en) Methods and compositions for assaying homocysteine
WO2007133586A3 (en) Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets
WO2010006201A3 (en) Methods of reducing non-specific interaction in metal nanoparticle assays
WO2003050291A3 (en) Sensor for the use in testing biological chemical or environmental samples
WO2004091481A3 (en) Methods and kits for detecting cerebrospinal fluid in a sample

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006532327

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2004775840

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004775840

Country of ref document: EP