WO2005011620A3 - Methods and apparatus for creating particle derivatives of hdl with reduced lipid content - Google Patents

Methods and apparatus for creating particle derivatives of hdl with reduced lipid content Download PDF

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Publication number
WO2005011620A3
WO2005011620A3 PCT/US2004/006988 US2004006988W WO2005011620A3 WO 2005011620 A3 WO2005011620 A3 WO 2005011620A3 US 2004006988 W US2004006988 W US 2004006988W WO 2005011620 A3 WO2005011620 A3 WO 2005011620A3
Authority
WO
WIPO (PCT)
Prior art keywords
hdl
cholesterol
methods
derivatives
lipid content
Prior art date
Application number
PCT/US2004/006988
Other languages
French (fr)
Other versions
WO2005011620A2 (en
Inventor
Marc Bellotti
H Bryan Brewer Jr
Hassibullah Akeefe
Adam Paul Conner
Timothy Jon Perlman
Original Assignee
Lipid Sciences Inc
Marc Bellotti
H Bryan Brewer Jr
Hassibullah Akeefe
Adam Paul Conner
Timothy Jon Perlman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipid Sciences Inc, Marc Bellotti, H Bryan Brewer Jr, Hassibullah Akeefe, Adam Paul Conner, Timothy Jon Perlman filed Critical Lipid Sciences Inc
Priority to EP04718501.2A priority Critical patent/EP1641421B1/en
Priority to ES04718501T priority patent/ES2715496T3/en
Priority to DK04718501.2T priority patent/DK1641421T3/en
Priority to JP2006518606A priority patent/JP2007527387A/en
Priority to AU2004260632A priority patent/AU2004260632A1/en
Priority to CA002531227A priority patent/CA2531227A1/en
Publication of WO2005011620A2 publication Critical patent/WO2005011620A2/en
Publication of WO2005011620A3 publication Critical patent/WO2005011620A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides

Abstract

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.
PCT/US2004/006988 2003-07-03 2004-03-08 Methods and apparatus for creating particle derivatives of hdl with reduced lipid content WO2005011620A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP04718501.2A EP1641421B1 (en) 2003-07-03 2004-03-08 Methods and apparatus for creating particle derivatives of hdl with reduced lipid content
ES04718501T ES2715496T3 (en) 2003-07-03 2004-03-08 Methods and apparatus for creating derivatives of HDL particles with a reduced lipid content
DK04718501.2T DK1641421T3 (en) 2003-07-03 2004-03-08 Methods and apparatus for producing HDL particle derivatives of reduced lipid content
JP2006518606A JP2007527387A (en) 2003-07-03 2004-03-08 Method and apparatus for producing particle derivatives of HDL with reduced lipid content
AU2004260632A AU2004260632A1 (en) 2003-07-03 2004-03-08 Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
CA002531227A CA2531227A1 (en) 2003-07-03 2004-03-08 Methods and apparatus for creating particle derivatives of hdl with reduced lipid content

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48469003P 2003-07-03 2003-07-03
US60/484,690 2003-07-03

Publications (2)

Publication Number Publication Date
WO2005011620A2 WO2005011620A2 (en) 2005-02-10
WO2005011620A3 true WO2005011620A3 (en) 2006-05-18

Family

ID=34115319

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/006988 WO2005011620A2 (en) 2003-07-03 2004-03-08 Methods and apparatus for creating particle derivatives of hdl with reduced lipid content

Country Status (9)

Country Link
US (5) US7375191B2 (en)
EP (2) EP1641421B1 (en)
JP (1) JP2007527387A (en)
AU (1) AU2004260632A1 (en)
CA (1) CA2531227A1 (en)
DK (2) DK2368565T3 (en)
ES (2) ES2715496T3 (en)
PT (2) PT2368565E (en)
WO (1) WO2005011620A2 (en)

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US7393826B2 (en) * 2003-07-03 2008-07-01 Lipid Sciences, Inc. Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
PT2368565E (en) * 2003-07-03 2015-10-19 Hdl Therapeutics Inc Enrichment of pre-beta high density lipoproteins
EP1685852A1 (en) * 2005-02-01 2006-08-02 Fondation pour la Recherche Diagnostique Set of disposable bags for viral inactivation of biological fluids
PT1917029E (en) * 2005-07-27 2013-03-13 Lilly Co Eli A method of treating cancer cells to create a modified cancer cell that provokes an immunogenic response
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ITMO20060097A1 (en) * 2006-03-24 2007-09-25 Giuseppe Zucca DEVICE AND METHOD FOR DILUTION AND PREPARATION OF ANTIBLASTIC DRUGS
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AU2007200908B2 (en) * 2007-03-01 2012-08-16 Csl Limited Treatment of endothelial dysfunction in diabetic patients
US7956035B2 (en) * 2007-03-01 2011-06-07 Csl Limited Treatment of endothelial dysfunction in diabetic patients
WO2011046504A1 (en) * 2009-10-18 2011-04-21 Glycorex Ab Method and product for blood treatment and purification
US9494605B2 (en) * 2009-11-20 2016-11-15 Pharnext Diagnostic tools for charcot-marie-tooth disease
EP3466969A1 (en) 2011-02-07 2019-04-10 Cerenis Therapeutics Holding SA Lipoprotein complexes and manufacturing and use thereof
US10624924B2 (en) * 2012-03-12 2020-04-21 Grifols, S.A. Method and device for treating blood cholesterol disorders
JP2017515893A (en) 2014-05-02 2017-06-15 セレニス セラピューティクス ホールディング エスアー HDL treatment marker
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US20190021674A1 (en) * 2017-01-23 2019-01-24 Hdl Therapeutics, Inc. Methods for Treating Cholesterol-Related Diseases
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CA3083194A1 (en) 2017-11-22 2019-05-31 Hdl Therapeutics, Inc. Systems and methods for priming fluid circuits of a plasma processing system
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