WO2005017936A3 - Electrosonic spray ionization method and device for the atmospheric ionization of molecules - Google Patents

Electrosonic spray ionization method and device for the atmospheric ionization of molecules Download PDF

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Publication number
WO2005017936A3
WO2005017936A3 PCT/US2004/023989 US2004023989W WO2005017936A3 WO 2005017936 A3 WO2005017936 A3 WO 2005017936A3 US 2004023989 W US2004023989 W US 2004023989W WO 2005017936 A3 WO2005017936 A3 WO 2005017936A3
Authority
WO
WIPO (PCT)
Prior art keywords
solution
gas
molecules
ionization
stream
Prior art date
Application number
PCT/US2004/023989
Other languages
French (fr)
Other versions
WO2005017936A2 (en
Inventor
Zoltan Takats
Robert Graham Cooks
Original Assignee
Purdue Research Foundation
Zoltan Takats
Robert Graham Cooks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Zoltan Takats, Robert Graham Cooks filed Critical Purdue Research Foundation
Priority to CA002532587A priority Critical patent/CA2532587A1/en
Priority to EP04786110A priority patent/EP1649486A4/en
Publication of WO2005017936A2 publication Critical patent/WO2005017936A2/en
Publication of WO2005017936A3 publication Critical patent/WO2005017936A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • B05B5/03—Discharge apparatus, e.g. electrostatic spray guns characterised by the use of gas, e.g. electrostatically assisted pneumatic spraying

Abstract

There is described a device and method for generating gaseous ions of a sample material such as molecules in solution at atmospheric pressure. The device includes a conduit for receiving a solution containing the material to be ionized and form a stream. A jet of gas at supersonic velocity is directed at the stream and interacts therewith. Droplets are formed and by the adiabatic expansion of the gas and vigorous evaporation of the solution gaseous ions are generated. In the method a stream of the sample solution is delivered from a conduit with an electric potential. A gas jet at supersonic velocity interacts with the delivered solution and through the action of adiabatic expansion of the gas and evaporation of the solution gaseous ions are formed.
PCT/US2004/023989 2003-07-24 2004-07-23 Electrosonic spray ionization method and device for the atmospheric ionization of molecules WO2005017936A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002532587A CA2532587A1 (en) 2003-07-24 2004-07-23 Electrosonic spray ionization method and device for the atmospheric ionization of molecules
EP04786110A EP1649486A4 (en) 2003-07-24 2004-07-23 Electrosonic spray ionization method and device for the atmospheric ionization of molecules

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US49018303P 2003-07-24 2003-07-24
US60/490,183 2003-07-24
US54309604P 2004-02-09 2004-02-09
US60/543,096 2004-02-09
US10/888,869 US7015466B2 (en) 2003-07-24 2004-07-09 Electrosonic spray ionization method and device for the atmospheric ionization of molecules
US10/888,869 2004-07-09

Publications (2)

Publication Number Publication Date
WO2005017936A2 WO2005017936A2 (en) 2005-02-24
WO2005017936A3 true WO2005017936A3 (en) 2005-08-11

Family

ID=34119794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/023989 WO2005017936A2 (en) 2003-07-24 2004-07-23 Electrosonic spray ionization method and device for the atmospheric ionization of molecules

Country Status (4)

Country Link
US (1) US7015466B2 (en)
EP (1) EP1649486A4 (en)
CA (1) CA2532587A1 (en)
WO (1) WO2005017936A2 (en)

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Also Published As

Publication number Publication date
EP1649486A2 (en) 2006-04-26
WO2005017936A2 (en) 2005-02-24
US20050029442A1 (en) 2005-02-10
US7015466B2 (en) 2006-03-21
EP1649486A4 (en) 2008-01-09
CA2532587A1 (en) 2005-02-24

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