WO2005018697A3 - Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods - Google Patents

Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods Download PDF

Info

Publication number
WO2005018697A3
WO2005018697A3 PCT/US2004/025952 US2004025952W WO2005018697A3 WO 2005018697 A3 WO2005018697 A3 WO 2005018697A3 US 2004025952 W US2004025952 W US 2004025952W WO 2005018697 A3 WO2005018697 A3 WO 2005018697A3
Authority
WO
WIPO (PCT)
Prior art keywords
active agent
polymer blend
methods
single layer
agent delivery
Prior art date
Application number
PCT/US2004/025952
Other languages
French (fr)
Other versions
WO2005018697A2 (en
Inventor
Thomas Q Dinh
Randall V Sparer
Suping Lyu
Kiem Dang
Christopher M Hobot
Original Assignee
Medtronic Inc
Thomas Q Dinh
Randall V Sparer
Suping Lyu
Kiem Dang
Christopher M Hobot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc, Thomas Q Dinh, Randall V Sparer, Suping Lyu, Kiem Dang, Christopher M Hobot filed Critical Medtronic Inc
Priority to CA002535346A priority Critical patent/CA2535346A1/en
Priority to JP2006523314A priority patent/JP2008511339A/en
Priority to EP04780737A priority patent/EP1660145A2/en
Publication of WO2005018697A2 publication Critical patent/WO2005018697A2/en
Publication of WO2005018697A3 publication Critical patent/WO2005018697A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Abstract

An active agent delivery system that includes two or more active agents in a layer of a miscible polymer blend having at least two miscible polymers; wherein delivery of at least one of the active agents occurs predominantly under permeation control; and further wherein the permeability of the active agent that is to be released faster is greater than the permeability of the other one or more active agents.
PCT/US2004/025952 2003-08-13 2004-08-11 Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods WO2005018697A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002535346A CA2535346A1 (en) 2003-08-13 2004-08-11 Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods
JP2006523314A JP2008511339A (en) 2003-08-13 2004-08-11 Active drug delivery system, medical device and method comprising monolayers of compatible polymer blends
EP04780737A EP1660145A2 (en) 2003-08-13 2004-08-11 Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49502203P 2003-08-13 2003-08-13
US60/495,022 2003-08-13

Publications (2)

Publication Number Publication Date
WO2005018697A2 WO2005018697A2 (en) 2005-03-03
WO2005018697A3 true WO2005018697A3 (en) 2005-12-15

Family

ID=34215912

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/025952 WO2005018697A2 (en) 2003-08-13 2004-08-11 Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods

Country Status (5)

Country Link
US (1) US20050064038A1 (en)
EP (1) EP1660145A2 (en)
JP (1) JP2008511339A (en)
CA (1) CA2535346A1 (en)
WO (1) WO2005018697A2 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2179646T3 (en) * 1998-04-27 2003-01-16 Surmodics Inc COATING THAT RELEASES A BIOACTIVE AGENT.
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
KR20020067545A (en) * 1999-12-16 2002-08-22 테바 파마슈티컬 인더스트리즈 리미티드 Novel processes for making- and a new crystalline form of- leflunomide
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US7361368B2 (en) * 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US20040047911A1 (en) * 2002-08-13 2004-03-11 Medtronic, Inc. Active agent delivery system including a poly(ethylene-co-(meth)Acrylate), medical device, and method
AU2003258206A1 (en) * 2002-08-13 2004-02-25 Medtronic, Inc. Active agent delivery system including a polyurethane, medical device, and method
WO2004014448A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method
CA2495172A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
DE10239391B4 (en) * 2002-08-28 2004-11-25 Werner Kammann Maschinenfabrik Gmbh Holder for an object to be decorated
US20040111144A1 (en) * 2002-12-06 2004-06-10 Lawin Laurie R. Barriers for polymeric coatings
US8088404B2 (en) * 2003-03-20 2012-01-03 Medtronic Vasular, Inc. Biocompatible controlled release coatings for medical devices and related methods
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US7641643B2 (en) * 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
WO2005018702A2 (en) * 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems including a miscible polymer blend, medical devices, and methods
US9687368B2 (en) * 2003-08-13 2017-06-27 Medtronic Vascular, Inc. Biocompatible controlled release coatings for medical devices and related methods
US7985592B2 (en) * 2004-02-13 2011-07-26 Chevron Oronite Company Llc High throughput screening methods for lubricating oil compositions
US20050220842A1 (en) * 2004-04-06 2005-10-06 Dewitt David M Coating compositions for bioactive agents
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
BRPI0503201B8 (en) * 2005-07-28 2021-05-25 Sci Tech Produtos Medicos Ltda stents coated with hydrophilic polymer blends, eluting nitric oxide and s-nitrosothiols
EP2044142A2 (en) * 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US7732190B2 (en) * 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US8741326B2 (en) 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
KR101144984B1 (en) 2007-01-21 2012-05-21 헤모텍 아게 Medical product for treating stenosis of body passages and for preventing threatening restenosis
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US20090074831A1 (en) * 2007-09-18 2009-03-19 Robert Falotico LOCAL VASCULAR DELIVERY OF mTOR INHIBITORS IN COMBINATION WITH PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR STIMULATORS
US8017396B2 (en) * 2008-02-22 2011-09-13 Vijay Kumar Cellulose based heart valve prosthesis
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US7964697B2 (en) 2008-08-13 2011-06-21 General Electric Company Polyarylether membranes
US7834134B2 (en) * 2008-08-13 2010-11-16 General Electric Company Polyarylethers, blends and methods for making
US20100041837A1 (en) * 2008-08-13 2010-02-18 Gary William Yeager Polyarylethers, blends and methods for making
US7985339B2 (en) * 2008-08-25 2011-07-26 General Electric Company Polyarylether compositions bearing zwitterion functionalities
EP2451496B1 (en) 2009-07-10 2015-07-22 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
WO2011008393A2 (en) 2009-07-17 2011-01-20 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US9050264B2 (en) 2009-11-07 2015-06-09 University Of Iowa Research Foundation Cellulose capsules and methods for making them
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CA2935808C (en) * 2014-02-12 2018-08-21 Toray Industries, Inc. Artificial blood vessel
JP2021172812A (en) * 2020-04-21 2021-11-01 Jsr株式会社 Thermoplastic elastomer composition and molded body

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2202855A (en) * 1987-03-27 1988-10-05 Tyndale Plains Hunter Ltd Hydrophilic polyurethane composition
US4904247A (en) * 1984-08-31 1990-02-27 Kendall Company Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery
US5919835A (en) * 1991-02-01 1999-07-06 Massachusetts Institute Of Technology Biodegradable polymer blends for drug delivery
US6214901B1 (en) * 1998-04-27 2001-04-10 Surmodics, Inc. Bioactive agent release coating
US20020018795A1 (en) * 2000-04-13 2002-02-14 Whitbourne Richard J. Targeted therapeutic agent release devices and methods of making and using the same
WO2004014448A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986A (en) * 1848-12-26 Bolt-heading machine
US2120326A (en) * 1937-07-19 1938-06-14 Doerschlen Edward Digger
US3598127A (en) * 1968-06-06 1971-08-10 James G Wepsic Catheter having antibacterial substance therein provided with means permitting slow release of said substance
US4100309A (en) * 1977-08-08 1978-07-11 Biosearch Medical Products, Inc. Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
US4861830A (en) * 1980-02-29 1989-08-29 Th. Goldschmidt Ag Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
DE3582754D1 (en) * 1984-06-04 1991-06-13 Terumo Corp MEDICAL TOOL AND PRODUCTION METHOD.
US5024875A (en) * 1986-09-09 1991-06-18 Burlington Industries, Inc. Antimicrobial microporous coating
US4873308A (en) * 1988-09-30 1989-10-10 Medtronic, Inc. Biostable, segmented aliphatic polyurethanes and process therefor
US5702716A (en) * 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5061254A (en) * 1989-06-21 1991-10-29 Becton, Dickinson And Company Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter
US5496359A (en) * 1989-07-25 1996-03-05 Smith & Nephew Richards, Inc. Zirconium oxide and zirconium nitride coated biocompatible leads
US5069899A (en) * 1989-11-02 1991-12-03 Sterilization Technical Services, Inc. Anti-thrombogenic, anti-microbial compositions containing heparin
US5525348A (en) * 1989-11-02 1996-06-11 Sts Biopolymers, Inc. Coating compositions comprising pharmaceutical agents
US5059166A (en) * 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
JPH08507715A (en) * 1993-03-18 1996-08-20 シーダーズ サイナイ メディカル センター Drug-inducing and releasable polymeric coatings for bioartificial components
US5676972A (en) * 1995-02-16 1997-10-14 The University Of Akron Time-release delivery matrix composition and corresponding controlled-release compositions
US6147168A (en) * 1995-03-06 2000-11-14 Ethicon, Inc. Copolymers of absorbable polyoxaesters
US5837313A (en) * 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
NL1001746C2 (en) * 1995-11-27 1997-05-30 Belden Wire & Cable Bv Guide wire for medical application.
US5722984A (en) * 1996-01-16 1998-03-03 Iso Stent, Inc. Antithrombogenic radioactive coating for an intravascular stent
US5871437A (en) * 1996-12-10 1999-02-16 Inflow Dynamics, Inc. Radioactive stent for treating blood vessels to prevent restenosis
US5997517A (en) * 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
US6111052A (en) * 1997-04-30 2000-08-29 Medtronic, Inc. Polyurethane and polyurea biomaterials for use in medical devices
US6077916A (en) * 1997-06-04 2000-06-20 The Penn State Research Foundation Biodegradable mixtures of polyphoshazene and other polymers
US6110483A (en) * 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
PT1003476E (en) * 1997-08-11 2005-05-31 Alza Corp ACTIVE AGGREGATE AGGREGATE DOSAGE FORM ADAPTED FOR GASTRIC RETENTION
US6890546B2 (en) * 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
DE69817863T2 (en) * 1997-10-31 2004-07-15 Children's Medical Center Corp., Boston BLADDER RECONSTRUCTION
US6074660A (en) * 1998-04-20 2000-06-13 Ethicon, Inc. Absorbable polyoxaesters containing amines and/ or amido groups
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6630231B2 (en) * 1999-02-05 2003-10-07 3M Innovative Properties Company Composite articles reinforced with highly oriented microfibers
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
WO2001036007A2 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions of a combination of radioactive therapy and cell-cycle inhibitors
JP5100951B2 (en) * 2000-09-29 2012-12-19 コーディス・コーポレイション Coated medical device
US6471980B2 (en) * 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US20020082679A1 (en) * 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
US20020127263A1 (en) * 2001-02-27 2002-09-12 Wenda Carlyle Peroxisome proliferator-acitvated receptor gamma ligand eluting medical device
JP2004526499A (en) * 2001-03-16 2004-09-02 エスティーエス バイオポリマーズ，インコーポレイティド Drug-loaded stent with multi-layer polymer coating
IN2014DN10834A (en) * 2001-09-17 2015-09-04 Psivida Inc
CN1646068A (en) * 2002-02-07 2005-07-27 拉特格斯,新泽西州立大学 Therapeutic polyesters and polyamides
US20040047911A1 (en) * 2002-08-13 2004-03-11 Medtronic, Inc. Active agent delivery system including a poly(ethylene-co-(meth)Acrylate), medical device, and method
CA2494188A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a hydrophobic cellulose derivative
JP2006500088A (en) * 2002-08-13 2006-01-05 メドトロニック・インコーポレーテッド Medical device showing improved adhesion between polymer coating and support
AU2003258206A1 (en) * 2002-08-13 2004-02-25 Medtronic, Inc. Active agent delivery system including a polyurethane, medical device, and method
CA2495172A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
WO2005018702A2 (en) * 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems including a miscible polymer blend, medical devices, and methods

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904247A (en) * 1984-08-31 1990-02-27 Kendall Company Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery
GB2202855A (en) * 1987-03-27 1988-10-05 Tyndale Plains Hunter Ltd Hydrophilic polyurethane composition
US5919835A (en) * 1991-02-01 1999-07-06 Massachusetts Institute Of Technology Biodegradable polymer blends for drug delivery
US6214901B1 (en) * 1998-04-27 2001-04-10 Surmodics, Inc. Bioactive agent release coating
US20020018795A1 (en) * 2000-04-13 2002-02-14 Whitbourne Richard J. Targeted therapeutic agent release devices and methods of making and using the same
WO2004014448A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method

Also Published As

Publication number Publication date
JP2008511339A (en) 2008-04-17
US20050064038A1 (en) 2005-03-24
CA2535346A1 (en) 2005-03-03
WO2005018697A2 (en) 2005-03-03
EP1660145A2 (en) 2006-05-31

Similar Documents

Publication Publication Date Title
WO2005018697A3 (en) Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods
WO2005018702A3 (en) Active agent delivery systems including a miscible polymer blend, medical devices, and methods
WO2005044224A3 (en) Drug delivery system based on polymer nanoshells
WO2001060335A3 (en) Delivery systems using preformed biodegradable polymer compositions and methods
DE60316579D1 (en) SYSTEM FOR THE DELIVERY OF ACTIVE SUBSTANCES WITH A HYDROPHOBIC CELLULOSE DERIVATIVE
WO2004056311A3 (en) Stimuli-responsive systems for controlled drug delivery
AU2003265446A1 (en) Active agent delivery system including a hydrophilic polymer, medical device, and method
WO2006008320A3 (en) Device for transdermal delivery of active principles
HK1039054A1 (en) Controlled release tablet comprising a hypoglycemic drug and an antihyperglycemic drug.
WO2004039427A3 (en) Transdermal delivery system for anti-emetic medication
WO2002005800A3 (en) Compositions for sustained release of analgesic agents, and methods of making and using the same
WO2005025499A3 (en) Hydrophobic drug compositions containing reconstitution enhancer
ATE459380T1 (en) DOSAGE SYSTEMS OF ACTIVE INGREDIENTS WITH POLY(ETHYLENE-CO(METH)ACRYLATES, MEDICAL DEVICE AND METHOD
ATE515949T1 (en) CONFESSIONALS
HK1087031A1 (en) Subcutaneous implants having limited initial release of the active principle and subsequent linearlyvarying extended release thereof
WO2000040203A3 (en) Polymeric delivery agents and delivery agent compounds
AU2003220598A1 (en) Fluid-assisted medical devices, systems and methods
AU2003239473A1 (en) Fluid-assisted medical devices, systems and methods
CL2003002277A1 (en) INJECTABLE PHARMACEUTICAL COMPOSITION, DEPOSIT OF PROLONGED RELEASE, THAT INCLUDES A BENEFICIAL AGENT DISSOLVED OR DISPERSED IN A GEL CONSTITUTED BY A BIOEROSIONABLE AND BIOCOMPATIBLE POLYMER; AND A SOLVENT.
WO2005099667A3 (en) Drug delivery compositions
WO2004103415A3 (en) Multi-dressing system for managing skin wounds
WO2004075776A3 (en) Method and system for prevention of radiocontrast nephropathy
WO2004045549A3 (en) Medical devices employing novel polymers
WO2006071649A3 (en) Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chitosan
WO2008065388A3 (en) Biogel

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2535346

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006523314

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2004780737

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004780737

Country of ref document: EP