WO2005019795A3 - Electrochemical sensors including electrode systems with increased oxygen generation - Google Patents

Electrochemical sensors including electrode systems with increased oxygen generation Download PDF

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Publication number
WO2005019795A3
WO2005019795A3 PCT/US2004/023650 US2004023650W WO2005019795A3 WO 2005019795 A3 WO2005019795 A3 WO 2005019795A3 US 2004023650 W US2004023650 W US 2004023650W WO 2005019795 A3 WO2005019795 A3 WO 2005019795A3
Authority
WO
WIPO (PCT)
Prior art keywords
electrode
oxygen
electrochemical sensors
oxygen generation
systems
Prior art date
Application number
PCT/US2004/023650
Other languages
French (fr)
Other versions
WO2005019795A2 (en
Inventor
Peter C Simpson
Paul Goode
Mark A Tapsak
Victoria Carr-Brendel
Original Assignee
Dexcom Inc
Peter C Simpson
Paul Goode
Mark A Tapsak
Victoria Carr-Brendel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dexcom Inc, Peter C Simpson, Paul Goode, Mark A Tapsak, Victoria Carr-Brendel filed Critical Dexcom Inc
Publication of WO2005019795A2 publication Critical patent/WO2005019795A2/en
Publication of WO2005019795A3 publication Critical patent/WO2005019795A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels

Abstract

The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors (10) in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems (16b) with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. The electrochemical sensor (10) can include a body with a sensing region (14), and a membrane system (18) disposed over the electroactive surfaces of the electrode system (16b).
PCT/US2004/023650 2003-07-25 2004-07-21 Electrochemical sensors including electrode systems with increased oxygen generation WO2005019795A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49020803P 2003-07-25 2003-07-25
US60/490,208 2003-07-25

Publications (2)

Publication Number Publication Date
WO2005019795A2 WO2005019795A2 (en) 2005-03-03
WO2005019795A3 true WO2005019795A3 (en) 2006-03-16

Family

ID=34215834

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/023650 WO2005019795A2 (en) 2003-07-25 2004-07-21 Electrochemical sensors including electrode systems with increased oxygen generation

Country Status (2)

Country Link
US (1) US7108778B2 (en)
WO (1) WO2005019795A2 (en)

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