WO2005027962A3 - 4’-thionucleosides and oligomeric compounds - Google Patents

4’-thionucleosides and oligomeric compounds Download PDF

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Publication number
WO2005027962A3
WO2005027962A3 PCT/US2004/030874 US2004030874W WO2005027962A3 WO 2005027962 A3 WO2005027962 A3 WO 2005027962A3 US 2004030874 W US2004030874 W US 2004030874W WO 2005027962 A3 WO2005027962 A3 WO 2005027962A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligomeric compounds
thionucleosides
asrna
modified oligomeric
compositions
Prior art date
Application number
PCT/US2004/030874
Other languages
French (fr)
Other versions
WO2005027962A9 (en
WO2005027962A1 (en
Inventor
Balkrishen Bhat
Prasad Dande
Thazha P Prakash
Charles Allerson
Eric E Swayze
Richard H Griffey
Original Assignee
Isis Pharmaceuticals Inc
Balkrishen Bhat
Prasad Dande
Thazha P Prakash
Charles Allerson
Eric E Swayze
Richard H Griffey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Balkrishen Bhat, Prasad Dande, Thazha P Prakash, Charles Allerson, Eric E Swayze, Richard H Griffey filed Critical Isis Pharmaceuticals Inc
Priority to CA2538252A priority Critical patent/CA2538252C/en
Priority to JP2006527130A priority patent/JP5379347B2/en
Priority to EP04816222.6A priority patent/EP1677822B1/en
Priority to AU2004274021A priority patent/AU2004274021B2/en
Publication of WO2005027962A1 publication Critical patent/WO2005027962A1/en
Publication of WO2005027962A9 publication Critical patent/WO2005027962A9/en
Publication of WO2005027962A3 publication Critical patent/WO2005027962A3/en
Priority to AU2009222605A priority patent/AU2009222605B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.
PCT/US2004/030874 2003-09-18 2004-09-20 4’-thionucleosides and oligomeric compounds WO2005027962A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2538252A CA2538252C (en) 2003-09-18 2004-09-20 4'-thionucleosides and oligomeric compounds
JP2006527130A JP5379347B2 (en) 2003-09-18 2004-09-20 4'-thionucleosides and oligomeric compounds
EP04816222.6A EP1677822B1 (en) 2003-09-18 2004-09-20 4'-thionucleosides and oligomeric compounds
AU2004274021A AU2004274021B2 (en) 2003-09-18 2004-09-20 4'-thionucleosides and oligomeric compounds
AU2009222605A AU2009222605B2 (en) 2003-09-18 2009-10-07 4'-Thionucleosides and oligomeric compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50399703P 2003-09-18 2003-09-18
US60/503,997 2003-09-18

Publications (3)

Publication Number Publication Date
WO2005027962A1 WO2005027962A1 (en) 2005-03-31
WO2005027962A9 WO2005027962A9 (en) 2006-08-10
WO2005027962A3 true WO2005027962A3 (en) 2007-07-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/030874 WO2005027962A1 (en) 2003-09-18 2004-09-20 4’-thionucleosides and oligomeric compounds

Country Status (6)

Country Link
US (2) US7875733B2 (en)
EP (1) EP1677822B1 (en)
JP (1) JP5379347B2 (en)
AU (2) AU2004274021B2 (en)
CA (1) CA2538252C (en)
WO (1) WO2005027962A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation

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