WO2005030401A1 - A dispensing apparatus - Google Patents

A dispensing apparatus Download PDF

Info

Publication number
WO2005030401A1
WO2005030401A1 PCT/GB2004/003790 GB2004003790W WO2005030401A1 WO 2005030401 A1 WO2005030401 A1 WO 2005030401A1 GB 2004003790 W GB2004003790 W GB 2004003790W WO 2005030401 A1 WO2005030401 A1 WO 2005030401A1
Authority
WO
WIPO (PCT)
Prior art keywords
metering chamber
piston
fluid
inlet
seal
Prior art date
Application number
PCT/GB2004/003790
Other languages
French (fr)
Inventor
Andrew David Wright
Original Assignee
Bespak Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bespak Plc filed Critical Bespak Plc
Priority to BRPI0414820-7A priority Critical patent/BRPI0414820A/en
Priority to US10/595,214 priority patent/US20090173752A1/en
Priority to DE602004022685T priority patent/DE602004022685D1/en
Priority to EP04768337A priority patent/EP1667801B1/en
Publication of WO2005030401A1 publication Critical patent/WO2005030401A1/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001Piston pumps
    • B05B11/1023Piston pumps having an outlet valve opened by deformation or displacement of the piston relative to its actuating stem
    • B05B11/1025Piston pumps having an outlet valve opened by deformation or displacement of the piston relative to its actuating stem a spring urging the outlet valve in its closed position
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1038Pressure accumulation pumps, i.e. pumps comprising a pressure accumulation chamber
    • B05B11/104Pressure accumulation pumps, i.e. pumps comprising a pressure accumulation chamber the outlet valve being opened by pressure after a defined accumulation stroke
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042Components or details
    • B05B11/1066Pump inlet valves
    • B05B11/107Gate valves; Sliding valves

Definitions

  • the present invention relates to a dispensing apparatus particularly a multi- dose dispensing apparatus for dispensing metered quantities of fluid.
  • Conventional multi-dose dispensers have a metering chamber with a piston arranged therein.
  • the metering chamber draws the fluid to be dispensed from a reservoir through a dip tube.
  • the dip tube is connected to the base of the metering chamber via a one-way valve.
  • the piston is depressed axially within the metering chamber to force the fluid from the chamber through an outlet.
  • the one-way valve which usually comprises a ball or rubber flap, seals the passage from the metering chamber to the dip tube.
  • the piston After the fluid has been dispensed, the piston is released and returns to its original rest position drawing more fluid from the reservoir, up the dip tube, through the one-way valve in the base of the metering chamber and into the metering chamber as it rises.
  • the one-way valves are known to be inefficient and contribute to variations in the shot weight dispensed.
  • the shot weight dispensed by different dispensers is found to vary due to the tolerance stack-up of a number of mass- produced components which cause differences in the rest position of the pistons. It is an object of the present invention to reduce variations in the shot weight of a multi-dose dispenser.
  • a hand-held multi-dose dispensing apparatus comprising a metering chamber having an axis, an end portion at one axial end of the chamber and a side body portion extending from the axial end portion, a piston arrangement movable with a piston stroke along the axis of the metering chamber with a seal portion of the piston arrangement being slidably engageable with a side portion of the metering chamber, an inlet for fluid to enter the metering chamber, and an outlet for fluid to be dispensed from the metering chamber, wherein the inlet is provided on the side body portion of the metering chamber and, in use, during a first portion of the piston stroke the inlet is in fluid communication with the metering chamber and during a second portion of the piston stroke the seal portion of the piston arrangement blocks the inlet preventing fluid from passing from the inlet into or out of the metering chamber.
  • the positioning of the inlet on the side portion of the metering chamber and the action of the piston to respectively provide fluid communication and block the inlet to the metering chamber during first and second portions of the piston stroke eliminates the need for a one-way valve, reducing costs and increasing reliability of the dispenser. Furthermore, since the volume of fluid dispensed is determined by the point at which the piston enters the second portion of it's stroke as it blocks off the inlet and prevents further fluid from entering the metering chamber, a more consistent volume of fluid is dispensed. This eliminates variations produced by tolerance stack-up of dispenser components causing the rest position of the piston and thus the shot weight to var - between dispensers.
  • a resilient member is preferably provided between the end portion of the metering chamber and the piston.
  • the resilient member urges the piston into a rest position at the furthest point in its stroke from the end portion of the metering chamber.
  • the resilient member may be an elastic member or a spring for example.
  • the piston arrangement preferably comprises a first portion and a piston seal, the piston seal being arranged to slidably engage and seal against the inside surface of the metering chamber and to be moveable relative to the first portion of the piston arrangement, such that during a second portion of the piston stroke when the pressure in the metering chamber exceeds a particular level, the first portion and the piston seal move relative to each other to open an outlet for fluid to be dispensed.
  • Figure 1 shows a cross-sectional view of a dispensing apparatus with the piston in the rest position
  • Figure 2 shows the cross-sectional view of the dispensing apparatus of Figure 1 with a piston arrangement blocking an inlet
  • Figure 3 shows the cross-sectional view of the dispensing apparatus of Figure 1 with the piston arrangement in the bottomed out position.
  • Figure 1 shows a cross-sectional view of a dispensing apparatus 10 prior to actuation.
  • the dispensing apparatus 10 has a metering chamber 20 with an axis 21, an end portion 22 at one end and a side body portion 23 extending therefrom surrounding the metermg chamber 20.
  • the side body portion 23 has a narrower section 24 adjacent the end portion 22 then a frusto-conical portion 25 leading to a wider section 26.
  • the metering chamber could be any desired shape such as cylindrical for example.
  • the side body portion 23 has an inlet 27 formed therein. In use, the inlet 27 is connected via collar 28 to a dip tube to draw fluid to be dispensed from a reservoir (not shown).
  • the reservoir could be any suitable container which is preferably, but need not be attached to the dispensing apparatus 10.
  • a piston arrangement 30 is provided inside the metering chamber 20.
  • the piston arrangement comprises an insert rod 31 with an annular core 32 slid over a portion of its length.
  • the core 32 rests on a first annular seat 33 extending out from the insert rod 31.
  • the piston arrangement also has a piston seal 34 slid over the core 32.
  • An outer surface of the piston seal 34 slidably engages and seals against the inside surface of the side body portion 23 of the metering chamber 20.
  • the piston seal 34 rests on a second annular seat 35 which, like the first annular seat 33, also extends out from insert rod 31.
  • a resilient member, in this example a spring 36 is provided between an annular seat 37 on the core 32 and the piston seal 34 to urge the piston seal 34 on to the annular seat 35 on the insert rod 31.
  • a further resilient member in this example another spring 38, is provided between the end portion 22 of the metering chamber and an annular seat 39 on the underside of insert rod 31 to urge the piston arrangement 30 into the rest position shown in figure 1 with an annular projection 40 of the core 32 engaging a cap 50 provided on the metering chamber 20.
  • An upper section of the core 32 extends through a circular aperture 51 provided in the cap 50.
  • An appropriate actuator (not shown) is attached to the upper section of the core which extends through the aperture 51 provided in the cap 50.
  • the actuator will be adapted for the application to which the dispensing apparatus is to be put, such as a nasal dispenser or oral dispenser for example.
  • a ferrule 60 is provided attached to the cap 50.
  • FIG. 2 shows the dispensing apparatus 10 beginning to be actuated with, the upper section of the core 32 which extends out through the cap 50 being manually depressed by a user to push it towards the end portion 22 of the metering chamber 20.
  • the annular projection 40 disengages the cap 50 and the piston seal 34 slides downwards over the inside surface of the metering chamber to block the inlet 27 preventing further fluid from entering the metering chamber 20.
  • the pressure within the metering chamber 20 which causes the piston seal 34 to unseat relative to the insert rod 31 is set at a predetermined level by selection of a suitable spring 36.
  • the piston seal 34 can be arranged to unseat relative to the insert rod 31 at any desired pressure within the metering chamber 20. Fluid from the metering chamber 20 is forced through openings (not shown) exposed in the lower portion of the core 32 by the unseating of the seal 34 from the insert rod 31 and up through the core 32 to an outlet in the actuator. Fluid continues to be dispensed as the core 32 is manually pressed further into the metering chamber 20 until the piston arrangement bottoms out.
  • the dispensing apparatus could be used to dispense any suitable fluid.
  • the fluid is preferably a pharmaceutical product and may include, for example, a pure drug or a drug with a liquid and/or pharmaceutical acceptable excipient.
  • the metering chamber 20 could be any suitable shape.
  • fluid could be passed out of the metering chamber through any suitable outlet.
  • the dispensing apparatus is preferably made from a plastics material but could be made from any suitable material.
  • any closure system could be used to attach the dispensing apparatus to a container of fluid to be dispensed such as a screw-on or snap closure.

Abstract

A hand-held multi-dose dispensing apparatus (10) comprising a metering chamber (20) having an axis (21), an end portion (22) at one axial end of the chamber (20) and a side body portion (23) extending from the axial end portion (22), a piston arrangement (30) movable with a piston stroke along the axis of the metering chamber (20) with a seal portion (34) of the piston arrangement (30) being slidably engageable with an inside surface of a side portion (23) of the metering chamber, an inlet (27) for fluid to enter the metering chamber (20), and an outlet (31, 32) for fluid to be dispensed from the metering chamber (20), wherein the inlet (27) is provided on the side body portion (23) of the metering chamber and, in use, during a first portion of the piston stroke, the inlet (27) is in fluid communication with the metering chamber (20) and during a second portion of the piston stroke, the seal portion (34) of the piston arrangement (30) blocks the inlet (27) preventing fluid from passing from the inlet (27) into the metering chamber (20). This dispensing apparatus (10) reduces variations in the shot weight dispensed, by the metering of the fluid commencing at the point at which the piston enters the second portion of its stroke blocking off the inlet.

Description

A Dispensing Apparatus
The present invention relates to a dispensing apparatus particularly a multi- dose dispensing apparatus for dispensing metered quantities of fluid. Conventional multi-dose dispensers have a metering chamber with a piston arranged therein. The metering chamber draws the fluid to be dispensed from a reservoir through a dip tube. The dip tube is connected to the base of the metering chamber via a one-way valve. When fluid is to be dispensed, the piston is depressed axially within the metering chamber to force the fluid from the chamber through an outlet. As pressure is applied to the fluid in the metering chamber the one-way valve which usually comprises a ball or rubber flap, seals the passage from the metering chamber to the dip tube. After the fluid has been dispensed, the piston is released and returns to its original rest position drawing more fluid from the reservoir, up the dip tube, through the one-way valve in the base of the metering chamber and into the metering chamber as it rises. However, the one-way valves are known to be inefficient and contribute to variations in the shot weight dispensed. Furthermore, the shot weight dispensed by different dispensers is found to vary due to the tolerance stack-up of a number of mass- produced components which cause differences in the rest position of the pistons. It is an object of the present invention to reduce variations in the shot weight of a multi-dose dispenser. According to the present invention there is provided a hand-held multi-dose dispensing apparatus comprising a metering chamber having an axis, an end portion at one axial end of the chamber and a side body portion extending from the axial end portion, a piston arrangement movable with a piston stroke along the axis of the metering chamber with a seal portion of the piston arrangement being slidably engageable with a side portion of the metering chamber, an inlet for fluid to enter the metering chamber, and an outlet for fluid to be dispensed from the metering chamber, wherein the inlet is provided on the side body portion of the metering chamber and, in use, during a first portion of the piston stroke the inlet is in fluid communication with the metering chamber and during a second portion of the piston stroke the seal portion of the piston arrangement blocks the inlet preventing fluid from passing from the inlet into or out of the metering chamber. The positioning of the inlet on the side portion of the metering chamber and the action of the piston to respectively provide fluid communication and block the inlet to the metering chamber during first and second portions of the piston stroke eliminates the need for a one-way valve, reducing costs and increasing reliability of the dispenser. Furthermore, since the volume of fluid dispensed is determined by the point at which the piston enters the second portion of it's stroke as it blocks off the inlet and prevents further fluid from entering the metering chamber, a more consistent volume of fluid is dispensed. This eliminates variations produced by tolerance stack-up of dispenser components causing the rest position of the piston and thus the shot weight to var - between dispensers. A resilient member is preferably provided between the end portion of the metering chamber and the piston. The resilient member urges the piston into a rest position at the furthest point in its stroke from the end portion of the metering chamber. The resilient member may be an elastic member or a spring for example. When activating the dispensing apparatus, a user preferably pushes the piston from its rest position, through the first portion of its stroke to the second portion at which the inlet is blocked, preventing further fluid from entering the metering chamber. As the piston progresses further into the second portion of its stroke, fluid is forced out of the metering chamber through the outlet to be dispensed until the piston bottoms out. After the piston has bottomed out, the user releases the piston and the resilient member urges the piston back to its rest position. As the piston travels back through the second portion of its stroke with the inlet blocked, the pressure within the expanding metering chamber is reduced. When the piston reaches the first portion of it's stroke with the inlet in fluid communication with the metering chamber, fluid is sucked into the metering chamber by the reduced pressure therein and the piston is urged into its rest position by the resilient member ready for the next actuation. The piston arrangement preferably comprises a first portion and a piston seal, the piston seal being arranged to slidably engage and seal against the inside surface of the metering chamber and to be moveable relative to the first portion of the piston arrangement, such that during a second portion of the piston stroke when the pressure in the metering chamber exceeds a particular level, the first portion and the piston seal move relative to each other to open an outlet for fluid to be dispensed. Embodiments of the present invention will now be described, by way of example only, with reference to the accompanying drawings, in which: Figure 1 shows a cross-sectional view of a dispensing apparatus with the piston in the rest position; Figure 2 shows the cross-sectional view of the dispensing apparatus of Figure 1 with a piston arrangement blocking an inlet and Figure 3 shows the cross-sectional view of the dispensing apparatus of Figure 1 with the piston arrangement in the bottomed out position. Figure 1 shows a cross-sectional view of a dispensing apparatus 10 prior to actuation. The dispensing apparatus 10 has a metering chamber 20 with an axis 21, an end portion 22 at one end and a side body portion 23 extending therefrom surrounding the metermg chamber 20. In this example, the side body portion 23 has a narrower section 24 adjacent the end portion 22 then a frusto-conical portion 25 leading to a wider section 26. However, the metering chamber ,could be any desired shape such as cylindrical for example. The side body portion 23 has an inlet 27 formed therein. In use, the inlet 27 is connected via collar 28 to a dip tube to draw fluid to be dispensed from a reservoir (not shown). The reservoir could be any suitable container which is preferably, but need not be attached to the dispensing apparatus 10. A piston arrangement 30 is provided inside the metering chamber 20. The piston arrangement comprises an insert rod 31 with an annular core 32 slid over a portion of its length. The core 32 rests on a first annular seat 33 extending out from the insert rod 31. The piston arrangement also has a piston seal 34 slid over the core 32. An outer surface of the piston seal 34 slidably engages and seals against the inside surface of the side body portion 23 of the metering chamber 20. The piston seal 34 rests on a second annular seat 35 which, like the first annular seat 33, also extends out from insert rod 31. A resilient member, in this example a spring 36, is provided between an annular seat 37 on the core 32 and the piston seal 34 to urge the piston seal 34 on to the annular seat 35 on the insert rod 31. A further resilient member, in this example another spring 38, is provided between the end portion 22 of the metering chamber and an annular seat 39 on the underside of insert rod 31 to urge the piston arrangement 30 into the rest position shown in figure 1 with an annular projection 40 of the core 32 engaging a cap 50 provided on the metering chamber 20. An upper section of the core 32 extends through a circular aperture 51 provided in the cap 50. An appropriate actuator (not shown) is attached to the upper section of the core which extends through the aperture 51 provided in the cap 50. The actuator will be adapted for the application to which the dispensing apparatus is to be put, such as a nasal dispenser or oral dispenser for example. A ferrule 60 is provided attached to the cap 50. In use a container of fluid to be dispensed (not shown) may be attached to the ferrule 60 so that the metering chamber 20 is surrounded by the container and fluid to be dispensed may be drawn from the container up a dip tube (not shown) connected to the inlet 27. Figure 2 shows the dispensing apparatus 10 beginning to be actuated with, the upper section of the core 32 which extends out through the cap 50 being manually depressed by a user to push it towards the end portion 22 of the metering chamber 20. As a user depresses the core 32, the annular projection 40 disengages the cap 50 and the piston seal 34 slides downwards over the inside surface of the metering chamber to block the inlet 27 preventing further fluid from entering the metering chamber 20. Metering of the fluid commences once the piston seal 34 blocks the inlet 27 as it is pushed downwards. As the volume of fluid dispensed is controlled by only one dimension of the metering chamber 20, i.e. the bottom of the inlet 27 to the end portion 22 of the metering chamber 20, shot weight variance is significantly reduced. As the core 32 is pushed further towards the end portion 22 of the metering chamber 20, the pressure within the metering chamber 20 increases. When the pressure within the metering chamber 20 overcomes the force generated by the spring 36 acting on the piston seal 34, the piston seal 34 unseats relative to the insert rod 3 1. In this example the pressure within the metering chamber 20 which causes the piston seal 34 to unseat relative to the insert rod 31 is set at a predetermined level by selection of a suitable spring 36. However, by selection of a suitable spring the piston seal 34 can be arranged to unseat relative to the insert rod 31 at any desired pressure within the metering chamber 20. Fluid from the metering chamber 20 is forced through openings (not shown) exposed in the lower portion of the core 32 by the unseating of the seal 34 from the insert rod 31 and up through the core 32 to an outlet in the actuator. Fluid continues to be dispensed as the core 32 is manually pressed further into the metering chamber 20 until the piston arrangement bottoms out. At this point a user stops pushing down the actuator and core 32 and the spring 38 pushes the piston arrangement 30 back up the metering chamber 20. As the piston arrangement 30 passes through this portion of its stroke, the piston seal 34 keeps the inlet 27 blocked and the pressure within the metering chamber 20 reduces as its volume expands. When the piston seal 34 rises such that the inlet 27 is in fluid communication with the metering chamber 20, the reduced pressure within the metering chamber 20 draws fluid from the reservoir and dip tube (not shown) into the metering chamber ready for the next actuation. The piston arrangement 30 is urged by spring 38 back into the rest position shown in Figure 1 with the annular projection 40 of the over moulded core 32 engaging the cap 50 ready for the next actuation. The dispensing apparatus could be used to dispense any suitable fluid. However, the fluid is preferably a pharmaceutical product and may include, for example, a pure drug or a drug with a liquid and/or pharmaceutical acceptable excipient. Many variations may be made to the example described above whilst still falling within the scope of the invention. For example the metering chamber 20 could be any suitable shape. Furthermore fluid could be passed out of the metering chamber through any suitable outlet. The dispensing apparatus is preferably made from a plastics material but could be made from any suitable material. Furthermore any closure system could be used to attach the dispensing apparatus to a container of fluid to be dispensed such as a screw-on or snap closure.

Claims

1. A hand-held multi-dose dispensing apparatus comprising a metering chamber having an axis, an end portion at one axial end of the chamber and a side body portion extending from the axial end portion, a piston arrangement movable with a piston stroke along the axis of the metering chamber with a seal portion of the piston arrangement being slidably engageable with an inside surface of a side portion of the metering chamber, an inlet for fluid to enter the metering chamber, and an outlet for fluid to be dispensed from the metering chamber, wherein the inlet is provided on the side body portion of the metering chamber and, in use, during a first portion of the piston stroke, the inlet is in fluid communication with the metering chamber and during a second portion of the piston stroke, the seal portion of the piston arrangement blocks the inlet preventing fluid from passing from the inlet into or out of the metering chamber.
2. An apparatus according to claim 1, wherein a resilient means is provided between the piston arrangement and the end portion of the chamber.
3. An apparatus according to claim 2, wherein the resilient means is a spring.
4. An apparatus according to any one of the preceding claims, wherein the inlet is connectable to a reservoir of fluid to be dispensed.
5. An apparatus according to claim 4, wherein the reservoir of fluid is a container attachable to the dispensing apparatus.
6. An apparatus according to any one of the preceding claims, wherein the piston arrangement comprises a first portion and a piston seal, the piston seal being arranged to slidably engage and seal against the inside surface of the metering chamber and to be movable relative to the first portion of the piston arrangement, such that during a second portion of the piston stroke when the pressure in the metering chamber exceeds a particular level, the first portion and the piston seal move relative to each other to open an outlet for fluid to be dispensed.
7. An apparatus according to any one of the preceding claims, wherein during a second portion of the piston stroke with the piston arrangement moving away from the end portion of the metering chamber and with the seal portion of the piston arrangement blocking the inlet, the pressure within the metering chamber reduces until the first portion of the piston stroke is reached in which the inlet is in fluid communication with the metering chamber and the reduced pressure within the metering chamber draws fluid into the metering chamber ready for the next actuation.
8. An apparatus substantially as hereinbefore described with reference to the accompanying drawings.
PCT/GB2004/003790 2003-09-29 2004-09-06 A dispensing apparatus WO2005030401A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BRPI0414820-7A BRPI0414820A (en) 2003-09-29 2004-09-06 multi-dose dispensing device
US10/595,214 US20090173752A1 (en) 2003-09-29 2004-09-06 Dispensing Apparatus
DE602004022685T DE602004022685D1 (en) 2003-09-29 2004-09-06 DISPENSER
EP04768337A EP1667801B1 (en) 2003-09-29 2004-09-06 A dispensing apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0322758.4 2003-09-29
GB0322758A GB2406330B (en) 2003-09-29 2003-09-29 A dispensing apparatus

Publications (1)

Publication Number Publication Date
WO2005030401A1 true WO2005030401A1 (en) 2005-04-07

Family

ID=29287036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/003790 WO2005030401A1 (en) 2003-09-29 2004-09-06 A dispensing apparatus

Country Status (7)

Country Link
US (1) US20090173752A1 (en)
EP (1) EP1667801B1 (en)
CN (1) CN1859983A (en)
BR (1) BRPI0414820A (en)
DE (1) DE602004022685D1 (en)
GB (1) GB2406330B (en)
WO (1) WO2005030401A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8678243B2 (en) 2007-05-30 2014-03-25 Glaxo Group Limited Fluid dispenser
EP2762238A3 (en) * 2013-01-30 2017-06-21 AERO Pump GmbH, Zerstäuberpumpen Manual pump system for an inhaler
FR3083997A1 (en) * 2018-07-19 2020-01-24 Albea Services PUMP FOR DISPENSING A FLUID PRODUCT, DISPENSING HEAD EQUIPPED WITH SUCH A PUMP AND BOTTLE THEREOF

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
EP1556009B2 (en) 2002-10-25 2021-07-21 Foamix Pharmaceuticals Ltd. Cosmetic and pharmaceutical foam
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009056991A2 (en) 2007-09-04 2009-05-07 Foamix Ltd. Device for delivery of a foamable composition
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2010041141A2 (en) 2008-10-07 2010-04-15 Foamix Ltd. Oil-based foamable carriers and formulations
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
CA2712120A1 (en) 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
CA2760186C (en) 2009-04-28 2019-10-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US8871184B2 (en) 2009-10-02 2014-10-28 Foamix Ltd. Topical tetracycline compositions
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US8978936B2 (en) 2010-07-12 2015-03-17 Foamix Pharmaceuticals Ltd. Apparatus and method for releasing a unit dose of content from a container
GB2489216B (en) * 2011-03-16 2013-08-07 Consort Medical Plc Fluid delivery device
FR2993483B1 (en) * 2012-07-19 2016-12-09 Aptar France Sas PUMP AND DISPENSER OF FLUID PRODUCT COMPRISING SUCH A PUMP.
MX2020012139A (en) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Compositions and methods for treating rosacea and acne.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020047027A1 (en) * 2000-10-19 2002-04-25 Sogaro Alberto C. Dosing dispenser for flowable media
WO2002094708A1 (en) * 2001-05-23 2002-11-28 Cohen, Ben, Z. Accurate dosing pump
US20040050858A1 (en) * 2002-07-13 2004-03-18 Aero Pump Gmbh Double-acting pump for ejecting a product from a container
FR2852934A1 (en) * 2003-03-27 2004-10-01 Rexam Dispensing Sys PRODUCT DISPENSER COMPRISING A PUSH-OPERATED PUMP

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1283457A (en) * 1916-05-12 1918-11-05 George E Bates Liquid-dispensing device.
US2283529A (en) * 1938-12-27 1942-05-19 Arthur L Bobrick Dispenser for liquid soap and the like
GB798683A (en) * 1954-08-16 1958-07-23 Lawrence Thomas Ward Improvements in or relating to fluid dispensing devices
US3952918A (en) * 1974-03-18 1976-04-27 Highland Laboratories Fluid dispenser apparatus
US4674659A (en) * 1978-04-24 1987-06-23 Leeds And Micallef Universal sequential dispensing pump system
US6776310B2 (en) * 2002-07-29 2004-08-17 Globe Union Industrial Corp. Soap dispenser head

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020047027A1 (en) * 2000-10-19 2002-04-25 Sogaro Alberto C. Dosing dispenser for flowable media
WO2002094708A1 (en) * 2001-05-23 2002-11-28 Cohen, Ben, Z. Accurate dosing pump
US20040050858A1 (en) * 2002-07-13 2004-03-18 Aero Pump Gmbh Double-acting pump for ejecting a product from a container
FR2852934A1 (en) * 2003-03-27 2004-10-01 Rexam Dispensing Sys PRODUCT DISPENSER COMPRISING A PUSH-OPERATED PUMP

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8678243B2 (en) 2007-05-30 2014-03-25 Glaxo Group Limited Fluid dispenser
US9821333B2 (en) 2007-05-30 2017-11-21 Glaxo Group Limited Fluid dispenser
EP2762238A3 (en) * 2013-01-30 2017-06-21 AERO Pump GmbH, Zerstäuberpumpen Manual pump system for an inhaler
FR3083997A1 (en) * 2018-07-19 2020-01-24 Albea Services PUMP FOR DISPENSING A FLUID PRODUCT, DISPENSING HEAD EQUIPPED WITH SUCH A PUMP AND BOTTLE THEREOF

Also Published As

Publication number Publication date
GB2406330A (en) 2005-03-30
US20090173752A1 (en) 2009-07-09
BRPI0414820A (en) 2006-11-14
DE602004022685D1 (en) 2009-10-01
GB0322758D0 (en) 2003-10-29
EP1667801B1 (en) 2009-08-19
EP1667801A1 (en) 2006-06-14
CN1859983A (en) 2006-11-08
GB2406330B (en) 2005-12-07

Similar Documents

Publication Publication Date Title
EP1667801B1 (en) A dispensing apparatus
CA1056351A (en) Atomizing pump dispenser
US4222501A (en) Dual chamber, continuous action dispenser
US7726520B2 (en) Metered dispenser with feed-containing piston drive mechanism
US4735347A (en) Single puff atomizing pump dispenser
EP0835820B1 (en) Dispensing apparatus
US8720746B2 (en) One turn actuated duration spray pump mechanism
WO2002054926A9 (en) Dosing pump for liquid dispensers
WO1985004852A1 (en) Pump for dispensing liquid from a container
US20090140010A1 (en) Fluid dispenser pump
WO1986004984A1 (en) Apparatus for dispensing products from a self-sealing dispenser
CN107636426B (en) Dispenser and method of using same
US10151692B2 (en) Method for dispensing a product from a container
EP1532067B1 (en) Medically accurate pump system
HU206476B (en) Feeding device for feeding materials being under pressure
CZ282318B6 (en) Apparatus for spraying, dispensing or dosage of liquid substance
CN117440863A (en) All-plastic continuous spraying trigger sprayer
EP1364719A1 (en) Dispenser
US7051903B2 (en) Viscous liquid dispenser having leak prevention device
EP2785466B1 (en) Pumping device for a fluid container
IE20010774A1 (en) A liquid dispenser
AU2002235223A1 (en) Dosing pump for liquid dispensers

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200480028056.2

Country of ref document: CN

AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2004768337

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1056/CHENP/2006

Country of ref document: IN

WWP Wipo information: published in national office

Ref document number: 2004768337

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0414820

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: 10595214

Country of ref document: US