WO2005034789A3 - Methods for treating dental conditions using tissue scaffolds - Google Patents

Methods for treating dental conditions using tissue scaffolds Download PDF

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Publication number
WO2005034789A3
WO2005034789A3 PCT/US2004/033347 US2004033347W WO2005034789A3 WO 2005034789 A3 WO2005034789 A3 WO 2005034789A3 US 2004033347 W US2004033347 W US 2004033347W WO 2005034789 A3 WO2005034789 A3 WO 2005034789A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
vivo
dental
tissue scaffold
wafer
Prior art date
Application number
PCT/US2004/033347
Other languages
French (fr)
Other versions
WO2005034789A2 (en
Inventor
Bruce Rutherford
Christopher Somogyl
Clinton White
Eric Rabins
Original Assignee
Dentigenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dentigenix Inc filed Critical Dentigenix Inc
Priority to AT04809901T priority Critical patent/ATE536855T1/en
Priority to EP04809901A priority patent/EP1682030B1/en
Publication of WO2005034789A2 publication Critical patent/WO2005034789A2/en
Publication of WO2005034789A3 publication Critical patent/WO2005034789A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C5/00—Filling or capping teeth
    • A61C5/50—Implements for filling root canals; Methods or instruments for medication of tooth nerve channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/891—Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The invention provides methods, apparatus and kits for regenerating dental tissue in vivo that are useful for treating a variety of dental conditions, exemplified by treatment of caries. The invention uses tissue scaffold wafers, preferably made of PGA, PLLA, PDLLA or PLGA dimensioned to fit into a hole of corresponding sized drilled into the tooth of subject to expose dental pulp in vivo. In certain embodiments the tissue scaffold wafer further comprises calcium phosphate and fuloride. The tissue scaffold wafer may be secured into the hole with a hydrogel, a cement or other suitable material. Either the wafer or the hydrogel or both contain a morphogenic agent, such as a member encoded by the TGF-β surpergene family, that promotes regeneration and differentiation of healthy dental tissue in vivo, which in turn leads to remineralization of dentin and enamel. The tissue scaffold may further include an antibiotic or anti-inflammatory agent.
PCT/US2004/033347 2003-10-10 2004-10-08 Methods for treating dental conditions using tissue scaffolds WO2005034789A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT04809901T ATE536855T1 (en) 2003-10-10 2004-10-08 TISSUE FRAMEWORK COMPOSITIONS FOR THE TREATMENT OF DENTAL DISEASES
EP04809901A EP1682030B1 (en) 2003-10-10 2004-10-08 Tissue scaffold composition for dentin regeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/684,226 US7309232B2 (en) 2003-10-10 2003-10-10 Methods for treating dental conditions using tissue scaffolds
US10/684,226 2003-10-10

Publications (2)

Publication Number Publication Date
WO2005034789A2 WO2005034789A2 (en) 2005-04-21
WO2005034789A3 true WO2005034789A3 (en) 2005-12-08

Family

ID=34422943

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/033347 WO2005034789A2 (en) 2003-10-10 2004-10-08 Methods for treating dental conditions using tissue scaffolds

Country Status (4)

Country Link
US (2) US7309232B2 (en)
EP (1) EP1682030B1 (en)
AT (1) ATE536855T1 (en)
WO (1) WO2005034789A2 (en)

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US20070248933A1 (en) 2007-10-25
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