WO2005040346A3 - Devices and methods for hematopoietic rescue or restoration - Google Patents

Devices and methods for hematopoietic rescue or restoration Download PDF

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Publication number
WO2005040346A3
WO2005040346A3 PCT/US2004/035133 US2004035133W WO2005040346A3 WO 2005040346 A3 WO2005040346 A3 WO 2005040346A3 US 2004035133 W US2004035133 W US 2004035133W WO 2005040346 A3 WO2005040346 A3 WO 2005040346A3
Authority
WO
WIPO (PCT)
Prior art keywords
hematopoietic
methods
devices
chemotherapy
bone marrow
Prior art date
Application number
PCT/US2004/035133
Other languages
French (fr)
Other versions
WO2005040346A2 (en
Inventor
W French Anderson
Yi Zhao
Original Assignee
Univ Southern California
W French Anderson
Yi Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California, W French Anderson, Yi Zhao filed Critical Univ Southern California
Publication of WO2005040346A2 publication Critical patent/WO2005040346A2/en
Publication of WO2005040346A3 publication Critical patent/WO2005040346A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof

Abstract

Methods and devices are also provided for rescuing or restoring the proliferation potential of hematopoietic cells. In particular, methods and devices are provided for rescuing or restoring a subject’s hematopoietic system following radiation therapy and/or chemotherapy without the need for a bone marrow transplant. Implantation of certain biological compositions (such as low-density bone marrow or lineage-negative cells) within a cell-impermeable pouch or sac, into an animal whose own hematopoietic ability has been severely compromised by radiation and/or chemotherapy treatment, for example, rescues or restores the hematopoietic capacity of the animal. The treatment can replace or augment bone marrow transplants, providing numerous advantages in the treatment of hematopoietic diseases, particularly for diseases where chemotherapy and/or radiation is administered, such as cancers generally, and more particularly blood-related disorders such as leukemias and lymphomas.
PCT/US2004/035133 2003-10-24 2004-10-25 Devices and methods for hematopoietic rescue or restoration WO2005040346A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69257603A 2003-10-24 2003-10-24
US10/692,576 2003-10-24

Publications (2)

Publication Number Publication Date
WO2005040346A2 WO2005040346A2 (en) 2005-05-06
WO2005040346A3 true WO2005040346A3 (en) 2005-08-11

Family

ID=34522161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/035133 WO2005040346A2 (en) 2003-10-24 2004-10-25 Devices and methods for hematopoietic rescue or restoration

Country Status (1)

Country Link
WO (1) WO2005040346A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6464687B1 (en) * 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6464687B1 (en) * 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HERODIN ET AL.: "Short-term injection of antiapoptotic cytokine combination soon after lethal gamma irradiation promotes survival", BLOOD, vol. 101, no. 7, April 2003 (2003-04-01), pages 2609 - 2616 *
TABBARA: "Allogenic bone marrow transplantation", SOUTHERN MEDICAL JOURNAL, vol. 89, no. 9, 1996, pages 857 - 868 *

Also Published As

Publication number Publication date
WO2005040346A2 (en) 2005-05-06

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