WO2005050223A3 - Proteome epitope tags and methods of use thereof in protein modification analysis - Google Patents

Proteome epitope tags and methods of use thereof in protein modification analysis Download PDF

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Publication number
WO2005050223A3
WO2005050223A3 PCT/US2004/038283 US2004038283W WO2005050223A3 WO 2005050223 A3 WO2005050223 A3 WO 2005050223A3 US 2004038283 W US2004038283 W US 2004038283W WO 2005050223 A3 WO2005050223 A3 WO 2005050223A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
epitope tags
protein modification
proteins
modification analysis
Prior art date
Application number
PCT/US2004/038283
Other languages
French (fr)
Other versions
WO2005050223A2 (en
Inventor
Frank D Lee
Xun Meng
David Livingston
Original Assignee
Epitome Biosystems Inc
Frank D Lee
Xun Meng
David Livingston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epitome Biosystems Inc, Frank D Lee, Xun Meng, David Livingston filed Critical Epitome Biosystems Inc
Priority to AU2004292226A priority Critical patent/AU2004292226B2/en
Priority to JP2006539990A priority patent/JP2007511837A/en
Priority to EP04811121A priority patent/EP1683065A2/en
Priority to CA002545899A priority patent/CA2545899A1/en
Publication of WO2005050223A2 publication Critical patent/WO2005050223A2/en
Publication of WO2005050223A3 publication Critical patent/WO2005050223A3/en
Priority to AU2008227063A priority patent/AU2008227063A1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

Abstract

Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post­-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.
PCT/US2004/038283 2003-11-13 2004-11-15 Proteome epitope tags and methods of use thereof in protein modification analysis WO2005050223A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2004292226A AU2004292226B2 (en) 2003-11-13 2004-11-15 Proteome epitope tags and methods of use thereof in protein modification analysis
JP2006539990A JP2007511837A (en) 2003-11-13 2004-11-15 Proteome epitome tags and their use in protein modification analysis
EP04811121A EP1683065A2 (en) 2003-11-13 2004-11-15 Proteome epitope tags and methods of use thereof in protein modification analysis
CA002545899A CA2545899A1 (en) 2003-11-13 2004-11-15 Proteome epitope tags and methods of use thereof in protein modification analysis
AU2008227063A AU2008227063A1 (en) 2003-11-13 2008-09-25 Proteome epitome tags and methods of use thereof in protein modification analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/712,425 US7460960B2 (en) 2002-05-10 2003-11-13 Proteome epitope tags and methods of use thereof in protein modification analysis
US10/712,425 2003-11-13

Publications (2)

Publication Number Publication Date
WO2005050223A2 WO2005050223A2 (en) 2005-06-02
WO2005050223A3 true WO2005050223A3 (en) 2006-02-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/038283 WO2005050223A2 (en) 2003-11-13 2004-11-15 Proteome epitope tags and methods of use thereof in protein modification analysis

Country Status (6)

Country Link
US (2) US7460960B2 (en)
EP (1) EP1683065A2 (en)
JP (1) JP2007511837A (en)
AU (2) AU2004292226B2 (en)
CA (1) CA2545899A1 (en)
WO (1) WO2005050223A2 (en)

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