WO2005051348A3 - Enteric-coated tablets of pantoprazole - Google Patents

Enteric-coated tablets of pantoprazole Download PDF

Info

Publication number
WO2005051348A3
WO2005051348A3 PCT/HU2004/000111 HU2004000111W WO2005051348A3 WO 2005051348 A3 WO2005051348 A3 WO 2005051348A3 HU 2004000111 W HU2004000111 W HU 2004000111W WO 2005051348 A3 WO2005051348 A3 WO 2005051348A3
Authority
WO
WIPO (PCT)
Prior art keywords
film coating
enteric
coated tablets
active ingredient
weight
Prior art date
Application number
PCT/HU2004/000111
Other languages
French (fr)
Other versions
WO2005051348A2 (en
Inventor
Pal Fekete
Szell Zsuzsa Szlavyne
Papp Cecilia Buresne
Eva Furdyga
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Pal Fekete
Szell Zsuzsa Szlavyne
Papp Cecilia Buresne
Eva Furdyga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Pal Fekete, Szell Zsuzsa Szlavyne, Papp Cecilia Buresne, Eva Furdyga filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of WO2005051348A2 publication Critical patent/WO2005051348A2/en
Publication of WO2005051348A3 publication Critical patent/WO2005051348A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Abstract

The invention relates to enteric-coated tablets containing pantoprazole as active ingredient and a process for the preparation thereof. The tablets according to the invention comprise a.) a core consisting of 20-50% by weight (related to the weight of the tablet core) of the active ingredient, spray-dried or granulated mannitol having an average particle size between 100 µm and 500 µm, an alkalizing agent, a disintegrant and a lubricant conventionally applied in the pharmaceutical industry; b.) a water-soluble separating film coating; c.) an enterosolvent film coating insoluble in gastric juices; and d.) an optional water-soluble protecting film coating, and show increased stability during storage.
PCT/HU2004/000111 2003-11-25 2004-11-24 Enteric-coated tablets of pantoprazole WO2005051348A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0303791 2003-11-25
HU0303791A HU227317B1 (en) 2003-11-25 2003-11-25 Enteric coated tablet containing pantoprazole

Publications (2)

Publication Number Publication Date
WO2005051348A2 WO2005051348A2 (en) 2005-06-09
WO2005051348A3 true WO2005051348A3 (en) 2006-04-27

Family

ID=89981810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2004/000111 WO2005051348A2 (en) 2003-11-25 2004-11-24 Enteric-coated tablets of pantoprazole

Country Status (2)

Country Link
HU (1) HU227317B1 (en)
WO (1) WO2005051348A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007029124A2 (en) * 2005-05-13 2007-03-15 Combino Pharm, S.L. Formulations containing pantoprazole free acid and its salts
EP1747776A1 (en) 2005-07-29 2007-01-31 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising granular pantoprazole
HU230560B1 (en) 2010-07-30 2016-12-28 Péter Hajnal Ph dependent pulsatile and sustained release pharmaceutical composition
CN102429884A (en) * 2011-12-29 2012-05-02 天津市嵩锐医药科技有限公司 Methylphenidate hydrochloride oral cavity disintegrating pharmaceutical composition
CN114224861B (en) * 2022-02-22 2022-05-31 轩竹(北京)医药科技有限公司 Enteric-coated tablets of sodium anastrozole and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853230A (en) * 1986-04-30 1989-08-01 Aktiebolaget Hassle Pharmaceutical formulations of acid labile substances for oral use
WO1994002140A1 (en) * 1992-07-17 1994-02-03 Astra Aktiebolag Pharmaceutical composition containing antiulcer agent
WO1996024338A1 (en) * 1995-02-09 1996-08-15 Astra Aktiebolag New pharmaceutical formulation and process
US5997903A (en) * 1991-06-17 1999-12-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Oral-administration forms of a medicament containing pantoprazol

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853230A (en) * 1986-04-30 1989-08-01 Aktiebolaget Hassle Pharmaceutical formulations of acid labile substances for oral use
US5997903A (en) * 1991-06-17 1999-12-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Oral-administration forms of a medicament containing pantoprazol
WO1994002140A1 (en) * 1992-07-17 1994-02-03 Astra Aktiebolag Pharmaceutical composition containing antiulcer agent
WO1996024338A1 (en) * 1995-02-09 1996-08-15 Astra Aktiebolag New pharmaceutical formulation and process

Also Published As

Publication number Publication date
HUP0303791A3 (en) 2009-03-30
WO2005051348A2 (en) 2005-06-09
HU227317B1 (en) 2011-03-28
HUP0303791A2 (en) 2007-09-28
HU0303791D0 (en) 2004-03-01

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