WO2005065241A3 - Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors - Google Patents

Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors Download PDF

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Publication number
WO2005065241A3
WO2005065241A3 PCT/US2004/043087 US2004043087W WO2005065241A3 WO 2005065241 A3 WO2005065241 A3 WO 2005065241A3 US 2004043087 W US2004043087 W US 2004043087W WO 2005065241 A3 WO2005065241 A3 WO 2005065241A3
Authority
WO
WIPO (PCT)
Prior art keywords
small molecule
smmr
molecule metabolite
vivo glucose
glucose biosensors
Prior art date
Application number
PCT/US2004/043087
Other languages
French (fr)
Other versions
WO2005065241A2 (en
Inventor
Emile M Bellott
Dongsheng Bu
James J Childs
Christopher R Lambert
Hubert A Nienaber
Shirley J Shi
Zhaolin Wang
Jerome J Workman Jr
Alex R Zelenchuk
Original Assignee
Argose Inc
Emile M Bellott
Dongsheng Bu
James J Childs
Christopher R Lambert
Hubert A Nienaber
Shirley J Shi
Zhaolin Wang
Jerome J Workman Jr
Alex R Zelenchuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Argose Inc, Emile M Bellott, Dongsheng Bu, James J Childs, Christopher R Lambert, Hubert A Nienaber, Shirley J Shi, Zhaolin Wang, Jerome J Workman Jr, Alex R Zelenchuk filed Critical Argose Inc
Priority to US10/584,821 priority Critical patent/US8029765B2/en
Publication of WO2005065241A2 publication Critical patent/WO2005065241A2/en
Publication of WO2005065241A3 publication Critical patent/WO2005065241A3/en
Priority to US11/475,784 priority patent/US8008088B2/en
Priority to US13/215,061 priority patent/US8466286B2/en
Priority to US13/919,923 priority patent/US20140127137A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose

Abstract

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
PCT/US2004/043087 2003-12-24 2004-12-23 Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors WO2005065241A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/584,821 US8029765B2 (en) 2003-12-24 2004-12-23 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US11/475,784 US8008088B2 (en) 2003-12-24 2006-06-26 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US13/215,061 US8466286B2 (en) 2003-12-24 2011-08-22 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US13/919,923 US20140127137A1 (en) 2003-12-24 2013-06-17 Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53266703P 2003-12-24 2003-12-24
US60/532,667 2003-12-24
US57117004P 2004-05-14 2004-05-14
US60/571,170 2004-05-14

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/584,821 A-371-Of-International US8029765B2 (en) 2003-12-24 2004-12-23 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US11/475,784 Continuation US8008088B2 (en) 2003-12-24 2006-06-26 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
US13/215,061 Continuation US8466286B2 (en) 2003-12-24 2011-08-22 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors

Publications (2)

Publication Number Publication Date
WO2005065241A2 WO2005065241A2 (en) 2005-07-21
WO2005065241A3 true WO2005065241A3 (en) 2006-05-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/043087 WO2005065241A2 (en) 2003-12-24 2004-12-23 Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors

Country Status (2)

Country Link
US (4) US8029765B2 (en)
WO (1) WO2005065241A2 (en)

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US8979790B2 (en) 2007-11-21 2015-03-17 Medtronic Minimed, Inc. Use of an equilibrium sensor to monitor glucose concentration

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