WO2005087920A3 - Recombinant chondroitinase abc i and uses thereof - Google Patents

Recombinant chondroitinase abc i and uses thereof Download PDF

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Publication number
WO2005087920A3
WO2005087920A3 PCT/US2005/008194 US2005008194W WO2005087920A3 WO 2005087920 A3 WO2005087920 A3 WO 2005087920A3 US 2005008194 W US2005008194 W US 2005008194W WO 2005087920 A3 WO2005087920 A3 WO 2005087920A3
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WO
WIPO (PCT)
Prior art keywords
chondroitinase abc
treating
gags
enzymes
relates
Prior art date
Application number
PCT/US2005/008194
Other languages
French (fr)
Other versions
WO2005087920A2 (en
Inventor
Vikas Prabhakar
Ishan Capila
Rahul Raman
Carlos Bosques
Kevin Pojasek
Ram Sasisekharan
Original Assignee
Massachusetts Inst Technology
Vikas Prabhakar
Ishan Capila
Rahul Raman
Carlos Bosques
Kevin Pojasek
Ram Sasisekharan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan filed Critical Massachusetts Inst Technology
Priority to EP05735137A priority Critical patent/EP1737954A2/en
Priority to CA002558984A priority patent/CA2558984A1/en
Publication of WO2005087920A2 publication Critical patent/WO2005087920A2/en
Publication of WO2005087920A3 publication Critical patent/WO2005087920A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
PCT/US2005/008194 2004-03-10 2005-03-10 Recombinant chondroitinase abc i and uses thereof WO2005087920A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05735137A EP1737954A2 (en) 2004-03-10 2005-03-10 Recombinant chondroitinase abc i and uses thereof
CA002558984A CA2558984A1 (en) 2004-03-10 2005-03-10 Recombinant chondroitinase abc i and uses thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US55223204P 2004-03-10 2004-03-10
US60/552,232 2004-03-10
US57891704P 2004-06-10 2004-06-10
US60/578,917 2004-06-10
US62505204P 2004-11-03 2004-11-03
US60/625,052 2004-11-03

Publications (2)

Publication Number Publication Date
WO2005087920A2 WO2005087920A2 (en) 2005-09-22
WO2005087920A3 true WO2005087920A3 (en) 2006-02-02

Family

ID=34965511

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/008194 WO2005087920A2 (en) 2004-03-10 2005-03-10 Recombinant chondroitinase abc i and uses thereof

Country Status (4)

Country Link
US (5) US7507570B2 (en)
EP (1) EP1737954A2 (en)
CA (1) CA2558984A1 (en)
WO (1) WO2005087920A2 (en)

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KR102167443B1 (en) * 2019-03-25 2020-10-19 주식회사 카티프라임 In vitro osteoarthritis condition model and drug screening method for osteoarthritis using the same
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CN116042593B (en) * 2023-01-16 2023-07-14 山东省农业科学院畜牧兽医研究所 Clostridium perfringens bacteriophage lyase and application thereof in preparation of clostridium perfringens infection resistant medicines

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Also Published As

Publication number Publication date
CA2558984A1 (en) 2005-09-22
US20070148157A1 (en) 2007-06-28
US20060078959A1 (en) 2006-04-13
US7592152B2 (en) 2009-09-22
US7553950B2 (en) 2009-06-30
US8338119B2 (en) 2012-12-25
US20070148740A1 (en) 2007-06-28
US20070202563A1 (en) 2007-08-30
WO2005087920A2 (en) 2005-09-22
EP1737954A2 (en) 2007-01-03
US7662604B2 (en) 2010-02-16
US20070224670A1 (en) 2007-09-27
US7507570B2 (en) 2009-03-24

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