WO2005091805A3 - Methods and compositions for inhibition of metastasis - Google Patents

Methods and compositions for inhibition of metastasis Download PDF

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Publication number
WO2005091805A3
WO2005091805A3 PCT/US2005/004612 US2005004612W WO2005091805A3 WO 2005091805 A3 WO2005091805 A3 WO 2005091805A3 US 2005004612 W US2005004612 W US 2005004612W WO 2005091805 A3 WO2005091805 A3 WO 2005091805A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
metastasis
inhibition
metastatic
Prior art date
Application number
PCT/US2005/004612
Other languages
French (fr)
Other versions
WO2005091805A2 (en
Inventor
Brunhilde Felding-Habermann
Kim D Janda
Alan Saven
Original Assignee
Scripps Research Inst
Brunhilde Felding-Habermann
Kim D Janda
Alan Saven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst, Brunhilde Felding-Habermann, Kim D Janda, Alan Saven filed Critical Scripps Research Inst
Priority to EP05760713A priority Critical patent/EP1725111A4/en
Priority to CA002559480A priority patent/CA2559480A1/en
Priority to JP2006553317A priority patent/JP2007523650A/en
Publication of WO2005091805A2 publication Critical patent/WO2005091805A2/en
Publication of WO2005091805A3 publication Critical patent/WO2005091805A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Abstract

This invention generally relates to methods of producing an antibody phage population having affinity for a tumor cell target expressing a metastatic phenotype. The invention further relates to antibody compositions that specifically bind to a cell surface receptor on the metastatic cell.
PCT/US2005/004612 2004-02-13 2005-02-14 Methods and compositions for inhibition of metastasis WO2005091805A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05760713A EP1725111A4 (en) 2004-02-13 2005-02-14 Methods and compositions for inhibition of metastasis
CA002559480A CA2559480A1 (en) 2004-02-13 2005-02-14 Methods and compositions for inhibition of metastasis
JP2006553317A JP2007523650A (en) 2004-02-13 2005-02-14 Methods and compositions for inhibiting metastasis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US54480704P 2004-02-13 2004-02-13
US60/544,807 2004-02-13
US62672604P 2004-11-10 2004-11-10
US60/626,726 2004-11-10
US11/056,825 US7271245B2 (en) 2004-02-13 2005-02-11 Methods and compositions for inhibition of metastasis
US11/056,825 2005-02-11

Publications (2)

Publication Number Publication Date
WO2005091805A2 WO2005091805A2 (en) 2005-10-06
WO2005091805A3 true WO2005091805A3 (en) 2006-09-08

Family

ID=35056641

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004612 WO2005091805A2 (en) 2004-02-13 2005-02-14 Methods and compositions for inhibition of metastasis

Country Status (5)

Country Link
US (2) US7271245B2 (en)
EP (1) EP1725111A4 (en)
JP (1) JP2007523650A (en)
CA (1) CA2559480A1 (en)
WO (1) WO2005091805A2 (en)

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Publication number Priority date Publication date Assignee Title
WO2004003144A2 (en) * 2002-07-01 2004-01-08 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
AR045563A1 (en) 2003-09-10 2005-11-02 Warner Lambert Co ANTIBODIES DIRECTED TO M-CSF
KR101263079B1 (en) 2005-07-18 2013-05-09 암젠 인크 Human anti-b7rp1 neutralizing antibodies
EP2082234B1 (en) * 2006-11-02 2012-10-03 Procognia (Israel) Ltd. Methods for screening for therapeutic molecules and use of the molecules therefrom
US7943728B2 (en) * 2006-12-26 2011-05-17 National Cheng Kung University Disintegrin variants and their use in treating osteoporosis-induced bone loss and angiogenesis-related diseases
WO2009042917A1 (en) * 2007-09-28 2009-04-02 The General Hospital Corporation Methods and compositions for antibody production
WO2009070753A2 (en) * 2007-11-28 2009-06-04 The Scripps Research Institute Bivalent single chain fv antibody compositions that specifically bind to integrin receptor on a metastatic cell in a mammalian subject
MX2010007101A (en) * 2007-12-26 2011-07-01 Biotest Ag Methods and agents for improving targeting of cd138 expressing tumor cells.
WO2009114816A2 (en) * 2008-03-14 2009-09-17 The Board Of Trustees Of The University Of Illinois Therapeutic cancer antigens
WO2010017083A1 (en) * 2008-08-04 2010-02-11 Wayne State University Methods of treating cancer with cd11b antibodies
US11180812B2 (en) 2012-08-17 2021-11-23 Cornell University Use of DNA in circulating exosomes as a diagnostic marker for metastatic disease
JOP20140087B1 (en) 2013-03-13 2021-08-17 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
RU2015143696A (en) 2013-03-14 2017-04-19 Байер Хелскеа Ллк MONOCLONAL ANTIBODIES AGAINST β ANTITROMBIN
CA2924603A1 (en) * 2013-09-30 2015-04-02 X-Body, Inc. Antigen receptor screening assay
WO2015153732A2 (en) 2014-04-01 2015-10-08 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
US11397182B2 (en) 2014-10-07 2022-07-26 Cornell University Methods for prognosing and preventing metastatic liver disease
WO2019241847A1 (en) * 2018-06-22 2019-12-26 Baker Heart and Diabetes Institute A therapeutic gpiib/iiia binding-protein drug conjugate and use thereof
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity

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GB9125979D0 (en) * 1991-12-06 1992-02-05 Wellcome Found Antibody
ATE175241T1 (en) * 1992-04-03 1999-01-15 Genentech Inc ANTIBODIES AGAINST ALPHA V BETA 3 INTEGRIN
US5753230A (en) * 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
KR0119887B1 (en) * 1994-06-08 1997-10-30 김광호 Wafer burn-in testing circuit of semiconductor memory device
US6596850B1 (en) * 1998-01-30 2003-07-22 Ixsys, Incorporated Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same
WO1998046265A1 (en) * 1997-04-11 1998-10-22 G.D. Searle & Co. Methods for using antagonistic anti-avb3 integrin antibodies
WO1998046264A1 (en) * 1997-04-11 1998-10-22 G.D. Searle & Co. Antagonistic anti-avb3 integrin antibodies
US6406693B1 (en) * 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
WO2000034780A2 (en) * 1998-12-04 2000-06-15 Novartis Ag METHODS AND COMPOSITIONS USEFUL FOR TARGETING ACTIVATED VITRONECTIN RECEPTOR αvβ¿3?
US6531580B1 (en) * 1999-06-24 2003-03-11 Ixsys, Inc. Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same
WO2002008280A2 (en) * 2000-07-26 2002-01-31 The Burnham Institute SCREENING METHODS BASED ON SUPERACTIVATED αVβ3 INTEGRIN
WO2003034995A2 (en) * 2001-10-22 2003-05-01 The Scripps Research Institute Integrin targeting compounds
WO2003075957A1 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FELDING-HABERMANN B. ET AL.: "Involvement of Tumor Cell Integrin Alpha v Beta 3 in Hematogenous Metastasis of Human Melanoma Cells", CLIN. EXP. METASTASIS, vol. 19, no. 5, 2002, pages 427 - 436, XP019235607 *
VACCA A. ET AL.: "avbeta3 Integrin Engagement Modulates cell Adhesion, Proliferation, and Protease Secretion in Human Lymphoid Tumor Cells", EXP. HEMATOL., vol. 29, no. 8, August 2001 (2001-08-01), pages 993 - 1003, XP008097563 *

Also Published As

Publication number Publication date
JP2007523650A (en) 2007-08-23
US20090117096A1 (en) 2009-05-07
CA2559480A1 (en) 2005-10-06
US20050255109A1 (en) 2005-11-17
EP1725111A4 (en) 2008-08-06
EP1725111A2 (en) 2006-11-29
WO2005091805A2 (en) 2005-10-06
US7271245B2 (en) 2007-09-18

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