WO2005112952A3 - Geldanamycin compounds and method of use - Google Patents
Geldanamycin compounds and method of use Download PDFInfo
- Publication number
- WO2005112952A3 WO2005112952A3 PCT/US2005/017966 US2005017966W WO2005112952A3 WO 2005112952 A3 WO2005112952 A3 WO 2005112952A3 US 2005017966 W US2005017966 W US 2005017966W WO 2005112952 A3 WO2005112952 A3 WO 2005112952A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- geldanamycin compounds
- geldanamycin
- compounds
- inhibiting
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05779991A EP1747005A4 (en) | 2004-05-20 | 2005-05-19 | Geldanamycin compounds and method of use |
CA002563979A CA2563979A1 (en) | 2004-05-20 | 2005-05-19 | Geldanamycin compounds and method of use |
JP2007527525A JP2008505984A (en) | 2004-05-20 | 2005-05-19 | Geldanamycin compounds and methods of use |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57330604P | 2004-05-20 | 2004-05-20 | |
US60/573,306 | 2004-05-20 | ||
US58451504P | 2004-06-30 | 2004-06-30 | |
US60/584,515 | 2004-06-30 | ||
US11/133,880 US7259156B2 (en) | 2004-05-20 | 2005-05-17 | Geldanamycin compounds and method of use |
US11/133,880 | 2005-05-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005112952A2 WO2005112952A2 (en) | 2005-12-01 |
WO2005112952A3 true WO2005112952A3 (en) | 2007-09-27 |
Family
ID=35426141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/017966 WO2005112952A2 (en) | 2004-05-20 | 2005-05-19 | Geldanamycin compounds and method of use |
Country Status (5)
Country | Link |
---|---|
US (2) | US7259156B2 (en) |
EP (1) | EP1747005A4 (en) |
JP (1) | JP2008505984A (en) |
CA (1) | CA2563979A1 (en) |
WO (1) | WO2005112952A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100500668C (en) * | 2006-12-19 | 2009-06-17 | 中国人民解放军军事医学科学院毒物药物研究所 | Geldanamycin derivative and its preparing method and use for preparing medicine |
US20100113602A1 (en) * | 2007-02-27 | 2010-05-06 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Use of histone deacetylase inhibitors for the treatment of central nervous system metastases |
US20100098690A1 (en) * | 2007-03-05 | 2010-04-22 | Kyowa Hakko Kirin Co., Ltd. | Pharmaceutical composition |
WO2008116216A1 (en) * | 2007-03-22 | 2008-09-25 | Medical College Of Georgia Research Institute, Inc. | Compositions and methods for inhibiting cancer metastasis |
US8426396B2 (en) | 2008-01-08 | 2013-04-23 | Shriners Hospitals For Children | Treatment for achondroplasia |
CN101220068B (en) * | 2008-01-18 | 2012-06-13 | 中国医学科学院医药生物技术研究所 | A set of geldanamycin derivant and method for preparing the same |
DE102008060549A1 (en) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Drug-peptide construct for extracellular accumulation |
US8945627B2 (en) | 2011-05-05 | 2015-02-03 | Wisconsin Alumni Research Foundation | Micelles for the solubilization of gossypol |
US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670348B1 (en) * | 1997-05-14 | 2003-12-30 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US45570A (en) * | 1864-12-27 | abbeceombie | ||
US26894A (en) * | 1860-01-24 | Improvement in machinery for laying rope | ||
US53909A (en) * | 1866-04-10 | Improvement in seeding-machines | ||
US77279A (en) * | 1868-04-28 | Improvement in potato-diggek | ||
US1114450A (en) * | 1914-02-06 | 1914-10-20 | George Edmond Denman | Liquid-fuel burner. |
JPS55111470A (en) | 1979-02-19 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient |
US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
JPS55111419A (en) | 1979-02-20 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Antitumorigenic agent |
JPS63218620A (en) | 1987-03-09 | 1988-09-12 | Kyowa Hakko Kogyo Co Ltd | Normalizing agent for cancerated cell |
JPH0446120A (en) | 1990-06-11 | 1992-02-17 | Kyowa Hakko Kogyo Co Ltd | Arteralization inhibiting agent |
CA2146668A1 (en) | 1992-10-14 | 1994-04-28 | Luke Whitesell | Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies |
US5932566A (en) | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
US5534270A (en) | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
WO1996034525A1 (en) | 1995-05-02 | 1996-11-07 | The Regents Of The University Of California | Inducement of thermotolerance with benzoquinonoid ansamycins |
WO2000003737A2 (en) | 1998-07-17 | 2000-01-27 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Water-soluble drugs and methods for their production |
US6174875B1 (en) | 1999-04-01 | 2001-01-16 | University Of Pittsburgh | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
AU769235B2 (en) | 1999-04-09 | 2004-01-22 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases |
EP1466627A1 (en) | 1999-10-12 | 2004-10-13 | Cell Therapeutics, Inc. | Polyglutamate camptothecin conjugates |
WO2002036574A1 (en) | 2000-11-06 | 2002-05-10 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Geldanamycin derivatives useful for the treatment of cancer |
ES2268068T3 (en) | 2001-03-30 | 2007-03-16 | The Usa, Represented By The Secretary, Dept. Of Health And Human Services National Institutes Health | DERIVED FROM GELDANAMYCIN USEFUL FOR THE TREATMENT OF CANCER. |
WO2003013430A2 (en) * | 2001-08-06 | 2003-02-20 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
CA2468202A1 (en) * | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating hsp90 binding activity |
ATE433961T1 (en) | 2002-02-08 | 2009-07-15 | Conforma Therapeutics Corp | ANSAMYCINS WITH IMPROVED PHARMACOLOGICAL AND BIOLOGICAL PROPERTIES |
US7241754B2 (en) | 2003-06-13 | 2007-07-10 | Kosan Biosciences, Inc. | 2-Desmethyl ansamycin compounds |
US6875863B1 (en) | 2003-11-12 | 2005-04-05 | Kosan Biosciences, Inc. | 11-O-methylgeldanamycin compounds |
US6887993B1 (en) | 2003-11-12 | 2005-05-03 | Kosan Biosciences, Inc. | 11-O-methylgeldanamycin compounds |
US6855705B1 (en) | 2003-11-12 | 2005-02-15 | Kosan Biosciences, Inc. | 11-O-methylgeldanamycin compounds |
CA2545457A1 (en) | 2003-11-12 | 2005-06-23 | Kosan Biosciences, Inc. | 11-o-methylgeldanamycin compounds |
EP1737825A1 (en) * | 2004-03-26 | 2007-01-03 | Van Andel Research Institute | Geldanamycin and derivatives inhibit cancer invasion and identify novel targets |
-
2005
- 2005-05-17 US US11/133,880 patent/US7259156B2/en active Active
- 2005-05-19 JP JP2007527525A patent/JP2008505984A/en active Pending
- 2005-05-19 EP EP05779991A patent/EP1747005A4/en not_active Withdrawn
- 2005-05-19 WO PCT/US2005/017966 patent/WO2005112952A2/en active Application Filing
- 2005-05-19 CA CA002563979A patent/CA2563979A1/en not_active Abandoned
-
2007
- 2007-07-06 US US11/825,501 patent/US7378407B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670348B1 (en) * | 1997-05-14 | 2003-12-30 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for destruction of selected proteins |
Also Published As
Publication number | Publication date |
---|---|
CA2563979A1 (en) | 2005-12-01 |
JP2008505984A (en) | 2008-02-28 |
EP1747005A4 (en) | 2011-06-15 |
EP1747005A2 (en) | 2007-01-31 |
US7378407B2 (en) | 2008-05-27 |
US20050267046A1 (en) | 2005-12-01 |
US20070270396A1 (en) | 2007-11-22 |
US7259156B2 (en) | 2007-08-21 |
WO2005112952A2 (en) | 2005-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005112952A3 (en) | Geldanamycin compounds and method of use | |
GB0510143D0 (en) | Novel compounds A1 | |
EP1740581A4 (en) | 2, 4, 6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | |
ZA200802163B (en) | 5-(phenylisoxazolylethoxy)-triazol-3-YL substituted pyridine compounds for the treatment of neurological, psychiatric or pain disorders | |
IN2014DN08588A (en) | ||
TNSN08269A1 (en) | Derives de pyrimidine | |
PH12014502420B1 (en) | Iap bir domain binding compound | |
TW200745138A (en) | Process for stabilising thiophene derivatives | |
UA92355C2 (en) | urn:schemas-microsoft-com:office:smarttags2,4-DIAMINO-PYRIMIDINES USED AS AURORAINHIBITORS | |
EP1740559A4 (en) | 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | |
WO2009051670A3 (en) | Oxylipin compounds for the treatment of ophthalmic conditions | |
WO2005087771A3 (en) | 5,6-dialkyl-7-amino-triazolopyrimidines, method for their production, their use for controlling pathogenic fungi and agents containing said compounds | |
IL191629A0 (en) | Tricyclic amide derivatives useful for treating obesity | |
EP1817311A4 (en) | 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | |
WO2005087700A3 (en) | Bisphenyl compounds useful as vitamin d3 receptor agonists | |
EP1705251A4 (en) | PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY USING RNA INHIBITING THE FUNCTION OF a1,6-FUCOSYLTRANSFERASE | |
WO2003093269A3 (en) | Substituted pyrazolo-pyrimidine-4-ones | |
WO2006133391A3 (en) | Improved treatment for anemia using a hif-alpha stabilising agent | |
WO2008001195A3 (en) | Novel processes for the preparation of dpp iv inhibitors | |
WO2008040649A3 (en) | Pyrazine-2-carboxamide derivatives as cb2 receptor modulators | |
TW200621739A (en) | Asymmetric synthesis of substituted dihydrobenzofurans | |
MX2009006444A (en) | Method for producing c-glycoside derivative and synthetic intermediate thereof. | |
WO2009018065A3 (en) | Novel glucokinase activators and methods of using same | |
WO2008146914A1 (en) | Heterocyclic compound | |
WO2008045371A3 (en) | N-substituted-azacyclylamines as histamine-3 antagonists |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2563979 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007527525 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005779991 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2005779991 Country of ref document: EP |