WO2005112952A3 - Geldanamycin compounds and method of use - Google Patents

Geldanamycin compounds and method of use Download PDF

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Publication number
WO2005112952A3
WO2005112952A3 PCT/US2005/017966 US2005017966W WO2005112952A3 WO 2005112952 A3 WO2005112952 A3 WO 2005112952A3 US 2005017966 W US2005017966 W US 2005017966W WO 2005112952 A3 WO2005112952 A3 WO 2005112952A3
Authority
WO
WIPO (PCT)
Prior art keywords
geldanamycin compounds
geldanamycin
compounds
inhibiting
disease
Prior art date
Application number
PCT/US2005/017966
Other languages
French (fr)
Other versions
WO2005112952A2 (en
Inventor
Daniel V Santi
Zong-Qiang Tian
Yaoquan Liu
Zhan Wang
Original Assignee
Kosan Biosciences Inc
Daniel V Santi
Zong-Qiang Tian
Yaoquan Liu
Zhan Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc, Daniel V Santi, Zong-Qiang Tian, Yaoquan Liu, Zhan Wang filed Critical Kosan Biosciences Inc
Priority to JP2007527525A priority Critical patent/JP2008505984A/en
Priority to CA002563979A priority patent/CA2563979A1/en
Priority to EP05779991A priority patent/EP1747005A4/en
Publication of WO2005112952A2 publication Critical patent/WO2005112952A2/en
Publication of WO2005112952A3 publication Critical patent/WO2005112952A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom

Abstract

Geldanamycin compounds having a structure according to formula (I) where Q1, L, L1, R5, R6 and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
PCT/US2005/017966 2004-05-20 2005-05-19 Geldanamycin compounds and method of use WO2005112952A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2007527525A JP2008505984A (en) 2004-05-20 2005-05-19 Geldanamycin compounds and methods of use
CA002563979A CA2563979A1 (en) 2004-05-20 2005-05-19 Geldanamycin compounds and method of use
EP05779991A EP1747005A4 (en) 2004-05-20 2005-05-19 Geldanamycin compounds and method of use

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US57330604P 2004-05-20 2004-05-20
US60/573,306 2004-05-20
US58451504P 2004-06-30 2004-06-30
US60/584,515 2004-06-30
US11/133,880 2005-05-17
US11/133,880 US7259156B2 (en) 2004-05-20 2005-05-17 Geldanamycin compounds and method of use

Publications (2)

Publication Number Publication Date
WO2005112952A2 WO2005112952A2 (en) 2005-12-01
WO2005112952A3 true WO2005112952A3 (en) 2007-09-27

Family

ID=35426141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/017966 WO2005112952A2 (en) 2004-05-20 2005-05-19 Geldanamycin compounds and method of use

Country Status (5)

Country Link
US (2) US7259156B2 (en)
EP (1) EP1747005A4 (en)
JP (1) JP2008505984A (en)
CA (1) CA2563979A1 (en)
WO (1) WO2005112952A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100500668C (en) * 2006-12-19 2009-06-17 中国人民解放军军事医学科学院毒物药物研究所 Geldanamycin derivative and its preparing method and use for preparing medicine
WO2008106524A1 (en) * 2007-02-27 2008-09-04 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of histone deacetylase inhibitors for the treatment of central nervous system metastases
KR20090116794A (en) * 2007-03-05 2009-11-11 교와 핫꼬 기린 가부시키가이샤 Pharmaceutical composition
US20100111943A1 (en) * 2007-03-22 2010-05-06 Medical College Of Georgia Research Institute, Inc Compositions and methods for inhibiting cancer metastasis
US8426396B2 (en) 2008-01-08 2013-04-23 Shriners Hospitals For Children Treatment for achondroplasia
CN101220068B (en) * 2008-01-18 2012-06-13 中国医学科学院医药生物技术研究所 A set of geldanamycin derivant and method for preparing the same
DE102008060549A1 (en) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Drug-peptide construct for extracellular accumulation
WO2012151544A1 (en) 2011-05-05 2012-11-08 Wisconsin Alumni Research Foundation Micelles for the solubilization of gossypol
US10682415B2 (en) 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery

Citations (1)

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US6670348B1 (en) * 1997-05-14 2003-12-30 Sloan-Kettering Institute For Cancer Research Methods and compositions for destruction of selected proteins

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US6887993B1 (en) * 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
JP4717003B2 (en) * 2003-11-12 2011-07-06 コーサン バイオサイエンシーズ， インコーポレイテッド 11-O-methylgeldanamycin compound
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670348B1 (en) * 1997-05-14 2003-12-30 Sloan-Kettering Institute For Cancer Research Methods and compositions for destruction of selected proteins

Also Published As

Publication number Publication date
CA2563979A1 (en) 2005-12-01
US20050267046A1 (en) 2005-12-01
WO2005112952A2 (en) 2005-12-01
US20070270396A1 (en) 2007-11-22
JP2008505984A (en) 2008-02-28
US7259156B2 (en) 2007-08-21
EP1747005A2 (en) 2007-01-31
EP1747005A4 (en) 2011-06-15
US7378407B2 (en) 2008-05-27

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