WO2005117270A3 - Mass spectrometry with selective ion filtration by digital thresholding - Google Patents

Mass spectrometry with selective ion filtration by digital thresholding Download PDF

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Publication number
WO2005117270A3
WO2005117270A3 PCT/US2005/018337 US2005018337W WO2005117270A3 WO 2005117270 A3 WO2005117270 A3 WO 2005117270A3 US 2005018337 W US2005018337 W US 2005018337W WO 2005117270 A3 WO2005117270 A3 WO 2005117270A3
Authority
WO
WIPO (PCT)
Prior art keywords
selective ion
mass spectrometry
digital thresholding
ion filtration
digital
Prior art date
Application number
PCT/US2005/018337
Other languages
French (fr)
Other versions
WO2005117270A2 (en
Inventor
Steven A Hofstadler
Jared J Drader
Amy L Schink
Original Assignee
Isis Pharmaceuticals Inc
Steven A Hofstadler
Jared J Drader
Amy L Schink
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Steven A Hofstadler, Jared J Drader, Amy L Schink filed Critical Isis Pharmaceuticals Inc
Priority to JP2007515292A priority Critical patent/JP4810533B2/en
Priority to CA2567839A priority patent/CA2567839C/en
Priority to EP05753037A priority patent/EP1766659A4/en
Publication of WO2005117270A2 publication Critical patent/WO2005117270A2/en
Publication of WO2005117270A3 publication Critical patent/WO2005117270A3/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0009—Calibration of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Abstract

The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.
PCT/US2005/018337 2004-05-24 2005-05-24 Mass spectrometry with selective ion filtration by digital thresholding WO2005117270A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2007515292A JP4810533B2 (en) 2004-05-24 2005-05-24 Mass spectrometry using selective ion filtration by digital thresholding.
CA2567839A CA2567839C (en) 2004-05-24 2005-05-24 Mass spectrometry with selective ion filtration by digital thresholding
EP05753037A EP1766659A4 (en) 2004-05-24 2005-05-24 Mass spectrometry with selective ion filtration by digital thresholding

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57404204P 2004-05-24 2004-05-24
US60/574,042 2004-05-24

Publications (2)

Publication Number Publication Date
WO2005117270A2 WO2005117270A2 (en) 2005-12-08
WO2005117270A3 true WO2005117270A3 (en) 2007-02-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018337 WO2005117270A2 (en) 2004-05-24 2005-05-24 Mass spectrometry with selective ion filtration by digital thresholding

Country Status (6)

Country Link
US (4) US7714275B2 (en)
EP (2) EP2458619B1 (en)
JP (1) JP4810533B2 (en)
CA (1) CA2567839C (en)
ES (1) ES2641832T3 (en)
WO (1) WO2005117270A2 (en)

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US20160071710A1 (en) 2016-03-10
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US8173957B2 (en) 2012-05-08
US20100127165A1 (en) 2010-05-27
WO2005117270A2 (en) 2005-12-08
US20050270191A1 (en) 2005-12-08
US20130092830A1 (en) 2013-04-18
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