WO2006002140A3 - Compositions comprising amphotericin b - Google Patents

Compositions comprising amphotericin b Download PDF

Info

Publication number
WO2006002140A3
WO2006002140A3 PCT/US2005/021886 US2005021886W WO2006002140A3 WO 2006002140 A3 WO2006002140 A3 WO 2006002140A3 US 2005021886 W US2005021886 W US 2005021886W WO 2006002140 A3 WO2006002140 A3 WO 2006002140A3
Authority
WO
WIPO (PCT)
Prior art keywords
amphotericin
particles
mass median
compositions
particles including
Prior art date
Application number
PCT/US2005/021886
Other languages
French (fr)
Other versions
WO2006002140A2 (en
WO2006002140A9 (en
Inventor
Sarma Duddu
Srinivas Palakodaty
David Lechuga-Ballesteros
Danforth Miller
Alan R Kugler
Christopher Frantz
Trixie Tan
Richard Malcolmson
Keith Washco
Theresa Sweeney
Thomas E Tarara
Sarvajna Dwivedi
Michael A Eldon
Original Assignee
Nektar Therapeutics
Sarma Duddu
Srinivas Palakodaty
David Lechuga-Ballesteros
Danforth Miller
Alan R Kugler
Christopher Frantz
Trixie Tan
Richard Malcolmson
Keith Washco
Theresa Sweeney
Thomas E Tarara
Sarvajna Dwivedi
Michael A Eldon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics, Sarma Duddu, Srinivas Palakodaty, David Lechuga-Ballesteros, Danforth Miller, Alan R Kugler, Christopher Frantz, Trixie Tan, Richard Malcolmson, Keith Washco, Theresa Sweeney, Thomas E Tarara, Sarvajna Dwivedi, Michael A Eldon filed Critical Nektar Therapeutics
Priority to BRPI0512326-7A priority Critical patent/BRPI0512326A/en
Priority to CN2005800259782A priority patent/CN101442989B/en
Priority to JP2007518196A priority patent/JP2008503586A/en
Priority to CA002567785A priority patent/CA2567785A1/en
Priority to AU2005258040A priority patent/AU2005258040A1/en
Priority to MXPA06015220A priority patent/MXPA06015220A/en
Priority to EP05773044A priority patent/EP1773301A2/en
Publication of WO2006002140A2 publication Critical patent/WO2006002140A2/en
Publication of WO2006002140A9 publication Critical patent/WO2006002140A9/en
Priority to IL179835A priority patent/IL179835A0/en
Publication of WO2006002140A3 publication Critical patent/WO2006002140A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Abstract

A composition includes particles including at least about 95 wt% of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 µm to about 1.9 µm. Another composition also includes particles including at least about 95 wt% of amphotericin B, wherein at least about 80 wt% of the particles have a geometric diameter ranging from about 1.1 µm to about 1.9 gm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 µm, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.
PCT/US2005/021886 2004-06-21 2005-06-21 Compositions comprising amphotericin b WO2006002140A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BRPI0512326-7A BRPI0512326A (en) 2004-06-21 2005-06-21 compositions comprising amphotericin b, methods and systems
CN2005800259782A CN101442989B (en) 2004-06-21 2005-06-21 Compositions comprising amphotericin B
JP2007518196A JP2008503586A (en) 2004-06-21 2005-06-21 Compositions, methods and systems comprising amphotericin B
CA002567785A CA2567785A1 (en) 2004-06-21 2005-06-21 Composition comprising amphotericin b methods and systems
AU2005258040A AU2005258040A1 (en) 2004-06-21 2005-06-21 Compositions comprising amphotericin b
MXPA06015220A MXPA06015220A (en) 2004-06-21 2005-06-21 Compositions comprising amphotericin b.
EP05773044A EP1773301A2 (en) 2004-06-21 2005-06-21 Compositions comprising amphotericinb methods and systems
IL179835A IL179835A0 (en) 2004-06-21 2006-12-05 Pharmaceutical compositions containing amphotericin b and delivery systems containing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58158604P 2004-06-21 2004-06-21
US60/581,586 2004-06-21

Publications (3)

Publication Number Publication Date
WO2006002140A2 WO2006002140A2 (en) 2006-01-05
WO2006002140A9 WO2006002140A9 (en) 2006-04-20
WO2006002140A3 true WO2006002140A3 (en) 2007-03-01

Family

ID=35414832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/021886 WO2006002140A2 (en) 2004-06-21 2005-06-21 Compositions comprising amphotericin b

Country Status (10)

Country Link
US (1) US7326691B2 (en)
EP (1) EP1773301A2 (en)
JP (1) JP2008503586A (en)
CN (1) CN101442989B (en)
AU (1) AU2005258040A1 (en)
BR (1) BRPI0512326A (en)
CA (1) CA2567785A1 (en)
IL (1) IL179835A0 (en)
MX (1) MXPA06015220A (en)
WO (1) WO2006002140A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) * 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
JP2004517127A (en) * 2000-12-21 2004-06-10 ネクター セラピューティックス Pulmonary delivery of polyene antifungals
ES2364636T3 (en) 2001-12-19 2011-09-08 Novartis Ag PULMONARY ADMINISTRATION OF AMINOGLUCOSIDS.
JP4739672B2 (en) * 2001-12-21 2011-08-03 ネクター セラピューティクス Capsule package with moisture barrier
EP1697035B1 (en) * 2003-12-22 2017-11-15 Warren H. Finlay Powder formation by atmospheric spray-freeze drying
GB0503738D0 (en) * 2005-02-23 2005-03-30 Optinose As Powder delivery devices
US8524734B2 (en) * 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
WO2007041090A2 (en) * 2005-09-29 2007-04-12 Nektar Therapeutics Receptacles and kits, such as for dry powder packaging
US20120128728A1 (en) * 2005-12-28 2012-05-24 Novartis Pharma Ag Compositions Comprising Amphotericin B
EP2164518B1 (en) * 2007-05-25 2019-04-24 The University Of British Columbia Formulations for the oral administration of therapeutic agents and related methods
EP2050437A1 (en) * 2007-10-15 2009-04-22 Laboratoires SMB Improved pharmaceutical dry powder compositions for inhalation.
DE102008003971A1 (en) * 2008-01-11 2009-07-16 Ledon Lighting Jennersdorf Gmbh Light-emitting diode arrangement with protective frame
US20090271021A1 (en) * 2008-04-28 2009-10-29 Popp Shane M Execution system for the monitoring and execution of insulin manufacture
WO2009140587A1 (en) 2008-05-15 2009-11-19 Novartis Ag Pulmonary delivery of a fluoroquinolone
KR20110091510A (en) 2008-10-07 2011-08-11 엠펙스 파마슈티컬즈, 인코포레이티드 Aerosol fluoroquinolone formulations for improved pharmacokinetics
CA2739893C (en) 2008-10-07 2016-10-04 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
US8685458B2 (en) 2009-03-05 2014-04-01 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives
TR200904500A2 (en) 2009-06-10 2009-10-21 Öner Levent Methods and pharmaceutical formulations for the preparation of ezetimibe nanocrystals.
PL2473170T3 (en) 2009-09-04 2020-03-31 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
WO2011050457A1 (en) 2009-10-26 2011-05-05 The University Of British Columbia Stabilized formulation for oral administration of therapeutic agents and related methods
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
JOP20120023B1 (en) 2011-02-04 2022-03-14 Novartis Ag Dry powder formulations of particles that contain two or more active ingredients for treating obstructive or inflammatory airways diseases
US9060938B2 (en) 2011-05-10 2015-06-23 Bend Research, Inc. Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
DK3142672T3 (en) * 2014-05-16 2019-10-21 The Board Of Trustees Of The Univ Of Illionis AMPHOTERICIN B DERIVATIVE WITH REDUCED TOXICITY
US9675659B2 (en) * 2015-08-21 2017-06-13 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
RU2018120519A (en) * 2015-11-18 2019-12-18 ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед Pharmaceutical compositions of ribavirin
AU2018337955B2 (en) * 2017-09-20 2024-01-18 Atopic Medical, Inc. Compositions and methods for treating and ameliorating respiratory conditions and inflammation of mucosa

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049388A (en) * 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
US6228346B1 (en) * 1996-04-25 2001-05-08 Pari Gmbh Spezialisten Fur Effektive Inhalation Propellant mixtures and aerosols for micronizing medicaments with compressed gas
WO2002054868A2 (en) * 2000-12-21 2002-07-18 Inhale Therapeutic Syst Pulmonary delivery of polyene antifungal agents

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
IT1016489B (en) * 1974-03-18 1977-05-30 Isf Spa INHALER
SE408265B (en) * 1975-12-12 1979-06-05 Draco Ab DEVICE FOR CARBON DIOXIDE POWERED ENDOSAEROSOL, INTENDED FOR INHALATION
US4247066A (en) * 1978-02-21 1981-01-27 General Dynamics Corporation Airfoil variable cambering device and method
IT1116047B (en) * 1979-04-27 1986-02-10 Sigma Tau Ind Farmaceuti DEVICE FOR THE QUICK INHALATION OF POWDER DRUGS BY PERSONS SUFFERING FROM ASTHMA
DE3634952A1 (en) * 1986-10-14 1988-04-21 Bayer Ag IMIDAZO-PYRROLO-PYRIDINE DERIVATIVES
IT1228459B (en) * 1989-02-23 1991-06-19 Phidea S R L INHALER WITH REGULAR AND COMPLETE EMPTYING OF THE CAPSULE.
US5776904A (en) * 1990-11-16 1998-07-07 Nippon Shinyaku Co., Ltd. Dispersion preparation
AU662919B2 (en) * 1991-07-02 1995-09-21 Inhale, Inc. Method and device for delivering aerosolized medicaments
US5785049A (en) * 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
ES2218543T3 (en) 1994-03-07 2004-11-16 Nektar Therapeutics PROCEDURE AND PREPARATION FOR THE ADMINISTRATION OF INSULIN BY PULMONARY ROUTE.
JPH10500672A (en) 1994-05-18 1998-01-20 インヘイル セラピューティック システムズ，インコーポレイティド Methods and compositions relating to dry powder formulations of interferon
GB9413202D0 (en) 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
JP3388896B2 (en) * 1994-08-08 2003-03-24 株式会社日立ユニシアオートモティブ Inhalation type dispenser
DE4440337A1 (en) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmaceutical nanosuspensions for drug application as systems with increased saturation solubility and dissolution rate
US6136346A (en) * 1995-04-14 2000-10-24 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US6503480B1 (en) * 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
WO1998029140A1 (en) * 1996-12-31 1998-07-09 Inhale Therapeutic Systems Processes and compositions for spray drying hydrophobic drugs in organic solvent suspensions of hydrophilic excipients
GB9703673D0 (en) 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
EP1019023B1 (en) 1997-09-29 2003-05-07 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in nebulizers
WO1999016420A1 (en) 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in nebulizers
US6257233B1 (en) * 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
DE19835346A1 (en) 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Two-part capsule for pharmaceutical preparations for powder inhalers
ES2265944T3 (en) 1999-05-28 2007-03-01 Nektar Therapeutics APPARATUS AND PROCEDURE TO AEROSOLIZE A PHARMACEUTICAL POWDER COMPOSITION.
CA2376937C (en) 1999-06-30 2009-01-06 Inhale Therapeutics Systems Inc. Spray drying process for preparing dry powders
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
ES2525087T5 (en) 2000-05-10 2018-06-28 Novartis Ag Phospholipid-based powders for drug administration
US6357490B1 (en) * 2000-08-22 2002-03-19 Advanced Inhalation Research, Inc. System, method and apparatus for filling containers
US6766799B2 (en) 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049388A (en) * 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
US6228346B1 (en) * 1996-04-25 2001-05-08 Pari Gmbh Spezialisten Fur Effektive Inhalation Propellant mixtures and aerosols for micronizing medicaments with compressed gas
WO2002054868A2 (en) * 2000-12-21 2002-07-18 Inhale Therapeutic Syst Pulmonary delivery of polyene antifungal agents

Also Published As

Publication number Publication date
CN101442989B (en) 2013-04-03
IL179835A0 (en) 2007-05-15
US20060025355A1 (en) 2006-02-02
WO2006002140A2 (en) 2006-01-05
WO2006002140A9 (en) 2006-04-20
MXPA06015220A (en) 2007-12-13
AU2005258040A1 (en) 2006-01-05
EP1773301A2 (en) 2007-04-18
CA2567785A1 (en) 2006-01-05
CN101442989A (en) 2009-05-27
US7326691B2 (en) 2008-02-05
BRPI0512326A (en) 2008-02-26
JP2008503586A (en) 2008-02-07

Similar Documents

Publication Publication Date Title
WO2006002140A3 (en) Compositions comprising amphotericin b
WO2005041891A3 (en) Neutrophil activation by immune response modifier compounds
WO2001085257A3 (en) Opioid antagonist compositions and dosage forms
WO2007071581A3 (en) Pharmaceutical formulation for producing rapidly disintegrating tablets
WO2007072992A3 (en) Solid preparation containing an insulin sensitizer
WO2007030754A3 (en) Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
WO2004050058A3 (en) Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
EP1486195A3 (en) Personal product compositions comprising structured benefit agent pre-mix or delivery vehicle and providing enhanced effect of optical modifier separate from structured benefit agent
WO2002070438A3 (en) Compositions for delivering bisphosphonates
WO2002082902A3 (en) A concentrated, water-soluble, granular plant growth regulator formulation and methods for use of same
WO2008009379A3 (en) Active ingredient combinations having insecticide and acaricide properties
WO2008035020A3 (en) Galenic form for the trans-mucosal delivery of active ingredients
WO2006101882A3 (en) Medicament delivery formulations, devices and methods
WO2002043702A3 (en) Pharmaceutical compositions for inhalation
WO2004074266A8 (en) Hiv inhibiting 1,2,4-triazines
WO2005112633A3 (en) Compounds and compositions for delivering active agents
WO2007106723A3 (en) Pharmaceutical formulations comprising polyanionic materials and zinc-based preservatives
WO2008056375A3 (en) Pharmaceutical formulations comprising valsartan
EP1260147A3 (en) Method for improving the performance of a food product
WO2005079464A3 (en) Vitamin d receptor antagonists and their use in treating asthma
WO2006128847A3 (en) Medicament containing a betamimetic in conjunction with an anticholinergic and a pde iv inhibitor
AU2002356646A1 (en) Pharmaceutical compositions for the pulmonary delivery of aztreonam
WO2011056785A3 (en) Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients
WO2005011640A3 (en) Pharmaceutical desmopressin composition as solid dosage form and method for manufacturing thereof
WO2005123113A3 (en) Interferon compositions and methods of use thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
COP Corrected version of pamphlet

Free format text: PAGES 1/21-21/21, DRAWINGS, REPLACED BY NEW PAGES 1/20-20/20; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

WWE Wipo information: entry into national phase

Ref document number: 2005258040

Country of ref document: AU

REEP Request for entry into the european phase

Ref document number: 2005773044

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2005773044

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2567785

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 179835

Country of ref document: IL

ENP Entry into the national phase

Ref document number: 2005258040

Country of ref document: AU

Date of ref document: 20050621

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005258040

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2007518196

Country of ref document: JP

Ref document number: PA/a/2006/015220

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 1020067027004

Country of ref document: KR

Ref document number: 4691/CHENP/2006

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Ref document number: DE

WWE Wipo information: entry into national phase

Ref document number: 200580025978.2

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 1020067027004

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2005773044

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0512326

Country of ref document: BR