WO2006004774A3 - Laulimalide analogues as therapeutic agents - Google Patents

Laulimalide analogues as therapeutic agents Download PDF

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Publication number
WO2006004774A3
WO2006004774A3 PCT/US2005/022965 US2005022965W WO2006004774A3 WO 2006004774 A3 WO2006004774 A3 WO 2006004774A3 US 2005022965 W US2005022965 W US 2005022965W WO 2006004774 A3 WO2006004774 A3 WO 2006004774A3
Authority
WO
WIPO (PCT)
Prior art keywords
laulimalide
analogues
therapeutic agents
compounds
methods
Prior art date
Application number
PCT/US2005/022965
Other languages
French (fr)
Other versions
WO2006004774A2 (en
Inventor
Paul A Wender
Original Assignee
Univ Stanford
Paul A Wender
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Stanford, Paul A Wender filed Critical Univ Stanford
Priority to US11/630,858 priority Critical patent/US20080280973A1/en
Publication of WO2006004774A2 publication Critical patent/WO2006004774A2/en
Publication of WO2006004774A3 publication Critical patent/WO2006004774A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Abstract

Laulimalide analogues useful as microtubule stabilizing agents, and in the treatment of abnormal cell proliferation, are disclosed. Methods of making the compounds, as well as methods of using such compounds in treating abnormal cell proliferation diseases are also described.
PCT/US2005/022965 2004-06-28 2005-06-28 Laulimalide analogues as therapeutic agents WO2006004774A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/630,858 US20080280973A1 (en) 2004-06-28 2005-06-28 Laulimalide Analogues as Therapeutic Agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58391504P 2004-06-28 2004-06-28
US60/583,915 2004-06-28
US61458804P 2004-09-30 2004-09-30
US60/614,588 2004-09-30

Publications (2)

Publication Number Publication Date
WO2006004774A2 WO2006004774A2 (en) 2006-01-12
WO2006004774A3 true WO2006004774A3 (en) 2006-08-24

Family

ID=35783323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/022965 WO2006004774A2 (en) 2004-06-28 2005-06-28 Laulimalide analogues as therapeutic agents

Country Status (2)

Country Link
US (1) US20080280973A1 (en)
WO (1) WO2006004774A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090099252A1 (en) * 2007-08-10 2009-04-16 Wender Paul A Novel laulimalide analogues as therapeutic agents
CA2838401C (en) 2011-06-06 2021-01-12 The Board Of Regents Of The University Of Texas System Taccalonolide microtubule stabilizers
EP3554509A4 (en) * 2016-12-15 2020-11-11 The Board of Regents of The University of Texas System Taccalonolide microtubule stabilizers
CN110368717B (en) * 2019-05-30 2021-10-15 郑州大学 Polylactic acid non-woven filter cloth material for oil/water separation and preparation method thereof

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Also Published As

Publication number Publication date
US20080280973A1 (en) 2008-11-13
WO2006004774A2 (en) 2006-01-12

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