WO2006017044A3 - Topical antiviral formulations - Google Patents

Topical antiviral formulations Download PDF

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Publication number
WO2006017044A3
WO2006017044A3 PCT/US2005/023492 US2005023492W WO2006017044A3 WO 2006017044 A3 WO2006017044 A3 WO 2006017044A3 US 2005023492 W US2005023492 W US 2005023492W WO 2006017044 A3 WO2006017044 A3 WO 2006017044A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
topical antiviral
antiviral formulations
topical
nrtis
Prior art date
Application number
PCT/US2005/023492
Other languages
French (fr)
Other versions
WO2006017044A2 (en
Inventor
Terrence C Dahl
Original Assignee
Gilead Sciences Inc
Terrence C Dahl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35839705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006017044(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to RSP-2010/0030A priority Critical patent/RS51213B/en
Priority to US11/631,876 priority patent/US20080035155A1/en
Priority to EA200700311A priority patent/EA017763B1/en
Priority to BRPI0513196-0A priority patent/BRPI0513196A/en
Priority to DK05771562.5T priority patent/DK1773296T3/en
Priority to JP2007520399A priority patent/JP5121451B2/en
Priority to AP2007003873A priority patent/AP2666A/en
Priority to MX2007000122A priority patent/MX2007000122A/en
Priority to CA2570877A priority patent/CA2570877C/en
Priority to NZ552172A priority patent/NZ552172A/en
Priority to EP05771562A priority patent/EP1773296B1/en
Priority to AT05771562T priority patent/ATE447396T1/en
Priority to DE602005017497T priority patent/DE602005017497D1/en
Application filed by Gilead Sciences Inc, Terrence C Dahl filed Critical Gilead Sciences Inc
Priority to CN2005800232101A priority patent/CN1984640B/en
Priority to PL05771562T priority patent/PL1773296T3/en
Priority to AU2005272032A priority patent/AU2005272032B2/en
Priority to KR1020077002108A priority patent/KR101225707B1/en
Publication of WO2006017044A2 publication Critical patent/WO2006017044A2/en
Publication of WO2006017044A3 publication Critical patent/WO2006017044A3/en
Priority to IL180172A priority patent/IL180172A/en
Priority to IS8584A priority patent/IS8584A/en
Priority to HR20070040A priority patent/HRP20070040A2/en
Priority to NO20070762A priority patent/NO20070762L/en
Priority to HK07111247.1A priority patent/HK1103026A1/en
Priority to HR20100038T priority patent/HRP20100038T1/en
Priority to IL206031A priority patent/IL206031A0/en
Priority to US12/893,516 priority patent/US9060933B2/en
Priority to US14/715,519 priority patent/US20150366795A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/02—Contraceptive devices; Pessaries; Applicators therefor for use by males
    • A61F6/04—Condoms, sheaths or the like, e.g. combined with devices protecting against contagion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (NRTIs), preferably [2-(6-Amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid (tenofovir, PMPA), or a physiologically functional derivative thereof, suitable for topical application and their use in the prevention of HIV infections.
PCT/US2005/023492 2004-07-09 2005-07-01 Topical antiviral formulations WO2006017044A2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
KR1020077002108A KR101225707B1 (en) 2004-07-09 2005-07-01 Topical antiviral formulations
PL05771562T PL1773296T3 (en) 2004-07-09 2005-07-01 Pharmaceutical vaginal gel comprising tenofovir
CN2005800232101A CN1984640B (en) 2004-07-09 2005-07-01 Topical antiviral formulations
BRPI0513196-0A BRPI0513196A (en) 2004-07-09 2005-07-01 antiviral topical formulations
US11/631,876 US20080035155A1 (en) 2004-07-09 2005-07-01 Topical Antiviral Formulations
JP2007520399A JP5121451B2 (en) 2004-07-09 2005-07-01 Topical antimicrobial prescription
AP2007003873A AP2666A (en) 2004-07-09 2005-07-01 Topical antiviral formulations
MX2007000122A MX2007000122A (en) 2004-07-09 2005-07-01 Topical antiviral formulations.
CA2570877A CA2570877C (en) 2004-07-09 2005-07-01 Topical antiviral formulations
NZ552172A NZ552172A (en) 2004-07-09 2005-07-01 Topical antiviral formulations comprising [2-(6-amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir)
EP05771562A EP1773296B1 (en) 2004-07-09 2005-07-01 Pharmaceutical vaginal gel comprising tenofovir
AU2005272032A AU2005272032B2 (en) 2004-07-09 2005-07-01 Topical antiviral formulations
DE602005017497T DE602005017497D1 (en) 2004-07-09 2005-07-01 PHARMACEUTICAL VAGINAL GEL WITH TENOFOVIR
RSP-2010/0030A RS51213B (en) 2004-07-09 2005-07-01 Pharmacetical vaginal gel comprising tenofovir
EA200700311A EA017763B1 (en) 2004-07-09 2005-07-01 Pharmaceutical vaginal gel
DK05771562.5T DK1773296T3 (en) 2004-07-09 2005-07-01 Pharmaceutical vaginal gel containing tenofovir
AT05771562T ATE447396T1 (en) 2004-07-09 2005-07-01 PHARMACEUTICAL VAGINAL GEL WITH TENOFOVIR
IL180172A IL180172A (en) 2004-07-09 2006-12-19 Pharmaceutical vaginal gel comprising tenofovir
IS8584A IS8584A (en) 2004-07-09 2006-12-21 Topical preparations for virus protection
HR20070040A HRP20070040A2 (en) 2004-07-09 2007-02-07 Topical antiviral formulations
NO20070762A NO20070762L (en) 2004-07-09 2007-02-08 Topical antiviral preparations
HK07111247.1A HK1103026A1 (en) 2004-07-09 2007-10-18 Pharmaceutical vaginal gel comprising tenofovir
HR20100038T HRP20100038T1 (en) 2004-07-09 2010-01-21 Pharmaceutical vaginal gel comprising tenofovir
IL206031A IL206031A0 (en) 2004-07-09 2010-05-27 Topical antiviral formulations
US12/893,516 US9060933B2 (en) 2004-07-09 2010-09-29 Topical antiviral formulations
US14/715,519 US20150366795A1 (en) 2004-07-09 2015-05-18 Topical antiviral formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58683904P 2004-07-09 2004-07-09
US60/586,839 2004-07-09

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/631,876 A-371-Of-International US20080035155A1 (en) 2004-07-09 2005-07-01 Topical Antiviral Formulations
US12/893,516 Continuation US9060933B2 (en) 2004-07-09 2010-09-29 Topical antiviral formulations

Publications (2)

Publication Number Publication Date
WO2006017044A2 WO2006017044A2 (en) 2006-02-16
WO2006017044A3 true WO2006017044A3 (en) 2006-07-27

Family

ID=35839705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/023492 WO2006017044A2 (en) 2004-07-09 2005-07-01 Topical antiviral formulations

Country Status (31)

Country Link
US (5) US20080035155A1 (en)
EP (4) EP2138163A3 (en)
JP (2) JP5121451B2 (en)
KR (1) KR101225707B1 (en)
CN (1) CN1984640B (en)
AP (1) AP2666A (en)
AR (1) AR050424A1 (en)
AT (1) ATE447396T1 (en)
AU (1) AU2005272032B2 (en)
BR (1) BRPI0513196A (en)
CA (1) CA2570877C (en)
CY (1) CY1109757T1 (en)
DE (1) DE602005017497D1 (en)
DK (1) DK1773296T3 (en)
EA (2) EA201370001A1 (en)
ES (1) ES2336017T3 (en)
HK (1) HK1103026A1 (en)
HR (2) HRP20070040A2 (en)
IL (2) IL180172A (en)
IS (1) IS8584A (en)
MX (1) MX2007000122A (en)
NO (1) NO20070762L (en)
NZ (1) NZ552172A (en)
PL (2) PL382306A1 (en)
PT (1) PT1773296E (en)
RS (1) RS51213B (en)
SI (1) SI1773296T1 (en)
TW (1) TW200612955A (en)
UA (1) UA93354C2 (en)
WO (1) WO2006017044A2 (en)
ZA (1) ZA200700932B (en)

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