WO2006018425A3 - Multiphase biocompatible semi-permeable membrane for biosensors - Google Patents

Multiphase biocompatible semi-permeable membrane for biosensors Download PDF

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Publication number
WO2006018425A3
WO2006018425A3 PCT/EP2005/054000 EP2005054000W WO2006018425A3 WO 2006018425 A3 WO2006018425 A3 WO 2006018425A3 EP 2005054000 W EP2005054000 W EP 2005054000W WO 2006018425 A3 WO2006018425 A3 WO 2006018425A3
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
biosensors
multiphase
permeable membrane
biocompatible semi
Prior art date
Application number
PCT/EP2005/054000
Other languages
French (fr)
Other versions
WO2006018425A2 (en
Inventor
Charlotte C Rossmeisl
Mads Christian Sabra
Michael Gerstenberg
Kristian Glejboel
Thomas Buch-Rasmussen
Original Assignee
Novo Nordisk As
Charlotte C Rossmeisl
Mads Christian Sabra
Michael Gerstenberg
Kristian Glejboel
Thomas Buch-Rasmussen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Charlotte C Rossmeisl, Mads Christian Sabra, Michael Gerstenberg, Kristian Glejboel, Thomas Buch-Rasmussen filed Critical Novo Nordisk As
Priority to EP05775831A priority Critical patent/EP1784249A2/en
Priority to JP2007526455A priority patent/JP2008510154A/en
Publication of WO2006018425A2 publication Critical patent/WO2006018425A2/en
Publication of WO2006018425A3 publication Critical patent/WO2006018425A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/1411—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing dispersed material in a continuous matrix
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/70—Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only
    • B01D71/701—Polydimethylsiloxane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/54—Polyureas; Polyurethanes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/70—Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only

Abstract

This invention relates to a novel two phase biocompatible semi-permeable mem- brane for biosensors and more particularly to a homogenous membrane for us- age in in-vivo sensing of glucose by an enzyme. The membrane comprises of a continuous hydrophilic phase of water swellable polyurethane having discrete particles of polydimethyl siloxane dispersed therein. Furthermore, a membrane having good properties for use as the outer membrane in a biosensor continuous determination of the blood glucose level in vivo, can be prepared by spraying of a polymer solution in a big number of spraying steps, for example, more than 20 steps.
PCT/EP2005/054000 2004-08-16 2005-08-15 Multiphase biocompatible semi-permeable membrane for biosensors WO2006018425A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05775831A EP1784249A2 (en) 2004-08-16 2005-08-15 Multiphase biocompatible semi-permeable membrane for biosensors
JP2007526455A JP2008510154A (en) 2004-08-16 2005-08-15 Multiphase biocompatible semipermeable membrane for biosensors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200401234 2004-08-16
DKPA200401234 2004-08-16
DKPA200401235 2004-08-16
DKPA200401235 2004-08-16

Publications (2)

Publication Number Publication Date
WO2006018425A2 WO2006018425A2 (en) 2006-02-23
WO2006018425A3 true WO2006018425A3 (en) 2006-06-08

Family

ID=35276209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/054000 WO2006018425A2 (en) 2004-08-16 2005-08-15 Multiphase biocompatible semi-permeable membrane for biosensors

Country Status (3)

Country Link
EP (1) EP1784249A2 (en)
JP (1) JP2008510154A (en)
WO (1) WO2006018425A2 (en)

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US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
US8025658B2 (en) 2007-04-30 2011-09-27 Medtronic Minimed, Inc. Adhesive patch systems and methods
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US9339222B2 (en) 2008-09-19 2016-05-17 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US9351677B2 (en) 2009-07-02 2016-05-31 Dexcom, Inc. Analyte sensor with increased reference capacity
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