WO2006026713A3 - Topical benfotiamine and pyridoxamine compositions - Google Patents

Topical benfotiamine and pyridoxamine compositions Download PDF

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Publication number
WO2006026713A3
WO2006026713A3 PCT/US2005/031144 US2005031144W WO2006026713A3 WO 2006026713 A3 WO2006026713 A3 WO 2006026713A3 US 2005031144 W US2005031144 W US 2005031144W WO 2006026713 A3 WO2006026713 A3 WO 2006026713A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
benfotiamine
pyridoxamine
compositions
topical
Prior art date
Application number
PCT/US2005/031144
Other languages
French (fr)
Other versions
WO2006026713A2 (en
Inventor
Marius Morariu
Original Assignee
Tracie Martyn International Ll
Marius Morariu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tracie Martyn International Ll, Marius Morariu filed Critical Tracie Martyn International Ll
Publication of WO2006026713A2 publication Critical patent/WO2006026713A2/en
Publication of WO2006026713A3 publication Critical patent/WO2006026713A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Abstract

The present invention provides a composition comprising an effective amount of benfotiamine and an effective amount of pyridoxamine in a suitable vehicle for topical application. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles, loss of elasticity, and hyperpigmentation caused by chronoaging and/or photoaging of skin, by inhibiting particularly skin damage resulting from reactive carbonyl species (RCS), glycation of skin proteins, formation of advanced glycation endproducts (AGEs) and formation of advanced lipoxidation endproducts (ALEs).
PCT/US2005/031144 2004-08-31 2005-08-31 Topical benfotiamine and pyridoxamine compositions WO2006026713A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60575004P 2004-08-31 2004-08-31
US60/605,750 2004-08-31

Publications (2)

Publication Number Publication Date
WO2006026713A2 WO2006026713A2 (en) 2006-03-09
WO2006026713A3 true WO2006026713A3 (en) 2007-02-15

Family

ID=36000733

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/031144 WO2006026713A2 (en) 2004-08-31 2005-08-31 Topical benfotiamine and pyridoxamine compositions

Country Status (2)

Country Link
US (3) US7666442B2 (en)
WO (1) WO2006026713A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691300B2 (en) 2009-08-28 2014-04-08 Mary Kay Inc. Skin care formulations
CN108024933B (en) * 2015-03-20 2021-04-13 陶氏环球技术有限责任公司 Nitrones to inhibit oxidation of unsaturated fats

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140271788A1 (en) * 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
US20050063932A1 (en) * 2003-08-14 2005-03-24 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
US8211873B2 (en) * 2003-08-29 2012-07-03 Island Kinetics, Inc. Antiaging chirally-correct mitoprotectant amino acid and peptide complexes
US7666442B2 (en) * 2004-08-31 2010-02-23 Tracie Martyn International, Llc Topical compositions comprising benfotiamine and pyridoxamine
KR20060087817A (en) * 2005-01-31 2006-08-03 주식회사 태평양 Anti-aging cosmetic composition
US20060263320A1 (en) * 2005-05-17 2006-11-23 The Procter & Gamble Company Regulation of mammalian keratinous tissue using personal care compositions comprising ergothioneine
US7566464B2 (en) * 2005-09-01 2009-07-28 Belfer William A Cosmetic composition to accelerate repair of functional wrinkles
US20070065396A1 (en) * 2005-09-21 2007-03-22 Tracie Martyn International, Llc Topical macqui berry formulation
EP1993384A2 (en) * 2006-01-11 2008-11-26 Attune Foods Probiotic food, process for its preparation and dietary regimen
CA3123249A1 (en) 2006-01-19 2007-07-26 Mary Kay, Inc. Skin care compositions comprising kakadu plum extract and acai berry extract
US20070237735A1 (en) * 2006-03-31 2007-10-11 Laboratoires Dermo-Cosmetik Inc. Anti-aging composition, kit and method of use
RU2309740C1 (en) * 2006-08-03 2007-11-10 Исаак Григорьевич Гитлин Antioxidant used in prophylaxis if diseases associated with oxidative stress, method for its preparing, granulate containing thereof, and tabletted or capsulated formulated based on thereof
US9198896B2 (en) * 2006-08-21 2015-12-01 National Research Development Corporation In vivo assessment of toxicity and pharmacokinetics of methylglyoxal
US20080188541A1 (en) * 2006-08-21 2008-08-07 Manju Ray In vivo assessment of toxicity and pharmacokinetics of methylglyoxal
ITMI20061854A1 (en) * 2006-09-28 2008-03-29 Genalta S R L BEVERAGE SUITED TO SLOW DOWN CELL DEGENERATION THAT ACCOMPANIES AGING
WO2008045766A2 (en) * 2006-10-10 2008-04-17 True Look Skin Care Inc. Method for treating skin
WO2008074896A1 (en) * 2006-12-21 2008-06-26 Prendergast Patrick T Compositions and methods for treatment of chronic neurological disorders
US8691247B2 (en) * 2006-12-26 2014-04-08 Ad Lunam Labs Inc. Skin rejuvenation cream
JP2008214250A (en) * 2007-03-02 2008-09-18 Hokkaido Mitsui Chemicals Inc Maillard reaction inhibitor
CA2684601C (en) 2007-04-19 2014-04-29 Mary Kay Inc. Cosmetic methods of treating skin with magnolia and citrus grandis extracts containing compositions
CN101134048B (en) * 2007-05-31 2010-11-10 复旦大学附属中山医院 Medicament for preventing and treating alzheimer's disease and caducity
WO2009002500A1 (en) * 2007-06-25 2008-12-31 Smith, Walter, P. Methods and compositions for reducing the appearance of dynamic facial wrinkles
JP2009073764A (en) * 2007-09-20 2009-04-09 Fujifilm Corp Adhesive gel sheet for living body and sheet-like cosmetic using the same
JP2009108007A (en) * 2007-10-31 2009-05-21 Fujifilm Corp Gel sheet and sheet-like cosmetic using the same
EP2330910B1 (en) * 2008-09-11 2017-08-16 Israeli Biotechnology Research Ltd. Cosmetic use of leucojum bulb extracts
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
WO2010050980A1 (en) * 2008-10-31 2010-05-06 Laboratory Skin Care, Inc. Topical formulations comprising hydroxyapatite particles for stimulation and maintenance of collagen fibers
US8198091B2 (en) * 2008-12-24 2012-06-12 Brunswick Laboratories, Llc Method for assaying the antioxidant capacity of a skin care product
CN102325519B (en) 2009-02-23 2014-10-29 荷兰联合利华有限公司 Edible composition for treating cutaneous signs of ageing
US8178106B2 (en) * 2009-03-30 2012-05-15 Mary Kay Inc. Topical skin care formulations
US8765156B2 (en) * 2009-05-04 2014-07-01 Elc Management Llc Topical compositions comprising inorganic particulates and an alkoxylated diphenylacrylate compound
WO2010129313A2 (en) * 2009-05-04 2010-11-11 Elc Management Llc Cosmetic compositions comprising cyanodiphenylacrylates
WO2010151778A2 (en) * 2009-06-25 2010-12-29 Darlene Mccord Topical compositions and methods for wound care
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
US20110160143A1 (en) * 2009-12-28 2011-06-30 Perricone Nicholas V Topical Acyl Glutathione Psoriasis Compositions
KR101695372B1 (en) * 2010-01-07 2017-01-11 한림대학교 산학협력단 Composition for improving wrinkle and elasticity containing ribes nigrum extracts
US8309143B2 (en) 2010-04-16 2012-11-13 Doreen Campbell Hair and scalp care formulations for treating and preventing acne and related skin conditions
US8435541B2 (en) 2010-09-02 2013-05-07 Bath & Body Works Brand Management, Inc. Topical compositions for inhibiting matrix metalloproteases and providing antioxidative activities
CN101972223B (en) * 2010-10-19 2012-02-29 广东雅倩化妆品有限公司 Plant cell agerasia essence
US8609618B2 (en) * 2011-03-25 2013-12-17 N.V. Perricone Llc Topical palmitoyl glutathione formulations
KR101481208B1 (en) * 2011-06-17 2015-01-12 (주)아모레퍼시픽 Composition for skin external application comprising cryptotanshinone as the active ingredient
ITRM20110337A1 (en) * 2011-06-27 2012-12-28 Antonio Costantini VITAMIN B1 FOR USE IN THE TREATMENT OF TELEANGECTASIA.
US9089536B2 (en) 2012-06-06 2015-07-28 Brian J. Smith Ophthalmic solution for absorbing ultraviolet radiation and method for absorbing ultraviolet radiation
US10512655B1 (en) * 2013-03-12 2019-12-24 Jeffrey S. Brooks, Inc. Methods and compositions for the topical treatment of peripheral neuropathy
CN105431164A (en) * 2013-03-13 2016-03-23 斯特梅特里克斯公司 Skin compositions and uses
WO2015089376A1 (en) * 2013-12-12 2015-06-18 Kemin Industries, Inc. Personal care products containing extracts of rosemary
WO2015127163A1 (en) * 2014-02-20 2015-08-27 Phd Biosciences ( Formerly Nanometics Llc) Pyridoxamine for the treatment of sickle cell disease, thalassemia and related blood diseases
JP6403979B2 (en) * 2014-04-28 2018-10-10 株式会社ミルボン Evaluation method of degree of carbonylation
EP3187185A4 (en) 2014-08-29 2018-04-11 Project PM Co., Ltd. Pharmaceutical composition formed by combining pyridoxamine compound and thiamine compound
US20160089320A1 (en) * 2014-09-29 2016-03-31 Barrie Tan Non-Synthetic Emulsion-Based Lipid Formulations and Methods of Use
TWI788111B (en) 2015-01-02 2022-12-21 美商梅拉洛伊卡公司 Multi-supplement compositions
WO2016109853A2 (en) 2015-01-02 2016-07-07 Melaleuca, Inc. Dietary supplement compositions
TWI829098B (en) 2015-01-02 2024-01-11 美商梅拉洛伊卡公司 Bacterial compositions
PL3265053T3 (en) 2015-03-05 2020-03-31 Avon Products, Inc. Methods for treating skin
US10076479B1 (en) 2018-05-08 2018-09-18 Avon Products, Inc. Methods for treating skin
CN105287332B (en) * 2015-10-19 2017-12-05 广州瑾洋化妆品有限公司 A kind of skin whitening, moisturizing composition comprising flower extraction polypeptide, preparation method and application
GB2544046A (en) * 2015-10-30 2017-05-10 Boots Co Plc Skin care composition and method thereof
JP6105111B1 (en) * 2016-03-02 2017-03-29 国立大学法人東北大学 Composition for improving autism spectrum disorder
US20180360739A1 (en) * 2017-06-16 2018-12-20 Celeste Joy Kirsten Lorenz Non-Invasive Applications for Bioactive Agents
CN107815370A (en) * 2017-11-17 2018-03-20 华坪县腾辉酒业有限公司 A kind of blueberry alcoholic drink mixed with fruit juice and preparation method thereof
CN107898748B (en) * 2017-12-27 2021-02-19 大连民族大学 Preparation method of natural camellia oleifera lip balm
CN115969916A (en) * 2017-12-29 2023-04-18 大江生医股份有限公司 Preparation method of golden camellia extract
CN109468370A (en) * 2018-11-09 2019-03-15 广州益养生物科技有限公司 A kind of method of quick detection heredity skin glycosylation capabilities gene
WO2020160619A1 (en) * 2019-02-05 2020-08-13 Helium 3 Biotech Pty Ltd A glycation reducing composition and method of use thereof
US20220296558A1 (en) * 2019-04-26 2022-09-22 Cytosolve, Inc. Compositions for improving brain health and memory
CA3081963A1 (en) 2019-05-31 2020-11-30 American River Nutrition, Llc Compositions comprising quillaja extract and methods of preparations and use thereof
CN110361473B (en) * 2019-08-01 2020-08-25 江南大学 Method for preparing intermediate through reduced glutathione indicating amino acid Maillard reaction
CN110907579A (en) * 2019-12-04 2020-03-24 河南牧业经济学院 HPLC quantitative analysis method for aesculin and aesculetin in pulsatilla chinensis powder
DE202021004226U1 (en) * 2020-04-23 2023-03-21 Mary Kay, Inc. topical cosmetic compositions
CN112587593B (en) * 2020-11-17 2022-05-10 中山大学 Composition for treating acne and preparation method thereof
CN112611819B (en) * 2020-12-30 2022-09-06 上海日馨医药科技股份有限公司 Method for measuring related substances in benfotiamine raw material and preparation thereof
CN112772273A (en) * 2021-01-07 2021-05-11 延边特色产业发展中心 Greenhouse germination accelerating cultivation process for black fungus
EP4035651A1 (en) * 2021-01-11 2022-08-03 Mesoestetic Pharma Group, S.L. Depigmenting dermopharmaceutical or cosmetic composition and use thereof
BR112023018945A2 (en) * 2021-03-18 2023-12-12 Yuva Biosciences Inc COMPOSITIONS AND METHODS TO IMPROVE MITOCHONDRIAL FUNCTION
US11633425B2 (en) 2021-05-13 2023-04-25 Ahava—Dead Sea Laboratories Ltd. Anti-glycation compositions
CN113281433B (en) * 2021-05-19 2022-10-21 一力制药(罗定)有限公司 Content determination method of traditional Chinese medicine composition preparation for treating gastrointestinal type cold
CN115024993B (en) * 2022-05-12 2023-09-01 广州銮滢化妆品有限公司 Anti-saccharification thio composition and preparation method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819480A (en) * 1969-09-11 1974-06-25 R Hochschild Composition of methionine with 2-dimethylaminoethanol
JPS5821618A (en) * 1981-07-31 1983-02-08 Sankyo Co Ltd Immunoregulator composed of vitamin b composition
US5443834A (en) * 1991-03-08 1995-08-22 Fuji Sangyo Kaisha, Ltd. Soap compounded with vitamin B1 -containing garlic extract
US6011067A (en) * 1999-06-11 2000-01-04 Thione International, Inc. Antioxidant composition for the treatment of psoriasis and related diseases
US6455589B1 (en) * 1999-10-28 2002-09-24 The Regents Of The University Of California Primary N-hydroxylamines
US20030190337A1 (en) * 2002-03-28 2003-10-09 The Procter & Gamble Company Methods for regulating the condition of mammalian keratinous tissue via topical application of vitamin B6 compositions
US6759065B1 (en) * 1998-06-18 2004-07-06 Xenobiosis Extraction method, pharmaceutical composition and a cosmetic composition

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5106979A (en) * 1989-02-21 1992-04-21 University Of Pittsburgh Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
US6165500A (en) * 1990-08-24 2000-12-26 Idea Ag Preparation for the application of agents in mini-droplets
JP3545403B2 (en) * 1993-04-22 2004-07-21 スカイファルマ インコーポレイテッド Cyclodextrin liposomes encapsulating pharmaceutical compounds and methods of use
FR2711060B1 (en) * 1993-10-13 1995-11-17 Oreal Method for modifying the growth of hair and / or hair and compositions which can be used for this purpose.
CA2735293A1 (en) * 1995-01-17 1996-07-18 Menuco Corp. Nadh and nadph therapeutic agents for dermal administration
US6740668B1 (en) * 1995-08-28 2004-05-25 Kansas University Medical Center Methods for inhibiting diabetic complications
US6750209B1 (en) * 1995-09-12 2004-06-15 Kansas University Medical Center Advanced glycation end-product intermediaries and post-amadori inhibition
EP0927025A4 (en) * 1996-09-18 2001-07-25 Dragoco Inc Liposome encapsulated active agent dry powder composition
ZA99252B (en) * 1998-01-16 1999-07-14 Centaur Pharmaceuticals Inc Thioether furan nitrone compounds.
DE19838636A1 (en) * 1998-08-26 2000-03-02 Basf Ag Carotenoid formulations containing a mixture of beta-carotene, lycopene and lutein
US6093404A (en) * 1999-06-29 2000-07-25 Kattan; Maha Therapeutic composition
PT102509A (en) * 2000-08-16 2002-02-28 Fundacao Essprit Icarus PHARMACEUTICAL, COSMETIC AND DERMO-COSMETIC COMPOSITIONS, OF HYGIENE, FOOD AND FODDER, BASED ON FOCUS OIL, AND THEIR USE
US6447820B1 (en) * 2001-01-22 2002-09-10 Sarfaraz K Niazi Pharmaceutical composition for the prevention and treatment of scar tissue
JP2002275070A (en) * 2001-03-22 2002-09-25 Kowa Co Benfotiamine-containing oral pharmaceutical preparation
US20030165456A1 (en) * 2001-05-14 2003-09-04 Avon Products Skin care compositions and methods of improving aesthetic appearance of skin using same
US6783754B2 (en) * 2001-06-11 2004-08-31 Roy J. Mankovitz Plant-based non-toxic sunscreen products
US7226583B2 (en) * 2002-08-12 2007-06-05 Hair Systems, Inc. Composition containing leukocyte extract for the whitening or lightening of skin
US20040122061A1 (en) * 2002-08-30 2004-06-24 Biostratum, Inc. Inhibitors of post-amadori advanced glycation end products
US20040092482A1 (en) * 2002-11-07 2004-05-13 Gupta Shyam K. Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions
US20050019354A1 (en) 2003-07-23 2005-01-27 Perricone Nicholas V. Topical benfotiamine treatments
US7666442B2 (en) * 2004-08-31 2010-02-23 Tracie Martyn International, Llc Topical compositions comprising benfotiamine and pyridoxamine

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819480A (en) * 1969-09-11 1974-06-25 R Hochschild Composition of methionine with 2-dimethylaminoethanol
JPS5821618A (en) * 1981-07-31 1983-02-08 Sankyo Co Ltd Immunoregulator composed of vitamin b composition
US5443834A (en) * 1991-03-08 1995-08-22 Fuji Sangyo Kaisha, Ltd. Soap compounded with vitamin B1 -containing garlic extract
US6759065B1 (en) * 1998-06-18 2004-07-06 Xenobiosis Extraction method, pharmaceutical composition and a cosmetic composition
US6011067A (en) * 1999-06-11 2000-01-04 Thione International, Inc. Antioxidant composition for the treatment of psoriasis and related diseases
US6455589B1 (en) * 1999-10-28 2002-09-24 The Regents Of The University Of California Primary N-hydroxylamines
US20030190337A1 (en) * 2002-03-28 2003-10-09 The Procter & Gamble Company Methods for regulating the condition of mammalian keratinous tissue via topical application of vitamin B6 compositions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691300B2 (en) 2009-08-28 2014-04-08 Mary Kay Inc. Skin care formulations
US8895082B2 (en) 2009-08-28 2014-11-25 Mary Kay Inc. Skin care formulations
CN108024933B (en) * 2015-03-20 2021-04-13 陶氏环球技术有限责任公司 Nitrones to inhibit oxidation of unsaturated fats

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US20060045896A1 (en) 2006-03-02

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