WO2006033935A3 - Perfusion bioreactor for culturing cells - Google Patents

Perfusion bioreactor for culturing cells Download PDF

Info

Publication number
WO2006033935A3
WO2006033935A3 PCT/US2005/032818 US2005032818W WO2006033935A3 WO 2006033935 A3 WO2006033935 A3 WO 2006033935A3 US 2005032818 W US2005032818 W US 2005032818W WO 2006033935 A3 WO2006033935 A3 WO 2006033935A3
Authority
WO
WIPO (PCT)
Prior art keywords
unit
bioreactor
culturing cells
perfusion bioreactor
perfusion
Prior art date
Application number
PCT/US2005/032818
Other languages
French (fr)
Other versions
WO2006033935A2 (en
WO2006033935A9 (en
Inventor
Neil F Robbins
Jon Rowley
Mark Quinto
Abel Z Hastings
Bryan G Towns
Bradley R Snodgrass
Original Assignee
Becton Dickinson Co
Neil F Robbins
Jon Rowley
Mark Quinto
Abel Z Hastings
Bryan G Towns
Bradley R Snodgrass
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co, Neil F Robbins, Jon Rowley, Mark Quinto, Abel Z Hastings, Bryan G Towns, Bradley R Snodgrass filed Critical Becton Dickinson Co
Priority to AU2005287162A priority Critical patent/AU2005287162B2/en
Priority to CA002579680A priority patent/CA2579680A1/en
Priority to EP05796533A priority patent/EP1789528A4/en
Priority to JP2007532438A priority patent/JP4914835B2/en
Publication of WO2006033935A2 publication Critical patent/WO2006033935A2/en
Publication of WO2006033935A9 publication Critical patent/WO2006033935A9/en
Publication of WO2006033935A3 publication Critical patent/WO2006033935A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices

Abstract

A bioreactor system comprising a multi-well platform including an array of bioreactor units. The bioreactor system comprises a perfusion unit (86) and a fluid source unit (92) fluidly interconnected by a pumping unit (82). The perfusion unit comprises a multi-well plate including a plurality of main chambers (83) configured to house or contain a cell culture and in each bioreactor unit an independent cell study or experiment may be performed.
PCT/US2005/032818 2004-09-16 2005-09-16 Perfusion bioreactor for culturing cells WO2006033935A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2005287162A AU2005287162B2 (en) 2004-09-16 2005-09-16 Perfusion bioreactor for culturing cells
CA002579680A CA2579680A1 (en) 2004-09-16 2005-09-16 Perfusion bioreactor for culturing cells
EP05796533A EP1789528A4 (en) 2004-09-16 2005-09-16 Perfusion bioreactors for culturing cells
JP2007532438A JP4914835B2 (en) 2004-09-16 2005-09-16 Perfusion bioreactor for cell culture

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94189204A 2004-09-16 2004-09-16
US10/941,892 2004-09-16
US69984905P 2005-07-18 2005-07-18
US60/699,849 2005-07-18

Publications (3)

Publication Number Publication Date
WO2006033935A2 WO2006033935A2 (en) 2006-03-30
WO2006033935A9 WO2006033935A9 (en) 2006-05-26
WO2006033935A3 true WO2006033935A3 (en) 2006-10-26

Family

ID=36090481

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/032818 WO2006033935A2 (en) 2004-09-16 2005-09-16 Perfusion bioreactor for culturing cells

Country Status (5)

Country Link
EP (1) EP1789528A4 (en)
JP (1) JP4914835B2 (en)
AU (1) AU2005287162B2 (en)
CA (1) CA2579680A1 (en)
WO (1) WO2006033935A2 (en)

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US20100159590A1 (en) * 2006-10-05 2010-06-24 Nanopoint, Inc. Systems and methods for active microfluidic cell handling
PT104155B (en) 2008-08-06 2017-04-05 Ass For The Advancement Of Tissue Eng And Cell Based Tech & Therapies (A4Tec) MULTI-CAMERA BIOREACTOR WITH BIDIRECTIONAL PERFUSION INTEGRATED IN A CULTURE SYSTEM FOR APPLICATION IN STRATEGIES OF TISSUE ENGINEERING
JP2010207174A (en) * 2009-03-12 2010-09-24 Atto Corp Perfusion cultivation system
WO2010110754A1 (en) * 2009-03-26 2010-09-30 Agency For Science, Technology And Research Apparatus for cell or tissue culture
JP4903252B2 (en) * 2009-11-30 2012-03-28 株式会社日立製作所 Cell culture equipment
WO2011073261A2 (en) 2009-12-16 2011-06-23 Vivabiocell Spa A continuous culturing device
JP5881621B2 (en) * 2010-03-02 2016-03-09 ユニヴェルシテ テクノロジエ デ コンピエーニュ−ユテセ Multi-reactor box for dynamic cell culture
US9518249B2 (en) 2010-12-16 2016-12-13 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
US9453197B2 (en) 2010-12-16 2016-09-27 General Electric Company Methods of making cell carrier
US9453196B2 (en) 2010-12-16 2016-09-27 General Electric Company Cell carrier, methods of making and use
US9926523B2 (en) 2010-12-16 2018-03-27 General Electric Company Cell carriers and methods for culturing cells
US9534206B2 (en) 2010-12-16 2017-01-03 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
US20120156777A1 (en) * 2010-12-16 2012-06-21 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
PT2712918E (en) * 2012-09-28 2015-02-17 Tissuse Gmbh Multi-organ-chip with improved life time and homoeostasis
GB201223495D0 (en) * 2012-12-30 2013-02-13 Plummer Simon M A Bioreactor
EP3460049A1 (en) 2013-02-22 2019-03-27 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
WO2014130872A2 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
TWI743024B (en) * 2014-06-06 2021-10-21 美商健臻公司 Perfusion culturing methods and uses thereof
TWI776235B (en) 2014-06-09 2022-09-01 美商健臻公司 Seed train processes and uses thereof
BR112017013423B1 (en) 2014-12-22 2023-04-11 Genzyme Corporation MAMMALIAN CELL CULTIVATION METHODS
US20180105784A1 (en) * 2015-03-30 2018-04-19 Takasago Electric, Inc. Culture medium exchange unit
KR102170373B1 (en) 2016-05-02 2020-10-27 인테그리컬쳐 인코포레이티드 Growth induction system, growth induction control device, growth induction control method, and growth induction control program
JP6111510B1 (en) 2016-05-02 2017-04-12 インテグリカルチャー株式会社 Growth induction system, growth induction control device, growth induction control method, and growth induction control program
JP6968381B2 (en) * 2016-09-09 2021-11-17 国立大学法人 東京大学 Cell culture device
WO2018096054A1 (en) * 2016-11-24 2018-05-31 Alveolix Ag Cell culturing system and method
KR20200051700A (en) * 2017-09-19 2020-05-13 어드밴스드 솔루션즈 라이프 사이언스, 엘엘씨 Well-plate, fluid manifold assembly and method
CN107435023A (en) * 2017-09-19 2017-12-05 中国医学科学院输血研究所 A kind of bioreactor and biologic reaction equipment
US11680241B2 (en) 2018-02-08 2023-06-20 University Of Florida Research Foundation, Inc. Perfusion enabled bioreactors
CN112041422A (en) * 2018-02-08 2020-12-04 佛罗里达大学研究基金会公司 Bioreactor with perfusion function
JP7061356B2 (en) * 2018-02-28 2022-04-28 国立大学法人横浜国立大学 Culture equipment, methods for constructing two or more types of cell structures, and on-chip organ devices
JP7193612B2 (en) * 2019-03-07 2022-12-20 Ｐｈｃホールディングス株式会社 Medium exchange device
CN115052966A (en) 2020-02-05 2022-09-13 生命Taq分析学有限责任公司 Three-dimensional cell culture
CN113025491A (en) * 2021-03-17 2021-06-25 杭州电子科技大学 Perfusion reactor for in-vitro dynamic culture of cells

Citations (3)

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US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US6548263B1 (en) * 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US20030215941A1 (en) * 2002-03-12 2003-11-20 Stewart Campbell Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound

Family Cites Families (1)

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JP2005531300A (en) * 2002-04-08 2005-10-20 ミレニアム・バイオロジクス，インコーポレイテッド Automatic tissue engineering module

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548263B1 (en) * 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6197575B1 (en) * 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US20030215941A1 (en) * 2002-03-12 2003-11-20 Stewart Campbell Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound

Also Published As

Publication number Publication date
JP4914835B2 (en) 2012-04-11
WO2006033935A2 (en) 2006-03-30
AU2005287162A1 (en) 2006-03-30
AU2005287162B2 (en) 2010-12-23
CA2579680A1 (en) 2006-03-30
JP2008513013A (en) 2008-05-01
WO2006033935A9 (en) 2006-05-26
EP1789528A4 (en) 2011-07-20
EP1789528A2 (en) 2007-05-30

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