WO2006037059A3 - Point-of-care mass spectrometer system - Google Patents

Point-of-care mass spectrometer system Download PDF

Info

Publication number
WO2006037059A3
WO2006037059A3 PCT/US2005/034868 US2005034868W WO2006037059A3 WO 2006037059 A3 WO2006037059 A3 WO 2006037059A3 US 2005034868 W US2005034868 W US 2005034868W WO 2006037059 A3 WO2006037059 A3 WO 2006037059A3
Authority
WO
WIPO (PCT)
Prior art keywords
point
mass spectrometer
sample
structured
spectrometer system
Prior art date
Application number
PCT/US2005/034868
Other languages
French (fr)
Other versions
WO2006037059A2 (en
Inventor
Robert James Cotter
Original Assignee
Johns Hopkins Universtiy
Robert James Cotter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins Universtiy, Robert James Cotter filed Critical Johns Hopkins Universtiy
Priority to US11/663,844 priority Critical patent/US7576323B2/en
Publication of WO2006037059A2 publication Critical patent/WO2006037059A2/en
Publication of WO2006037059A3 publication Critical patent/WO2006037059A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

A point-of-care mass spectrometer system has a sampling system, an ionization component structured to receive a sample for analysis from the sampling system, a mass analyzer structured to receive a source of ions for analysis from the ionization component, and a detector structured to detect ions from the mass analyzer and to generate an output signal. The sampling system selects a subset of peptides from a sample by immunopurification of multiple histocompatability complexes and concentrates the subset of peptides to provide the sample to the ionization component.
PCT/US2005/034868 2004-09-27 2005-09-27 Point-of-care mass spectrometer system WO2006037059A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/663,844 US7576323B2 (en) 2004-09-27 2005-09-27 Point-of-care mass spectrometer system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61326904P 2004-09-27 2004-09-27
US60/613,269 2004-09-27

Publications (2)

Publication Number Publication Date
WO2006037059A2 WO2006037059A2 (en) 2006-04-06
WO2006037059A3 true WO2006037059A3 (en) 2007-02-22

Family

ID=36119577

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/034868 WO2006037059A2 (en) 2004-09-27 2005-09-27 Point-of-care mass spectrometer system

Country Status (2)

Country Link
US (1) US7576323B2 (en)
WO (1) WO2006037059A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576323B2 (en) * 2004-09-27 2009-08-18 Johns Hopkins University Point-of-care mass spectrometer system
US20100320377A1 (en) * 2007-11-09 2010-12-23 The Johns Hopkins University Low voltage, high mass range ion trap spectrometer and analyzing methods using such a device
WO2011084751A1 (en) * 2009-12-21 2011-07-14 Quest Diagnostics Investments Incorporated Glucagon detection and quantitation by mass spectrometry
US8642951B2 (en) 2011-05-04 2014-02-04 Agilent Technologies, Inc. Device, system, and method for reflecting ions

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498039B2 (en) * 1995-06-07 2002-12-24 Arizona Board Of Regents Sample presentation apparatus for mass spectrometry
US20030073145A1 (en) * 2001-10-15 2003-04-17 Richard Caprioli Methods and apparatus for analyzing biological samples by mass spectrometry
US6558902B1 (en) * 1998-05-07 2003-05-06 Sequenom, Inc. Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules
US20030119063A1 (en) * 2002-09-03 2003-06-26 Pham Thang T. High accuracy protein identification
US20030153007A1 (en) * 2001-12-28 2003-08-14 Jian Chen Automated systems and methods for analysis of protein post-translational modification
US20040005633A1 (en) * 2001-03-22 2004-01-08 Joel Vandekerckhove Methods and apparatuses for gel-free qualitative and quantitative proteome analysis, and uses therefore
US20040214783A1 (en) * 2002-05-08 2004-10-28 Terman David S. Compositions and methods for treatment of neoplastic disease
US20040224338A1 (en) * 1998-08-12 2004-11-11 Zycos Inc., A Delaware Corporation Profiling and cataloging expressed protein tags
US20050020485A1 (en) * 2002-01-11 2005-01-27 Winslow Robert M. Methods and compositions for oxygen transport comprising modified hemoglobin in plasma
US20050158745A1 (en) * 2003-11-25 2005-07-21 Ye Jack Z. Methods and compositions for detection of nasopharyngeal carcinoma

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830641A (en) 1986-01-22 1998-11-03 Institut Pasteur In vitro diagnostic assays for the detection of HIV-1 or HIV-2 employing viral-specific antigens and antibodies
US5101105A (en) 1990-11-02 1992-03-31 Univeristy Of Maryland, Baltimore County Neutralization/chemical reionization tandem mass spectrometry method and apparatus therefor
US5202563A (en) 1991-05-16 1993-04-13 The Johns Hopkins University Tandem time-of-flight mass spectrometer
US5399857A (en) 1993-05-28 1995-03-21 The Johns Hopkins University Method and apparatus for trapping ions by increasing trapping voltage during ion introduction
US5464985A (en) 1993-10-01 1995-11-07 The Johns Hopkins University Non-linear field reflectron
US6660276B1 (en) 1994-02-16 2003-12-09 The University Of Virginia Patent Foundation Peptides recognized by melanoma-specific cytotoxic lymphocytes, and uses therefor
WO1995029193A2 (en) 1994-04-22 1995-11-02 The Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services Melanoma antigens
US5874560A (en) 1994-04-22 1999-02-23 The United States Of America As Represented By The Department Of Health And Human Services Melanoma antigens and their use in diagnostic and therapeutic methods
US5770201A (en) 1994-12-23 1998-06-23 Rijsuniversiteit Te Leiden HA-2 antigenic peptide
US5572025A (en) 1995-05-25 1996-11-05 The Johns Hopkins University, School Of Medicine Method and apparatus for scanning an ion trap mass spectrometer in the resonance ejection mode
DE69637524D1 (en) 1995-07-27 2008-06-26 Univ Leiden THE H-Y ANTIGEN
US5696376A (en) 1996-05-20 1997-12-09 The Johns Hopkins University Method and apparatus for isolating ions in an ion trap with increased resolving power
US5814813A (en) 1996-07-08 1998-09-29 The Johns Hopkins University End cap reflection for a time-of-flight mass spectrometer and method of using the same
EP0966480A2 (en) 1997-01-30 1999-12-29 The University Of Virginia Patent Foundation Cysteine-depleted peptides recognized by a3-restricted cytotoxic lymphocytes, and uses therefor
US6139734A (en) 1997-10-20 2000-10-31 University Of Virginia Patent Foundation Apparatus for structural characterization of biological moieties through HPLC separation
AU1532999A (en) 1997-11-24 1999-06-15 Johns Hopkins University, The Method and apparatus for correction of initial ion velocity in a reflectron time-of-flight mass spectrometer
AU6197900A (en) 1999-06-11 2001-01-02 Johns Hopkins University, The Method and apparatus of mass-correlated pulsed extraction for a time-of-flight mass spectrometer
US7521202B2 (en) * 1999-12-17 2009-04-21 The Board Of Regents Of The University Of Oklahoma Method and apparatus for the production of soluble MHC antigens and uses thereof
KR20020089357A (en) * 2000-02-23 2002-11-29 자이오믹스, 인코포레이티드 Chips having elevated sample surfaces
AU2001259470A1 (en) * 2000-05-05 2001-11-20 Purdue Research Foundation Affinity selected signature peptides for protein identification and quantification
CA2419159A1 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
FR2824326B1 (en) * 2001-05-04 2004-03-19 Commissariat Energie Atomique MIXTURE OF PEPTIDES FROM PAPILLOMAVIRUS E6 AND / OR E7 PROTEINS AND THEIR APPLICATIONS
AU2003217384A1 (en) * 2002-02-13 2003-09-04 Ludwig Institute For Cancer Research Isolated peptides which bind to hla molecules and uses thereof
AU2003226331A1 (en) 2002-04-10 2003-10-27 Johns Hopkins University Miniaturized sample scanning mass analyzer
AU2003299457A1 (en) 2002-04-10 2004-05-25 Johns Hopkins University Combined chemical/biological agent mass spectrometer detector
CA2485695A1 (en) * 2002-05-24 2003-12-04 Fred W. Wagner Method for universal enzymatic production of bioactive peptides
AU2003238769A1 (en) 2002-05-30 2003-12-19 The Johns Hopkins University Time of flight mass specrometer combining fields non-linear in time and space
US7372021B2 (en) * 2002-05-30 2008-05-13 The Johns Hopkins University Time-of-flight mass spectrometer combining fields non-linear in time and space
WO2003107387A1 (en) 2002-05-30 2003-12-24 The Johns Hopkins University Non-linear time-of-flight mass spectrometer
US20040235186A1 (en) * 2002-07-16 2004-11-25 President And Fellows Of Harvard College Non-affinity based isotope tagged peptides and methods for using the same
US7271397B2 (en) 2002-07-18 2007-09-18 The Johns Hopkins University Combined chemical/biological agent detection system and method utilizing mass spectrometry
US20040209808A1 (en) * 2003-02-11 2004-10-21 Kornacker Michael G. Modulators of human G-protein coupled receptors
JP2006518918A (en) * 2003-02-21 2006-08-17 ジヨーンズ ホプキンズ ユニバーシティ Tandem time-of-flight mass spectrometer
CA2528370A1 (en) * 2003-06-06 2005-05-12 President And Fellows Of Harvard College Capture and release based isotope tagged peptides and methods for using the same
US20050202485A1 (en) 2004-03-03 2005-09-15 Ye Jack Z. Method and compositions for detection of liver cancer
JP2005262340A (en) * 2004-03-16 2005-09-29 Fanuc Ltd Industrial robot
US7723063B2 (en) * 2004-04-28 2010-05-25 Intrinsic Lifesciences Methods for measuring levels of bioactive human hepcidin
US7576323B2 (en) * 2004-09-27 2009-08-18 Johns Hopkins University Point-of-care mass spectrometer system

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498039B2 (en) * 1995-06-07 2002-12-24 Arizona Board Of Regents Sample presentation apparatus for mass spectrometry
US6558902B1 (en) * 1998-05-07 2003-05-06 Sequenom, Inc. Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules
US20040224338A1 (en) * 1998-08-12 2004-11-11 Zycos Inc., A Delaware Corporation Profiling and cataloging expressed protein tags
US20050196823A1 (en) * 2001-03-22 2005-09-08 Joel Vandekerckhove Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
US20040005633A1 (en) * 2001-03-22 2004-01-08 Joel Vandekerckhove Methods and apparatuses for gel-free qualitative and quantitative proteome analysis, and uses therefore
US6908740B2 (en) * 2001-03-22 2005-06-21 Joel Vandekerckhove Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
US20050029444A1 (en) * 2001-10-15 2005-02-10 Vanderbilt University Methods and apparatuses for analyzing biological samples by mass spectrometry
US20030073145A1 (en) * 2001-10-15 2003-04-17 Richard Caprioli Methods and apparatus for analyzing biological samples by mass spectrometry
US6756586B2 (en) * 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
US20030153007A1 (en) * 2001-12-28 2003-08-14 Jian Chen Automated systems and methods for analysis of protein post-translational modification
US20050020485A1 (en) * 2002-01-11 2005-01-27 Winslow Robert M. Methods and compositions for oxygen transport comprising modified hemoglobin in plasma
US20040214783A1 (en) * 2002-05-08 2004-10-28 Terman David S. Compositions and methods for treatment of neoplastic disease
US20030119063A1 (en) * 2002-09-03 2003-06-26 Pham Thang T. High accuracy protein identification
US20050158745A1 (en) * 2003-11-25 2005-07-21 Ye Jack Z. Methods and compositions for detection of nasopharyngeal carcinoma

Also Published As

Publication number Publication date
WO2006037059A2 (en) 2006-04-06
US20080258054A1 (en) 2008-10-23
US7576323B2 (en) 2009-08-18

Similar Documents

Publication Publication Date Title
WO2008112351A3 (en) Method of multiplexed analysis using ion mobility spectrometer
WO2005067582A3 (en) Methods and apparatus for enhanced sample identification based on combined analytical techniques
WO2005074584A3 (en) Compact sample analysis systems and related methods using combined chromatography and mobility spectrometry techniques
EP2086000A3 (en) Methods and Apparatus for Reducing Noise in Mass Spectrometry
WO2007120373A3 (en) Differential mobility spectrometer analyzer and pre-filter apparatus, methods and systems
WO2006110848A3 (en) Chromatographic and mass spectral data analysis
GB2421352B (en) Laser system for the ionisation of a sample by matrix-assisted laser desorption in mass spectrometric analysis
TW200729274A (en) Electrospray-assisted laser desorption ionization devices, mass spectrometers, and methods for mass spectrometry
WO2007084151A3 (en) Multiple trace portal detection systems
WO2008036616A3 (en) Apparatus and method for field asymmetric ion mobility spectrometry combined with mass spectrometry.
WO2008100941A3 (en) A method for calibrating an analytical instrument
WO2007103693A3 (en) A sampling system for use with surface ionization spectroscopy
WO2006107339A3 (en) Free thyroxine and free triiodothyronine analysis by mass spectrometry
WO2008008867A3 (en) Data acquisition system and method for a spectrometer
WO2006065617A3 (en) Matching receive signal strength data associated with radio emission sources for positioning applications
ATE538715T1 (en) SYSTEM FOR IN VIVO ANALYSIS
MX2009006600A (en) Sample analyser.
WO2010107654A3 (en) Split flow device for analyses of specific-binding partners
WO2015036447A3 (en) Targeted mass analysis
WO2010099108A3 (en) Multiplexing derivatized anayltes using mass spectroscopy
WO2007086831A3 (en) Tandem differential mobility ion mobility spectrometer for chemical vapor detection
WO2008112032A3 (en) Solid phase and catalyzed enabled automated isotope dilution and speciated isotope dilution mass spectrometry
WO2004040407A3 (en) Methods, systems and computer programs for deconvolving the spectral contribution of chemical constituents with overlapping signals
WO2007112234A3 (en) Means and method for analyzing samples by mass spectrometry
WO2011079269A3 (en) Stack gas measurement device and method therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 11663844

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05815136

Country of ref document: EP

Kind code of ref document: A2