WO2006062559A3 - Device for enhancing tissue glucose processing - Google Patents

Device for enhancing tissue glucose processing Download PDF

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Publication number
WO2006062559A3
WO2006062559A3 PCT/US2005/029199 US2005029199W WO2006062559A3 WO 2006062559 A3 WO2006062559 A3 WO 2006062559A3 US 2005029199 W US2005029199 W US 2005029199W WO 2006062559 A3 WO2006062559 A3 WO 2006062559A3
Authority
WO
WIPO (PCT)
Prior art keywords
glucose
processing
body tissue
subject
total body
Prior art date
Application number
PCT/US2005/029199
Other languages
French (fr)
Other versions
WO2006062559A2 (en
Inventor
Thomas T Aoki
Original Assignee
Thomas T Aoki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas T Aoki filed Critical Thomas T Aoki
Priority to CN2005800478050A priority Critical patent/CN101443033B/en
Publication of WO2006062559A2 publication Critical patent/WO2006062559A2/en
Publication of WO2006062559A3 publication Critical patent/WO2006062559A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration

Abstract

The present invention is a device for delivering insulin to a subject to improve impaired total body tissue glucose processing. The device delivers one or more pulses of insulin to the subject over a period of time accompanied by ingestion of glucose in the form of a carbohydrate containing meal. The number of pulses, the amount of insulin in each pulse, the interval between pulses and the amount of time to deliver each pulse to the subject are selected so that total body tissue processing of glucose is restored in the subject. In subjects whose total body tissue glucose processing has been restored, there is a subsequent fall in circulating blood glucose levels of 50 mg/dl or more primarily and directly as a result of improved total body tissue glucose processing.
PCT/US2005/029199 2004-12-08 2005-08-15 Device for enhancing tissue glucose processing WO2006062559A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2005800478050A CN101443033B (en) 2004-12-08 2005-08-15 Device for enhancing tissue glucose processing

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/007,390 2004-12-08
US11/007,390 US20060122099A1 (en) 2004-12-08 2004-12-08 Method for infusing insulin to a subject to improve impaired total body tissue glucose processing
US11/006,863 US20060122098A1 (en) 2004-12-08 2004-12-08 System for infusing insulin to a subject to imporve impaired total body tissue glucose processing
US11/006,863 2004-12-08

Publications (2)

Publication Number Publication Date
WO2006062559A2 WO2006062559A2 (en) 2006-06-15
WO2006062559A3 true WO2006062559A3 (en) 2009-04-16

Family

ID=36575097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029199 WO2006062559A2 (en) 2004-12-08 2005-08-15 Device for enhancing tissue glucose processing

Country Status (3)

Country Link
US (2) US20060122099A1 (en)
CN (1) CN101443033B (en)
WO (1) WO2006062559A2 (en)

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US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
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US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
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US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
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US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
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US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
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US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
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US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
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Citations (1)

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US4826810A (en) * 1983-12-16 1989-05-02 Aoki Thomas T System and method for treating animal body tissues to improve the dietary fuel processing capabilities thereof

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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826810A (en) * 1983-12-16 1989-05-02 Aoki Thomas T System and method for treating animal body tissues to improve the dietary fuel processing capabilities thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AOKI, T. T. ET AL.: "Effect of Intensive Insulin Therapy on Progression of Overt Nephropathy in Patients with Type 1 Diabetes Mellitus", ENDOCRINE PRACTICE, vol. 5, no. 4, July 1999 (1999-07-01), pages 174 - 178 *
HEINEMANN, L. ET AL.: "Pulsatile insulin infusion and glucose-homeostasis in well-controlled Type 1 (insulin-dependent) diabetic patients", JOURNAL OF INTERNAL MEDICINE, vol. 226, 1989, pages 325 - 330 *

Also Published As

Publication number Publication date
WO2006062559A2 (en) 2006-06-15
CN101443033B (en) 2012-01-11
US20060122098A1 (en) 2006-06-08
US20060122099A1 (en) 2006-06-08
CN101443033A (en) 2009-05-27

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