WO2006066074A3 - Lung-targeted drugs - Google Patents

Lung-targeted drugs Download PDF

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Publication number
WO2006066074A3
WO2006066074A3 PCT/US2005/045579 US2005045579W WO2006066074A3 WO 2006066074 A3 WO2006066074 A3 WO 2006066074A3 US 2005045579 W US2005045579 W US 2005045579W WO 2006066074 A3 WO2006066074 A3 WO 2006066074A3
Authority
WO
WIPO (PCT)
Prior art keywords
lung
targeted drugs
small cell
ethers
lycerol
Prior art date
Application number
PCT/US2005/045579
Other languages
French (fr)
Other versions
WO2006066074A2 (en
Inventor
Karl Y Hostetler
James R Beadle
Original Assignee
Univ California
Karl Y Hostetler
James R Beadle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Karl Y Hostetler, James R Beadle filed Critical Univ California
Priority to US11/793,276 priority Critical patent/US8101745B2/en
Priority to EP05854325A priority patent/EP1831235B1/en
Priority to ES05854325T priority patent/ES2401285T3/en
Publication of WO2006066074A2 publication Critical patent/WO2006066074A2/en
Publication of WO2006066074A3 publication Critical patent/WO2006066074A3/en
Priority to US13/353,034 priority patent/US8318700B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Abstract

Methods and compositions are provided for treating lung diseases, including but not limited to infections and small cell and non-small cell lung cancer, by conjugating a drug of interest to glycerol ethers or lycerol phosphate ethers.
PCT/US2005/045579 2004-12-16 2005-12-15 Lung-targeted drugs WO2006066074A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/793,276 US8101745B2 (en) 2004-12-16 2005-12-15 Lung-targeted drugs
EP05854325A EP1831235B1 (en) 2004-12-16 2005-12-15 Lung-targeted drugs
ES05854325T ES2401285T3 (en) 2004-12-16 2005-12-15 Drugs with lung as target
US13/353,034 US8318700B2 (en) 2004-12-16 2012-01-18 Lung-targeted drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63719504P 2004-12-16 2004-12-16
US60/637,195 2004-12-16

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/793,276 A-371-Of-International US8101745B2 (en) 2004-12-16 2005-12-15 Lung-targeted drugs
US13/353,034 Continuation US8318700B2 (en) 2004-12-16 2012-01-18 Lung-targeted drugs

Publications (2)

Publication Number Publication Date
WO2006066074A2 WO2006066074A2 (en) 2006-06-22
WO2006066074A3 true WO2006066074A3 (en) 2006-09-08

Family

ID=36570533

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/045579 WO2006066074A2 (en) 2004-12-16 2005-12-15 Lung-targeted drugs

Country Status (4)

Country Link
US (2) US8101745B2 (en)
EP (1) EP1831235B1 (en)
ES (1) ES2401285T3 (en)
WO (1) WO2006066074A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1868628B1 (en) 2005-04-08 2014-06-11 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
EP2842559A3 (en) * 2005-04-08 2015-03-18 Chimerix, Inc. Compounds, compositions and methods for the treatment of viral infections and other medical disorders
JP5320284B2 (en) * 2006-05-03 2013-10-23 キメリクス，インコーポレーテッド Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
WO2009094190A2 (en) 2008-01-25 2009-07-30 Chimerix, Inc. Methods of treating viral infections
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
EP3216789A1 (en) 2010-02-12 2017-09-13 Chimerix, Inc. Methods of treating viral infection
CN102939291B (en) * 2010-04-14 2016-09-07 加利福尼亚大学董事会 Phosphonate ester for the toxicity with reduction for the treatment of of viral infections
AU2011248620B2 (en) 2010-04-26 2015-11-26 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
ES2700117T3 (en) * 2010-08-31 2019-02-14 Chimerix Inc Derivatives of phosphonate ester and methods of synthesis thereof
EP2794624B1 (en) 2011-12-22 2019-05-15 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
WO2014143643A1 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California, A California Corporation Acyclic nucleoside phosphonate diesters
KR102589658B1 (en) 2014-09-15 2023-10-13 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Nucleotide analogs
EP3303359A1 (en) 2015-05-27 2018-04-11 Idenix Pharmaceuticals LLC Nucleotides for the treatment of cancer
CN104961786B (en) * 2015-06-05 2018-09-25 苏州大学 Pro-drug based on gemcitabine structure and its application
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs
TW202322824A (en) 2020-02-18 2023-06-16 美商基利科學股份有限公司 Antiviral compounds
KR20230057419A (en) 2020-08-24 2023-04-28 길리애드 사이언시즈, 인코포레이티드 Phospholipid compounds and uses thereof
TWI811812B (en) 2020-10-16 2023-08-11 美商基利科學股份有限公司 Phospholipid compounds and uses thereof
CN117120444A (en) 2021-04-16 2023-11-24 吉利德科学公司 Method for preparing carbanucleoside using amide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0262876A2 (en) * 1986-09-27 1988-04-06 Toyo Jozo Kabushiki Kaisha Nucleoside-phospholipid conjugate
WO1991019726A1 (en) * 1990-06-15 1991-12-26 Wake Forest University Ether lipid-nucleoside covalent conjugates
WO1992003462A1 (en) * 1990-08-20 1992-03-05 Boehringer Mannheim Gmbh New phospholipid derivatives of nucleosides, their preparation and their use as antiviral drugs
WO1995032984A1 (en) * 1994-05-28 1995-12-07 Boehringer Mannheim Gmbh New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs
WO1996039831A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
WO2002087465A2 (en) * 2001-04-27 2002-11-07 Wake Forest University Compositions and methods of double-targeting virus infections and cancer cells

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS264222B1 (en) 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
CS263955B1 (en) 1986-07-18 1989-05-12 Holy Antonin Method of heterocyclic bases' n-(3-hydroxy-2-phosphonylmethoxypropyl)derivatives production
CS263956B1 (en) 1986-07-18 1989-05-12 Holy Antonin Method of 9-(s)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine production
CS263953B1 (en) 1986-07-18 1989-05-12 Holy Antonin Method of 9-(s) or 9-(rs)-(3-hydroxy-2-phosponylmethoxypropyl)adenine production
US5650510A (en) 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US5033352A (en) 1989-01-19 1991-07-23 Yamaha Corporation Electronic musical instrument with frequency modulation
IT1229203B (en) 1989-03-22 1991-07-25 Bioresearch Spa USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
US5411947A (en) * 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
SK280313B6 (en) 1990-04-24 1999-11-08 �Stav Organick� Chemie A Biochemie Av �R N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, process for their preparation and their use
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
DE552178T1 (en) 1990-10-12 1994-02-03 Max Planck Gesellschaft MODIFIED RIBOZYMS.
GB9126209D0 (en) 1991-12-10 1992-02-12 Orion Yhtymae Oy Drug formulations for parenteral use
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5652094A (en) 1992-01-31 1997-07-29 University Of Montreal Nucleozymes
GB9205917D0 (en) 1992-03-18 1992-04-29 Smithkline Beecham Plc Pharmaceuticals
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US5532225A (en) 1992-07-31 1996-07-02 Sri International Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US6444656B1 (en) 1992-12-23 2002-09-03 Biochem Pharma, Inc. Antiviral phosphonate nucleotides
GB9226879D0 (en) 1992-12-23 1993-02-17 Iaf Biochem Int Anti-viral compounds
US6005107A (en) 1992-12-23 1999-12-21 Biochem Pharma, Inc. Antiviral compounds
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5817647A (en) 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
JPH09506333A (en) 1993-09-17 1997-06-24 ギリアード サイエンシーズ，インコーポレイテッド Method of administering therapeutic compound
US5656745A (en) 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
DE59506763D1 (en) 1994-06-29 1999-10-14 Ciba Sc Holding Ag New crystal modification of a diketopyrrolopyrrole pigment
IT1270594B (en) 1994-07-07 1997-05-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
WO1997000262A1 (en) 1995-06-15 1997-01-03 Mitsubishi Chemical Corporation Phosphonate nucleotide derivatives
US5717095A (en) 1995-12-29 1998-02-10 Gilead Sciences, Inc. Nucleotide analogs
TW369536B (en) 1996-01-18 1999-09-11 Mitsubishi Chem Corp Phosphonate nucleotide compounds
US5877166A (en) 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
US6686462B2 (en) 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
AU6473098A (en) 1997-03-24 1998-10-20 Eli Lilly And Company Difluoronucleoside phosphonic acids and derivatives thereof
SI1040094T1 (en) 1997-12-17 2009-10-31 Biocryst Pharm Inc Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
AU4125099A (en) 1998-06-01 1999-12-20 S & T Science And Technology Inc. Antiviral phosphorus derivatives of 4'-thio-5-ethyl-2'-deoxyuridine
AU2645199A (en) 1998-11-18 2000-06-05 Viktor Veniaminovich Tets Dialkyl-1-aryl-1-(2,4-dioxo-5-amino-1,3-pyrimidin-5-yl)methy lphosphonates
EP1233770B1 (en) 1999-12-03 2008-02-13 The Regents of The University of California at San Diego Phosphonate compounds
WO2001064693A1 (en) 2000-02-29 2001-09-07 Mitsubishi Pharma Corporation Phosphonate nucleotide compound
MY141789A (en) 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
CZ292199B6 (en) 2001-03-08 2003-08-13 Ústav organické chemie a biochemie AV ČR O-phosphonomethyl choline and alkyl esters thereof, process of their preparation and use
RU2187509C1 (en) 2001-03-26 2002-08-20 Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ" Derivatives of 3'-azido-3'-deoxythymidine 5'-h-phosphonate and pharmaceutical compositions based on thereof
KR20020097384A (en) 2001-06-20 2002-12-31 미쯔비시 도꾜 세이야꾸 가부시끼가이샤 A Medicament which is Effective for a Virus Having a Resistance Mutation against a Known Medicament
BRPI0210746B8 (en) 2001-06-29 2021-05-25 Inst Of Organic Chemistry And Biochemistry Ascr 6-'2-(phosphonomethoxy)alkoxy-pyrimidine derivatives and their method of preparation
US20040023928A1 (en) 2001-10-31 2004-02-05 Colacino Joseph Matthew Phosphonate nucleotide and thiadiazole compounds for the treatment of smallpox
CN1617877A (en) 2001-12-07 2005-05-18 三菱制药株式会社 Use of phosphonate nucleotide analogue for treating hepatitis b virus infections
CA2481449A1 (en) 2002-04-26 2003-11-06 Gilead Sciences, Inc. Method and compositions for identifying anti-hiv therapeutic compounds
US7247621B2 (en) 2002-04-30 2007-07-24 Valeant Research & Development Antiviral phosphonate compounds and methods therefor
AU2003242428A1 (en) 2002-05-24 2003-12-12 Mitsubishi Pharma Corporation Drugs improved in tissue selectivity
NZ542342A (en) 2003-04-25 2009-05-31 Gilead Sciences Inc Antiviral phosphonate analogs

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0262876A2 (en) * 1986-09-27 1988-04-06 Toyo Jozo Kabushiki Kaisha Nucleoside-phospholipid conjugate
WO1991019726A1 (en) * 1990-06-15 1991-12-26 Wake Forest University Ether lipid-nucleoside covalent conjugates
WO1992003462A1 (en) * 1990-08-20 1992-03-05 Boehringer Mannheim Gmbh New phospholipid derivatives of nucleosides, their preparation and their use as antiviral drugs
WO1995032984A1 (en) * 1994-05-28 1995-12-07 Boehringer Mannheim Gmbh New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs
WO1996039831A1 (en) * 1995-06-07 1996-12-19 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
WO2002087465A2 (en) * 2001-04-27 2002-11-07 Wake Forest University Compositions and methods of double-targeting virus infections and cancer cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALEXANDER RICHARD L ET AL: "Synthesis and cytotoxic activity of two novel 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid conjugates with gemcitabine and cytosine arabinoside.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 19, 11 September 2003 (2003-09-11), pages 4205 - 4208, XP002384925, ISSN: 0022-2623 *
KEITH K A ET AL: "Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 48, no. 5, 2004, pages 1869 - 1871, XP002342012, ISSN: 0066-4804 *

Also Published As

Publication number Publication date
WO2006066074A2 (en) 2006-06-22
ES2401285T3 (en) 2013-04-18
US8318700B2 (en) 2012-11-27
US20080221061A1 (en) 2008-09-11
EP1831235A2 (en) 2007-09-12
US20120122818A1 (en) 2012-05-17
EP1831235B1 (en) 2013-02-20
US8101745B2 (en) 2012-01-24

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