WO2006067122A3 - Binding molecules capable of neutralizing west nile virus and uses thereof - Google Patents

Binding molecules capable of neutralizing west nile virus and uses thereof Download PDF

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Publication number
WO2006067122A3
WO2006067122A3 PCT/EP2005/056926 EP2005056926W WO2006067122A3 WO 2006067122 A3 WO2006067122 A3 WO 2006067122A3 EP 2005056926 W EP2005056926 W EP 2005056926W WO 2006067122 A3 WO2006067122 A3 WO 2006067122A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding molecules
west nile
nile virus
neutralizing
human binding
Prior art date
Application number
PCT/EP2005/056926
Other languages
French (fr)
Other versions
WO2006067122A2 (en
Inventor
Mark Throsby
Kruif Cornelis Adriaan De
Original Assignee
Crucell Holland Bv
Mark Throsby
Kruif Cornelis Adriaan De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crucell Holland Bv, Mark Throsby, Kruif Cornelis Adriaan De filed Critical Crucell Holland Bv
Priority to AU2005318171A priority Critical patent/AU2005318171B2/en
Priority to AT05821472T priority patent/ATE516307T1/en
Priority to SI200531362T priority patent/SI1828247T1/en
Priority to CA2591665A priority patent/CA2591665C/en
Priority to DK05821472.7T priority patent/DK1828247T3/en
Priority to EP05821472A priority patent/EP1828247B1/en
Publication of WO2006067122A2 publication Critical patent/WO2006067122A2/en
Priority to US11/511,127 priority patent/US7537764B2/en
Priority to US11/625,613 priority patent/US7244430B2/en
Priority to IL183723A priority patent/IL183723A/en
Publication of WO2006067122A3 publication Critical patent/WO2006067122A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6839—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting material from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention provides human binding molecules specifically binding to West Nile virus and having West Nile virus neutralizing activity, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, post-exposure prophylaxis and/or treatment of a condition resulting from West Nile virus.
PCT/EP2005/056926 2004-12-20 2005-12-19 Binding molecules capable of neutralizing west nile virus and uses thereof WO2006067122A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2005318171A AU2005318171B2 (en) 2004-12-20 2005-12-19 Binding molecules capable of neutralizing West Nile virus and uses thereof
AT05821472T ATE516307T1 (en) 2004-12-20 2005-12-19 BINDING MOLECULES CAPABILITY FOR NEUTRALIZING WEST NILE VIRUS AND THEIR APPLICATIONS
SI200531362T SI1828247T1 (en) 2004-12-20 2005-12-19 Binding molecules capable of neutralizing west nile virus and uses thereof
CA2591665A CA2591665C (en) 2004-12-20 2005-12-19 Binding molecules capable of neutralizing west nile virus and uses thereof
DK05821472.7T DK1828247T3 (en) 2004-12-20 2005-12-19 Binding molecules capable of neutralizing West Nile virus as well as their applications
EP05821472A EP1828247B1 (en) 2004-12-20 2005-12-19 Binding molecules capable of neutralizing west nile virus and uses thereof
US11/511,127 US7537764B2 (en) 2004-12-20 2006-08-28 Binding molecules capable of neutralizing west nile virus and uses thereof
US11/625,613 US7244430B2 (en) 2004-12-20 2007-01-22 Binding molecules capable of neutralizing West Nile virus and uses thereof
IL183723A IL183723A (en) 2004-12-20 2007-06-06 Binding molecules capable of neutralizing west nile virus and uses thereof

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
EPPCT/EP2004/053609 2004-12-20
EPPCT/EP04/53609 2004-12-20
EPPCT/EP2005/052160 2005-05-12
EPPCT/EP05/52160 2005-05-12
EPPCT/EP05/52648 2005-06-08
EPPCT/EP2005/052648 2005-06-08
EPPCT/EP2005/052946 2005-06-23
EPPCT/EP05/52946 2005-06-23
EPPCT/EP05/54002 2005-08-15
EPPCT/EP2005/054002 2005-08-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EPPCT/EP05/54002 Continuation-In-Part 2004-12-20 2005-08-15

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EPPCT/EP04/53609 Continuation-In-Part 2004-12-20 2004-12-20
US11/511,127 Continuation-In-Part US7537764B2 (en) 2004-12-20 2006-08-28 Binding molecules capable of neutralizing west nile virus and uses thereof

Publications (2)

Publication Number Publication Date
WO2006067122A2 WO2006067122A2 (en) 2006-06-29
WO2006067122A3 true WO2006067122A3 (en) 2007-08-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/056926 WO2006067122A2 (en) 2004-12-20 2005-12-19 Binding molecules capable of neutralizing west nile virus and uses thereof

Country Status (5)

Country Link
US (2) US7537764B2 (en)
AU (1) AU2005318171B2 (en)
CA (1) CA2591665C (en)
IL (1) IL183723A (en)
WO (1) WO2006067122A2 (en)

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CA2591665C (en) 2015-05-05
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