WO2006075139A3 - Novel process for the preparation of substituted indoles - Google Patents

Novel process for the preparation of substituted indoles Download PDF

Info

Publication number
WO2006075139A3
WO2006075139A3 PCT/GB2006/000060 GB2006000060W WO2006075139A3 WO 2006075139 A3 WO2006075139 A3 WO 2006075139A3 GB 2006000060 W GB2006000060 W GB 2006000060W WO 2006075139 A3 WO2006075139 A3 WO 2006075139A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
novel process
substituted indoles
indoles
substituted
Prior art date
Application number
PCT/GB2006/000060
Other languages
French (fr)
Other versions
WO2006075139A2 (en
Inventor
Philip Keegan
Eric Merifield
Duncan Gill
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Philip Keegan
Eric Merifield
Duncan Gill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2007008348A priority Critical patent/MX2007008348A/en
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Philip Keegan, Eric Merifield, Duncan Gill filed Critical Astrazeneca Ab
Priority to NZ556147A priority patent/NZ556147A/en
Priority to CA002594391A priority patent/CA2594391A1/en
Priority to AU2006205697A priority patent/AU2006205697B2/en
Priority to BRPI0606639-9A priority patent/BRPI0606639A2/en
Priority to EP06700281A priority patent/EP1844012A2/en
Priority to JP2007550831A priority patent/JP2008526936A/en
Priority to US11/813,816 priority patent/US7781598B2/en
Priority to CN2006800023115A priority patent/CN101102999B/en
Publication of WO2006075139A2 publication Critical patent/WO2006075139A2/en
Publication of WO2006075139A3 publication Critical patent/WO2006075139A3/en
Priority to IL183965A priority patent/IL183965A0/en
Priority to NO20074047A priority patent/NO20074047L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Abstract

The invention relates to a novel process for the preparation of substituted indoles which are useful as therapeutic agents.
PCT/GB2006/000060 2005-01-13 2006-01-09 Novel process for the preparation of substituted indoles WO2006075139A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP06700281A EP1844012A2 (en) 2005-01-13 2006-01-09 Novel process for the preparation of substituted indoles
NZ556147A NZ556147A (en) 2005-01-13 2006-01-09 Novel process for the preparation of substituted indoles
CA002594391A CA2594391A1 (en) 2005-01-13 2006-01-09 Process for the preparation of substituted indoles
AU2006205697A AU2006205697B2 (en) 2005-01-13 2006-01-09 Novel process for the preparation of substituted indoles
BRPI0606639-9A BRPI0606639A2 (en) 2005-01-13 2006-01-09 new process for the preparation of substituted indoles
MX2007008348A MX2007008348A (en) 2005-01-13 2006-01-09 Novel process for the preparation of substituted indoles.
JP2007550831A JP2008526936A (en) 2005-01-13 2006-01-09 New method for producing substituted indoles
US11/813,816 US7781598B2 (en) 2005-01-13 2006-01-09 Process for the preparation of substituted indoles
CN2006800023115A CN101102999B (en) 2005-01-13 2006-01-09 Novel process for the preparation of substituted indoles
IL183965A IL183965A0 (en) 2005-01-13 2007-06-14 Novel process for the preparation of substituted indoles
NO20074047A NO20074047L (en) 2005-01-13 2007-08-06 New process for the production of substituted indoles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0500604.4A GB0500604D0 (en) 2005-01-13 2005-01-13 Novel process
GB0500604.4 2005-01-13

Publications (2)

Publication Number Publication Date
WO2006075139A2 WO2006075139A2 (en) 2006-07-20
WO2006075139A3 true WO2006075139A3 (en) 2006-10-19

Family

ID=34203986

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/000060 WO2006075139A2 (en) 2005-01-13 2006-01-09 Novel process for the preparation of substituted indoles

Country Status (15)

Country Link
US (1) US7781598B2 (en)
EP (1) EP1844012A2 (en)
JP (1) JP2008526936A (en)
KR (1) KR20070104350A (en)
CN (1) CN101102999B (en)
AU (1) AU2006205697B2 (en)
BR (1) BRPI0606639A2 (en)
CA (1) CA2594391A1 (en)
GB (1) GB0500604D0 (en)
IL (1) IL183965A0 (en)
MX (1) MX2007008348A (en)
NO (1) NO20074047L (en)
NZ (1) NZ556147A (en)
WO (1) WO2006075139A2 (en)
ZA (1) ZA200705216B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (en) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0301569D0 (en) * 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (en) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
SE0303180D0 (en) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
CN101454284A (en) * 2006-05-26 2009-06-10 阿斯利康(瑞典)有限公司 Bi-aryl or aryl-heteroaryl substituted indoles
AU2010270050B9 (en) * 2009-07-06 2013-06-27 Astrazeneca Ab Intermediates and processes for the preparation of 4- (acetylamino) ) -3- [ (4-chloro-phenyl) thio] -2-methyl-1H-indole-1-acetic acid
BR112014014558A8 (en) 2011-12-16 2017-07-04 Atopix Therapeutics Ltd pharmaceutical composition, use of a crth2 antagonist and a proton pump inhibitor, and kit for the treatment of eosinophilic esophagitis
CN103288707B (en) * 2013-05-28 2015-12-23 浙江大学 A kind of preparation method of 3-benzene sulfydryl indole derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106302A1 (en) * 2003-05-27 2004-12-09 Astrazeneca Ab Novel substituted 3-sulfur indoles

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BE790679A (en) 1971-11-03 1973-04-27 Ici Ltd INDOLE DERIVATIVES
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US5095031A (en) 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
WO1993005020A1 (en) 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
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PL175788B1 (en) 1993-02-24 1999-02-26 Merck & Co Inc Inhibitors of reverse hiv transcriptase
US5486525A (en) 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5567711A (en) 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
TW472045B (en) 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
WO1999009007A1 (en) 1997-08-21 1999-02-25 American Home Products Corporation Solid phase synthesis of 2,3-disubstituted indole compounds
WO1999032482A1 (en) 1997-12-19 1999-07-01 Eli Lilly And Company Hypoglycemic imidazoline compounds
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AU5886500A (en) 1999-06-23 2001-01-09 Sepracor, Inc. Indolyl-benzimidazole antibacterials, and methods of use thereof
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JP2003535078A (en) 2000-05-31 2003-11-25 アストラゼネカ アクチボラグ Indole derivatives with vascular damage activity
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
US20040242589A1 (en) * 2001-08-07 2004-12-02 Bromidge Steven Mark 3-arylsulfonyl-7-piperzinyl-indoles-benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
TWI317634B (en) 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
DK1501826T3 (en) 2002-02-01 2007-01-29 Hoffmann La Roche Substituted indoles as alpha-1 agonists
SE0200356D0 (en) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
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JP4484108B2 (en) 2002-05-16 2010-06-16 塩野義製薬株式会社 Compound having PGD2 receptor antagonistic action
SE0201635D0 (en) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
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SE0202241D0 (en) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0202463D0 (en) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
JP4332151B2 (en) * 2002-10-30 2009-09-16 メルク フロスト カナダ リミテツド Pyridopyrrolidine and pyridoindolizine derivatives
JP4339795B2 (en) * 2002-12-03 2009-10-07 エフ．ホフマン−ラ ロシュ アーゲー Aminoalkoxyindoles as 5-HT6 receptor ligands for the treatment of CNS disorders
SE0302232D0 (en) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106302A1 (en) * 2003-05-27 2004-12-09 Astrazeneca Ab Novel substituted 3-sulfur indoles

Also Published As

Publication number Publication date
BRPI0606639A2 (en) 2009-07-07
NZ556147A (en) 2010-01-29
MX2007008348A (en) 2007-08-03
GB0500604D0 (en) 2005-02-16
KR20070104350A (en) 2007-10-25
EP1844012A2 (en) 2007-10-17
CA2594391A1 (en) 2006-07-20
US20080051586A1 (en) 2008-02-28
CN101102999B (en) 2010-12-29
CN101102999A (en) 2008-01-09
ZA200705216B (en) 2008-09-25
JP2008526936A (en) 2008-07-24
AU2006205697A1 (en) 2006-07-20
WO2006075139A2 (en) 2006-07-20
IL183965A0 (en) 2007-10-31
NO20074047L (en) 2007-08-06
AU2006205697B2 (en) 2009-01-22
US7781598B2 (en) 2010-08-24

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