WO2006081135A3 - Temperature controller for small fluid samples having different heat capacities - Google Patents

Temperature controller for small fluid samples having different heat capacities Download PDF

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Publication number
WO2006081135A3
WO2006081135A3 PCT/US2006/001967 US2006001967W WO2006081135A3 WO 2006081135 A3 WO2006081135 A3 WO 2006081135A3 US 2006001967 W US2006001967 W US 2006001967W WO 2006081135 A3 WO2006081135 A3 WO 2006081135A3
Authority
WO
WIPO (PCT)
Prior art keywords
temperature controller
temperature
outer surfaces
fluid samples
different heat
Prior art date
Application number
PCT/US2006/001967
Other languages
French (fr)
Other versions
WO2006081135A2 (en
WO2006081135B1 (en
Inventor
James E Baumgardner
Original Assignee
Oscillogy Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oscillogy Llc filed Critical Oscillogy Llc
Priority to JP2007553141A priority Critical patent/JP4829252B2/en
Priority to CN2006800030157A priority patent/CN101107507B/en
Priority to US11/814,620 priority patent/US7841247B2/en
Priority to EP06718964A priority patent/EP1848979A4/en
Priority to CA2611700A priority patent/CA2611700C/en
Publication of WO2006081135A2 publication Critical patent/WO2006081135A2/en
Publication of WO2006081135A3 publication Critical patent/WO2006081135A3/en
Publication of WO2006081135B1 publication Critical patent/WO2006081135B1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L5/00—Gas handling apparatus

Abstract

A system for controlling the temperature of fluidic samples includes a device having a first outer surface and a second outer surface which are parallel to one another. The interior of the device contains two or more channels suitable for accommodating samples. The channels lay on a common plane that is also parallel to the first and second outer surfaces. A temperature sensor is positioned between the channels along the common plane. A heater is thermally coupled to one of the two outer surfaces while a heat sink is coupled to the other of the two outer surfaces, thereby establishing a temperature gradient between the first and second outer surfaces. A temperature controller receives sensed temperature input from the temperature sensor and adjusts the heater in response thereto.
PCT/US2006/001967 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities WO2006081135A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2007553141A JP4829252B2 (en) 2005-01-25 2006-01-20 Temperature controller for microfluidic samples with different heat capacities
CN2006800030157A CN101107507B (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities
US11/814,620 US7841247B2 (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples with different heat capacities
EP06718964A EP1848979A4 (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities
CA2611700A CA2611700C (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64651405P 2005-01-25 2005-01-25
US60/646,514 2005-01-25

Publications (3)

Publication Number Publication Date
WO2006081135A2 WO2006081135A2 (en) 2006-08-03
WO2006081135A3 true WO2006081135A3 (en) 2007-02-15
WO2006081135B1 WO2006081135B1 (en) 2007-04-19

Family

ID=36740959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/001967 WO2006081135A2 (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities

Country Status (6)

Country Link
US (1) US7841247B2 (en)
EP (2) EP2339320B1 (en)
JP (1) JP4829252B2 (en)
CN (2) CN101107507B (en)
CA (1) CA2611700C (en)
WO (1) WO2006081135A2 (en)

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WO2006093589A2 (en) * 2005-02-25 2006-09-08 O.I. Corporation Improved analyte system
US20100005867A1 (en) * 2006-07-17 2010-01-14 Agilent Technologies, Inc. Temperature adjustment of a fluidic sample within a fluidic device
KR100818273B1 (en) 2006-09-04 2008-04-01 삼성전자주식회사 Method of reducing temperature difference between a pair of substrates and fluid reaction device using the same
US20110097678A1 (en) * 2009-10-05 2011-04-28 Patch Keith D Method of heating and heating apparatus
WO2011126892A2 (en) 2010-03-30 2011-10-13 Advanced Liquid Logic, Inc. Droplet operations platform
DE102014115074A1 (en) * 2014-10-16 2016-04-21 Infineon Technologies Austria Ag Contactless arrangement for controlling a temperature of an on-chip sensor device
CN104946511A (en) * 2015-05-29 2015-09-30 上海交通大学 Laminated structure chamber internal temperature sensing PCR chip
IT201600104601A1 (en) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa MICROFLUID SYSTEM
US10935472B2 (en) * 2018-03-07 2021-03-02 Honeywell International Inc. Pumped cooling system in gas detector
WO2019178121A1 (en) * 2018-03-12 2019-09-19 The Penn State Research Foundation Method and apparatus for temperature gradient microfluidics
CN108844652B (en) * 2018-04-28 2020-05-01 北京机械设备研究所 MEMS gas sensor chip, sensor and preparation method of sensor
CN112799444A (en) * 2020-12-27 2021-05-14 北京工业大学 Hematoparasite detects control by temperature change heating appearance based on 51 singlechip

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US3646313A (en) * 1970-04-08 1972-02-29 Gilford Instr Labor Inc Temperature controlled flow cell
US4066365A (en) * 1976-05-28 1978-01-03 The Perkin-Elmer Corporation Temperature control apparatus
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5525300A (en) * 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
US5593838A (en) * 1994-11-10 1997-01-14 David Sarnoff Research Center, Inc. Partitioned microelectronic device array
US5736106A (en) * 1995-01-26 1998-04-07 Tosoh Corporation Thermal cycling reaction apparatus and reactor therefor
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US6337212B1 (en) * 1999-03-08 2002-01-08 Caliper Technologies Corp. Methods and integrated devices and systems for performing temperature controlled reactions and analyses
US6428749B1 (en) * 1999-12-15 2002-08-06 Hitachi, Ltd. Advanced thermal gradient DNA chip (ATGC), the substrate for ATGC, method for manufacturing for ATGC, method and apparatus for biochemical reaction, and storage medium
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US20020143437A1 (en) * 2001-03-28 2002-10-03 Kalyan Handique Methods and systems for control of microfluidic devices

Also Published As

Publication number Publication date
US7841247B2 (en) 2010-11-30
CN101107507A (en) 2008-01-16
CN101107507B (en) 2012-10-24
EP1848979A2 (en) 2007-10-31
WO2006081135A2 (en) 2006-08-03
CA2611700A1 (en) 2006-08-03
EP2339320B1 (en) 2012-06-20
CN102929309A (en) 2013-02-13
WO2006081135B1 (en) 2007-04-19
EP2339320A1 (en) 2011-06-29
US20080006099A1 (en) 2008-01-10
JP4829252B2 (en) 2011-12-07
JP2008529002A (en) 2008-07-31
EP1848979A4 (en) 2009-09-02
CA2611700C (en) 2012-08-21

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