WO2006081135B1 - Temperature controller for small fluid samples having different heat capacities - Google Patents

Temperature controller for small fluid samples having different heat capacities

Info

Publication number
WO2006081135B1
WO2006081135B1 PCT/US2006/001967 US2006001967W WO2006081135B1 WO 2006081135 B1 WO2006081135 B1 WO 2006081135B1 US 2006001967 W US2006001967 W US 2006001967W WO 2006081135 B1 WO2006081135 B1 WO 2006081135B1
Authority
WO
WIPO (PCT)
Prior art keywords
temperature
fluidic sample
channel
sample system
temperature controlled
Prior art date
Application number
PCT/US2006/001967
Other languages
French (fr)
Other versions
WO2006081135A3 (en
WO2006081135A2 (en
Inventor
James E Baumgardner
Original Assignee
Oscillogy Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oscillogy Llc filed Critical Oscillogy Llc
Priority to CA2611700A priority Critical patent/CA2611700C/en
Priority to EP06718964A priority patent/EP1848979A4/en
Priority to CN2006800030157A priority patent/CN101107507B/en
Priority to JP2007553141A priority patent/JP4829252B2/en
Priority to US11/814,620 priority patent/US7841247B2/en
Publication of WO2006081135A2 publication Critical patent/WO2006081135A2/en
Publication of WO2006081135A3 publication Critical patent/WO2006081135A3/en
Publication of WO2006081135B1 publication Critical patent/WO2006081135B1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L5/00—Gas handling apparatus

Abstract

A system for controlling the temperature of fluidic samples includes a device having a first outer surface and a second outer surface which are parallel to one another. The interior of the device contains two or more channels suitable for accommodating samples. The channels lay on a common plane that is also parallel to the first and second outer surfaces. A temperature sensor is positioned between the channels along the common plane. A heater is thermally coupled to one of the two outer surfaces while a heat sink is coupled to the other of the two outer surfaces, thereby establishing a temperature gradient between the first and second outer surfaces. A temperature controller receives sensed temperature input from the temperature sensor and adjusts the heater in response thereto.

Claims

25AMENDED CLAIMS Received by the International Bureau on 05 January 2007 (05.01.07)
1. A temperature controlled fluidic sample system comprising: a fluidic sample device comprising: a first substrate block having a first inner surface and a first outer surface; a second substrate block having a second inner surface and a second outer surface; a first groove formed in the first inner surface, the first groove having first and second ends opening to a peripheral edge of the first substrate block; the first and second inner surfaces of the first and second substrate blocks facing each other so as to form a first through channel between the first and second substrate, wherein: the first through channel has first and second ends opening to a peripheral edge of the fluidic sample device; the first through channel incorporates said first groove; the first through channel is located between two imaginary planes that are spaced apart by a height (h) of the first through channel, the two imaginary planes being parallel to one another and defining between them a first volume in which the first through channel resides; and at least one temperature sensor configured to measure a temperature within the first volume; a heater thermally coupled to said first outer surface; a heat sink thermally coupled to said second outer siurface; and a temperature controller configured to receive temperature information from said temperature sensor and cause the heater to provide heat and the heat sink to provide cooling, such that: a temperature gradient is formed between the first outer surface and the second outer surface; and a desired temperature is maintained within said first volume.
2. The temperature controlled fluidic sample system according to claim 1 , farther comprising: a second channel formed in the fluidic sample device.
3. The temperature controlled fluidic sample system according to claim 2, wherein the first channel is occupied by a first fluid, and the second channel is occupied by a second fluid, the first and second fluids having different heat capacities.
4. The temperature controlled fluidic sample system according to claim 3, wherein the first fluid is a liquid and the second fluid is a gas,
5. The temperature controlled fluidic sample system according to claim 2, wherein: the fluidic sample device has a peripheral edge provided with at least three edge surfaces; the first end of the first channel is formed in a first edge surface; the second end of the first channel is formed in a second edge surface; the first end of the second channel is formed in said first edge surface; and the second end of the second channel is formed in a third edge surface.
6. The temperature controlled fluidic sample system according to claim 5, wherein: the peripheral edge comprises two pairs of parallel edge surfaces; and the second and third edge surfaces are parallel to one another and face in opposite directions.
7. The temperature controlled fluidic sample system according to claim 2, further comprising: a first probe in fluid communication with the first channel at a point between the first and second ends of said first channel; and a second probe in communication with the second channel at a point between the first and second ends of said second channel.
S. The temperature controlled fluidic sample system according to claim 7, wherein: the fluidic sample device has a peripheral edge provided with at least four edge surfaces; the first end of the first channel is formed in a first edge surface; the first end of the second channel is formed in said first edge surface; the second end of the first channel is formed in a second edge surface; the second end of the second channel is formed in a third edge surface; 27
the second and third edge surfaces are parallel to one another and face in opposite directions; the first and second probes both enter the fluidic sample device via a fourth edge surface; and the first and fourth edge surfaces are parallel to one another and face in opposite directions.
9. The temperature controlled fluidic sample system according to claim S5 wherein: the first and second probes are connected to a mass spectrometer.
10. The temperature controlled fluidic sample system according to claim 9, wherein: a blood sample occupies the first channel; and a gas sample occupies the second channel.
11. The temperature controlled fluidic sample system according to claim 2, further comprising tubing material occupying the first and second channels.
12. The temperature controlled fluidic sample system according to claim 1 , wherein the first and second imaginary planes are parallel to the first and seeond outer surfaces.
13. The temperature controlled fluidic sample system according to claim 12, wherein the heater provides uniform heat over a surface of said first outer surface, such that a uniform heat flux passes through the fluidic sample device in a direction orthogonal to the first and second imaginary planes.
14. The temperature controlled fluidic sample system according to claim 1, wherein the heater is interposed between a first insulating material and said first outer surface.
15. The temperature controlled fluidic sample system according to claim 1, further comprising: a second groove formed in the second inner surface, and wherein: the first and second grooves and L-shaped and combine to jointly form the first channel, in the fluidic sample device. 28
16. The temperature controlled fluidic sample system according to claim 1 , wherein the heat sink is a thermoelectric device.
17. The temperature controlled fluidic sample system according to claim 1, wherein the heat sink is room temperature air.
18. The temperature controlled fluidic sample system according to claim 17, further comprising a fan to pass said air past the second outer surface.
19. The temperature controlled fluidic sample system according to claim 1, wherein the temperature sensor is a thermistor.
20. The temperature controlled fluidic sample system according to claim 1, wherein the temperature controller employs proportional-integral -derivative control,
21. A temperature controlled fluidic sample system comprising: a fluidic sample device having first and second outer surfaces and at least one internal compartment configured to hold a fluid sample, said compartment being located between two imaginary planes that are spaced apart by a height (h) of said compartment, the two imaginary planes being parallel to one another and also parallel to the first and second outer surfaces, the two imaginary planes defining between them a first volume in which the compartment resides; at least one temperature sensor configured to measure a temperature within the first volume; a heater thermally coupled to said first outer surface; a heat sink thermally coupled to said second outer surface; and a temperature controller configured to receive temperature information from said temperature sensor and cause the heater to provide heat and the heat sink to provide cooling, such that: a temperature gradient is formed between the first outer surface and the second outer surface; and a desired temperature is maintained within said first volume. 29
22. The temperature controlled fluidic sample system according to claim 21, wherein the temperature controller is configured to implement proportional-integral-derivative control.
23. A method of controlling temperature of at least two fluidic samples having different heat capacities, the method comprising: passing first and second fluidic samples along first said second paths formed in a common device, the first fluidic sample having a first heat capacity and the second fluidic sample having a second heat capacity, said first and second paths being substantially along a common plane within said device; forming a temperature gradient in a direction orthogonal to said plane such that a uniform heat flux passes through said plane, the temperature gradient being formed between a heater thermally coupled to said device and providing heat on one side of the plane, and a heat sink thermally coupled to said device and providing cooling on an opposite side of the plane; measuring a temperature of the device at a point in said plane, said point being between the first and second paths; and adjusting at least one of the heater and the heat sink, based on the measured temperature of the device.
24. The method of controlling temperature of at least two fluidic samples according to claim 23, wherein the first and second fluidic samples have different flow rates along respective first and second paths.
25- The method of controlling temperature of at least two fluidic samples according to claim 23, comprising employing proportional-integral-derivative control to adjust the heater.
26, A method of controlling temperature of at least two fluidic samples, the method comprising: passing first and second fluidic samples along first and second paths formed in a common device, the first fluidic sample having a first flow rate through the device and the second fluidic sample having a second flow rate through the device, said first and second paths being substantially along a common plane within said device; forming a temperature gradient in a direction orthogonal to said plane such that a uniform heat flux passes through said plane, the temperature gradient being formed between a 30
heater thermally coupled to said device and providing heat on one side of the plane, and a heat sink thermally coupled to said device and providing cooling on an opposite side of the plane; measuring a temperature of the device at a point in said plane, said point being between the first and second paths; and adjusting at least one of the heater and the heat sink, based on the measured temperature of the device.
27. The method of controlling temperature of at least two fluidic samples according to claim 26, comprising employing proportionai-integral-derivative control to adjust the heater,
28. The temperature controlled fluidic sample system according to claim 1, wherein the desired temperature at which said volume is maintained is within 0.1 0C of a predetermined value.
29. The temperature controlled fluidic sample system according to claim 21, wherein the desired temperature at which said volume is maintained is within 0.1 0C of a predetermined value.
30. The method of controlling temperature of at least two fluidic samples according to claim 23, wherein adjusting at least one of the heater and the heat sink maintains a temperature at said point within 0.1 0C of a predetermined value.
31. The method of controlling temperature of at least two fluidic samples according to claim 26, wherein adjusting at least one of the heater and the heat sink maintains a temperature at said point within 0,1 PC of a predetermined value.
PCT/US2006/001967 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities WO2006081135A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2611700A CA2611700C (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities
EP06718964A EP1848979A4 (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities
CN2006800030157A CN101107507B (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities
JP2007553141A JP4829252B2 (en) 2005-01-25 2006-01-20 Temperature controller for microfluidic samples with different heat capacities
US11/814,620 US7841247B2 (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples with different heat capacities

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64651405P 2005-01-25 2005-01-25
US60/646,514 2005-01-25

Publications (3)

Publication Number Publication Date
WO2006081135A2 WO2006081135A2 (en) 2006-08-03
WO2006081135A3 WO2006081135A3 (en) 2007-02-15
WO2006081135B1 true WO2006081135B1 (en) 2007-04-19

Family

ID=36740959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/001967 WO2006081135A2 (en) 2005-01-25 2006-01-20 Temperature controller for small fluid samples having different heat capacities

Country Status (6)

Country Link
US (1) US7841247B2 (en)
EP (2) EP2339320B1 (en)
JP (1) JP4829252B2 (en)
CN (2) CN102929309A (en)
CA (1) CA2611700C (en)
WO (1) WO2006081135A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006093589A2 (en) * 2005-02-25 2006-09-08 O.I. Corporation Improved analyte system
WO2008009311A1 (en) * 2006-07-17 2008-01-24 Agilent Technologies, Inc. Temperature adjustment of a fluidic sample within a fluidic device
KR100818273B1 (en) 2006-09-04 2008-04-01 삼성전자주식회사 Method of reducing temperature difference between a pair of substrates and fluid reaction device using the same
US20110097678A1 (en) * 2009-10-05 2011-04-28 Patch Keith D Method of heating and heating apparatus
EP2553473A4 (en) 2010-03-30 2016-08-10 Advanced Liquid Logic Inc Droplet operations platform
DE102014115074A1 (en) * 2014-10-16 2016-04-21 Infineon Technologies Austria Ag Contactless arrangement for controlling a temperature of an on-chip sensor device
CN104946511A (en) * 2015-05-29 2015-09-30 上海交通大学 Laminated structure chamber internal temperature sensing PCR chip
IT201600104601A1 (en) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa MICROFLUID SYSTEM
US10935472B2 (en) * 2018-03-07 2021-03-02 Honeywell International Inc. Pumped cooling system in gas detector
US20210041379A1 (en) * 2018-03-12 2021-02-11 The Penn State Research Foundation Method and apparatus for temperature gradient microfluidics
CN108844652B (en) * 2018-04-28 2020-05-01 北京机械设备研究所 MEMS gas sensor chip, sensor and preparation method of sensor
CN112799444A (en) * 2020-12-27 2021-05-14 北京工业大学 Hematoparasite detects control by temperature change heating appearance based on 51 singlechip

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646313A (en) 1970-04-08 1972-02-29 Gilford Instr Labor Inc Temperature controlled flow cell
US4066365A (en) * 1976-05-28 1978-01-03 The Perkin-Elmer Corporation Temperature control apparatus
DK421880A (en) 1980-10-06 1982-04-07 Radiometer As DEVICE FOR ANALYSIS OF BIOLOGICAL LIQUIDS
US4443407A (en) 1981-04-02 1984-04-17 Instrumentation Laboratory Inc. Analysis system
CN2081105U (en) * 1990-10-31 1991-07-17 北京市电子工艺技术研究中心 Temp controller for heating fluid
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5343747A (en) * 1992-06-08 1994-09-06 Jay Rosen Normalized relative humidity calibration
US5349833A (en) * 1993-02-22 1994-09-27 Xontech, Inc. Cryotrap for air pollution analyzer
US5525300A (en) 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
US5700695A (en) * 1994-06-30 1997-12-23 Zia Yassinzadeh Sample collection and manipulation method
US6133567A (en) 1994-09-23 2000-10-17 The Trustees Of The University Of Pennsylvania Probe for the measurement of gas tensions
US5641400A (en) 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
JP3361200B2 (en) 1994-12-12 2003-01-07 日本原子力研究所 Exhaust gas treatment method and equipment for electron beam irradiation
JPH08196299A (en) * 1995-01-26 1996-08-06 Tosoh Corp Thermal cycling reaction apparatus and reaction vessel therefor
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
AU7016396A (en) * 1995-10-10 1997-04-30 Donald Kuhnel Fluid heater with improved heating elements controller
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6558947B1 (en) 1997-09-26 2003-05-06 Applied Chemical & Engineering Systems, Inc. Thermal cycler
US6459080B1 (en) * 1998-06-12 2002-10-01 Agilent Technologies, Inc. Miniaturized device for separating the constituents of a sample and delivering the constituents of the separated sample to a mass spectrometer
US6171850B1 (en) * 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
WO2000069561A1 (en) 1999-05-14 2000-11-23 Hitachi Chemical Research Center, Inc. Liquid metal-heating apparatus for biological/chemical sample
ATE419384T1 (en) * 1999-07-28 2009-01-15 Merck Serono Biodevelopment FLOW MICROREACTOR IN WHICH LOCAL TEMPERATURE CYCLES ACTION ON A FLOWING SAMPLE
US6657169B2 (en) 1999-07-30 2003-12-02 Stratagene Apparatus for thermally cycling samples of biological material with substantial temperature uniformity
US6346383B1 (en) 1999-12-15 2002-02-12 Hitachi, Ltd. Advanced thermal gradient DNA chip (ATGC) the substrate for ATGC, method for manufacturing for ATGC method and apparatus for biochemical reaction and storage medium
IT1313967B1 (en) 1999-12-27 2002-09-26 Thermoquest Italia Spa SYSTEM AND METHOD TO CONTROL THE TEMPERATURE OF A PERCHROMATOGRAPHIC COLUMN.
EP1123739B1 (en) 2000-02-11 2006-11-29 STMicroelectronics S.r.l. Integrated device for microfluid thermoregulation, and manufacturing process thereof
US6692700B2 (en) * 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7010391B2 (en) * 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
EP1467945A2 (en) * 2002-01-18 2004-10-20 Avery Dennison Corporation Covered microchamber structures
US6666907B1 (en) 2002-01-31 2003-12-23 Sandia Corporation Temperature programmable microfabricated gas chromatography column
KR100459896B1 (en) * 2002-03-06 2004-12-04 삼성전자주식회사 Thermostatic control Method and apparatus for Driving a PCR(polymerize chain reaction) chip
ITRM20020244A1 (en) * 2002-05-06 2003-11-06 Idiogenes S P A INTEGRATED DEVICE FOR THE PERFORMANCE OF A GENETIC INVESTIGATION AND RELATED EXAMINATION AND READING EQUIPMENT.
AU2003254093A1 (en) * 2002-07-19 2004-02-09 Isis Pharmaceuticals, Inc. Methods for mass spectrometry analysis utilizing an integrated microfluidics sample platform
US6730883B2 (en) 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
CN1812839A (en) * 2003-06-06 2006-08-02 精密公司 System and method for heating, cooling and heat cycling on microfluidic device

Also Published As

Publication number Publication date
WO2006081135A3 (en) 2007-02-15
EP1848979A4 (en) 2009-09-02
JP2008529002A (en) 2008-07-31
EP2339320A1 (en) 2011-06-29
JP4829252B2 (en) 2011-12-07
US7841247B2 (en) 2010-11-30
EP2339320B1 (en) 2012-06-20
CN102929309A (en) 2013-02-13
CA2611700C (en) 2012-08-21
US20080006099A1 (en) 2008-01-10
WO2006081135A2 (en) 2006-08-03
EP1848979A2 (en) 2007-10-31
CN101107507A (en) 2008-01-16
CA2611700A1 (en) 2006-08-03
CN101107507B (en) 2012-10-24

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